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Journal of Pharmacokinetics and Pharmacodynamics, ISSN 1567-567X, 2/2016, Volume 43, Issue 1, pp. 111 - 122
We discuss the question of model identifiability within the context of nonlinear mixed effects models. Although there has been extensive research in the area... 
Biomedical Engineering | Biochemistry, general | Parameter estimation | Biomedicine | Structural identifiability | Pharmacy | Practical identifiability | Veterinary Medicine | Mixed effects model | Pharmacology/Toxicology | Pharmacokinetics | Model identifiability | Likelihood Functions | Algorithms | Computer Simulation | Humans | Population | Models, Statistical
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 1/2015, Volume 32, Issue 1, pp. 144 - 157
Journal Article
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 02/2012, Volume 45, Issue 3, p. 302
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 6/2015, Volume 32, Issue 6, pp. 1864 - 1883
To develop a population physiologically-based pharmacokinetic (PBPK) model for simvastatin (SV) and its active metabolite, simvastatin acid (SVA), that allows... 
Biochemistry, general | Biomedical Engineering | drug-drug interactions | Biomedicine | Pharmacy | PBPK | simvastatin | Medical Law | population model | Pharmacology/Toxicology | OATP1B1 | HYDROXY ACID | VARIANTS | DRUG-INTERACTIONS | "simvastatin" | QUANTIFICATION | IN-VITRO DATA | "population model" | "OATP1B1" | STATINS | CHEMISTRY, MULTIDISCIPLINARY | DISPOSITION | PRIOR DISTRIBUTIONS | "PBPK" | PHARMACOLOGY & PHARMACY | "drug-drug interactions" | PRAVASTATIN | INHIBITORS | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Activation, Metabolic | Cytochrome P-450 Enzyme Inhibitors - therapeutic use | Simvastatin - adverse effects | Humans | Hydroxymethylglutaryl-CoA Reductase Inhibitors - blood | Biological Availability | Muscle, Skeletal - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry | Healthy Volunteers | Simvastatin - blood | Organic Anion Transporters - metabolism | Tissue Distribution | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics | Organic Anion Transporters - genetics | Drug Interactions | Liver - drug effects | Muscle, Skeletal - drug effects | Muscular Diseases - chemically induced | Pharmacogenetics | Reproducibility of Results | Simvastatin - chemistry | Muscular Diseases - metabolism | Simvastatin - administration & dosage | Liver - metabolism | Simvastatin - pharmacokinetics | Simvastatin - analogs & derivatives | Polymorphism, Genetic | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Models, Biological | Solute Carrier Organic Anion Transporter Family Member 1b1 | Metabolites | Simvastatin | Drug interactions | Liver | Cytochrome P-450 | Antilipemic agents | Side effects | Pharmacology | Kinetics | Statins | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 10/2018, Volume 82, Issue 4, pp. 669 - 675
Epidermal growth factor receptor (EGFR) is thought to play a role in the regulation of cell proliferation; with its activation stimulating tumour growth. EGFR... 
Resistance | Bioluminescence | Xenograft | Medicine & Public Health | Brain metastasis | EGFR inhibitor | Oncology | Cancer Research | Pharmacology/Toxicology | ANIMALS | EGFR-TARGETED THERAPIES | ACQUIRED-RESISTANCE | TUMOR-CELLS | MECHANISMS | STRATEGIES | TYROSINE KINASE INHIBITORS | LUNG-CANCER | ONCOLOGY | OVERCOME RESISTANCE | PHARMACOLOGY & PHARMACY | Carcinoma, Non-Small-Cell Lung - pathology | Brain - diagnostic imaging | ErbB Receptors - antagonists & inhibitors | Apoptosis - drug effects | Brain Neoplasms - pathology | Lung Neoplasms - pathology | Treatment Outcome | Brain Neoplasms - drug therapy | Luminescent Measurements - methods | Piperazines - pharmacology | Xenograft Model Antitumor Assays | Brain Neoplasms - secondary | Animals | Brain - pathology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Neoplasm Staging | Quinazolines - pharmacology | Drug Resistance, Neoplasm - drug effects | Brain | Models | Epidermal growth factor | Metastasis | Lung cancer, Non-small cell | Analysis | Cell proliferation | Animal models | Parameter estimation | Growth rate | Epidermal growth factor receptors | Xenotransplantation | Lung cancer | Non-small cell lung carcinoma | Regrowth | Pharmacology | Dosage | Resistance factors | Metastases | Cell activation | Rodents | Xenografts | Inhibition | Mutation | Tumors | Cancer | Original
Journal Article