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1. Full Text Regulation of the Epstein−Barr Virus LMP1-mediated NF-kappaB Signaling Pathway by a Novel Adaptor Protein STAP-2
by Ikeda, Osamu, Undergraduate, Department of Immunology, Graduate School of Pharmaceutical Sciences Hokkaido University, Sapporo, Japan and Sekine, Yuichi, Assistant, Department of Immunology, Graduate School of Pharmaceutical Sciences Hokkaido University, Sapporo, Japan and Yasui, Teruhito, Assistant, Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Japan and Sugiyma, Suita Kenji, PhD, Nippon Boehringer Ingelheim Co. Ltd. Kawanishi Pharma Research Institute, Kawanishi, Japan and Oritani, Kenji, Assistant, Department of Hematology and Oncology, Graduate School of Medicine, Osaka University, Japan and Yoshimura, Suita Akihiko, Professor, Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Japan and Matsuda, Tadashi, Professor, Department of Immunology, Graduate School of Pharmaceutical Sciences Hokkaido University, Sapporo, Japan
Clinical immunology (Orlando, Fla.), ISSN 1521-6616, 2006, Volume 123, pp. S33 - S34
Allergy and Immunology
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2. Full Text Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin vesicles, can be safely used under conditions of hepatic impairment
by Taguchi, Kazuaki and Miyasato, Mayumi and Ujihira, Hayato and Watanabe, Hiroshi and Kadowaki, Daisuke and Sakai, Hiromi and Tsuchida, Eishun and Horinouchi, Hirohisa and Kobayashi, Koichi and Maruyama, Toru and Otagiri, Masaki
Toxicology and applied pharmacology, ISSN 0041-008X, 2010, Volume 248, Issue 3, pp. 234 - 241
Hemoglobin vesicle | Chronic cirrhosis | Safety and toxicology evaluations | Artificial oxygen carrier | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Biological and medical sciences | Medical sciences | Liver. Biliary tract. Portal circulation. Exocrine pancreas | Other diseases. Semiology | Liposomes - administration & dosage | Chemical and Drug Induced Liver Injury, Chronic - metabolism | Humans | Hemoglobins - metabolism | Rats | Male | Random Allocation | Rats, Sprague-Dawley | Blood Substitutes - metabolism | Oxygen - metabolism | Liposomes - adverse effects | Hemoglobins - administration & dosage | Hemoglobins - adverse effects | Oxygen - administration & dosage | Animals | Blood Substitutes - administration & dosage | Carbon Tetrachloride Poisoning - metabolism | Liposomes - metabolism | Chemical and Drug Induced Liver Injury, Chronic - therapy | Blood Substitutes - adverse effects | Antioxidants | Urea | Phosphatases | Analysis | Carbon tetrachloride | Albumin | Glycosylated hemoglobin | Aspartate | Bilirubin | Lipase | Polyols | Liver cirrhosis | Index Medicus | BODY FLUIDS | BLOOD SERUM | HEMOSIDERIN | DIGESTIVE SYSTEM | LUNGS | PORPHYRINS | RATS | HETEROCYCLIC COMPOUNDS | 60 APPLIED LIFE SCIENCES | PIGMENTS | KIDNEYS | SPLEEN | GLANDS | GLOBINS | VERTEBRATES | ORGANIC NITROGEN COMPOUNDS | BLOOD | MAMMALS | HEMOGLOBIN | ANIMALS | HETEROCYCLIC ACIDS | RODENTS | BIOLOGICAL MATERIALS | ORGANIC COMPOUNDS | METALLOPROTEINS | ORGANIC ACIDS | TOXICITY | BLOOD PLASMA | MORPHOLOGICAL CHANGES | ORGANS | RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS | RESPIRATORY SYSTEM | LIVER | CARBOXYLIC ACIDS | PROTEINS | BODY | MATERIALS
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3. Full Text Age-related disruption of autophagy in dermal fibroblasts modulates extracellular matrix components
by Tashiro, Kanae and Shishido, Mayumi and Fujimoto, Keiko and Hirota, Yuko and Yo, Kazuyuki and Gomi, Takamasa and Tanaka, Yoshitaka
Biochemical and biophysical research communications, ISSN 0006-291X, 01/2014, Volume 443, Issue 1, pp. 167 - 172
Extracellular matrix | Dermal fibroblast | Autophagosome | Autophagy | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Skin - cytology | Fibroblasts - physiology | Microtubule-Associated Proteins - metabolism | Humans | Middle Aged | Cells, Cultured | Phagosomes - physiology | Skin Aging | Proteasome Endopeptidase Complex - physiology | Extracellular Matrix - physiology | Adult | Female | Matrix Metalloproteinase 1 - metabolism | Index Medicus | TRANSMISSION ELECTRON MICROSCOPY | COLLAGEN | INHIBITION | MICROTUBULES | LIGHT BULBS | AGING | SKIN | RECEPTORS | 60 APPLIED LIFE SCIENCES | PHOSPHOENOLPYRUVATE | FIBROBLASTS
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4. Full Text Identification and characterization of a nuclear localization signal of TRIM28 that overlaps with the HP1 box
by Moriyama, Tetsuji and Sangel, Percival and Yamaguchi, Hiroki and Obuse, Chikashi and Miyamoto, Yoichi and Oka, Masahiro and Yoneda, Yoshihiro
Biochemical and biophysical research communications, ISSN 0006-291X, 07/2015, Volume 462, Issue 3, pp. 201 - 207
HP1 | TIF1β | Importin α | TRIM28 | KAP1 | NLS | TIF1 β | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | alpha Karyopherins - metabolism | beta Karyopherins - classification | Nuclear Localization Signals - genetics | Humans | Molecular Sequence Data | Tripartite Motif-Containing Protein 28 | Recombinant Fusion Proteins - metabolism | Protein Interaction Domains and Motifs | Active Transport, Cell Nucleus | Binding Sites | Repressor Proteins - metabolism | alpha Karyopherins - chemistry | Amino Acid Sequence | beta Karyopherins - chemistry | Repressor Proteins - chemistry | Chromosomal Proteins, Non-Histone - metabolism | Nuclear Localization Signals - metabolism | Repressor Proteins - genetics | Recombinant Fusion Proteins - chemistry | Chromosomal Proteins, Non-Histone - genetics | Nuclear Localization Signals - chemistry | Models, Biological | alpha Karyopherins - classification | Protein Binding | Recombinant Fusion Proteins - genetics | HeLa Cells | beta Karyopherins - metabolism | Chromosomal Proteins, Non-Histone - chemistry | Goods and services tax | Chemical properties | Index Medicus | FLUORESCENCE | GLUTATHIONE | IN VITRO | COMPLEXES | HETEROCHROMATIN | TRANSCRIPTION | SIGNALS | ARGININE | INTERACTIONS | 60 APPLIED LIFE SCIENCES | DELIVERY
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5. Full Text Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells
by Negoro, Ryosuke and Takayama, Kazuo and Nagamoto, Yasuhito and Sakurai, Fuminori and Tachibana, Masashi and Mizuguchi, Hiroyuki
Biochemical and biophysical research communications, ISSN 0006-291X, 04/2016, Volume 472, Issue 4, pp. 631 - 636
Enterocyte-like cells | Nuclear receptor | CYP3A4 induction | Human iPS cells | Caco-2 Cells | Cell Line | Drug Evaluation, Preclinical - methods | Enterocytes - metabolism | Humans | Cells, Cultured | Transcriptome | Cell Culture Techniques - methods | Enterocytes - drug effects | Cytochrome P-450 CYP3A - metabolism | Cell Differentiation | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Drugs | Corticosteroids | Analysis | Cytochrome P-450 | Stem cells | Models | Molecular biology | Gene expression | Fatty acids | Biomedical engineering | Protein binding | Calcifediol | Vitamin D | Fibroblast growth factors | Alfacalcidol | Rifampin | Index Medicus | ANTIBIOTICS | DEXAMETHASONE | INTESTINES | PHENOBARBITAL | SIMULATION | 60 APPLIED LIFE SCIENCES | FIBROBLASTS | GROWTH FACTORS | ENZYMES | CARBOXYLIC ACIDS | STEM CELLS | RECEPTORS | VITAMIN D | PLANT GROWTH
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6. Full Text A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor
by Yashiroda, Yoko and Okamoto, Reika and Hatsugai, Kaori and Takemoto, Yasushi and Goshima, Naoki and Saito, Tamio and Hamamoto, Makiko and Sugimoto, Yoshikazu and Osada, Hiroyuki and Seimiya, Hiroyuki and Yoshida, Minoru
Biochemical and biophysical research communications, ISSN 0006-291X, 2010, Volume 394, Issue 3, pp. 569 - 573
High-throughput screening | Schizosaccharomyces pombe | Tankyrase 1 | Inhibitor | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Tankyrases - genetics | Cell Line | Schizosaccharomyces - drug effects | Flavones | Humans | Enzyme Inhibitors - pharmacology | Drug Discovery - methods | Tankyrases - antagonists & inhibitors | Enzyme Inhibitors - isolation & purification | Schizosaccharomyces - genetics | High-Throughput Screening Assays | Enzyme Inhibitors - chemistry | Flavonoids - isolation & purification | Flavonoids - pharmacology | Drug Evaluation, Preclinical | Flavonoids - chemistry | Enzymes | Chemotherapy | Oncology, Experimental | Biochemical genetics | Research | Universities and colleges | Robotics | Cancer | Index Medicus | THERAPY | NEOPLASMS | ENZYMES | GENES | RIBOSE | YEASTS | PHENOTYPE | SCREENING | 60 APPLIED LIFE SCIENCES | ADP
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7. Full Text Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila
by Igaki, Tatsushi and Suzuki, Yasuyuki and Tokushige, Naoko and Aonuma, Hiroka and Takahashi, Ryosuke and Miura, Masayuki
Biochemical and biophysical research communications, ISSN 0006-291X, 2007, Volume 356, Issue 4, pp. 993 - 997
Mitochondria | HtrA2/Omi | Cell death | Drosophila | Apoptosis | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cells, Cultured | Drosophila Proteins - metabolism | Mitochondria - ultrastructure | Apoptosis Regulatory Proteins - metabolism | High-Temperature Requirement A Serine Peptidase 2 | Animals | Mitochondrial Proteins - metabolism | Signal Transduction - physiology | Inhibitor of Apoptosis Proteins - metabolism | Serine Endopeptidases - metabolism | Apoptosis - physiology | Mitochondria - physiology | Biochemistry | Index Medicus | APOPTOSIS | IRRADIATION | RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS | SERINE | IN VITRO | MITOCHONDRIA | STIMULI | IN VIVO | PROTEINS | DROSOPHILA
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8. Full Text CD45(low)c-Kit(high) cells have hematopoietic properties in the mouse aorta-gonad-mesonephros region
by Nobuhisa, Ikuo and Yamasaki, Shoutarou and Ramadan, Ahmed and Taga, Tetsuya
Experimental cell research, ISSN 0014-4827, 04/2012, Volume 318, Issue 6, pp. 705 - 715
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Gonads - embryology | Leukocyte Common Antigens - metabolism | Mesonephros - cytology | Aorta - embryology | Hematopoietic Stem Cells - metabolism | Aorta - metabolism | Proto-Oncogene Proteins c-kit - metabolism | Gonads - cytology | Gonads - metabolism | Animals | Mesonephros - embryology | Hematopoietic Stem Cells - cytology | Cell Differentiation | Mice | Aorta - cytology | Index Medicus | BLOOD FORMATION | IN VITRO | AORTA | MICE | STEM CELLS | 60 APPLIED LIFE SCIENCES | EMBRYOS | GONADS
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9. Full Text Synthesis and evaluation of a radioiodinated peptide probe targeting αvβ6 integrin for the detection of pancreatic ductal adenocarcinoma
by Ueda, Masashi and Fukushima, Takahiro and Ogawa, Kei and Kimura, Hiroyuki and Ono, Masahiro and Yamaguchi, Takashi and Ikehara, Yuzuru and Saji, Hideo
Biochemical and biophysical research communications, ISSN 0006-291X, 03/2014, Volume 445, Issue 3, pp. 661 - 666
Nuclear medical imaging | Small animal SPECT/CT | Pancreatic ductal adenocarcinoma | αvβ6 Integrin | Amino Acid Sequence | Tomography, Emission-Computed, Single-Photon - methods | Peptides - chemistry | Pancreatic Neoplasms - diagnosis | Humans | Peptides - pharmacokinetics | Molecular Sequence Data | Pancreas - pathology | Iodine Radioisotopes - pharmacokinetics | Integrins - analysis | Carcinoma, Pancreatic Ductal - diagnostic imaging | Tissue Distribution | Animals | Peptides - chemical synthesis | Carcinoma, Pancreatic Ductal - diagnosis | Cell Line, Tumor | Iodine Radioisotopes - chemistry | Mice | Antigens, Neoplasm - analysis | Pancreatic Neoplasms - diagnostic imaging | Pancreas - diagnostic imaging | Index Medicus | BIOMEDICAL RADIOGRAPHY | PANCREAS | IN VIVO | 60 APPLIED LIFE SCIENCES | IODINE 125 | IODINE 123 | PROBES | PEPTIDES | AFFINITY | CARCINOMAS | MICE | AUTORADIOGRAPHY | SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
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10. Full Text Up-regulation of K(ir)2.1 by ER stress facilitates cell death of brain capillary endothelial cells
by Kito, Hiroaki and Yamazaki, Daiju and Ohya, Susumu and Yamamura, Hisao and Asai, Kiyofumi and Imaizumi, Yuji
Biochemical and biophysical research communications, ISSN 0006-291X, 07/2011, Volume 411, Issue 2, pp. 293 - 298
Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Endothelium, Vascular - cytology | Cell Line | Up-Regulation | Stress, Physiological | Endoplasmic Reticulum - metabolism | Endothelium, Vascular - drug effects | Endothelium, Vascular - physiology | Potassium Channels, Inwardly Rectifying - biosynthesis | Brain - blood supply | Animals | Cattle | Tunicamycin - pharmacology | Capillaries | Index Medicus | APOPTOSIS | HOMEOSTASIS | CALCIUM IONS | CATTLE | MEMBRANES | CELL PROLIFERATION | BLOOD-BRAIN BARRIER | 60 APPLIED LIFE SCIENCES | CAPILLARIES | ENDOPLASMIC RETICULUM | GENE REGULATION | BRAIN | RECTIFIERS
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11. Full Text Hypo-osmotic shock induces nuclear export and proteasome-dependent decrease of UBL5
by Hatanaka, Ken and Ikegami, Koji and Takagi, Hiroshi and Setou, Mitsutoshi
Biochemical and biophysical research communications, ISSN 0006-291X, 2006, Volume 350, Issue 3, pp. 610 - 615
Ubiquitin | Ubiquitin-like | Osmolarity | Oxytocin | Homeostasis | Hypothalamus | Vasopressin | Nuclear export | NIH-3T3 | Decrease | mRNA splicing | Hypo-osmotic | UBL | Proteasome | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Nerve Tissue Proteins - metabolism | Osmotic Pressure | Animals | Cell Nucleus - metabolism | Active Transport, Cell Nucleus - physiology | Down-Regulation | Mice, Inbred C57BL | Male | Mice | Proteasome Endopeptidase Complex - metabolism | Diuretics | Pituitary hormones | Messenger RNA | Cytochemistry | Neurons | Index Medicus | BODY FLUIDS | HOMEOSTASIS | TRANSCRIPTION | OXYTOCIN | VASOPRESSIN | 60 APPLIED LIFE SCIENCES | HYPOTHALAMUS | NERVE CELLS
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12. Full Text CrxOS maintains the self-renewal capacity of murine embryonic stem cells
by Saito, Ryota and Yamasaki, Tokiwa and Nagai, Yoko and Wu, Jinzhan and Kajiho, Hiroaki and Yokoi, Tadashi and Noda, Eiichiro and Nishina, Sachiko and Niwa, Hitoshi and Azuma, Noriyuki and Katada, Toshiaki and Nishina, Hiroshi
Biochemical and biophysical research communications, ISSN 0006-291X, 2009, Volume 390, Issue 4, pp. 1129 - 1135
Embryonic stem cell | CrxOS | In silico | Self-renewal | Homeoprotein | foxD3 | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Embryonic Stem Cells - metabolism | Mice | Animals | Homeodomain Proteins - biosynthesis | Homeodomain Proteins - genetics | RNA | Embryonic stem cells | Analysis | Index Medicus | CAPACITY | GENES | CELL PROLIFERATION | STEM CELLS | 60 APPLIED LIFE SCIENCES | MORPHOLOGY
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13. Full Text USP14 inhibits ER-associated degradation via interaction with IRE1[alpha]
by Nagai, Atsushi and Kadowaki, Hisae and Maruyama, Takeshi and Takeda, Kohsuke and Nishitoh, Hideki and Ichijo, Hidenori
Biochemical and biophysical research communications, ISSN 0006-291X, 02/2009, Volume 379, Issue 4, p. 995
Ubiquitin | Synthesis | RNA | Proteases | Physiological aspects | Control systems | Lipids | Universities and colleges | ENDOPLASMIC RETICULUM | QUALITY CONTROL | INTERACTIONS | RECEPTORS | 60 APPLIED LIFE SCIENCES | STRESSES
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14. Full Text Involvement of DNA hypermethylation in down-regulation of the zinc transporter ZIP8 in cadmium-resistant metallothionein-null cells
by Fujishiro, Hitomi and Okugaki, Satomi and Yasumitsu, Saori and Enomoto, Shuichi and Himeno, Seiichiro
Toxicology and applied pharmacology, ISSN 0041-008X, 2009, Volume 241, Issue 2, pp. 195 - 201
Resistance | Epigenetics | Cadmium | DNA hypermethylation | Transport | Zinc | Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Biological and medical sciences | Medical sciences | Chemical and industrial products toxicology. Toxic occupational diseases | Metals and various inorganic compounds | Cation Transport Proteins - biosynthesis | DNA Modification Methylases - antagonists & inhibitors | Epigenesis, Genetic | Cells, Cultured | Gene Silencing | Cadmium - pharmacology | Azacitidine - analogs & derivatives | Decitabine | Cadmium - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Azacitidine - pharmacology | RNA, Messenger - biosynthesis | DNA Methylation | Animals | Metallothionein - genetics | CpG Islands | Cation Transport Proteins - genetics | Mice | Cysteine | Messenger RNA | Methyltransferases | Ligases | DNA | Genetic research | Universities and colleges | Glutamate | Metallothionein | Index Medicus | METALLOTHIONEIN | RNA | ORGANIC COMPOUNDS | METALLOPROTEINS | NUCLEOSIDES | RIBOSIDES | SENSITIVITY | PYRIMIDINES | HETEROCYCLIC COMPOUNDS | TOXICITY | 60 APPLIED LIFE SCIENCES | AZINES | NUCLEIC ACIDS | ZINC | ELEMENTS | NUCLEOTIDES | CADMIUM | MESSENGER-RNA | METALS | DEOXYCYTIDINE | GENES | ORGANIC NITROGEN COMPOUNDS | PROTEINS
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