Journal of Molecular Biology, ISSN 0022-2836, 04/2017, Volume 429, Issue 7, pp. 948 - 963
The stability of folded proteins is critical to their biological function and for the efficacy of protein therapeutics. Predicting the energetic effects of...
protein engineering | protein folding | molecular dynamics | protein stability | MUTANT DATABASE | DOMAIN | THERMODYNAMIC DATABASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | RESOLUTION | MISSENSE MUTATION | FAMILIAL ALZHEIMERS-DISEASE | FORCE-FIELD | MOLECULAR-DYNAMICS SIMULATIONS | BINDING | Point Mutation | Thermodynamics | Mutant Proteins - chemistry | Computational Biology | Mutant Proteins - genetics | Mutation, Missense | Protein Stability | Amino Acid Substitution | Proteins | Gene mutations | Analysis | Molecular dynamics | Amino acids | Genetic aspects
protein engineering | protein folding | molecular dynamics | protein stability | MUTANT DATABASE | DOMAIN | THERMODYNAMIC DATABASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | RESOLUTION | MISSENSE MUTATION | FAMILIAL ALZHEIMERS-DISEASE | FORCE-FIELD | MOLECULAR-DYNAMICS SIMULATIONS | BINDING | Point Mutation | Thermodynamics | Mutant Proteins - chemistry | Computational Biology | Mutant Proteins - genetics | Mutation, Missense | Protein Stability | Amino Acid Substitution | Proteins | Gene mutations | Analysis | Molecular dynamics | Amino acids | Genetic aspects
Journal Article
The Journal of Physical Chemistry B, ISSN 1520-6106, 10/2015, Volume 119, Issue 41, pp. 13113 - 13133
The micellar structure of sophorolipids, a glycolipid bolaamphiphile, is analyzed using a combination of small-angle X-ray scattering (SAXS), small-angle...
UNSYMMETRICAL BOLAAMPHIPHILES | SOFT MATTER | OLEIC-ACID | CHEMISTRY, PHYSICAL | X-RAY-SCATTERING | BOLA-AMPHIPHILES | DODECYL BENZENE SULFONATE | MOLECULAR-DYNAMICS SIMULATIONS | ANGLE NEUTRON-SCATTERING | AQUEOUS-SOLUTION | WATER | Molecular simulation | Usage | Glycolipids | Analysis | Scattering | Molecular dynamics | Neutrons | Chemical properties | Structure | Molecular structure | Computer simulation | Micelles | Styrene acrylonitrile resins | Dynamical systems | Ellipsoids | SAXS | Material chemistry | Chemical Sciences
UNSYMMETRICAL BOLAAMPHIPHILES | SOFT MATTER | OLEIC-ACID | CHEMISTRY, PHYSICAL | X-RAY-SCATTERING | BOLA-AMPHIPHILES | DODECYL BENZENE SULFONATE | MOLECULAR-DYNAMICS SIMULATIONS | ANGLE NEUTRON-SCATTERING | AQUEOUS-SOLUTION | WATER | Molecular simulation | Usage | Glycolipids | Analysis | Scattering | Molecular dynamics | Neutrons | Chemical properties | Structure | Molecular structure | Computer simulation | Micelles | Styrene acrylonitrile resins | Dynamical systems | Ellipsoids | SAXS | Material chemistry | Chemical Sciences
Journal Article
The Journal of Bone and Joint Surgery, ISSN 0021-9355, 06/2017, Volume 99, Issue 11, p. e59
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 135, Issue 6, pp. 1558 - 1568.e2
Background Invasive infections of the central nervous system (CNS) or digestive tract caused by commensal fungi of the genus Candida are rare and...
Allergy and Immunology | colitis | inherited CARD9 deficiency | invasive fungal diseases | primary immunodeficiency | Inborn error of immunity | Candida species | human | central nervous system | CHRONIC GRANULOMATOUS-DISEASE | IMMUNOLOGY | CEREBROSPINAL-FLUID | CHRONIC MUCOCUTANEOUS CANDIDIASIS | FUNGAL-INFECTIONS | INBORN-ERRORS | HYPER-IGE SYNDROME | CEREBRAL CANDIDIASIS | MASS LESION | ALLERGY | CENTRAL-NERVOUS-SYSTEM | IL-17 IMMUNITY | Colitis - genetics | Humans | CARD Signaling Adaptor Proteins - deficiency | Central Nervous System - pathology | Colitis - pathology | Male | Candidiasis, Invasive - genetics | Genetic Loci | Central Nervous System - immunology | Gastrointestinal Tract - pathology | CARD Signaling Adaptor Proteins - genetics | Meningoencephalitis - immunology | Gastrointestinal Tract - immunology | Adult | Female | Candida - immunology | Candidiasis, Invasive - pathology | Colitis - immunology | Child | Central Nervous System - microbiology | CARD Signaling Adaptor Proteins - immunology | Gene Expression | Genome-Wide Association Study | Meningoencephalitis - genetics | Gastrointestinal Tract - microbiology | Sequence Analysis, DNA | Homozygote | Colitis - microbiology | Candidiasis, Invasive - immunology | Pedigree | Meningoencephalitis - microbiology | Meningoencephalitis - pathology | Adolescent | Consanguinity | Candidiasis, Invasive - microbiology | Immunodeficiency | Mycoses | Respiratory tract diseases | Cross infection | Colitis | Nosocomial infections | Meningoencephalitis | Substance abuse treatment | Nuclear magnetic resonance--NMR | Headaches | Infections | Patients | Proteins | Inflammatory bowel disease | Infectious diseases | Plasmids | Biopsy | Vomiting | Deaths | Mutation | Age | Life Sciences | Allergology | Immunology
Allergy and Immunology | colitis | inherited CARD9 deficiency | invasive fungal diseases | primary immunodeficiency | Inborn error of immunity | Candida species | human | central nervous system | CHRONIC GRANULOMATOUS-DISEASE | IMMUNOLOGY | CEREBROSPINAL-FLUID | CHRONIC MUCOCUTANEOUS CANDIDIASIS | FUNGAL-INFECTIONS | INBORN-ERRORS | HYPER-IGE SYNDROME | CEREBRAL CANDIDIASIS | MASS LESION | ALLERGY | CENTRAL-NERVOUS-SYSTEM | IL-17 IMMUNITY | Colitis - genetics | Humans | CARD Signaling Adaptor Proteins - deficiency | Central Nervous System - pathology | Colitis - pathology | Male | Candidiasis, Invasive - genetics | Genetic Loci | Central Nervous System - immunology | Gastrointestinal Tract - pathology | CARD Signaling Adaptor Proteins - genetics | Meningoencephalitis - immunology | Gastrointestinal Tract - immunology | Adult | Female | Candida - immunology | Candidiasis, Invasive - pathology | Colitis - immunology | Child | Central Nervous System - microbiology | CARD Signaling Adaptor Proteins - immunology | Gene Expression | Genome-Wide Association Study | Meningoencephalitis - genetics | Gastrointestinal Tract - microbiology | Sequence Analysis, DNA | Homozygote | Colitis - microbiology | Candidiasis, Invasive - immunology | Pedigree | Meningoencephalitis - microbiology | Meningoencephalitis - pathology | Adolescent | Consanguinity | Candidiasis, Invasive - microbiology | Immunodeficiency | Mycoses | Respiratory tract diseases | Cross infection | Colitis | Nosocomial infections | Meningoencephalitis | Substance abuse treatment | Nuclear magnetic resonance--NMR | Headaches | Infections | Patients | Proteins | Inflammatory bowel disease | Infectious diseases | Plasmids | Biopsy | Vomiting | Deaths | Mutation | Age | Life Sciences | Allergology | Immunology
Journal Article
The Journal of Bone and Joint Surgery, ISSN 0021-9355, 06/2017, Volume 99, Issue 11, pp. e59 - e59
Journal Article
AJIC: American Journal of Infection Control, ISSN 0196-6553, 2012, Volume 40, Issue 5, pp. 396 - 407
The results of a surveillance study conducted by the International Nosocomial Infection Control Consortium (INICC) from January 2004 through December 2009 in...
Infectious Disease | Infection Control | Nosocomial infection | Ventilator-associated pneumonia | Low-income countries | Bloodstream infection | Developing countries | Central line-associated bloodstream infection | Limited-resources countries | Health care-associated infection | Urinary tract infection | Catheter-associated urinary tract infection | Network | Antibiotic resistance | Hospital infection | Device-associated infection | MORTALITY | INTENSIVE-CARE UNITS | CONTROL PROGRAM | RATES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | PERFORMANCE FEEDBACK | SAFETY NETWORK | INFECTIOUS DISEASES | LENGTH-OF-STAY | ARGENTINEAN HOSPITALS | BLOOD-STREAM INFECTIONS | Africa - epidemiology | Prevalence | Prospective Studies | Humans | Middle Aged | Cross Infection - mortality | Child, Preschool | Infant | Male | Young Adult | Aged, 80 and over | Bacteria - classification | Adult | Female | Child | Infant, Newborn | Cross Infection - epidemiology | Latin America - epidemiology | Intensive Care Units | Europe - epidemiology | International Cooperation | Asia - epidemiology | Bacteria - isolation & purification | Adolescent | Bacterial Infections - epidemiology | Aged | Bacterial Infections - mortality | Consortia | Medical colleges | Pneumonia | Hotels and motels | Bacterial pneumonia | Staphylococcus aureus infections | Urinary tract infections | Health aspects | Antibacterial agents | Public health | Infection control
Infectious Disease | Infection Control | Nosocomial infection | Ventilator-associated pneumonia | Low-income countries | Bloodstream infection | Developing countries | Central line-associated bloodstream infection | Limited-resources countries | Health care-associated infection | Urinary tract infection | Catheter-associated urinary tract infection | Network | Antibiotic resistance | Hospital infection | Device-associated infection | MORTALITY | INTENSIVE-CARE UNITS | CONTROL PROGRAM | RATES | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | PERFORMANCE FEEDBACK | SAFETY NETWORK | INFECTIOUS DISEASES | LENGTH-OF-STAY | ARGENTINEAN HOSPITALS | BLOOD-STREAM INFECTIONS | Africa - epidemiology | Prevalence | Prospective Studies | Humans | Middle Aged | Cross Infection - mortality | Child, Preschool | Infant | Male | Young Adult | Aged, 80 and over | Bacteria - classification | Adult | Female | Child | Infant, Newborn | Cross Infection - epidemiology | Latin America - epidemiology | Intensive Care Units | Europe - epidemiology | International Cooperation | Asia - epidemiology | Bacteria - isolation & purification | Adolescent | Bacterial Infections - epidemiology | Aged | Bacterial Infections - mortality | Consortia | Medical colleges | Pneumonia | Hotels and motels | Bacterial pneumonia | Staphylococcus aureus infections | Urinary tract infections | Health aspects | Antibacterial agents | Public health | Infection control
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 1, pp. 241 - 248.e3
Background Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused by inborn errors of the phagocyte nicotinamide adenine dinucleotide...
Allergy and Immunology | primary immunodeficiency | Mycobacteria | chronic granulomatous disease | BCG | tuberculosis | SUSCEPTIBILITY | VACCINATION | 1ST REPORT | CLINICAL-FEATURES | KINDREDS | IMMUNOLOGY | DEFICIENCY | ALLERGY | INFECTION | 2 CHILDREN | MUTATIONS | Granulomatous Disease, Chronic - mortality | Mycoses - epidemiology | Mycobacterium Infections - diagnosis | Bacterial Infections - etiology | Humans | Tuberculosis - etiology | Child, Preschool | Infant | Male | Granulomatous Disease, Chronic - complications | Tuberculosis - diagnosis | Granulomatous Disease, Chronic - epidemiology | Female | Retrospective Studies | Child | Mycobacterium Infections - epidemiology | Mycobacterium Infections - etiology | Mycobacterium Infections - mortality | Granulomatous Disease, Chronic - therapy | Patient Outcome Assessment | Bacterial Infections - epidemiology | Mycoses - diagnosis | Bacterial Infections - diagnosis | Mycoses - mortality | Mycoses - etiology | BCG Vaccine - administration & dosage | Bacterial Infections - mortality | Care and treatment | Chronic granulomatous disease | Bacterial infections | Analysis | Cytochrome | Pathogens | Immunization | Tuberculosis | Infectious diseases | Laboratories | Infections | Mutation | Patients | Mycoses | Mycobacterium Infections | Life Sciences | Granulomatous Disease, Chronic | BCG Vaccine | Bacterial Infections
Allergy and Immunology | primary immunodeficiency | Mycobacteria | chronic granulomatous disease | BCG | tuberculosis | SUSCEPTIBILITY | VACCINATION | 1ST REPORT | CLINICAL-FEATURES | KINDREDS | IMMUNOLOGY | DEFICIENCY | ALLERGY | INFECTION | 2 CHILDREN | MUTATIONS | Granulomatous Disease, Chronic - mortality | Mycoses - epidemiology | Mycobacterium Infections - diagnosis | Bacterial Infections - etiology | Humans | Tuberculosis - etiology | Child, Preschool | Infant | Male | Granulomatous Disease, Chronic - complications | Tuberculosis - diagnosis | Granulomatous Disease, Chronic - epidemiology | Female | Retrospective Studies | Child | Mycobacterium Infections - epidemiology | Mycobacterium Infections - etiology | Mycobacterium Infections - mortality | Granulomatous Disease, Chronic - therapy | Patient Outcome Assessment | Bacterial Infections - epidemiology | Mycoses - diagnosis | Bacterial Infections - diagnosis | Mycoses - mortality | Mycoses - etiology | BCG Vaccine - administration & dosage | Bacterial Infections - mortality | Care and treatment | Chronic granulomatous disease | Bacterial infections | Analysis | Cytochrome | Pathogens | Immunization | Tuberculosis | Infectious diseases | Laboratories | Infections | Mutation | Patients | Mycoses | Mycobacterium Infections | Life Sciences | Granulomatous Disease, Chronic | BCG Vaccine | Bacterial Infections
Journal Article
The Journal of Modern African Studies, ISSN 0022-278X, 03/2017, Volume 55, Issue 1, pp. 158 - 159
Journal Article
Journal of Biomolecular Structure and Dynamics, ISSN 0739-1102, 01/2017, Volume 35, Issue 1, pp. 159 - 181
In this paper, we describe the derivation and the validation of original RESP atomic partial charges for the N, N-dimethyl-dodecylamine oxide (LDAO)...
MD simulation | micelle | fluorescence spectroscopy | LDAO surfactant | lipid kinase PI4KA | molecular modeling | FORCE-FIELD LIBRARIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | AB-INITIO | NUCLEIC-ACIDS | BIOPHYSICS | SODIUM DODECYL-SULFATE | PHASE-BEHAVIOR | CONSTANT-TEMPERATURE | LIQUID WATER | MOLECULAR-DYNAMICS SIMULATIONS | MEMBRANE-PROTEIN CRYSTALLIZATION | ANGLE NEUTRON-SCATTERING | Phosphotransferases (Alcohol Group Acceptor) - chemistry | Molecular Conformation | Static Electricity | Molecular Dynamics Simulation | Lipids - chemistry | Proteins - metabolism | Micelles | Protein Binding | Dimethylamines - chemistry | Surface-Active Agents - chemistry | Amber - chemistry | Proteins - chemistry | Minor Histocompatibility Antigens - chemistry | Life Sciences
MD simulation | micelle | fluorescence spectroscopy | LDAO surfactant | lipid kinase PI4KA | molecular modeling | FORCE-FIELD LIBRARIES | BIOCHEMISTRY & MOLECULAR BIOLOGY | AB-INITIO | NUCLEIC-ACIDS | BIOPHYSICS | SODIUM DODECYL-SULFATE | PHASE-BEHAVIOR | CONSTANT-TEMPERATURE | LIQUID WATER | MOLECULAR-DYNAMICS SIMULATIONS | MEMBRANE-PROTEIN CRYSTALLIZATION | ANGLE NEUTRON-SCATTERING | Phosphotransferases (Alcohol Group Acceptor) - chemistry | Molecular Conformation | Static Electricity | Molecular Dynamics Simulation | Lipids - chemistry | Proteins - metabolism | Micelles | Protein Binding | Dimethylamines - chemistry | Surface-Active Agents - chemistry | Amber - chemistry | Proteins - chemistry | Minor Histocompatibility Antigens - chemistry | Life Sciences
Journal Article
Journal of Pediatrics, The, ISSN 0022-3476, 2010, Volume 157, Issue 4, pp. 623 - 629.e1
Objective To test the hypothesis that predisposition to childhood herpes simplex virus (HSV) type 1 encephalitis (HSE) may be determined in part by human...
Pediatrics | DIAGNOSIS | INTERFERON-ALPHA | ACYCLOVIR | INFECTIONS | RESISTANCE | PEDIATRICS | MICE | CEREBROSPINAL-FLUID | DEFICIENCY | FRANCE | CHILDREN | Genetic Predisposition to Disease | Acyclovir - therapeutic use | Age Factors | Antiviral Agents - therapeutic use | Humans | Risk Factors | Child, Preschool | Infant | Male | Young Adult | Simplexvirus | Encephalitis, Herpes Simplex - virology | Adolescent | Age of Onset | Encephalitis, Herpes Simplex - drug therapy | Encephalitis, Herpes Simplex - genetics | Female | Genetic Variation - genetics | Toll-Like Receptor 3 - genetics | Child | Virus diseases | Medical colleges | Encephalitis | Antiviral agents | Herpes simplex | Biological response modifiers | Herpes simplex virus
Pediatrics | DIAGNOSIS | INTERFERON-ALPHA | ACYCLOVIR | INFECTIONS | RESISTANCE | PEDIATRICS | MICE | CEREBROSPINAL-FLUID | DEFICIENCY | FRANCE | CHILDREN | Genetic Predisposition to Disease | Acyclovir - therapeutic use | Age Factors | Antiviral Agents - therapeutic use | Humans | Risk Factors | Child, Preschool | Infant | Male | Young Adult | Simplexvirus | Encephalitis, Herpes Simplex - virology | Adolescent | Age of Onset | Encephalitis, Herpes Simplex - drug therapy | Encephalitis, Herpes Simplex - genetics | Female | Genetic Variation - genetics | Toll-Like Receptor 3 - genetics | Child | Virus diseases | Medical colleges | Encephalitis | Antiviral agents | Herpes simplex | Biological response modifiers | Herpes simplex virus
Journal Article
Lancet Global Health, ISSN 2214-109X, 2014, Volume 2, Issue 7, pp. e422 - e430
Summary Background Buruli ulcer, caused by Mycobacterium ulcerans , was identified as a neglected emerging infectious disease by WHO in 1998. Although Buruli...
Internal Medicine | TRANSMISSION | OSTEOMYELITIS | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | RISK-FACTORS | DISEASE | MYCOBACTERIUM-MARINUM INFECTION | FRACTIONAL POLYNOMIALS | GHANA | CAMEROON | SKIN | REGION | Age Distribution | Prospective Studies | Follow-Up Studies | Comorbidity | Humans | Buruli Ulcer - blood | Male | Buruli Ulcer - epidemiology | Edema - diagnosis | Young Adult | Benin - epidemiology | Edema - blood | Buruli Ulcer - diagnosis | Osteomyelitis - diagnosis | Edema - epidemiology | Adolescent | Sex Distribution | Adult | Female | Causality | Osteomyelitis - epidemiology | Child | Osteomyelitis - blood | Cohort Studies
Internal Medicine | TRANSMISSION | OSTEOMYELITIS | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | RISK-FACTORS | DISEASE | MYCOBACTERIUM-MARINUM INFECTION | FRACTIONAL POLYNOMIALS | GHANA | CAMEROON | SKIN | REGION | Age Distribution | Prospective Studies | Follow-Up Studies | Comorbidity | Humans | Buruli Ulcer - blood | Male | Buruli Ulcer - epidemiology | Edema - diagnosis | Young Adult | Benin - epidemiology | Edema - blood | Buruli Ulcer - diagnosis | Osteomyelitis - diagnosis | Edema - epidemiology | Adolescent | Sex Distribution | Adult | Female | Causality | Osteomyelitis - epidemiology | Child | Osteomyelitis - blood | Cohort Studies
Journal Article