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International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2011, Volume 80, Issue 1, pp. 169 - 175
Purpose Avoidance radiotherapy or reduction of irradiation doses in patients with primary central nervous system lymphoma (PCNSL) in complete remission (CR)... 
Radiology | Hematology, Oncology and Palliative Medicine | Brain tumor | Neurotoxicity | Radiotherapy | Local control | Central nervous system lymphoma | PRIMARY CNS LYMPHOMA | ONCOLOGY | STRATEGY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Procarbazine - administration & dosage | Follow-Up Studies | Humans | Middle Aged | Male | Cranial Irradiation - methods | Lymphoma - mortality | Central Nervous System Neoplasms - radiotherapy | Lymphoma - drug therapy | Time Factors | Mental Status Schedule | Vincristine - administration & dosage | Adult | Female | Lymphoma - radiotherapy | Remission Induction - methods | Retrospective Studies | Brain Neoplasms - mortality | Brain Neoplasms - radiotherapy | Radiotherapy Dosage | Drug Administration Schedule | Neoplasm Recurrence, Local | Brain Neoplasms - drug therapy | Cranial Irradiation - adverse effects | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Combined Modality Therapy - methods | Central Nervous System Neoplasms - drug therapy | Central Nervous System Neoplasms - mortality | Chemotherapy | Patient outcomes | Radiation | Central nervous system | Lymphomas | Dosage and administration | Methotrexate | Cancer | Computed tomography | Remission | Disease control | Lymphoma | Survival | Tumors | Index Medicus | TOMOGRAPHY | IMMUNE SYSTEM DISEASES | NERVOUS SYSTEM | RADIATION DOSES | MEDICINE | LYMPHOMAS | ANTIMETABOLITES | THERAPY | MINIMIZATION | DRUGS | RADIOLOGY AND NUCLEAR MEDICINE | RADIOTHERAPY | BRAIN | RADIOLOGY | DIAGNOSTIC TECHNIQUES | NEOPLASMS | METHOTREXATE | CENTRAL NERVOUS SYSTEM | COMPUTERIZED TOMOGRAPHY | CHEMOTHERAPY | NUCLEAR MEDICINE | ORGANS | DISEASES | DOSES | OPTIMIZATION | BODY
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 03/2015, Volume 458, Issue 4, pp. 823 - 829
Recently GLP-1 was found to have cardioprotective effects independent of those attributable to tight glycemic control. We employed ultrasound targeted... 
Piggybac transposon gene delivery plasmids | Glucagon-like peptide-1 | Adriamycin cardiomyopathy | Myocardial regeneration | Ultrasound targeted microbubble destruction | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | DEDIFFERENTIATION | PROLIFERATION | CARDIAC PROGENITOR CELLS | CARDIOMYOCYTES | FAILURE | FORKHEAD TRANSCRIPTION FACTORS | DELIVERY | HEART | BIOPHYSICS | Genetic Therapy | Up-Regulation | Cell Proliferation | Doxorubicin | Glucagon-Like Peptide 1 - genetics | Cardiomyopathies - genetics | Forkhead Transcription Factors - metabolism | Myocardium - metabolism | Plasmids - genetics | Microbubbles | Cell Differentiation | Gene Transfer Techniques - instrumentation | Glucagon-Like Peptide 1 - metabolism | Myocytes, Cardiac - cytology | Rats | Cardiomyopathies - pathology | Myocardium - pathology | Plasmids - therapeutic use | Cardiomyopathies - therapy | Myocardium - cytology | Nerve Tissue Proteins - metabolism | Ultrasonography - instrumentation | Myocytes, Cardiac - pathology | Animals | Cyclin D1 - genetics | Myocytes, Cardiac - metabolism | Cardiomyopathies - chemically induced | Ultrasound imaging | Anthracyclines | Index Medicus | PLASMIDS | GENE THERAPY | PHOSPHORYLATION | REGENERATION | DOXORUBICIN | RATS | SIGNALS | CELL PROLIFERATION | 60 APPLIED LIFE SCIENCES | GENES | CYTOPLASM | STEM CELLS | MUSCLES | GLUCAGON
Journal Article
和漢医薬学雑誌, ISSN 1340-6302, 08/2003, Volume 20, pp. 143 - 149
柴胡桂枝湯(TJ-10)は慢性膵炎の経口治療薬として臨床的に使用されてきた。本総説ではWBN/Kobラットにおける自然発症慢性膵炎に対するTJ-10の治療効果の分子機構について我々の実験結果を中心に述べた。 RT-PCR解析によるpancreatitis-associated... 
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 03/2016, Volume 294, pp. 54 - 64
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 09/2014, Volume 279, Issue 3, pp. 351 - 363
Oxidized LDL (oxLDL) induces a pro-oxidative environment and promotes apoptosis, causing the progression of renal diseases in humans. Taurine is a... 
oxLDL | Taurine | HK-2 cells | ROS | Apoptosis | OxLDL | OXIDATIVE STRESS | OXYGEN RADICALS | DAMAGE-INDUCED PHOSPHORYLATION | DNA-DAMAGE | PERMEABILITY TRANSITION | LIPOPROTEIN-INDUCED APOPTOSIS | ENDOTHELIAL-CELLS | RENAL-FAILURE | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | TOXICOLOGY | Reactive Oxygen Species - metabolism | Humans | Caspase 3 - metabolism | Membrane Potential, Mitochondrial - drug effects | Antioxidants | Tumor Suppressor Protein p53 - physiology | Lipid Peroxidation - drug effects | Lipoproteins - metabolism | DNA - biosynthesis | Superoxide Dismutase - metabolism | In Situ Nick-End Labeling | Cell Line | Cell Survival - drug effects | Lipoproteins - isolation & purification | Kidney - drug effects | Epithelial Cells | Kidney - cytology | Mitochondria - drug effects | Blotting, Western | DNA - genetics | Microscopy, Confocal | Lipoproteins, LDL - toxicity | Lipoproteins, LDL - antagonists & inhibitors | Calcium Signaling - drug effects | Signal Transduction - physiology | Apoptosis - physiology | Taurine - pharmacology | Mitochondria - physiology | Index Medicus | CATALASE | APOPTOSIS | SUPEROXIDE DISMUTASE | ANTIOXIDANTS | PERMEABILITY | PHOSPHORYLATION | MITOCHONDRIA | SUPEROXIDE RADICALS | TOXICITY | 60 APPLIED LIFE SCIENCES | STRESSES | ALKOXY RADICALS | KIDNEYS | OXYGEN | HYDROXYL RADICALS | GLUTATHIONE | AMINO ACIDS | CALCIUM | TAURINE
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2012, Volume 425, Issue 2, pp. 328 - 332
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 11/2015, Volume 288, Issue 3, pp. 359 - 373
Gefitinib is the first-line chemotherapeutic drug for treating non-small cell lung cancer (NSCLC), which comprises nearly 85% of all lung cancer cases... 
Resistance | DIGE | Proteomics | Lung adenocarcinoma | Gefitinib | PCNT | mPR | CELLS | NSCLC | BREAST-CANCER | THERAPY | GROWTH | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PROTEOMIC ANALYSIS | CONTRIBUTES | UTERINE-CANCER | Lung Neoplasms - drug therapy | RNA, Small Interfering - genetics | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Humans | Lung Neoplasms - metabolism | ErbB Receptors - genetics | Drug Resistance, Neoplasm | Lung Neoplasms - pathology | Cell Line, Tumor - drug effects | Receptors, Progesterone - genetics | Receptors, Progesterone - metabolism | Adenocarcinoma - metabolism | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Proteomics - methods | Carcinoma, Non-Small-Cell Lung - pathology | Cell Survival - drug effects | ErbB Receptors - metabolism | Signal Transduction | Membrane Proteins - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Gene Silencing | Antigens - metabolism | Quinazolines - pharmacology | Antigens - genetics | RNA, Small Interfering - metabolism | Adenocarcinoma | Proteins | Chemotherapy | Hormones, Sex | Drug resistance | Lung cancer, Non-small cell | Cancer | Index Medicus | LASERS | GELS | PROGESTERONE | RNA | LUNGS | MASS SPECTROSCOPY | 60 APPLIED LIFE SCIENCES | DESORPTION | ELECTROPHORESIS | BIOLOGICAL MARKERS | DRUGS | CARCINOMAS | RECEPTORS | IONIZATION
Journal Article
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2014, Volume 88, Issue 5, pp. 1203 - 1211
Purpose There are limited therapeutic options for patients with recurrent head and neck cancer after radiation therapy failure. To assess the use of tumor... 
Radiology | Hematology, Oncology and Palliative Medicine | APOPTOSIS | HEAD | THERAPY | ONCOLOGY | ADENOCARCINOMA | GENE-EXPRESSION | DRUG-RESISTANCE | IONIZING-RADIATION | IDENTIFICATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | NECK-CANCER | CHEMOTHERAPY | Immunohistochemistry | Laryngeal Neoplasms - radiotherapy | Neoplasm Recurrence, Local - radiotherapy | Oligonucleotide Array Sequence Analysis | Apoptosis - radiation effects | Epigenesis, Genetic | Humans | Middle Aged | Azacitidine - chemistry | Male | Carcinoma, Squamous Cell - radiotherapy | Flow Cytometry | DNA Methylation - radiation effects | Female | Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics | TNF-Related Apoptosis-Inducing Ligand - chemistry | Gene Silencing | Azacitidine - analogs & derivatives | CpG Islands - radiation effects | Reverse Transcriptase Polymerase Chain Reaction | Cell Survival - radiation effects | Cell Line, Tumor | Aged | Dose-Response Relationship, Radiation | TNF-Related Apoptosis-Inducing Ligand - genetics | Cell Proliferation - radiation effects | Sects | Medical colleges | Chemotherapy | Squamous cell carcinoma | Nuclear radiation | Radiotherapy | Cancer | Index Medicus | SURGERY | PATIENTS | METHYLATION | POLYMERASE CHAIN REACTION | DNA | DEOXYCYTIDINE | CARCINOMAS | RADIOLOGY AND NUCLEAR MEDICINE | NECK | RADIOTHERAPY | RADIOPROTECTIVE SUBSTANCES | RECEPTORS
Journal Article