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1. Full Text Solubility shift and SUMOylaltion of promyelocytic leukemia (PML) protein in response to arsenic(III) and fate of the SUMOylated PML
by Hirano, Seishiro and Tadano, Mihoko and Kobayashi, Yayoi and Udagawa, Osamu and Kato, Ayaka
Toxicology and Applied Pharmacology, ISSN 0041-008X, 09/2015, Volume 287, Issue 3, pp. 191 - 201
Promyelocytic leukemia (PML), which is a tumor suppressor protein that nevertheless plays an important role in the maintenance of leukemia initiating cells, is... 
Promyelocytic leukemia | SUMO | Arsenic | Metalloid | Immunofluorescence | ONCOPROTEIN | TRIOXIDE | ACID | RAR-ALPHA | ARSENITE | NUCLEAR-BODIES | GLUTATHIONE | PATHWAY | RESISTANCE | DEGRADATION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Tumor Suppressor Proteins - metabolism | Transcription Factors - chemistry | Antimony - toxicity | Glutathione - metabolism | Small Ubiquitin-Related Modifier Proteins - metabolism | Humans | Solubility | Chlorides - toxicity | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Transcription Factors - metabolism | Transfection | Protein Processing, Post-Translational - drug effects | Sodium Compounds - toxicity | Time Factors | Arsenites - toxicity | Tumor Suppressor Proteins - chemistry | HEK293 Cells | Sumoylation | SUMO-1 Protein - metabolism | Ubiquitins - metabolism | Promyelocytic Leukemia Protein | Index Medicus | ANTIMONY IONS | MONOMERS | METALLOTHIONEIN | CARCINOGENS | LYSIS | BISMUTH | 60 APPLIED LIFE SCIENCES | SOLUBILITY | ARSENIC | CHEMICAL BONDS | MUTANTS | CHELATES | CULTURE MEDIA | GENES | BISMUTH IONS | LEUKEMIA | ARSENIC IONS | ANTIMONY
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2. Full Text Age-related disruption of autophagy in dermal fibroblasts modulates extracellular matrix components
by Tashiro, Kanae and Shishido, Mayumi and Fujimoto, Keiko and Hirota, Yuko and Yo, Kazuyuki and Gomi, Takamasa and Tanaka, Yoshitaka
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2014, Volume 443, Issue 1, pp. 167 - 172
Autophagy is an intracellular degradative system that is believed to be involved in the aging process. The contribution of autophagy to age-related changes in... 
Extracellular matrix | Dermal fibroblast | Autophagosome | Autophagy | LOCALIZATION | LIPOFUSCIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | KERATINOCYTES | BIOPHYSICS | GROWTH | DEGRADATION | ACCUMULATION | DIFFERENTIATION | PROTEINS | SKIN IN-VIVO | LC3 | Skin - cytology | Fibroblasts - physiology | Microtubule-Associated Proteins - metabolism | Humans | Middle Aged | Cells, Cultured | Phagosomes - physiology | Skin Aging | Proteasome Endopeptidase Complex - physiology | Extracellular Matrix - physiology | Adult | Female | Matrix Metalloproteinase 1 - metabolism | Index Medicus | TRANSMISSION ELECTRON MICROSCOPY | COLLAGEN | INHIBITION | MICROTUBULES | LIGHT BULBS | AGING | SKIN | RECEPTORS | 60 APPLIED LIFE SCIENCES | PHOSPHOENOLPYRUVATE | FIBROBLASTS
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3. Full Text Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells
by Negoro, Ryosuke and Takayama, Kazuo and Nagamoto, Yasuhito and Sakurai, Fuminori and Tachibana, Masashi and Mizuguchi, Hiroyuki
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2016, Volume 472, Issue 4, pp. 631 - 636
Many drugs have potential to induce the expression of drug-metabolizing enzymes, particularly cytochrome P450 3A4 (CYP3A4), in small intestinal enterocytes.... 
Enterocyte-like cells | Nuclear receptor | CYP3A4 induction | Human iPS cells | Caco-2 Cells | Cell Line | Drug Evaluation, Preclinical - methods | Enterocytes - metabolism | Humans | Cells, Cultured | Transcriptome | Cell Culture Techniques - methods | Enterocytes - drug effects | Cytochrome P-450 CYP3A - metabolism | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Drugs | Corticosteroids | Analysis | Cytochrome P-450 | Stem cells | Models | Molecular biology | Gene expression | Fatty acids | Biomedical engineering | Protein binding | Calcifediol | Vitamin D | Fibroblast growth factors | Alfacalcidol | Rifampin | Index Medicus | ANTIBIOTICS | DEXAMETHASONE | INTESTINES | PHENOBARBITAL | SIMULATION | 60 APPLIED LIFE SCIENCES | FIBROBLASTS | GROWTH FACTORS | ENZYMES | CARBOXYLIC ACIDS | STEM CELLS | RECEPTORS | VITAMIN D | PLANT GROWTH
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4. Full Text Synthesis and evaluation of a radioiodinated peptide probe targeting αvβ6 integrin for the detection of pancreatic ductal adenocarcinoma
by Ueda, Masashi and Fukushima, Takahiro and Ogawa, Kei and Kimura, Hiroyuki and Ono, Masahiro and Yamaguchi, Takashi and Ikehara, Yuzuru and Saji, Hideo
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2014, Volume 445, Issue 3, pp. 661 - 666
Pancreatic ductal adenocarcinoma (PDAC) remains a major cause of cancer-related death. Since significant upregulation of αvβ6 integrin has been reported in... 
Nuclear medical imaging | Small animal SPECT/CT | Pancreatic ductal adenocarcinoma | αvβ6 Integrin | Amino Acid Sequence | Tomography, Emission-Computed, Single-Photon - methods | Peptides - chemistry | Pancreatic Neoplasms - diagnosis | Humans | Peptides - pharmacokinetics | Molecular Sequence Data | Pancreas - pathology | Iodine Radioisotopes - pharmacokinetics | Integrins - analysis | Carcinoma, Pancreatic Ductal - diagnostic imaging | Tissue Distribution | Animals | Peptides - chemical synthesis | Carcinoma, Pancreatic Ductal - diagnosis | Cell Line, Tumor | Iodine Radioisotopes - chemistry | Mice | Antigens, Neoplasm - analysis | Pancreatic Neoplasms - diagnostic imaging | Pancreas - diagnostic imaging | Index Medicus | BIOMEDICAL RADIOGRAPHY | PANCREAS | IN VIVO | 60 APPLIED LIFE SCIENCES | IODINE 125 | IODINE 123 | PROBES | PEPTIDES | AFFINITY | CARCINOMAS | MICE | AUTORADIOGRAPHY | SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
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5. Full Text Evidence for toxicity differences between inorganic arsenite and thioarsenicals in human bladder cancer cells
by Naranmandura, Hua and Ogra, Yasumitsu and Iwata, Katsuya and Lee, Jane and Suzuki, Kazuo T and Weinfeld, Michael and Le, X. Chris
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2009, Volume 238, Issue 2, pp. 133 - 140
Arsenic toxicity is dependent on its chemical species. In humans, the bladder is one of the primary target organs for arsenic-induced carcinogenicity. However,... 
Dimethylmonothioarsinic acid | Reactive oxygen species | Arsenic | Arsenite | Bladder cancer | Dimethyldithioarsinic acid | Dimethylarsinic acid | Thioarsenical | RAT-BLOOD | DNA-DAMAGE | THIO-DIMETHYLARSINATE | MAMMALIAN-CELLS | DIMETHYLTHIOARSENICALS | CULTURED HUMAN-CELLS | ENDOTHELIAL-CELLS | MONOMETHYLARSONOUS ACID | PHARMACOLOGY & PHARMACY | TOXICOLOGY | METHYLATED TRIVALENT ARSENICALS | Reactive Oxygen Species - metabolism | Cacodylic Acid - pharmacokinetics | Environmental Pollutants - pharmacokinetics | Carcinoma, Squamous Cell - metabolism | Humans | Aquaporins - metabolism | Lethal Dose 50 | Carcinogenicity Tests | Aquaporins - drug effects | Arsenic Poisoning - metabolism | Cacodylic Acid - analogs & derivatives | Arsenites - toxicity | Vulvar Neoplasms - metabolism | Cell Line, Tumor | Arsenites - pharmacokinetics | Female | Arsenicals - pharmacokinetics | Carcinoma - metabolism | Environmental Pollutants - toxicity | Cacodylic Acid - toxicity | Urinary Bladder Neoplasms - metabolism | Phosphates | Messenger RNA | Oncology, Experimental | Analysis | Aquaporins | Liquid chromatography | Research | Sugars | Arsenic compounds | Monosaccharides | Cancer | Index Medicus | HUMAN POPULATIONS | APOPTOSIS | ARSENIC | ARSENIC COMPOUNDS | POLYMERASE CHAIN REACTION | ORGANIC ARSENIC COMPOUNDS | ORGANIC SULFUR COMPOUNDS | CARCINOMAS | BLADDER | ICP MASS SPECTROSCOPY | 60 APPLIED LIFE SCIENCES
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6. Full Text Effects of arsenic on modification of promyelocytic leukemia (PML): PML responds to low levels of arsenite
by Hirano, Seishiro and Watanabe, Takayuki and Kobayashi, Yayoi
Toxicology and Applied Pharmacology, ISSN 0041-008X, 12/2013, Volume 273, Issue 3, pp. 590 - 599
Inorganic arsenite (iAs ) is a two-edged sword. iAs is a well-known human carcinogen; nevertheless, it has been used as a therapeutic drug for acute... 
Promyelocytic leukemia | Western blot | Oxidative stress | SUMO | Arsenic | ICP–MS | ICP-MS | CELLS | ONCOPROTEIN | METHYLATION | RAR-ALPHA | NUCLEAR-BODIES | GLUTATHIONE | TRIVALENT ARSENICALS | DEGRADATION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PROTEINS | BINDING | Arsenites - pharmacology | Oncogene Proteins, Fusion - metabolism | Leukemia, Promyelocytic, Acute - pathology | Cricetulus | Humans | Receptors, Retinoic Acid - metabolism | Antioxidant Response Elements | Transcription Factors - genetics | Receptors, Retinoic Acid - genetics | Transcription Factors - metabolism | Animals | SUMO-1 Protein - genetics | Oncogene Proteins, Fusion - genetics | HEK293 Cells | Antineoplastic Agents - pharmacology | SUMO-1 Protein - metabolism | Oxidative Stress - drug effects | Retinoic Acid Receptor alpha | CHO Cells | Leukemia, Promyelocytic, Acute - drug therapy | Ubiquitin | Cysteine | Leukemia | Arsenic compounds | Index Medicus | OXIDATION | TRANSCRIPTION FACTORS | ANTIOXIDANTS | CARCINOGENS | CYSTEINE | 60 APPLIED LIFE SCIENCES | LUCIFERASE | STRESSES | ARSENIC | RETINOIC ACID | DRUGS | LEUKEMIA | RECEPTORS
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7. Full Text Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 box
by Moriyama, Tetsuji and Sangel, Percival and Yamaguchi, Hiroki and Obuse, Chikashi and Miyamoto, Yoichi and Oka, Masahiro and Yoneda, Yoshihiro
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2015, Volume 462, Issue 3, pp. 201 - 207
Tripartite motif-containing 28 (TRIM28) is a transcription regulator, which forms a repressor complex containing heterochromatin protein 1 (HP1). Here, we... 
HP1 | TIF1β | Importin α | TRIM28 | KAP1 | NLS | TIF1 β | DNA-BINDING | EPIGENETIC CONTROL | Importin alpha | BIOCHEMISTRY & MOLECULAR BIOLOGY | ZINC-FINGER PROTEINS | DOUBLE-STRAND BREAKS | IMPORTIN-ALPHA | BIOPHYSICS | HISTONE H3 | REPRESSOR DOMAIN | EMBRYONIC STEM-CELLS | TIF1 beta | LYSINE 9 | alpha Karyopherins - metabolism | beta Karyopherins - classification | Nuclear Localization Signals - genetics | Humans | Molecular Sequence Data | Tripartite Motif-Containing Protein 28 | Recombinant Fusion Proteins - metabolism | Protein Interaction Domains and Motifs | Active Transport, Cell Nucleus | Binding Sites | Repressor Proteins - metabolism | alpha Karyopherins - chemistry | Amino Acid Sequence | beta Karyopherins - chemistry | Repressor Proteins - chemistry | Chromosomal Proteins, Non-Histone - metabolism | Nuclear Localization Signals - metabolism | Repressor Proteins - genetics | Recombinant Fusion Proteins - chemistry | Chromosomal Proteins, Non-Histone - genetics | Nuclear Localization Signals - chemistry | Models, Biological | alpha Karyopherins - classification | Protein Binding | Recombinant Fusion Proteins - genetics | HeLa Cells | beta Karyopherins - metabolism | Chromosomal Proteins, Non-Histone - chemistry | Goods and services tax | Chemical properties | Index Medicus | FLUORESCENCE | GLUTATHIONE | IN VITRO | COMPLEXES | HETEROCHROMATIN | TRANSCRIPTION | SIGNALS | ARGININE | INTERACTIONS | 60 APPLIED LIFE SCIENCES | DELIVERY
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8. Full Text Eph receptor A10 has a potential as a target for a prostate cancer therapy
by Nagano, Kazuya and Yamashita, Takuya and Inoue, Masaki and Higashisaka, Kazuma and Yoshioka, Yasuo and Abe, Yasuhiro and Mukai, Yohei and Kamada, Haruhiko and Tsutsumi, Yasuo and Tsunoda, Shin-ichi
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2014, Volume 450, Issue 1, pp. 545 - 549
We recently identified Eph receptor A10 (EphA10) as a novel breast cancer-specific protein. Moreover, we also showed that an in-house developed anti-EphA10... 
Prostate cancer | Eph receptor A10 | Antibody drug | SURVIVAL | BIOPHYSICS | ANGIOGENESIS | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIBODY | MICE | METASTATIC PROGRESSION | TUMOR-GROWTH | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Antineoplastic Agents - immunology | Cell Survival | Colonic Neoplasms - drug therapy | Humans | Antibodies, Monoclonal - therapeutic use | Male | Treatment Outcome | Antineoplastic Agents - therapeutic use | Breast Neoplasms - drug therapy | Colonic Neoplasms - metabolism | Breast Neoplasms - metabolism | Breast Neoplasms - pathology | Colonic Neoplasms - pathology | Biomarkers, Tumor - metabolism | Cell Line, Tumor | Female | Receptors, Eph Family - metabolism | Drug Delivery Systems - methods | Antibodies, Monoclonal - immunology | Prostatic Neoplasms - drug therapy | Receptors, Eph Family - immunology | Antimitotic agents | Care and treatment | RNA | Colorectal cancer | Antineoplastic agents | Health aspects | Cancer | Index Medicus | HUMAN POPULATIONS | PROSTATE | LARGE INTESTINE | MAMMARY GLANDS | MONOCLONAL ANTIBODIES | NEOPLASMS | CELL PROLIFERATION | ANIMAL TISSUES | TOXICITY | 60 APPLIED LIFE SCIENCES | THERAPY | MESSENGER-RNA | DNA | DRUGS | SCREENING | RECEPTORS
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9. Full Text Solid-state NMR analysis of the [beta]-strand orientation of the protofibrils of amyloid [beta]-protein
by Doi, Takashi and Masuda, Yuichi and Irie, Kazuhiro and Akagi, Ken-Ichi and Monobe, Youko and Imazawa, Takayoshi and Takegoshi, K
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2012, Volume 428, Issue 4, p. 458
a* The supramolecular structure of A[beta]42 protofibrils was analyzed by solid-state NMR. a* The Ala-21 residue in the A[beta]42 protofibrils is included in a... 
Ionization | Analysis | Biological apparatus and supplies | Liquid chromatography | Universities and colleges | Nuclear magnetic resonance | Mass spectrometry | Alzheimer's disease | TIME-OF-FLIGHT METHOD | HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY | DESORPTION | NERVOUS SYSTEM DISEASES | NUCLEAR MAGNETIC RESONANCE | MASS SPECTROSCOPY | AMPLITUDES | PROTEINS | 60 APPLIED LIFE SCIENCES | BRAIN
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10. Full Text Blockade of the ERK pathway enhances the therapeutic efficacy of the histone deacetylase inhibitor MS-275 in human tumor xenograft models
by Sakamoto, Toshiaki and Ozaki, Kei-ichi and Fujio, Kohsuke and Kajikawa, Shu-hei and Uesato, Shin-ichi and Watanabe, Kazushi and Tanimura, Susumu and Koji, Takehiko and Kohno, Michiaki
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2013, Volume 433, Issue 4, pp. 456 - 462
The ERK pathway is up-regulated in various human cancers and represents a prime target for mechanism-based approaches to cancer treatment. Specific blockade of... 
ERK pathway | HDAC inhibitor | MEK inhibitor | Combination therapy | Synergistic drug interaction | ERR pathway | CELLS | APOPTOSIS | CONSTITUTIVE ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAP KINASES | CANCER-THERAPY | BIOPHYSICS | MICROTUBULE-DESTABILIZING AGENTS | SIGNALING PATHWAY | AZD6244 ARRY-142886 | CYTOTOXICITY | REGULATED KINASE PATHWAY | In Situ Nick-End Labeling | Phosphorylation | Oxidative Stress | Humans | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Antineoplastic Combined Chemotherapy Protocols - pharmacology | MAP Kinase Signaling System | Drug Synergism | HT29 Cells | Xenograft Model Antitumor Assays | Animals | Time Factors | Mice, Nude | Benzimidazoles - pharmacology | Female | Histone Deacetylase Inhibitors - pharmacology | Benzamides - pharmacology | Mice | Mice, Inbred BALB C | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Apoptosis | Care and treatment | Health aspects | Tumors | Cancer | Index Medicus | OXIDATION | PATIENTS | THERAPY | NEOPLASMS | IN VITRO | DRUGS | MICE | TOXICITY | TUMOR CELLS | 60 APPLIED LIFE SCIENCES | DNA DAMAGES
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11. Full Text Up-regulation of K(ir)2.1 by ER stress facilitates cell death of brain capillary endothelial cells
by Kito, H and Yamazaki, D and Ohya, S and Yamamura, H and Asai, K and Imaizumi, Y
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 07/2011, Volume 411, Issue 2, pp. 293 - 298
Brain capillary endothelial cells (BCECs) form blood brain barrier (BBB) to maintain brain homeostasis. Cell turnover of BCECs by the balance of cell... 
KIR2.1 CHANNELS | RECTIFYING POTASSIUM CHANNELS | APOPTOSIS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | Tunicamycin | TRANSCRIPTION | ER stress | MECHANISMS | BIOPHYSICS | Cell death | Inward rectifier K+ channel | RELEVANCE | DISEASE | Membrane hyperpolarization | Brain capillary endothelial cell | ATP | K+ CHANNELS | Endothelium, Vascular - cytology | Cell Line | Up-Regulation | Stress, Physiological | Endoplasmic Reticulum - metabolism | Endothelium, Vascular - drug effects | Endothelium, Vascular - physiology | Potassium Channels, Inwardly Rectifying - biosynthesis | Brain - blood supply | Animals | Cattle | Tunicamycin - pharmacology | Capillaries | Index Medicus | HOMEOSTASIS | CALCIUM IONS | CATTLE | MEMBRANES | CELL PROLIFERATION | BLOOD-BRAIN BARRIER | 60 APPLIED LIFE SCIENCES | CAPILLARIES | ENDOPLASMIC RETICULUM | GENE REGULATION | BRAIN | RECTIFIERS
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12. Full Text CD45(low)c-Kit(high) cells have hematopoietic properties in the mouse aorta-gonad-mesonephros region
by Nobuhisa, I and Yamasaki, S and Ramadan, A and Taga, T
EXPERIMENTAL CELL RESEARCH, ISSN 0014-4827, 04/2012, Volume 318, Issue 6, pp. 705 - 715
Long-term reconstituting hematopoietic stem cells first arise from the aorta of the aorta-gonad-mesonephros (AGM) region in a mouse embryo. We have previously... 
STEM-CELLS | c-Kit | CIRCULATION | Mouse embryo | YOLK-SAC | AGM | BONE-MARROW | CELL BIOLOGY | AGM REGION | EMBRYO | ONCOLOGY | Hematopoiesis | VASCULATURE | ENDOTHELIAL-CELLS | IN-VIVO | DIFFERENTIATION | CD45 | Gonads - embryology | Leukocyte Common Antigens - metabolism | Mesonephros - cytology | Aorta - embryology | Hematopoietic Stem Cells - metabolism | Aorta - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Gonads - cytology | Gonads - metabolism | Animals | Mesonephros - embryology | Hematopoietic Stem Cells - cytology | Cell Differentiation | Mice | Aorta - cytology | Index Medicus | BLOOD FORMATION | IN VITRO | AORTA | MICE | STEM CELLS | 60 APPLIED LIFE SCIENCES | EMBRYOS | GONADS
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13. Full Text Distribution and metabolism of four different dimethylated arsenicals in hamsters
by Naranmandura, Hua and Iwata, Katsuya and Suzuki, Kazuo T and Ogra, Yasumitsu
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2010, Volume 245, Issue 1, pp. 67 - 75
Arsenic toxicity and distribution are highly dependent on animal species and its chemical species. Recently, thioarsenical has been recognized in highly toxic... 
Dimethylmonothioarsinic acid | Arsenic | Dimethyldithioarsinic acid | Thioarsenic | Dimethylarsinic acid | Thioarsenical | RAT-BLOOD | TOXICITY | THIO-DIMETHYLARSINATE | METHYLATED ARSENICALS | TISSUE DISTRIBUTION | ENDOTHELIAL-CELLS | DIMETHYLARSINOUS ACID | TRIVALENT ARSENICALS | PHARMACOLOGY & PHARMACY | RED-BLOOD-CELLS | TOXICOLOGY | PENTAVALENT | Cricetinae | Cacodylic Acid - urine | Cacodylic Acid - pharmacokinetics | Skin - metabolism | Liver - metabolism | Male | Cacodylic Acid - blood | Kidney - metabolism | Animals | Cacodylic Acid - analogs & derivatives | Erythrocytes - metabolism | Mesocricetus | Lung - metabolism | Proteins | Sulfides | Metabolites | Environmental health | Physiological aspects | Liquid chromatography | Universities and colleges | Hamsters | Protein binding | Arsenic compounds | Index Medicus | Animal wastes | BODY FLUIDS | SEMIMETALS | ARSENATES | OXYGEN COMPOUNDS | DIGESTIVE SYSTEM | LUNGS | 60 APPLIED LIFE SCIENCES | PRIMATES | KIDNEYS | ARSENIC | ELEMENTS | METABOLISM | GLANDS | URINE | VERTEBRATES | BLOOD CELLS | BIOLOGICAL WASTES | BLOOD | MAMMALS | ANIMALS | ARSENIC COMPOUNDS | METABOLITES | VEINS | RODENTS | BIOLOGICAL MATERIALS | WASTES | CARDIOVASCULAR SYSTEM | ORGANS | BLOOD VESSELS | DOSES | RESPIRATORY SYSTEM | HAMSTERS | LIVER | MEN | MAN | BODY | MALES | MATERIALS | MUSCLES
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14. Full Text Structure of the second RRM domain of Nrd1, a fission yeast MAPK target RNA binding protein, and implication for its RNA recognition and regulation
by Kobayashi, Ayaho and Kanaba, Teppei and Satoh, Ryosuke and Fujiwara, Toshinobu and Ito, Yutaka and Sugiura, Reiko and Mishima, Masaki
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2013, Volume 437, Issue 1, pp. 12 - 17
Negative regulator of differentiation 1 (Nrd1) is known as a negative regulator of sexual differentiation in fission yeast. Recently, it has been revealed that... 
Phosphorylation | Nrd1 | MAPK | RRM | SIDE-CHAIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CRYSTALLOGRAPHY | HOMOLOG | GENE ENCODES | NMR | CYTOKINESIS | BIOPHYSICS | MESSENGER-RNA | SEXUAL-DIFFERENTIATION | RESONANCES | SCHIZOSACCHAROMYCES-POMBE | Protein Structure, Tertiary | Schizosaccharomyces pombe Proteins - chemistry | Magnetic Resonance Spectroscopy | RNA-Binding Proteins - chemistry | Models, Molecular | Ribonucleoproteins - metabolism | Structure-Activity Relationship | RNA, Fungal - metabolism | Solutions | Schizosaccharomyces pombe Proteins - metabolism | Protein Binding | Structural Homology, Protein | Ribonucleoproteins - chemistry | Binding Sites | RNA-Binding Proteins - metabolism | Mitogen-Activated Protein Kinases - metabolism | RNA | Chemical properties | Protein binding | Index Medicus | MUTANTS | ACTIN | SPECTROSCOPY | GLUTATHIONE | MYOSIN | NUCLEAR MAGNETIC RESONANCE | PHOSPHORYLATION | PHOSPHINES | YEASTS | OVERHAUSER EFFECT | 60 APPLIED LIFE SCIENCES
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15. Full Text A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor
by Yashiroda, Yoko and Okamoto, Reika and Hatsugai, Kaori and Takemoto, Yasushi and Goshima, Naoki and Saito, Tamio and Hamamoto, Makiko and Sugimoto, Yoshikazu and Osada, Hiroyuki and Seimiya, Hiroyuki and Yoshida, Minoru
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 2010, Volume 394, Issue 3, pp. 569 - 573
The telomere-associated protein tankyrase 1 is a poly(ADP-ribose) polymerase and is considered to be a promising target for cancer therapy, especially for... 
High-throughput screening | Schizosaccharomyces pombe | Tankyrase 1 | Inhibitor | POLY(ADP-RIBOSE) POLYMERASE | FISSION YEAST | THERAPEUTIC STRATEGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLOBAL ANALYSIS | TRF1 | BIOPHYSICS | GENE | TELOMERASE ACTIVITY | SUPERFAMILY | HUMAN CANCER | SCHIZOSACCHAROMYCES-POMBE | Tankyrases - genetics | Cell Line | Schizosaccharomyces - drug effects | Flavones | Humans | Enzyme Inhibitors - pharmacology | Drug Discovery - methods | Tankyrases - antagonists & inhibitors | Enzyme Inhibitors - isolation & purification | Schizosaccharomyces - genetics | High-Throughput Screening Assays | Enzyme Inhibitors - chemistry | Flavonoids - isolation & purification | Flavonoids - pharmacology | Drug Evaluation, Preclinical | Flavonoids - chemistry | Enzymes | Chemotherapy | Oncology, Experimental | Biochemical genetics | Research | Universities and colleges | Robotics | Cancer | Index Medicus | THERAPY | NEOPLASMS | ENZYMES | GENES | RIBOSE | YEASTS | PHENOTYPE | SCREENING | 60 APPLIED LIFE SCIENCES | ADP
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16. Full Text Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin vesicles, can be safely used under conditions of hepatic impairment
by Taguchi, Kazuaki and Miyasato, Mayumi and Ujihira, Hayato and Watanabe, Hiroshi and Kadowaki, Daisuke and Sakai, Hiromi and Tsuchida, Eishun and Horinouchi, Hirohisa and Kobayashi, Koichi and Maruyama, Toru and Otagiri, Masaki
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2010, Volume 248, Issue 3, pp. 234 - 241
The hemoglobin vesicle (HbV) is an artificial oxygen carrier in which a concentrated Hb solution is encapsulated in lipid vesicles. Our previous studies... 
Hemoglobin vesicle | Chronic cirrhosis | Safety and toxicology evaluations | Artificial oxygen carrier | RETICULOENDOTHELIAL SYSTEM | BLOOD SUBSTITUTES | INJURY | HEMORRHAGIC-SHOCK | EXCHANGE-TRANSFUSION | HEME OXYGENASE | LIVER | PHARMACOLOGY & PHARMACY | TOXICOLOGY | FERRITIN | ANESTHETIZED RATS | RESUSCITATION | Liposomes - administration & dosage | Chemical and Drug Induced Liver Injury, Chronic - metabolism | Humans | Hemoglobins - metabolism | Rats | Male | Random Allocation | Rats, Sprague-Dawley | Blood Substitutes - metabolism | Oxygen - metabolism | Liposomes - adverse effects | Hemoglobins - administration & dosage | Hemoglobins - adverse effects | Oxygen - administration & dosage | Animals | Blood Substitutes - administration & dosage | Carbon Tetrachloride Poisoning - metabolism | Liposomes - metabolism | Chemical and Drug Induced Liver Injury, Chronic - therapy | Blood Substitutes - adverse effects | Antioxidants | Urea | Phosphatases | Analysis | Carbon tetrachloride | Albumin | Glycosylated hemoglobin | Aspartate | Bilirubin | Lipase | Polyols | Liver cirrhosis | Index Medicus | BODY FLUIDS | BLOOD SERUM | HEMOSIDERIN | DIGESTIVE SYSTEM | LUNGS | PORPHYRINS | RATS | HETEROCYCLIC COMPOUNDS | 60 APPLIED LIFE SCIENCES | PIGMENTS | KIDNEYS | SPLEEN | GLANDS | GLOBINS | VERTEBRATES | ORGANIC NITROGEN COMPOUNDS | BLOOD | MAMMALS | HEMOGLOBIN | ANIMALS | HETEROCYCLIC ACIDS | RODENTS | BIOLOGICAL MATERIALS | ORGANIC COMPOUNDS | METALLOPROTEINS | ORGANIC ACIDS | TOXICITY | BLOOD PLASMA | MORPHOLOGICAL CHANGES | ORGANS | RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS | RESPIRATORY SYSTEM | CARBOXYLIC ACIDS | PROTEINS | BODY | MATERIALS
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