PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 9, p. e44454
Background: The SMART study was a trial of intermittent use of antiretroviral therapy (ART) (drug conservation [DC]) versus continuous use of ART (viral...
BIOMARKERS | EVENTS | THROMBOSIS | MULTIDISCIPLINARY SCIENCES | RISK | ANTIRETROVIRAL THERAPY | DEATH | CORONARY-HEART-DISEASE | OPPORTUNISTIC DISEASE | INTERLEUKIN-6 | D-DIMER | Inflammation - complications | Cardiovascular Diseases - complications | Humans | HIV Infections - complications | Anti-HIV Agents - therapeutic use | HIV Infections - drug therapy | Blood Coagulation Disorders - complications | Medical research | Antiviral agents | Usage | C-reactive protein | Mortality | HIV patients | HIV (Viruses) | Risk factors | Highly active antiretroviral therapy | Interleukins | Analysis | Medicine, Experimental | Cardiovascular diseases | Health aspects | HIV infection | Toxicity | Interleukin | Health risks | Cardiovascular disease | Regression analysis | Risk analysis | Medical diagnosis | Morbidity | Antiretroviral therapy | Interleukin 6 | Regression models | Acquired immune deficiency syndrome--AIDS | Antiretroviral agents | Human immunodeficiency virus--HIV | Predictions | Biomarkers | Sampling methods | Health risk assessment | AIDS | HIV | Acquired immune deficiency syndrome | Human immunodeficiency virus
BIOMARKERS | EVENTS | THROMBOSIS | MULTIDISCIPLINARY SCIENCES | RISK | ANTIRETROVIRAL THERAPY | DEATH | CORONARY-HEART-DISEASE | OPPORTUNISTIC DISEASE | INTERLEUKIN-6 | D-DIMER | Inflammation - complications | Cardiovascular Diseases - complications | Humans | HIV Infections - complications | Anti-HIV Agents - therapeutic use | HIV Infections - drug therapy | Blood Coagulation Disorders - complications | Medical research | Antiviral agents | Usage | C-reactive protein | Mortality | HIV patients | HIV (Viruses) | Risk factors | Highly active antiretroviral therapy | Interleukins | Analysis | Medicine, Experimental | Cardiovascular diseases | Health aspects | HIV infection | Toxicity | Interleukin | Health risks | Cardiovascular disease | Regression analysis | Risk analysis | Medical diagnosis | Morbidity | Antiretroviral therapy | Interleukin 6 | Regression models | Acquired immune deficiency syndrome--AIDS | Antiretroviral agents | Human immunodeficiency virus--HIV | Predictions | Biomarkers | Sampling methods | Health risk assessment | AIDS | HIV | Acquired immune deficiency syndrome | Human immunodeficiency virus
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e56249
Background: Despite advances in HIV treatment, bacterial pneumonia continues to cause considerable morbidity and mortality in patients with HIV infection....
C-REACTIVE PROTEIN | COMMUNITY-ACQUIRED PNEUMONIA | STATIN THERAPY | MULTIDISCIPLINARY SCIENCES | ACTIVE ANTIRETROVIRAL THERAPY | DISEASE | ALPHA | SERUM | COHORT | HUMAN-IMMUNODEFICIENCY-VIRUS | HOSPITALIZATION | Fibrin Fibrinogen Degradation Products | HIV Infections - blood | Pneumonia, Bacterial - blood | C-Reactive Protein | Humans | Middle Aged | Pneumonia, Bacterial - etiology | Risk Factors | Pulmonary Surfactant-Associated Protein D - blood | Male | Pneumonia, Bacterial - virology | Biomarkers - blood | Pneumonia, Bacterial - diagnosis | Case-Control Studies | Uteroglobin - blood | Lung - virology | Interleukin-6 - blood | HIV Infections - complications | Adult | Anti-HIV Agents - therapeutic use | Female | HIV Infections - drug therapy | Medical research | Antiviral agents | Care and treatment | Pneumonia | C-reactive protein | AIDS treatment | Bacterial pneumonia | Mortality | HIV patients | HIV (Viruses) | Risk factors | Infection control | Highly active antiretroviral therapy | Control | Surface active agents | Interleukins | Medicine, Experimental | Biological markers | Health aspects | HIV infection | Cases | Therapy | Interleukin | Critical care | Risk | Systematic review | Infections | Family medical history | Interleukin 6 | Proteins | Hepatitis | Acquired immune deficiency syndrome--AIDS | Antiretroviral agents | Human immunodeficiency virus--HIV | Bacteria | Tumor necrosis factor-TNF | Chronic obstructive pulmonary disease | Hepatitis B virus | Drug therapy | Antiretroviral drugs | Statistical analysis | Diabetes mellitus | Health risks | Protein D | Inflammation | Gene expression | Patients | Antiretroviral therapy | Morbidity | CD4 antigen | Infectious diseases | Surfactant protein D | Biomarkers | Hepatitis B | Smoking | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
C-REACTIVE PROTEIN | COMMUNITY-ACQUIRED PNEUMONIA | STATIN THERAPY | MULTIDISCIPLINARY SCIENCES | ACTIVE ANTIRETROVIRAL THERAPY | DISEASE | ALPHA | SERUM | COHORT | HUMAN-IMMUNODEFICIENCY-VIRUS | HOSPITALIZATION | Fibrin Fibrinogen Degradation Products | HIV Infections - blood | Pneumonia, Bacterial - blood | C-Reactive Protein | Humans | Middle Aged | Pneumonia, Bacterial - etiology | Risk Factors | Pulmonary Surfactant-Associated Protein D - blood | Male | Pneumonia, Bacterial - virology | Biomarkers - blood | Pneumonia, Bacterial - diagnosis | Case-Control Studies | Uteroglobin - blood | Lung - virology | Interleukin-6 - blood | HIV Infections - complications | Adult | Anti-HIV Agents - therapeutic use | Female | HIV Infections - drug therapy | Medical research | Antiviral agents | Care and treatment | Pneumonia | C-reactive protein | AIDS treatment | Bacterial pneumonia | Mortality | HIV patients | HIV (Viruses) | Risk factors | Infection control | Highly active antiretroviral therapy | Control | Surface active agents | Interleukins | Medicine, Experimental | Biological markers | Health aspects | HIV infection | Cases | Therapy | Interleukin | Critical care | Risk | Systematic review | Infections | Family medical history | Interleukin 6 | Proteins | Hepatitis | Acquired immune deficiency syndrome--AIDS | Antiretroviral agents | Human immunodeficiency virus--HIV | Bacteria | Tumor necrosis factor-TNF | Chronic obstructive pulmonary disease | Hepatitis B virus | Drug therapy | Antiretroviral drugs | Statistical analysis | Diabetes mellitus | Health risks | Protein D | Inflammation | Gene expression | Patients | Antiretroviral therapy | Morbidity | CD4 antigen | Infectious diseases | Surfactant protein D | Biomarkers | Hepatitis B | Smoking | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e69266
Background: Non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant mutants have been shown to emerge after interruption of suppressive NNRTI-based...
INFECTED INDIVIDUALS | HIV | VARIANTS | MULTIDISCIPLINARY SCIENCES | EFAVIRENZ | REGIMEN | NEVIRAPINE | ASSOCIATION | DRUG-RESISTANCE MUTATIONS | INTERRUPTION | PLASMA PHARMACOKINETICS | Anti-Retroviral Agents - therapeutic use | Reverse Transcriptase Inhibitors - blood | Humans | Middle Aged | Logistic Models | Male | Chromatography, High Pressure Liquid | HIV-1 - genetics | Nevirapine - blood | Drug Resistance, Viral - genetics | DNA Mutational Analysis | Adult | Benzoxazines - blood | Female | HIV Infections - drug therapy | High-Throughput Nucleotide Sequencing | Reverse Transcriptase Inhibitors - therapeutic use | Odds Ratio | Highly active antiretroviral therapy | Antiviral agents | Medical research | Analysis | Nucleosides | Medicine, Experimental | DNA polymerases | Biological products industry | Nucleotide sequencing | High performance liquid chromatography | DNA sequencing | Drugs | Therapy | RNA-directed DNA polymerase | Nevirapine | Viremia | Population studies | Drug resistance | Efavirenz | Confidence intervals | Restarting | Rams | Acquired immune deficiency syndrome--AIDS | Antiretroviral agents | Human immunodeficiency virus--HIV | Antiretroviral drugs | Interruption | Liquid chromatography | High-performance liquid chromatography | Patients | Antiretroviral therapy | Mutants | Inhibitors | Protease inhibitors | Mutation | Acquired immune deficiency syndrome | AIDS | Human immunodeficiency virus
INFECTED INDIVIDUALS | HIV | VARIANTS | MULTIDISCIPLINARY SCIENCES | EFAVIRENZ | REGIMEN | NEVIRAPINE | ASSOCIATION | DRUG-RESISTANCE MUTATIONS | INTERRUPTION | PLASMA PHARMACOKINETICS | Anti-Retroviral Agents - therapeutic use | Reverse Transcriptase Inhibitors - blood | Humans | Middle Aged | Logistic Models | Male | Chromatography, High Pressure Liquid | HIV-1 - genetics | Nevirapine - blood | Drug Resistance, Viral - genetics | DNA Mutational Analysis | Adult | Benzoxazines - blood | Female | HIV Infections - drug therapy | High-Throughput Nucleotide Sequencing | Reverse Transcriptase Inhibitors - therapeutic use | Odds Ratio | Highly active antiretroviral therapy | Antiviral agents | Medical research | Analysis | Nucleosides | Medicine, Experimental | DNA polymerases | Biological products industry | Nucleotide sequencing | High performance liquid chromatography | DNA sequencing | Drugs | Therapy | RNA-directed DNA polymerase | Nevirapine | Viremia | Population studies | Drug resistance | Efavirenz | Confidence intervals | Restarting | Rams | Acquired immune deficiency syndrome--AIDS | Antiretroviral agents | Human immunodeficiency virus--HIV | Antiretroviral drugs | Interruption | Liquid chromatography | High-performance liquid chromatography | Patients | Antiretroviral therapy | Mutants | Inhibitors | Protease inhibitors | Mutation | Acquired immune deficiency syndrome | AIDS | Human immunodeficiency virus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e90978
Background: Higher plasma D-dimer levels are strong predictors of mortality in HIV+ individuals. The factors associated with D-dimer levels during HIV...
ALL-CAUSE MORTALITY | ELDERLY PERSONS | BIOMARKERS | FIBRIN D-DIMER | MULTIDISCIPLINARY SCIENCES | DISEASE | ADULTS | COAGULATION | ANTIRETROVIRAL THERAPY | PLASMA D-DIMER | INTERLEUKIN-6 | HIV Infections - blood | Cross-Sectional Studies | Fibrin Fibrinogen Degradation Products - metabolism | Humans | Middle Aged | Hepatitis - blood | Linear Models | Male | CD4 Lymphocyte Count | Biomarkers - blood | Coinfection - virology | Viral Load | Randomized Controlled Trials as Topic | Inflammation - metabolism | C-Reactive Protein - metabolism | Interleukin-6 - blood | Sex Factors | Adult | Female | HIV Infections - mortality | Medical research | Antiviral agents | C-reactive protein | RNA | Mortality | HIV patients | HIV (Viruses) | Diseases | Highly active antiretroviral therapy | Hepatitis | Body mass index | Interleukins | Medicine, Experimental | Diabetes | Hyaluronic acid | HIV infection | Antiretroviral drugs | Infectious diseases | Cytokines | Laboratories | Research & development--R&D | Human immunodeficiency virus--HIV | Biomarkers | Infections | Inflammation | Drug therapy | Morbidity | HIV infections | Fibrinòlisi | Plasma sanguini | HIV-positive persons | Infeccions per VIH | Persones seropositives | Fibrinolysis | Blood plasma | Research & development | R&D | HIV | Human immunodeficiency virus
ALL-CAUSE MORTALITY | ELDERLY PERSONS | BIOMARKERS | FIBRIN D-DIMER | MULTIDISCIPLINARY SCIENCES | DISEASE | ADULTS | COAGULATION | ANTIRETROVIRAL THERAPY | PLASMA D-DIMER | INTERLEUKIN-6 | HIV Infections - blood | Cross-Sectional Studies | Fibrin Fibrinogen Degradation Products - metabolism | Humans | Middle Aged | Hepatitis - blood | Linear Models | Male | CD4 Lymphocyte Count | Biomarkers - blood | Coinfection - virology | Viral Load | Randomized Controlled Trials as Topic | Inflammation - metabolism | C-Reactive Protein - metabolism | Interleukin-6 - blood | Sex Factors | Adult | Female | HIV Infections - mortality | Medical research | Antiviral agents | C-reactive protein | RNA | Mortality | HIV patients | HIV (Viruses) | Diseases | Highly active antiretroviral therapy | Hepatitis | Body mass index | Interleukins | Medicine, Experimental | Diabetes | Hyaluronic acid | HIV infection | Antiretroviral drugs | Infectious diseases | Cytokines | Laboratories | Research & development--R&D | Human immunodeficiency virus--HIV | Biomarkers | Infections | Inflammation | Drug therapy | Morbidity | HIV infections | Fibrinòlisi | Plasma sanguini | HIV-positive persons | Infeccions per VIH | Persones seropositives | Fibrinolysis | Blood plasma | Research & development | R&D | HIV | Human immunodeficiency virus
Journal Article
PLoS Medicine, ISSN 1549-1277, 10/2008, Volume 5, Issue 10, pp. 1496 - 1508
Background In the Strategies for Management of Anti-Retroviral Therapy trial, all-cause mortality was higher for participants randomized to intermittent,...
C-REACTIVE PROTEIN | CARDIOVASCULAR HEALTH | MEDICINE, GENERAL & INTERNAL | RISK-FACTORS | MYOCARDIAL-INFARCTION | IMMUNE ACTIVATION | LOGISTIC-REGRESSION ANALYSIS | ANTIRETROVIRAL THERAPY | CORONARY-HEART-DISEASE | ENDOTHELIAL FUNCTION | ACTIVATION MARKERS | HIV Infections - blood | Follow-Up Studies | Fibrin Fibrinogen Degradation Products - analysis | Humans | Logistic Models | Male | Survival Rate | Treatment Outcome | Biomarkers - blood | Case-Control Studies | Cause of Death | Inflammation - blood | Serum Amyloid P-Component - analysis | Randomized Controlled Trials as Topic | Multicenter Studies as Topic | Interleukin-6 - blood | Blood Coagulation | Anti-HIV Agents - therapeutic use | Female | HIV Infections - drug therapy | HIV Infections - mortality | C-Reactive Protein - analysis | Odds Ratio | Serum Amyloid A Protein - analysis | Assaigs clínics | Antiretrovirals | Sida | Antiretroviral agents | AIDS (Disease) | Clinical trials | Marcadors bioquímics | Biochemical markers | Public Health and Epidemiology | Immunology and allergy | Chronic Disease Management | Infectious Diseases | AIDS | Epidemiology | HIV Infection
C-REACTIVE PROTEIN | CARDIOVASCULAR HEALTH | MEDICINE, GENERAL & INTERNAL | RISK-FACTORS | MYOCARDIAL-INFARCTION | IMMUNE ACTIVATION | LOGISTIC-REGRESSION ANALYSIS | ANTIRETROVIRAL THERAPY | CORONARY-HEART-DISEASE | ENDOTHELIAL FUNCTION | ACTIVATION MARKERS | HIV Infections - blood | Follow-Up Studies | Fibrin Fibrinogen Degradation Products - analysis | Humans | Logistic Models | Male | Survival Rate | Treatment Outcome | Biomarkers - blood | Case-Control Studies | Cause of Death | Inflammation - blood | Serum Amyloid P-Component - analysis | Randomized Controlled Trials as Topic | Multicenter Studies as Topic | Interleukin-6 - blood | Blood Coagulation | Anti-HIV Agents - therapeutic use | Female | HIV Infections - drug therapy | HIV Infections - mortality | C-Reactive Protein - analysis | Odds Ratio | Serum Amyloid A Protein - analysis | Assaigs clínics | Antiretrovirals | Sida | Antiretroviral agents | AIDS (Disease) | Clinical trials | Marcadors bioquímics | Biochemical markers | Public Health and Epidemiology | Immunology and allergy | Chronic Disease Management | Infectious Diseases | AIDS | Epidemiology | HIV Infection
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2014, Volume 9, Issue 4, p. e95061
Background: Non-AIDS conditions such as cardiovascular disease and non-AIDS defining cancers dominate causes of morbidity and mortality among persons with HIV...
AIDS EVENTS | POPULATION | HEART-DISEASE | ERA | MULTIDISCIPLINARY SCIENCES | PREVENTION | RISK | DEATH | HEALTH | HUMAN-IMMUNODEFICIENCY-VIRUS | CANCER | Age Factors | Follow-Up Studies | HIV Infections - epidemiology | Humans | Middle Aged | Mortality | Risk Factors | Male | Treatment Outcome | Cause of Death | Morbidity | Antiretroviral Therapy, Highly Active | Young Adult | Adult | Female | HIV Infections - drug therapy | HIV Infections - mortality | Aged | Highly active antiretroviral therapy | United States | Patient outcomes | Research | Drug therapy | Health aspects | HIV infection | End-stage renal disease | Therapy | Liver | Interleukin | Medical records | Cardiovascular disease | Medical diagnosis | Risk factors | Interleukin 6 | Liver cancer | Acquired immune deficiency syndrome--AIDS | Antiretroviral agents | Human immunodeficiency virus--HIV | Chronology | Age | Antiretroviral drugs | Liver diseases | Health risks | Risk analysis | Ribonucleic acid--RNA | Age factors | Estimates | Antiretroviral therapy | CD4 antigen | Kidney diseases | Cardiovascular diseases | Cancer | Smoking | RNA | Acquired immune deficiency syndrome | Ribonucleic acid | AIDS | HIV | Human immunodeficiency virus
AIDS EVENTS | POPULATION | HEART-DISEASE | ERA | MULTIDISCIPLINARY SCIENCES | PREVENTION | RISK | DEATH | HEALTH | HUMAN-IMMUNODEFICIENCY-VIRUS | CANCER | Age Factors | Follow-Up Studies | HIV Infections - epidemiology | Humans | Middle Aged | Mortality | Risk Factors | Male | Treatment Outcome | Cause of Death | Morbidity | Antiretroviral Therapy, Highly Active | Young Adult | Adult | Female | HIV Infections - drug therapy | HIV Infections - mortality | Aged | Highly active antiretroviral therapy | United States | Patient outcomes | Research | Drug therapy | Health aspects | HIV infection | End-stage renal disease | Therapy | Liver | Interleukin | Medical records | Cardiovascular disease | Medical diagnosis | Risk factors | Interleukin 6 | Liver cancer | Acquired immune deficiency syndrome--AIDS | Antiretroviral agents | Human immunodeficiency virus--HIV | Chronology | Age | Antiretroviral drugs | Liver diseases | Health risks | Risk analysis | Ribonucleic acid--RNA | Age factors | Estimates | Antiretroviral therapy | CD4 antigen | Kidney diseases | Cardiovascular diseases | Cancer | Smoking | RNA | Acquired immune deficiency syndrome | Ribonucleic acid | AIDS | HIV | Human immunodeficiency virus
Journal Article