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PLoS ONE, ISSN 1932-6203, 2018, Volume 13, Issue 6, p. e0198187
Neurodegenerative disorders are associated with impaired cognitive function and worse physical health outcomes. This study aims to test whether polygenic risk... 
E280A PRESENILIN-1 MUTATION | UK BIOBANK | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | FRONTOTEMPORAL DEMENTIA | AMYOTROPHIC-LATERAL-SCLEROSIS | DYSFUNCTION | CARRIERS | GENOME-WIDE ASSOCIATION | POLYGENIC RISK | IMPAIRMENT | Frontotemporal Dementia - genetics | Frontotemporal Dementia - physiopathology | Alzheimer Disease - physiopathology | Genome-Wide Association Study | Amyotrophic Lateral Sclerosis - physiopathology | Genetic Association Studies | Risk Assessment | Amyotrophic Lateral Sclerosis - genetics | Humans | Middle Aged | Amyotrophic Lateral Sclerosis - psychology | United Kingdom | Cognition | Frontotemporal Dementia - psychology | Mental Status and Dementia Tests | Multifactorial Inheritance | Forced Expiratory Volume | Adult | Physical Fitness | Aged | Alzheimer Disease - genetics | Peak Expiratory Flow Rate | Muscle Strength | Alzheimer Disease - psychology | Analysis | Outcome and process assessment (Health Care) | Nervous system | Degeneration | Genetic aspects | Research | Risk factors | Research parks | Memory | Genomics | Cognitive ability | Disorders | Schizophrenia | Risk | Epidemiology | Consortia | Dementia disorders | Aging | Genetics | Alzheimer's disease | Age | Neurodegenerative diseases | Motor neurone disease | Health | Health risks | Amyotrophic lateral sclerosis | Medicine | Neurology | Cognition & reasoning | Mutation | Frontotemporal dementia | Alzheimers disease | Cognitive tasks | Psychiatry | Dementia
Journal Article
by Broce, Iris and Karch, Celeste M and Wen, Natalie and Fan, Chun C and Wang, Yunpeng and Hong Tan, Chin and Kouri, Naomi and Ross, Owen A and Höglinger, Günter U and Muller, Ulrich and Hardy, John and Momeni, Parastoo and Hess, Christopher P and Dillon, William P and Miller, Zachary A and Bonham, Luke W and Rabinovici, Gil D and Rosen, Howard J and Schellenberg, Gerard D and Franke, Andre and Karlsen, Tom H and Veldink, Jan H and Ferrari, Raffaele and Yokoyama, Jennifer S and Miller, Bruce L and Andreassen, Ole A and Dale, Anders M and Desikan, Rahul S and Sugrue, Leo P and Ferrari, Raffaele and Hernandez, Dena G and Nalls, Michael A and Rohrer, Jonathan D and Ramasamy, Adaikalavan and Kwok, John B.J and Dobson-Stone, Carol and Brooks, William S and Schofield, Peter R and Halliday, Glenda M and Hodges, John R and Piguet, Olivier and Bartley, Lauren and Thompson, Elizabeth and Haan, Eric and Hernández, Isabel and Ruiz, Agustín and Boada, Mercè and Borroni, Barbara and Padovani, Alessandro and Cruchaga, Carlos and Cairns, Nigel J and Benussi, Luisa and Binetti, Giuliano and Ghidoni, Roberta and Forloni, Gianluigi and Albani, Diego and Galimberti, Daniela and Fenoglio, Chiara and Serpente, Maria and Scarpini, Elio and Clarimón, Jordi and Lleó, Alberto and Blesa, Rafael and Landqvist Waldö, Maria and Nilsson, Karin and Nilsson, Christer and Mackenzie, Ian R.A and Hsiung, Ging-Yuek R and Mann, David M.A and Grafman, Jordan and Morris, Christopher M and Attems, Johannes and Griffiths, Timothy D and G McKeith, Ian and Thomas, Alan J and Pietrini, Pietro and Huey, Edward D and Wassermann, Eric M and Baborie, Atik and Jaros, Evelyn and Tierney, Michael C and Pastor, Pau and Razquin, Cristina and Ortega-Cubero, Sara and Alonso, Elena and Perneczky, Robert and Diehl-Schmid, Janine and Alexopoulos, Panagiotis and Kurz, Alexander and Rainero, Innocenzo and Rubino, Elisa and Pinessi, Lorenzo and Rogaeva, Ekaterina and St George-Hyslop, Peter and Rossi, Giacomina and Tagliavini, Fabrizio and Giaccone, Giorgio and Rowe, James B and Schlachetzki, Johannes C.M and Uphill, James and ... and Int FTD-Genomics Consortium and International FTD-Genomics Consortium
PLoS Medicine, ISSN 1549-1277, 01/2018, Volume 15, Issue 1, p. e1002487
Background Converging evidence suggests that immune-mediated dysfunction plays an important role in the pathogenesis of frontotemporal dementia (FTD). Although... 
COMMON VARIANTS | MEDICINE, GENERAL & INTERNAL | LOBAR DEGENERATION | TAU | LOCI | AMYOTROPHIC-LATERAL-SCLEROSIS | RISK VARIANTS | IDENTIFIES 7 | PROGRESSIVE SUPRANUCLEAR PALSY | CORTICOBASAL DEGENERATION | PARKINSONS-DISEASE | Frontotemporal Dementia - genetics | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Humans | Middle Aged | Aged | Polymorphism, Single Nucleotide | Medical research | Psoriasis | Genes | Genomics | HLA histocompatibility antigens | Amyotrophic lateral sclerosis | Genomes | Crohn's disease | Disease susceptibility | Research | Rheumatoid factor | Histocompatibility antigens | Analysis | Medicine, Experimental | Genetic aspects | Single nucleotide polymorphisms | Ulcerative colitis | Protein binding | Care and treatment | Immune response | Development and progression | Genotype | Frontotemporal dementia | Health aspects | Brain | Disease | Pathogenesis | Central nervous system | Disorders | Consortia | Signal transduction | Autopsy | Neurodegeneration | LRRK2 protein | University colleges | Internal medicine | Gene expression | Patients | Diseases | Microglia | Celiac disease | Neurology | Pathology | Pleiotropy | Hospitals | Rheumatoid arthritis | Clinical medicine | Mutation | Dementia | Enrichment | Neurosciences | Mental disorders | Laboratories | Linkage disequilibrium | Mental health | Clinical trials | Diabetes mellitus (insulin dependent) | Arthritis | Leucine | Macrophages | Genetic analysis | Dementia disorders | Degeneration | Paralysis | Supervision | Transposons | Diabetes mellitus | Loci | Medicine | White blood cells | Brain research | Histocompatibility antigen HLA | Autoimmune diseases | Psychiatry
Journal Article
by Bonham, LW and Steele, NZR and Karch, CM and Broce, I and Geier, EG and Wen, NL and Momeni, P and Hardy, J and Miller, ZA and Gorno-Tempini, ML and Hess, CP and Lewis, P and Miller, BL and Seeley, WW and Manzoni, C and Desikan, RS and Baranzini, SE and Ferraris, R and Yokoyama, JS and Hernandez, DG and Nalls, MA and Rohrer, JD and Ramasamy, A and Kwok, JBJ and Dobson-Stone, C and Schofield, PR and Halliday, GM and Hodges, JR and Piguet, O and Bartley, L and Thompson, E and Haan, E and Hernandez, I and Ruiz, A and Boada, M and Borroni, B and Padovani, A and Cruchaga, C and Cairns, NJ and Benussi, L and Binetti, G and Ghidoni, R and Forloni, G and Albani, D and Galimberti, D and Fenoglio, C and Serpente, M and Scarpini, E and Clarimon, J and Lleo, A and Blesa, R and Waldo, ML and Nilsson, K and Nilsson, C and Mackenzie, IRA and Hsiung, GYR and Mann, DMA and Grafman, J and Morris, CM and Attems, J and Griffiths, TD and McKeith, IG and Thomas, AJ and Pietrini, P and Huey, ED and Wassermann, EM and Baborie, A and Jaros, E and Tierney, MC and Pastor, P and Razquin, C and Ortega-Cubero, S and Alonso, E and Perneczky, R and Diehl-Schmid, J and Alexopoulos, P and Kurz, A and Rainero, I and Rubino, E and Pinessi, L and Rogaeva, E and St George-Hyslop, P and Rossi, G and Tagliavini, F and Giaccone, G and Rowe, JB and Schlachetzki, JCM and Uphill, J and Collinge, J and Mead, S and Danek, A and Van Deerlin, VM and Grossman, M and Trojanowski, JQ and van der Zee, J and Cruts, M and Van Broeckhoven, C and Cappa, SF and Leber, I and Hannequin, D and ... and Int FTD-Genomics Consortium and International FTD-Genomics Consortium (IFGC) and Klinisk minnesforskning and Lund University and Psychiatry (Lund) and MultiPark: Multidisciplinary research focused on Parkinson´s disease and Psykiatri, Lund and Clinical Memory Research and Lunds universitet
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 10854 - 10
Journal Article
by Bonham, Luke W and Karch, Celeste M and Fan, Chun C and Tan, Chin and Geier, Ethan G and Wang, Yunpeng and Wen, Natalie and Broce, Iris J and Li, Yi and Barkovich, Matthew J and Ferrari, Raffaele and Hardy, John and Momeni, Parastoo and Höglinger, Günter and Müller, Ulrich and Hess, Christopher P and Sugrue, Leo P and Dillon, William P and Schellenberg, Gerard D and Miller, Bruce L and Andreassen, Ole A and Dale, Anders M and Barkovich, A. James and Yokoyama, Jennifer S and Desikan, Rahul S and Hernandez, D.G and Nalls, M.A and Rohrer, J.D and Ramasamy, A and Kwok, J.B.J and Dobson-Stone, C and Schofield, P.R and Halliday, G.M and Hodges, J.R and Piguet, O and Bartley, L and Thompson, E and Haan, E and Hernández, I and Ruiz, A and Boada, M and Borroni, B and Padovani, A and Cruchaga, C and Cairns, N.J and Benussi, L and Binetti, G and Ghidoni, R and Forloni, G and Albani, D and Galimberti, D and Fenoglio, C and Serpente, M and Scarpini, E and Clarimón, J and Lleó, A and Blesa, R and Waldö, M. Landqvist and Nilsson, K and Nilsson, C and MacKenzie, I.R.A and Hsiung, G.-Y.R and Mann, D.M.A and Grafman, J and Morris, C.M and Attems, J and Griffiths, T.D and McKeith, I.G and Thomas, A.J and Pietrini, P and Huey, E.D and Wassermann, E.M and Baborie, A and Jaros, E and Tierney, M.C and Pastor, P and Razquin, C and Ortega-Cubero, S and Alonso, E and Perneczky, R and Diehl-Schmid, J and Alexopoulos, P and Kurz, A and Rainero, I and Rubino, E and Pinessi, L and Rogaeva, E and George-Hyslop, P. St and Rossi, G and Tagliavini, F and Giaccone, G and Rowe, J.B and Schlachetzki, J.C.M and Uphill, J and Collinge, J and Mead, S and Danek, A and Van Deerlin, V.M and Grossman, M and Trojanowski, J.Q and ... and IPDGC and IFGC and IGAP and International Parkinson’s Disease Genetics Consortium (IPDGC) and International Genomics of Alzheimer’s Project (IGAP) and International FTD-Genomics Consortium (IFGC)
Translational Psychiatry, ISSN 2158-3188, 12/2018, Volume 8, Issue 1, pp. 73 - 10
Journal Article
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