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science & technology (39) 39
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mice (12) 12
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cell biology (10) 10
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melanoma (9) 9
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proto-oncogene proteins b-raf - metabolism (7) 7
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biochemistry & molecular biology (6) 6
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proto-oncogene proteins b-raf - genetics (6) 6
stem cells (6) 6
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neoplasms (3) 3
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pharmacology. drug treatments (3) 3
phosphorylation (3) 3
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tumors of the skin and soft tissue. premalignant lesions (3) 3
xenograft model antitumor assays (3) 3
ac133 antigen (2) 2
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1. Full Text GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration
by Winkler, Ethan A and Nishida, Yoichiro and Sagare, Abhay P and Rege, Sanket V and Bell, Robert D and Perlmutter, David and Sengillo, Jesse D and Hillman, Sara and Kong, Pan and Nelson, Amy R and Sullivan, John S and Zhao, Zhen and Meiselman, Herbert J and Wenby, Rosalinda B and Soto, Jamie and Abel, E Dale and Makshanoff, Jacob and Zuniga, Edward and De Vivo, Darryl C and Zlokovic, Berislav V
Nature neuroscience, ISSN 1097-6256, 04/2015, Volume 18, Issue 4, pp. 521 - 530
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Alzheimer Disease - physiopathology | Cerebrovascular Circulation - physiology | Mice, Inbred C57BL | Blood-Brain Barrier - physiopathology | Endothelium, Vascular - physiopathology | Mice, Transgenic | Alzheimer Disease - pathology | Blood-Brain Barrier - metabolism | Blood-Brain Barrier - pathology | Animals | Glucose Transporter Type 1 - deficiency | Endothelium, Vascular - metabolism | Alzheimer Disease - metabolism | Amyloid beta-Peptides - metabolism | Endothelium, Vascular - pathology | Mice | Disease Models, Animal | Physiological aspects | Glucose | Blood-brain barrier | Neurons | Alzheimer's disease | Dextrose | Index Medicus
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2. Full Text Biology and Clinical Applications of Pancreatic Cancer Stem Cells
by Abel, Ethan V and Simeone, Diane M
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2013, Volume 144, Issue 6, pp. 1241 - 1248
Gastroenterology and Hepatology | Tumor Microenvironment | Pancreatic Cancer Stem Cells | Drug Resistance | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Cell Proliferation | Pancreatic Neoplasms - metabolism | Signal Transduction | Neoplastic Stem Cells - drug effects | Stromal Cells - pathology | Humans | Pancreatic Neoplasms - pathology | Stromal Cells - metabolism | Carcinoma, Pancreatic Ductal - metabolism | Cell Communication | Antineoplastic Agents - therapeutic use | Carcinoma, Pancreatic Ductal - therapy | Molecular Targeted Therapy | Carcinoma, Pancreatic Ductal - pathology | Animals | Neoplastic Stem Cells - metabolism | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Cell Differentiation | Pancreatic Neoplasms - therapy | Care and treatment | Pancreatic cancer | Stem cells | Physiological aspects | Development and progression | Aldehydes | Cancer | Index Medicus | Abridged Index Medicus
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3. Full Text Beta 1 integrin signaling mediates pancreatic ductal adenocarcinoma resistance to MEK inhibition
by Brannon, Arthur and Drouillard, Donovan and Steele, Nina and Schoettle, Shadae and Abel, Ethan V and Crawford, Howard C and Pasca di Magliano, Marina
Scientific reports, ISSN 2045-2322, 07/2020, Volume 10, Issue 1, pp. 11133 - 11133
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Pancreatic Neoplasms - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Drug Resistance, Neoplasm | Integrin beta1 - drug effects | Integrin beta1 - metabolism | Pancreatic Neoplasms - drug therapy | Carcinoma, Pancreatic Ductal - drug therapy | Animals | MAP Kinase Signaling System - drug effects | Cell Line, Tumor | Mice | Apoptosis | Proto-Oncogene Proteins p21(ras) - metabolism | Adenocarcinoma | Cell culture | Pancreatic cancer | MEK inhibitors | Extracellular matrix | MAP kinase | Mutants | Index Medicus
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4. Full Text FOXD3 is a mutant B-RAF-regulated inhibitor of G1-S progression in melanoma cells
by Abel, Ethan V and Aplin, Andrew E
Cancer research (Chicago, Ill.), ISSN 0008-5472, 04/2010, Volume 70, Issue 7, pp. 2891 - 2900
Tumors of the skin and soft tissue. Premalignant lesions | Dermatology | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | p21Cip1 | FOXD3 | melanoma | B-RAF | p53
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5. Full Text FOXD3 Is a Mutant B-RAF-Regulated Inhibitor of G(1)-S Progression in Melanoma Cells
by Abel, Ethan V and Aplin, Andrew E
Cancer research (Chicago, Ill.), ISSN 0008-5472, 04/2010, Volume 70, Issue 7, pp. 2891 - 2900
Life Sciences & Biomedicine | Oncology | Science & Technology | RNA, Small Interfering - genetics | Up-Regulation | Tumor Suppressor Protein p53 - biosynthesis | Humans | Gene Expression Regulation, Neoplastic | Cell Growth Processes - physiology | Tumor Suppressor Protein p53 - genetics | Gene Knockdown Techniques | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Transfection | Forkhead Transcription Factors - metabolism | Melanoma - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | MAP Kinase Kinase Kinases - antagonists & inhibitors | Cell Differentiation - physiology | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Forkhead Transcription Factors - biosynthesis | Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis | Down-Regulation | MAP Kinase Kinase Kinases - metabolism | Melanoma - pathology | Forkhead Transcription Factors - genetics | G1 Phase - physiology | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | S Phase - physiology | Index Medicus
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6. Full Text Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3
by Abel, Ethan V and Basile, Kevin J and Kugel III, Curtis H and Witkiewicz, Agnieszka K and Le, Kaitlyn and Amaravadi, Ravi K and Karakousis, Giorgos C and Xu, Xiaowei and Xu, Wei and Schuchter, Lynn M and Lee, Jason B and Ertel, Adam and Fortina, Paolo and Aplin, Andrew E
The Journal of clinical investigation, ISSN 0021-9738, 05/2013, Volume 123, Issue 5, pp. 2155 - 2168
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Immunohistochemistry | Melanoma - metabolism | Phosphorylation | Receptor, ErbB-3 - metabolism | Oligonucleotide Array Sequence Analysis | Signal Transduction | Cell Survival | raf Kinases - antagonists & inhibitors | Humans | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Neoplastic | MAP Kinase Kinase Kinases - metabolism | Sulfonamides - pharmacology | raf Kinases - metabolism | Skin Neoplasms - metabolism | Forkhead Transcription Factors - metabolism | Indoles - pharmacology | Transcription, Genetic | MAP Kinase Kinase Kinases - antagonists & inhibitors | Quinazolines - pharmacology | Care and treatment | Usage | Enzyme inhibitors | Analysis | Melanoma | Genetic aspects | Cellular signal transduction | Research | Gene expression | Statistical analysis | Genes | Genomics | Software | Mutation | RNA polymerase | Laboratory animals | Experiments | Patients | Skin cancer | Index Medicus | Abridged Index Medicus
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7. Full Text ATDC mediates a TP63-regulated basal cancer invasive program
by Palmbos, Phillip L and Wang, Yin and Bankhead III, Armand and Kelleher, Alan J and Wang, Lidong and Yang, Huibin and Ahmet, McKenzie L and Gumkowski, Erica R and Welling, Samuel D and Magnuson, Brian and Leflein, Jacob and Lorenzatti Hiles, Guadalupe and Abel, Ethan V and Dziubinski, Michele L and Urs, Sumithra and Day, Mark L and Ljungman, Mats E and Simeone, Diane M
Oncogene, ISSN 0950-9232, 2019, Volume 38, Issue 18, pp. 3340 - 3354
Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms, Basal Cell - metabolism | Tumor Suppressor Proteins - metabolism | Humans | Neoplasms, Basal Cell - pathology | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Transcription, Genetic - physiology | Neoplasm Invasiveness - pathology | Urinary Bladder Neoplasms - pathology | Cell Line, Tumor | Gene Expression Regulation, Neoplastic - physiology | Urinary Bladder Neoplasms - metabolism | Neoplasms, Squamous Cell - pathology | Neoplasms, Squamous Cell - metabolism | Genetic aspects | Research | Genetic transcription | Gene expression | Cancer | Transcription | Invasiveness | Ataxia telangiectasia | Lethality | Regulatory sequences | Bladder cancer | Tumors | Metastases | Index Medicus | basal cancer | ATDC | TRIM29 | TP63
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8. Full Text PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
by Paraiso, Kim H. T and Xiang, Yun and Rebecca, Vito W and Abel, Ethan V and Chen, Y. Ann and Munko, A. Cecilia and Wood, Elizabeth and Fedorenko, Inna V and Sondak, Vernon K and Anderson, Alexander R. A and Ribas, Antoni and Palma, Maurizia Dalla and Nathanson, Katherine L and Koomen, John M and Messina, Jane L and Smalley, Keiran S. M
Cancer research (Chicago, Ill.), ISSN 0008-5472, 04/2011, Volume 71, Issue 7, pp. 2750 - 2760
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the skin and soft tissue. Premalignant lesions | Dermatology | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | RNA, Small Interfering - genetics | Up-Regulation | Humans | Drug Resistance, Neoplasm | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - biosynthesis | Bcl-2-Like Protein 11 | Melanoma - genetics | Apoptosis Regulatory Proteins - genetics | Indoles - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Apoptosis Regulatory Proteins - biosynthesis | Melanoma - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | PTEN Phosphohydrolase - deficiency | Membrane Proteins - genetics | PTEN Phosphohydrolase - biosynthesis | Proto-Oncogene Proteins - genetics | Melanoma - pathology | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Membrane Proteins - biosynthesis | Membrane Proteins - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Apoptosis - physiology | Mutation | RNA, Small Interfering - administration & dosage | Index Medicus | PTEN | melanoma | BRAF | PLX4032 | therapy | resistance
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9. Full Text Mcl-1 Is Required for Melanoma Cell Resistance to Anoikis
by Karen Boisvert-Adamo and Whitney Longmate and Ethan V. Abel and Andrew E. Aplin
Molecular Cancer Research, ISSN 1541-7786, 04/2009, Volume 7, Issue 4, pp. 549 - 556
Mcl-1 | Melanoma | Apoptosis | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Melanoma - metabolism | Skin Neoplasms - pathology | Phosphorylation | Proto-Oncogene Proteins c-bcl-2 - physiology | Signal Transduction | Humans | RNA, Small Interfering - pharmacology | Melanocytes - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Melanoma - pathology | Fibronectins - metabolism | Skin Neoplasms - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | RNA Interference | Cell Adhesion - physiology | Myeloid Cell Leukemia Sequence 1 Protein | Skin Neoplasms - genetics | bcl-Associated Death Protein - metabolism | Anoikis | Tumor Cells, Cultured | bcl-X Protein - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Index Medicus
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10. Full Text Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma
by Kim, Edward J and Sahai, Vaibhav and Abel, Ethan V and Griffith, Kent A and Greenson, Joel K and Takebe, Naoko and Khan, Gazala N and Blau, John L and Craig, Ronald and Balis, Ulysses G and Zalupski, Mark M and Simeone, Diane M
Clinical cancer research, ISSN 1078-0432, 12/2014, Volume 20, Issue 23, pp. 5937 - 5945
Life Sciences & Biomedicine | Oncology | Science & Technology | Adenocarcinoma - pathology | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Hedgehog Proteins - metabolism | Male | Pancreatic Neoplasms - drug therapy | Neoplasm Metastasis | Neoplastic Stem Cells - metabolism | Aged, 80 and over | Female | Pancreatic Neoplasms - mortality | Biomarkers - metabolism | Pyridines - administration & dosage | Deoxycytidine - administration & dosage | Pancreatic Neoplasms - pathology | Treatment Outcome | Adenocarcinoma - drug therapy | Anilides - administration & dosage | Signal Transduction - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Biopsy | Aged | Deoxycytidine - analogs & derivatives | Adenocarcinoma - mortality | Index Medicus | GDC-0449 | stem cells | hedgehog | SMO | PTCH1 | fibrosis | GLI1
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11. Full Text Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells
by Fedorenko, I.V and Abel, E.V and Koomen, J.M and Fang, B and Wood, E.R and Chen, Y.A and Fisher, K.J and Iyengar, S and Dahlman, K.B and Wargo, J.A and Flaherty, K.T and Sosman, J.A and Sondak, V.K and Messina, J.L and Gibney, G.T and Smalley, K.S.M
Oncogene, ISSN 0950-9232, 03/2016, Volume 35, Issue 10, pp. 1225 - 1235
Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Proto-Oncogene Proteins B-raf - deficiency | Cell Survival - drug effects | PTEN Phosphohydrolase - genetics | RNA, Small Interfering - genetics | PTEN Phosphohydrolase - deficiency | Humans | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | Melanoma - pathology | Fibronectins - metabolism | Gene Knockdown Techniques | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Proteomics | Cell Line, Tumor | Female | Mice | Protein Kinase Inhibitors - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Integrin alpha5beta1 - metabolism | Care and treatment | Gene mutations | Melanoma | Development and progression | Cellular signal transduction | Genetic aspects | Health aspects | Models | Gene expression | Proteins | Mutation | Cellular biology | Kinases | Index Medicus
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