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PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0143846
Restoring vision in inherited retinal degenerations remains an unmet medical need. In mice exhibiting a genetically engineered block of the visual cycle,... 
Vitamin A - pharmacology | Vitamin A - analogs & derivatives | Humans | Middle Aged | Male | Visual Fields - drug effects | Acyltransferases - metabolism | Acyltransferases - genetics | Retinal Ganglion Cells - pathology | Young Adult | Drug Dosage Calculations | Visual Acuity - drug effects | Adult | Female | cis-trans-Isomerases - metabolism | Anticarcinogenic Agents - adverse effects | Anticarcinogenic Agents - pharmacology | Child | Anticarcinogenic Agents - therapeutic use | Administration, Oral | Retinitis Pigmentosa - drug therapy | Treatment Outcome | Cerebral Cortex - diagnostic imaging | Radiography | Vitamin A - therapeutic use | cis-trans-Isomerases - genetics | Polymorphism, Single Nucleotide | Retinal Neurons - pathology | Vitamin A - adverse effects | Physiological aspects | Research | Retinoids | Lecithin | Drug therapy | Retinitis pigmentosa | Headache | Disease | Retina | Defects | Acuity | Vitamin A | Coherence length | Hemispheres | Vomiting | Functional magnetic resonance imaging | Eye (anatomy) | Safety | Visual fields | Congenital diseases | Abnormalities | Cortex (occipital) | Oral administration | Visual acuity | Nausea | Cortex (visual) | Metabolism | Acyltransferase | Patients | Hospitals | Optical Coherence Tomography | Vision | Retinal degeneration | Photoreceptors | Genetic engineering | Retinitis | Mutation | Gene therapy | Acetic acid | Structure-function relationships
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