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Cell Reports, ISSN 2211-1247, 03/2015, Volume 10, Issue 8, pp. 1239 - 1245
Clonal hemopoiesis driven by leukemia-associated gene mutations can occur without evidence of a blood disorder. To investigate this phenomenon, we interrogated... 
TWINS | SEQUENCE | STEM-CELL NICHE | ACUTE MYELOID-LEUKEMIA | IDENTIFICATION | DISEASE EVOLUTION | CANCER | MYELODYSPLASTIC SYNDROMES | MOSAICISM | CELL BIOLOGY
Journal Article
by Brazel, David M and Jiang, Yu and Hughey, Jordan M and Turcot, Valérie and Zhan, Xiaowei and Gong, Jian and Batini, Chiara and Weissenkampen, J. Dylan and Liu, MengZhen and Liu, Dajiang J and Surendran, Praveen and Young, Robin and Barnes, Daniel R and Nielsen, Sune Fallgaard and Rasheed, Asif and Samuel, Maria and Zhao, Wei and Kontto, Jukka and Perola, Markus and Caslake, Muriel and de Craen, Anton J.M and Trompet, Stella and Uria-Nickelsen, Maria and Malarstig, Anders and Reily, Dermot F and Hoek, Maarten and Vogt, Thomas and Jukema, J. Wouter and Sattar, Naveed and Ford, Ian and Packard, Chris J and Alam, Dewan S and Majumder, Abdulla al Shafi and Di Angelantonio, Emanuele and Chowdhury, Rajiv and Amouyel, Philippe and Arveiler, Dominique and Blankenberg, Stefan and Ferrières, Jean and Kee, Frank and Kuulasmaa, Kari and Müller-Nurasyid, Martina and Veronesi, Giovanni and Virtamo, Jarmo and EPIC-CVD Consortium and Frossard, Philippe and Nordestgaard, Børge Grønne and Saleheen, Danish and Danesh, John and Butterworth, Adam S and Howson, Joanna M.M and Erzurumluoglu, A. Mesut and Jackson, Victoria E and Melbourne, Carl A and Varga, Tibor V and Warren, Helen R and Tragante, Vinicius and Tachmazidou, Ioanna and Harris, Sarah E and Evangelou, Evangelos and Marten, Jonathan and Zhang, Weihua and Altmaier, Elisabeth and Luan, Jian’an and Langenberg, Claudia and Scott, Robert A and Yaghootkar, Hanieh and Stirrups, Kathleen and Kanoni, Stavroula and Marouli, Eirini and Karpe, Fredrik and Dominiczak, Anna F and Sever, Peter and Poulter, Neil and Rolandsson, Olov and Baumbach, Clemens and Afaq, Saima and Chambers, John C and Kooner, Jaspal S and Wareham, Nicholas J and Renström, Frida and Hallmans, Göran and Marioni, Riccardo E and Corley, Janie and Starr, John M and Verweij, Niek and de Boer, Rudolf A and van der Meer, Peter and Yavas, Ersin and Vaartjes, Ilonca and Bots, Michiel L and Asselbergs, Folkert W and Grabe, Hans J and Völzke, Henry and Nauck, Matthias and Weiss, Stefan and Pharoah, Paul D.P and Dunning, Alison M and Dennis, Joe G and Thompson, Deborah J and ...
Biological Psychiatry, ISSN 0006-3223, 06/2019, Volume 85, Issue 11, pp. 946 - 955
Smoking and alcohol use have been associated with common genetic variants in multiple loci. Rare variants within these loci hold promise in the identification... 
Alcohol | Tobacco | Heritability | GWAS | Behavioral genetics | Nicotine
Journal Article
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 09/2019, Volume 10, Issue 1, pp. 1 - 10
Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major... 
MIXED-MODEL | BIOBANK | GENOMICS | BLOOD-LIPIDS | VARIANTS | MULTIDISCIPLINARY SCIENCES | DISEASE | WIDE ASSOCIATION | HEALTH | TRAITS | GENETIC ASSOCIATIONS | Lipoproteins (low density) | Health risks | Lipids | Genomes | Triglycerides | Risk analysis | Population genetics | Loci | Cholesterol | Ethnic factors | Risk factors | Serum levels | Food intake | Nutrients | Cardiovascular diseases
Journal Article
International Journal of Epidemiology, ISSN 0300-5771, 06/2017, Volume 46, Issue 3, pp. 894 - 904
Journal Article
Journal Article
by Erzurumluoglu, A. Mesut and Liu, Mengzhen and Jackson, Victoria E and Barnes, Daniel R and Datta, Gargi and Melbourne, Carl A and Young, Robin and Batini, Chiara and Surendran, Praveen and Jiang, Tao and Adnan, Sheikh Daud and Afaq, Saima and Agrawal, Arpana and Altmaier, Elisabeth and Antoniou, Antonis C and Asselbergs, Folkert W and Baumbach, Clemens and Bierut, Laura and Bertelsen, Sarah and Boehnke, Michael and Bots, Michiel L and Brazel, David M and Chambers, John C and Chang-Claude, Jenny and Chen, Chu and Corley, Janie and Chou, Yi-Ling and David, Sean P and de Boer, Rudolf A and de Leeuw, Christiaan A and Dennis, Joe G and Dominiczak, Anna F and Dunning, Alison M and Easton, Douglas F and Eaton, Charles and Elliott, Paul and Evangelou, Evangelos and Faul, Jessica D and Foroud, Tatiana and Goate, Alison and Gong, Jian and Grabe, Hans J and Haessler, Jeff and Haiman, Christopher and Hallmans, Göran and Hammerschlag, Anke R and Harris, Sarah E and Hattersley, Andrew and Heath, Andrew and Hsu, Chris and Iacono, William G and Kanoni, Stavroula and Kapoor, Manav and Kaprio, Jaakko and Kardia, Sharon L and Karpe, Fredrik and Kontto, Jukka and Kooner, Jaspal S and Kooperberg, Charles and Kuulasmaa, Kari and Laakso, Markku and Lai, Dongbing and Langenberg, Claudia and Le, Nhung and Lettre, Guillaume and Loukola, Anu and Luan, Jian’an and Madden, Pamela A. F and Mangino, Massimo and Marioni, Riccardo E and Marouli, Eirini and Marten, Jonathan and Martin, Nicholas G and McGue, Matt and Michailidou, Kyriaki and Mihailov, Evelin and Moayyeri, Alireza and Moitry, Marie and Müller-Nurasyid, Martina and Naheed, Aliya and Nauck, Matthias and Neville, Matthew J and Nielsen, Sune Fallgaard and North, Kari and Perola, Markus and Pharoah, Paul D. P and Pistis, Giorgio and Polderman, Tinca J and Posthuma, Danielle and Poulter, Neil and Qaiser, Beenish and Rasheed, Asif and Reiner, Alex and Renström, Frida and Rice, John and Rohde, Rebecca and Rolandsson, Olov and Samani, Nilesh J and Samuel, Maria and Schlessinger, David and ... and Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium
Molecular Psychiatry, ISSN 1359-4184, 2019
Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen... 
Journal Article
by Wain, LV and Shrine, N and Artigas, MS and Erzurumluoglu, AM and Noyvert, B and Bossini-Castillo, L and Obeidat, M and Henry, AP and Portelli, MA and Hall, RJ and Billington, CK and Rimington, TL and Fenech, AG and John, C and Blake, T and Jackson, VE and Allen, RJ and Prins, Bram Peter and Understanding Society Scientific Group and Campbell, A and Porteous, DJ and Jarvelin, M-R and Wielscher, M and James, AL and Hui, J and Wareham, Nicholas John and Zhao, Jing Hua and Wilson, JF and Joshi, PK and Stubbe, B and Rawal, R and Schulz, H and Imboden, M and Probst-Hensch, NM and Karrasch, S and Gieger, C and Deary, IJ and Harris, SE and Marten, J and Rudan, I and Enroth, S and Gyllensten, U and Kerr, SM and Polasek, O and Kähönen, M and Surakka, I and Vitart, V and Hayward, C and Lehtimäki, T and Raitakari, OT and Evans, DM and Henderson, AJ and Pennell, CE and Wang, CA and Sly, PD and Wan, ES and Busch, R and Hobbs, BD and Litonjua, AA and Sparrow, DW and Gulsvik, A and Bakke, PS and Crapo, JD and Beaty, TH and Hansel, NN and Mathias, RA and Ruczinski, I and Barnes, KC and Bossé, Y and Joubert, P and van den Berge, M and Brandsma, C-A and Paré, PD and Sin, DD and Nickle, DC and Hao, K and Gottesman, O and Dewey, FE and Bruse, SE and Carey, DJ and Kirchner, HL and Geisinger-Regeneron DiscovEHR Collaboration and Jonsson, S and Thorleifsson, G and Jonsdottir, I and Gislason, T and Stefansson, K and Schurmann, C and Nadkarni, G and Bottinger, EP and Loos, RJF and Walters, RG and Chen, Z and Millwood, IY and Vaucher, J and Kurmi, OP and Li, L and Hansell, AL and Brightling, C and Zeggini, E and ...
ISSN 1061-4036, 2017
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide... 
Journal Article
by Tachmazidou, I and Süveges, D and Min, JL and Ritchie, GRS and Steinberg, J and Walter, K and Iotchkova, V and Schwartzentruber, J and Huang, J and Memari, Y and McCarthy, Shane Alan and Crawford, AA and Bombieri, C and Cocca, M and Farmaki, A-E and Gaunt, TR and Jousilahti, P and Kooijman, MN and Lehne, B and Malerba, G and Männistö, S and Matchan, A and Medina-Gomez, C and Metrustry, SJ and Nag, A and Ntalla, I and Paternoster, L and Rayner, NW and Sala, C and Scott, WR and Shihab, HA and Southam, L and St Pourcain, B and Traglia, M and Trajanoska, K and Zaza, G and Zhang, W and Artigas, MS and Bansal, Narinder and Benn, M and Chen, Z and Danecek, P and Lin, W-Y and Locke, A and Luan, Jian'an and Manning, AK and Mulas, A and Sidore, C and Tybjaerg-Hansen, A and Varbo, A and Zoledziewska, M and Finan, C and Hatzikotoulas, K and Hendricks, AE and Kemp, JP and Moayyeri, A and Panoutsopoulou, K and Szpak, M and Wilson, SG and Boehnke, M and Cucca, F and Di Angelantonio, Emanuele and Langenberg, Claudia and Lindgren, C and McCarthy, MI and Morris, AP and Nordestgaard, BG and Scott, RA and Tobin, MD and Wareham, Nicholas John and SpiroMeta Consortium and GoT2D Consortium and Burton, P and Chambers, JC and Smith, GD and Dedoussis, G and Felix, JF and Franco, OH and Gambaro, G and Gasparini, P and Hammond, CJ and Hofman, A and Jaddoe, VWV and Kleber, M and Kooner, JS and Perola, M and Relton, C and Ring, SM and Rivadeneira, F and Salomaa, V and Spector, TD and Stegle, O and Toniolo, D and Uitterlinden, AG and arcOGEN Consortium and Understanding Society Scientific Group and UK10K Consortium and Barroso, Ines and Greenwood, CMT and Perry, John Richard and ...
ISSN 0002-9297, 2017
Deep sequence-based imputation can enhance the discovery power of genome-wide association studies by assessing previously unexplored variation across the... 
imputation | UK10K | anthropometry | next-generation whole-genome sequencing | DXA traits | UK Biobank | genetic association study
Journal Article
by Turcot, Valérie and Lu, Yingchang and Highland, Heather M and Schurmann, Claudia and Justice, Anne E and Fine, Rebecca S and Bradfield, Jonathan P and Esko, Tõnu and Giri, Ayush and Graff, Mariaelisa and Guo, Xiuqing and Hendricks, Audrey E and Karaderi, Tugce and Lempradl, Adelheid and Locke, Adam E and Mahajan, Anubha and Marouli, Eirini and Sivapalaratnam, Suthesh and Young, Kristin L and Alfred, Tamuno and Feitosa, Mary F and Masca, Nicholas GD and Manning, Alisa K and Medina-Gomez, Carolina and Mudgal, Poorva and Ng, Maggie CY and Reiner, Alex P and Vedantam, Sailaja and Willems, Sara M and Winkler, Thomas W and Abecasis, Gonçalo and Aben, Katja K and Alam, Dewan S and Alharthi, Sameer E and Allison, Matthew and Amouyel, Philippe and Asselbergs, Folkert W and Auer, Paul L and Balkau, Beverley and Bang, Lia E and Barroso, Ines and Bastarache, Lisa and Benn, Marianne and Bergmann, Sven and Bielak, Lawrence F and Blüher, Matthias and Boehnke, Michael and Boeing, Heiner and Boerwinkle, Eric and Böger, Carsten A and Bork-Jensen, Jette and Bots, Michiel L and Bottinger, Erwin P and Bowden, Donald W and Brandslund, Ivan and Breen, Gerome and Brilliant, Murray H and Broer, Linda and Brumat, Marco and Burt, Amber A and Butterworth, Adam Stuart and Campbell, Peter T and Cappellani, Stefania and Carey, David J and Catamo, Eulalia and Caulfield, Mark J and Chambers, John C and Chasman, Daniel I and Chen, Yii-Der I and Chowdhury, Rajiv and Christensen, Cramer and Chu, Audrey Y and Cocca, Massimiliano and Collins, Francis S and Cook, James P and Corley, Janie and Corominas Galbany, Jordi and Cox, Amanda J and Crosslin, David S and Cuellar-Partida, Gabriel and D'Eustacchio, Angela and Danesh, John and Davies, Gail and Bakker, Paul IW and Groot, Mark CH and Mutsert, Renée and Deary, Ian J and Dedoussis, George and Demerath, Ellen W and Heijer, Martin and Hollander, Anneke I and Ruijter, Hester M and Dennis, Joe G and Denny, Josh C and Di Angelantonio, Emanuele and Drenos, Fotios and Du, Mengmeng and Dubé, Marie-Pierre and Dunning, Alison Margaret and Easton, Douglas Frederick and ... and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Kardiologi and Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm and Geriatrik and Kardiovaskulär epidemiologi and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi and Institutionen för folkhälso- och vårdvetenskap and Uppsala kliniska forskningscentrum (UCR)
Nature Genetics, ISSN 1061-4036, 2018, Volume 50, Issue 1, p. 26
Journal Article
by Warren, Helen R and Evangelou, Evangelos and Cabrera, Claudia P and Gao, He and Ren, Meixia and Mifsud, Borbala and Ntalla, Ioanna and Surenan, Praveen and Liu, Chunyu and Cook, James P and Kraja, Aldi T and nos, Fotios and Loh, Marie and Verweij, Niek and Marten, Jonathan and Karaman, Ibrahim and Lepe, Marcelo P. Segura and O'Reilly, Paul F and Knight, Joanne and Snieder, Harold and Kato, Norihiro and He, Jiang and Tai, E. Shyong and Said, M. Abdullah and Porteous, David and Alver, Maris and Poulter, Neil and Farrall, Martin and Gansevoort, Ron T and Padmanabhan, Sandosh and Magi, Reedik and Stanton, Alice and Connell, John and Bakker, Stephan J. L and Metspalu, Anes and Shields, Denis C and Thom, Simon and Brown, Morris and Sever, Peter and Esko, Tonu and Hayward, Caroline and van der Harst, Pim and Saleheen, Danish and Chowdhury, Rajiv and Chambers, John C and Chasman, Daniel I and Chakravarti, Aravinda and Newton-Cheh, Christopher and Lindgren, Cecilia M and Levy, Daniel and Kooner, Jaspal S and Keavney, Bernard and Tomaszewski, Maciej and Samani, Nilesh J and Howson, Joanna M. M and Tobin, Martin D and Munroe, Patricia B and Ehret, Georg B and Wain, Louise V and Barnes, Michael R and Tzoulaki, Joanna and Caulfield, Mark J and Elliott, Paul and Vaez, Ahmad and Jansen, Rick and Joehanes, Roby and van der Most, Peter J and Erzurumluoglu, A. Mesut and O'Reilly, Paul and Rose, Lynda M and Verwoert, Germaine C and Hottenga, Jouke-Jan and Strawbridge, Rona J and Arking, Dan E and Hwang, Shih-Jen and Guo, Xiuqing and Kutalik, Zoltan and Trompet, Stella and Shrine, Nick and Teumer, Alexander and Ried, Janina S and Bis, Joshua C and Smith, Albert V and Amin, Najaf and Nolte, Ilja M and Lyytikainen, Leo-Pekka and Mahajan, Anubha and Wareham, Nicholas J and Hofer, Edith and Joshi, Peter K and Kristiansson, Kati and Traglia, Michela and Havulinna, Aki S and Goel, Anuj and Nalls, Mike A and Sober, Siim and Vuckovic, gana and Luan, Jian'an and Del Greco M, Fabiola and Ayers, Kristin L and ... and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Medicinsk genetik och genomik and Geriatrik and Kardiovaskulär epidemiologi and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi and Institutionen för folkhälso- och vårdvetenskap
Nature Genetics, ISSN 1061-4036, 03/2017, Volume 49, Issue 3, pp. 403 - 415
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic,... 
genome-wide association studies | hypertension | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
by Surenan, Praveen and nos, Fotios and Young, Robin and Warren, Helen and Cook, James P and Manning, Alisa K and Grarup, Niels and Sim, Xueling and Barnes, Daniel R and Witkowska, Kate and Staley, James R and Tragante, Vinicius and Tukiainen, Taru and Yaghootkar, Hanieh and Masca, Nicholas and Freitag, Daniel F and Ferreira, Teresa and Giannakopoulou, Olga and Tinker, Anew and Harakalova, Magdalena and Mihailov, Evelin and Liu, Chunyu and Kraja, Aldi T and Nielsen, Sune Fallgaard and Rasheed, Asif and Samue, Maria and Zhao, Wei and Bonnycastle, Lori L and Jackson, Anne U and Narisu, Narisu and Swift, Amy J and Southam, Lorraine and Marten, Jonathan and Huyghe, Jeroen R and Stancakova, Alena and Fava, Cristiano and Ohlsson, Therese and Matchan, Angela and Stirrups, Kathleen E and Bork-Jensen, Jette and Gjesing, Anette P and Kontto, Jukka and Perola, Markus and Shaw-Hawkins, Susan and Havulinna, Aki S and Zhang, He and Donnelly, Louise A and Groves, Christopher J and Rayner, N. William and Neville, Matt J and Robertson, Neil R and Yiorkas, Anianos M and Herzig, Karl-Heinz and Kajantie, Eero and Zhang, Weihua and Willems, Sara M and Lannfelt, Lars and Malerba, Giovanni and Soranzo, Nicole and Trabetti, Elisabetta and Verweij, Niek and Evangelou, Evangelos and Moayyeri, Alireza and Vergnaud, Anne-Claire and Nelson, Christopher P and Poveda, Alaitz and Varga, Tibor V and Caslake, Muriel and de Craen, Anton J. M and Trompet, Stella and Luan, Jian'an and Scott, Robert A and Harris, Sarah E and Liewald, David C. M and Marioni, Riccardo and Menni, Cristina and Farmaki, Aliki-Eleni and Hallmans, Goran and Renstrom, Frida and Huffman, Jennifer E and Hassinen, Maija and Burgess, Stephen and Vasan, Ramachanan S and Felix, Janine F and Uria-Nickelsen, Maria and Malarstign, Anders and Reilly, Dermot F and Hoek, Maarten and Vogt, Thomas F and Lin, Honghuang and Lieb, Wolfgang and Traylor, Matthew and Markus, Hugh S and Highland, Heather M and Justice, Anne E and Marouli, Eirini and Lindstrom, Jaana and Uusitupa, Matti and Komulainen, Pirjo and Lakka, Timo A and ... and Medicinska fakulteten and Science for Life Laboratory, SciLifeLab and Medicinska och farmaceutiska vetenskapsområdet and Geriatrik and Uppsala universitet and Institutionen för medicinska vetenskaper and Molekylär epidemiologi and Institutionen för folkhälso- och vårdvetenskap
Nature Genetics, ISSN 1061-4036, 10/2016, Volume 48, Issue 10, pp. 1151 - 1161
High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and... 
Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
by Jackson, Victoria E and Latourelle, Jeanne C and Wain, Louise V and Smith, Albert V and Grove, Megan L and Bartz, Traci M and Obeidat, Ma'en and Province, Michael A and Gao, Wei and Qaiser, Beenish and Porteous, David J and Cassano, Patricia A and Ahluwalia, Tarunveer S and Grarup, Niels and Li, Jin and Altmaier, Elisabeth and Marten, Jonathan and Harris, Sarah E and Manichaikul, Ani and Pottinger, Tess D and Li-Gao, Ruifang and Lind-Thomsen, Allan and Mahajan, Anubha and Lahousse, Lies and Imboden, Medea and Teumer, Alexander and Prins, Bram and Lyytikäinen, Leo-Pekka and Eiriksdottir, Gudny and Franceschini, Nora and Sitlani, Colleen M and Brody, Jennifer A and Bossé, Yohan and Timens, Wim and Kraja, Aldi and Loukola, Anu and Tang, Wenbo and Liu, Yongmei and Bork-Jensen, Jette and Justesen, Johanne M and Linneberg, Allan and Lange, Leslie A and Rawal, Rajesh and Karrasch, Stefan and Huffman, Jennifer E and Smith, Blair H and Davies, Gail and Burkart, Kristin M and Mychaleckyj, Josyf C and Bonten, Tobias N and Enroth, Stefan and Lind, Lars and Brusselle, Guy G and Kumar, Ashish and Stubbe, Beate and Kähönen, Mika and Wyss, Annah B and Psaty, Bruce M and Heckbert, Susan R and Hao, Ke and Rantanen, Taina and Kritchevsky, Stephen B and Lohman, Kurt and Skaaby, Tea and Pisinger, Charlotta and Hansen, Torben and Schulz, Holger and Polasek, Ozren and Campbell, Archie and Starr, John M and Rich, Stephen S and Mook-Kanamori, Dennis O and Johansson, Åsa and Ingelsson, Erik and Uitterlinden, André G and Weiss, Stefan and Raitakari, Olli T and Gudnason, Vilmundur and North, Kari E and Gharib, Sina A and Sin, Don D and Taylor, Kent D and O'Connor, George T and Kaprio, Jaakko and Harris, Tamara B and Pederson, Oluf and Vestergaard, Henrik and Wilson, James G and Strauch, Konstantin and Hayward, Caroline and Kerr, Shona and Deary, Ian J and Barr, R. Graham and de Mutsert, Renée and Gyllensten, Ulf and Morris, Andrew P and Ikram, M. Arfan and Probst-Hensch, Nicole and Gläser, Sven and Zeggini, Eleftheria and ... and Understanding Society Scientific Group
Wellcome Open Research, ISSN 2398-502X, 2018, Volume 3, p. 4
Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive... 
Genomics
Journal Article