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Pain, ISSN 0304-3959, 05/2019, Volume 160 Suppl 1, pp. S17 - S22
Peripheral neuropathy is the most common neurodegenerative disease affecting hundreds of millions of patients worldwide and is an important cause of chronic... 
ACTIVATION | PROTEIN | Sarmoptosis | DLK kinase | SELF-DESTRUCTION | WALLERIAN DEGENERATION | INJURY | NMNAT2 | NEUROSCIENCES | CLINICAL NEUROLOGY | CELL-DEATH | NAD | SYNAPTIC GROWTH | SARM1 | ANESTHESIOLOGY | NEUROMUSCULAR-JUNCTION | PHR1 ligase | LEUCINE-ZIPPER KINASE
Journal Article
Cell Reports, ISSN 2211-1247, 09/2019, Volume 28, Issue 10, pp. 2581 - 2593.e5
Fragile X syndrome (FXS) is the leading heritable cause of intellectual disability and commonly co-occurs with autism spectrum disorder. Silencing of the Fmr1... 
neurodevelopment | neuromuscular junction | JNK | neurodegeneration | synaptic transmission | highwire | GNE-3511 | grooming behavior | Index Medicus
Journal Article
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 10/2010, Volume 191, Issue 1, pp. 211 - 223
Regenerative responses to axonal injury involve changes in gene expression; however, little is known about how such changes can be induced from a distant site... 
Axons | Regeneration | Larvae | Neuroscience | Neurons | Drosophila | Nerves | Physical trauma | Gene expression regulation | Physiological regulation | CYTOPLASMIC DYNEIN | DROSOPHILA NEUROMUSCULAR-JUNCTION | SYNAPTIC GROWTH | NERVOUS-SYSTEM | MIXED LINEAGE KINASE | VESICULAR GLUTAMATE TRANSPORTER | ZIPPER-BEARING KINASE | JNK PATHWAY | MICROTUBULE DYNAMICS | N-TERMINAL KINASES | CELL BIOLOGY | Drosophila melanogaster - physiology | Proto-Oncogene Proteins c-jun - physiology | Phosphoprotein Phosphatases - metabolism | Neurons - cytology | Axons - physiology | Drosophila Proteins - metabolism | Drosophila Proteins - physiology | Cell Nucleus - metabolism | Neurons - physiology | Neurons - metabolism | Nerve Tissue Proteins - physiology | Signal Transduction | MAP Kinase Kinase Kinases - genetics | Drosophila melanogaster - cytology | Gene Expression Regulation | MAP Kinase Kinase Kinases - metabolism | Nerve Regeneration | Cell Nucleus - ultrastructure | Nerve Tissue Proteins - genetics | Protein Transport | Nerve Tissue Proteins - metabolism | Animals | Proto-Oncogene Proteins c-jun - metabolism | Drosophila melanogaster - enzymology | MAP Kinase Kinase Kinases - physiology | Drosophila Proteins - genetics | Mutation | Proteins | Research | Properties | Phosphotransferases | Biochemistry | Insects | Kinases | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2018, Volume 115, Issue 37, pp. E8746 - E8754
Journal Article
Neuron, ISSN 0896-6273, 2006, Volume 51, Issue 1, pp. 57 - 69
Highwire is an extremely large, evolutionarily conserved E3 ubiquitin ligase that negatively regulates synaptic growth at the NMJ. Highwire has been proposed... 
DEVBIO | MOLNEURO | SIGNALING | DROSOPHILA NEUROMUSCULAR-JUNCTION | ACTIVATED PROTEIN-KINASE | GENE | II RECEPTOR | ENDODERM INDUCTION | MOLECULAR-CLONING | C-ELEGANS | ZIPPER-BEARING KINASE | EXPRESSION | NEUROSCIENCES | MOUSE EMBRYO | Drosophila melanogaster - embryology | MAP Kinase Signaling System - physiology | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Drosophila Proteins - metabolism | Central Nervous System - embryology | Central Nervous System - growth & development | Cell Differentiation - genetics | Female | Growth Inhibitors - genetics | Hydrolases - metabolism | MAP Kinase Kinase Kinases - genetics | Drosophila melanogaster - cytology | Proto-Oncogene Proteins c-fos - metabolism | Ubiquitin-Protein Ligases - metabolism | Synapses - enzymology | Synapses - ultrastructure | Chromosome Mapping | MAP Kinase Kinase Kinases - metabolism | Nerve Tissue Proteins - genetics | Drosophila Proteins - isolation & purification | Growth Cones - enzymology | MAP Kinase Kinase Kinases - isolation & purification | Growth Inhibitors - metabolism | Nerve Tissue Proteins - metabolism | Animals | Central Nervous System - cytology | Growth Cones - ultrastructure | Drosophila melanogaster - growth & development | Drosophila Proteins - genetics | Ubiquitin | Enzymes | Hydrolases | Gene expression | Growth | Ligases | Proteins | Mutation | Insects | Kinases | Neurons | Colleges & universities | Index Medicus
Journal Article
Journal Article
Neuron, ISSN 0896-6273, 2010, Volume 65, Issue 3, pp. 293 - 294
The branching of dendrites and axons is a key determinant of neural circuit formation. In this issue of , Kawabe et al. demonstrate that the ubiquitin ligase... 
DEGRADATION | NEUROSCIENCES | UBIQUITIN | KINASE | GROWTH | Animals | Neurites - physiology | Humans | Ubiquitin-Protein Ligases - metabolism | PTEN Phosphohydrolase - metabolism | Neurons - cytology | Axons - physiology | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Phosphatases | Proteins | Genotype & phenotype | Hypotheses | Kinases | Neurons | Index Medicus
Journal Article