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1. Full Text Tau drives translational selectivity by interacting with ribosomal proteins
by Koren, Shon A and Hamm, Matthew J and Meier, Shelby E and Weiss, Blaine E and Nation, Grant K and Chishti, Emad A and Arango, Juan Pablo and Chen, Jing and Zhu, Haining and Blalock, Eric M and Abisambra, Jose F
Acta Neuropathologica, ISSN 0001-6322, 4/2019, Volume 137, Issue 4, pp. 571 - 583
There is a fundamental gap in understanding the consequences of tau–ribosome interactions. Tau oligomers and filaments hinder protein synthesis in vitro, and... 
Pathology | Neurosciences | Translation | Ribosome | Medicine & Public Health | rpS6 | Transcriptome | Tau | Nascent proteomics | S6 PHOSPHORYLATION | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | MESSENGER-RNAS | MEDIATED NEURODEGENERATION | MEMORY | GENE | MOUSE MODEL | PLASTICITY DEFICITS | ACCUMULATION | BINDING | ALZHEIMERS | Neurodegenerative diseases | Memory | Cognitive ability | Transgenic mice | Ribosomes | Protein biosynthesis | Ribosomal protein S6 | Gene expression | Ribonucleic acid--RNA | Learning | Proteins | Ribosomal proteins | Tau protein | Protein synthesis | Filaments | Transgenic animals | Proteomics | Original Paper
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2. Full Text Non-invasive detection of adeno-associated viral gene transfer using a genetically encoded CEST-MRI reporter gene in the murine heart
by Meier, Shelby and Gilad, Assaf A and Brandon, J. Anthony and Qian, Chenghao and Gao, Erhe and Abisambra, Jose F and Vandsburger, Moriel
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 4638 - 10
Research into gene therapy for heart failure has gained renewed interest as a result of improved safety and availability of adeno-associated viral vectors... 
TRIAL | THERAPY | SATURATION-TRANSFER MRI | MULTIDISCIPLINARY SCIENCES | SYSTEMIC INJECTION | TRACKING | MAGNETIC-RESONANCE | CHEMICAL-EXCHANGE | CELL-SURVIVAL | EXPRESSION | FAILURE | Heart failure | Nuclear magnetic resonance--NMR | Injection | Quantitation | Gene expression | Reporter gene | Biopsy | Lysine | Functional magnetic resonance imaging | Myocardium | Ventricle | Gene therapy | Heart diseases | Structure-function relationships
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3. Full Text Proteomic Techniques to Examine Neuronal Translational Dynamics
by Koren, SA and Gillett, DA and D'Alton, SV and Hamm, MJ and Abisambra, JF
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1661-6596, 07/2019, Volume 20, Issue 14, p. 3524
Impairments in translation have been increasingly implicated in the pathogenesis and progression of multiple neurodegenerative diseases. Assessing the... 
PUROMYCIN | VISUALIZATION | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | neurodegeneration | NEWLY SYNTHESIZED PROTEINS | VULNERABILITY | IDENTIFICATION | SYNAPTIC PLASTICITY | CHEMISTRY, MULTIDISCIPLINARY | AMINO-ACIDS | translation | ribosome | nascent proteomics | Alzheimer's disease | MODULATION | REVEALS | Alzheimer’s disease
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4. Full Text A new opportunity for MEMRI
by Cloyd, Ryan and Vandsburger, Moriel and Abisambra, Jose F
Aging, ISSN 1945-4589, 2017, Volume 9, Issue 8, pp. 1855 - 1856
MEMRI | MnDPDP | Neurodegeneration | Manganese | neurodegeneration | manganese | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | Manganese Compounds - administration & dosage | Pyridoxal Phosphate - administration & dosage | Pyridoxal Phosphate - therapeutic use | Humans | Magnetic Resonance Imaging - methods | Manganese Compounds - adverse effects | Mice, Transgenic | Edetic Acid - administration & dosage | Edetic Acid - analogs & derivatives | Animals | Contrast Media - adverse effects | Chlorides - administration & dosage | Chlorides - adverse effects | Contrast Media - administration & dosage | Pyridoxal Phosphate - analogs & derivatives | Edetic Acid - therapeutic use | Neurodegenerative Diseases - diagnostic imaging
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5. Full Text Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration
by Cloyd, RA and Koren, SA and Abisambra, JF
FRONTIERS IN AGING NEUROSCIENCE, ISSN 1663-4365, 12/2018, Volume 10, p. 403
Manganese-enhanced magnetic resonance imaging (MEMRI) rose to prominence in the 1990s as a sensitive approach to high contrast imaging. Following the discovery... 
TEMPORAL-LOBE EPILEPSY | MRI | CNS imaging | INDUCED PERIPHERAL NEUROPATHY | DIVALENT METAL TRANSPORTER | AXONAL-TRANSPORT | SUDDEN UNEXPECTED DEATH | manganese | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | STATE FUNCTIONAL CONNECTIVITY | HEPATOBILIARY CONTRAST AGENT | MEMRI | TRAUMATIC BRAIN-INJURY | IN-VIVO DETECTION | mangafodipir | MANGAFODIPIR TRISODIUM MNDPDP | Magnetic resonance imaging | Technology application | Neuroimaging | Calcium channels | Animal models | Nuclear magnetic resonance--NMR | Central nervous system | Nervous system | Calcium permeability | Studies | Contrast agents | Brain research | Neurodegeneration | Physiology | Magnetic fields | Manganese
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6. Brain Injury in the Context of Tauopathies
by Abisambra, Jose F and Scheff, Stephen
Journal of Alzheimer's Disease, ISSN 1387-2877, 01/2014, Volume 40, Issue 3, pp. 495 - 518
Traumatic brain injury (TBI) is the most common form of head injury and is a leading cause of death worldwide. Due to the vast variability in the types and... 
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7. PERK-opathies: An Endoplasmic Reticulum Stress Mechanism Underlying Neurodegeneration
by Bell, Michelle C and Meier, Shelby E and Ingram, Alexandria L and Abisambra, Jose F
Current Alzheimer Research, ISSN 1567-2050, 02/2016, Volume 13, Issue 2, pp. 150 - 163
The unfolded protein response (UPR) plays a vital role in maintaining cell homeostasis as a consequence of endoplasmic reticulum (ER) stress. However,... 
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8. Full Text Primary age-related tauopathy (PART): a common pathology associated with human aging
by Crary, John F and Trojanowski, John Q and Schneider, Julie A and Abisambra, Jose F and Abner, Erin L and Alafuzoff, Irina and Arnold, Steven E and Attems, Johannes and Beach, Thomas G and Bigio, Eileen H and Cairns, Nigel J and Dickson, Dennis W and Gearing, Marla and Grinberg, Lea T and Hof, Patrick R and Hyman, Bradley T and Jellinger, Kurt and Jicha, Gregory A and Kovacs, Gabor G and Knopman, David S and Kofler, Julia and Kukull, Walter A and Mackenzie, Ian R and Masliah, Eliezer and McKee, Ann and Montine, Thomas J and Murray, Melissa E and Neltner, Janna H and Santa-Maria, Ismael and Seeley, William W and Serrano-Pozo, Alberto and Shelanski, Michael L and Stein, Thor and Takao, Masaki and Thal, Dietmar R and Toledo, Jonathan B and Troncoso, Juan C and Vonsattel, Jean Paul and White 3rd, Charles L and Wisniewski, Thomas and Woltjer, Randall L and Yamada, Masahito and Nelson, Peter T and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Molekylär och morfologisk patologi and Uppsala universitet
Acta Neuropathologica, ISSN 0001-6322, 12/2014, Volume 128, Issue 6, pp. 755 - 766
We recommend a new term, “primary age-related tauopathy” (PART), to describe a pathology that is commonly observed in the brains of aged individuals. Many... 
Pathology | Neurosciences | Medicine & Public Health | Neuropathology | TOD | TPSD | Braak | Consensus | ARGYROPHILIC GRAIN DISEASE | THORN-SHAPED ASTROCYTES | PATHOLOGY | FRONTOTEMPORAL LOBAR DEGENERATION | MILD COGNITIVE IMPAIRMENT | NEUROSCIENCES | CLINICAL NEUROLOGY | SENILE-DEMENTIA | POSTERIOR CORTICAL ATROPHY | PAIRED HELICAL FILAMENTS | NEUROFIBRILLARY TANGLE TYPE | PRECLINICAL ALZHEIMERS-DISEASE | NEUROPATHOLOGICALLY DEFINED SUBTYPES | Diagnosis, Differential | Plaque, Amyloid - pathology | Tauopathies - diagnosis | Humans | Brain - pathology | Tauopathies - pathology | Terminology as Topic | Aging - pathology | Tauopathies - classification | Brain | Alzheimer's disease | Activities of daily living | consensus | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
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9. Full Text Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
by Lourenco, Mychael V and Frozza, Rudimar L and de Freitas, Guilherme B and Zhang, Hong and Kincheski, Grasielle C and Ribeiro, Felipe C and Gonçalves, Rafaella A and Clarke, Julia R and Beckman, Danielle and Staniszewski, Agnieszka and Berman, Hanna and Guerra, Lorena A and Forny-Germano, Letícia and Meier, Shelby and Wilcock, Donna M and de Souza, Jorge M and Alves-Leon, Soniza and Prado, Vania F and Prado, Marco A. M and Abisambra, Jose F and Tovar-Moll, Fernanda and Mattos, Paulo and Arancio, Ottavio and Ferreira, Sergio T and De Felice, Fernanda G
Nature Medicine, ISSN 1078-8956, 01/2019, Volume 25, Issue 1, pp. 165 - 175
Defective brain hormonal signaling has been associated with Alzheimer’s disease (AD), a disorder characterized by synapse and memory failure. Irisin is an... 
Potentiation | Physical exercise | Neuroprotection | Brain | Animal models | Long-term potentiation | Memory | Impairment | Cerebrospinal fluid | Pattern recognition | Object recognition | Fibronectin | Membrane proteins | Proteins | Plasticity (synaptic) | Plasticity | Mice | Alzheimer's disease | Hippocampus | FNDC5 | memory | synaptic plasticity | Alzheimer’s disease | irisin | physical exercise
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10. Full Text Brain injury in the context of tauopathies
by Abisambra, Jose F and Scheff, Stephen
Journal of Alzheimer's Disease, ISSN 1387-2877, 2014, Volume 40, Issue 3, pp. 495 - 518
Traumatic brain injury (TBI) is the most common form of head injury and is a leading cause of death worldwide. Due to the vast variability in the types and... 
traumatic brain injury | tau | tau post-translational modification | chronic traumatic encephalopathy | Alzheimer's disease | CONTROLLED CORTICAL IMPACT | ALZHEIMERS-DISEASE | ABNORMALLY PHOSPHORYLATED-TAU | CEREBROSPINAL-FLUID | NEUROSCIENCES | NEUROFIBRILLARY TANGLE FORMATION | FLUID PERCUSSION INJURY | MOUSE MODEL | CLOSED-HEAD-INJURY | INTRACRANIAL-PRESSURE | PROGRESSIVE SUPRANUCLEAR PALSY | Brain - metabolism | Tauopathies - etiology | Animals | Brain Injuries - cerebrospinal fluid | Humans | Brain - pathology | Brain Injuries - blood | Brain Injuries - complications | tau Proteins - cerebrospinal fluid | Brain Injuries - pathology | tau Proteins - blood | Disease Models, Animal
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11. Full Text Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models
by Lourenco, MV and Frozza, RL and de Freitas, GB and Zhang, H and Kincheski, GC and Ribeiro, FC and Goncalves, RA and Clarke, JR and Beckman, D and Staniszewski, A and Berman, H and Guerra, LA and Forny-Germano, L and Meier, S and Wilcock, DM and de Souza, JM and Alves-Leon, S and Prado, VF and Prado, MAM and Abisambra, JF and Tovar-Moll, F and Mattos, P and Arancio, O and Ferreira, ST and De Felice, FG
NATURE MEDICINE, ISSN 1078-8956, 01/2019, Volume 25, Issue 1, pp. 165 - 165
Defective brain hormonal signaling has been associated with Alzheimer's disease (AD), a disorder characterized by synapse and memory failure. Irisin is an... 
MEDICINE, RESEARCH & EXPERIMENTAL | DEPRESSIVE-LIKE BEHAVIOR | EIF2-ALPHA KINASES | HIPPOCAMPAL INSULIN-RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENERGY-INTAKE | CELL BIOLOGY | MOUSE MODEL | DISEASE | GENE-EXPRESSION | PHYSICAL-ACTIVITY | BRAIN | AMYLOID-BETA OLIGOMERS | Neuroprotective Agents - therapeutic use | Recombinant Proteins - therapeutic use | Fibronectins - cerebrospinal fluid | Memory Disorders - physiopathology | Humans | Middle Aged | Male | Memory Disorders - complications | RNA, Messenger - metabolism | Brain - metabolism | Neuroprotective Agents - pharmacology | Adult | Female | Physical Conditioning, Animal | Disease Models, Animal | Alzheimer Disease - physiopathology | Signal Transduction | Down-Regulation | Mice, Inbred C57BL | RNA, Messenger - genetics | Recombinant Proteins - pharmacology | Alzheimer Disease - cerebrospinal fluid | Fibronectins - metabolism | Animals | Neuronal Plasticity | Adolescent | Alzheimer Disease - metabolism | Long-Term Potentiation | Brain - pathology | Aged | Fibronectins - genetics | Alzheimer Disease - genetics | Fibronectins | Research | Alzheimer's disease | Analysis | Protein binding
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12. Full Text Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity
by Vanderweyde, Tara and Apicco, Daniel J and Youmans-Kidder, Katherine and Ash, Peter E.A and Cook, Casey and Lummertz da Rocha, Edroaldo and Jansen-West, Karen and Frame, Alissa A and Citro, Allison and Leszyk, John D and Ivanov, Pavel and Abisambra, Jose F and Steffen, Martin and Li, Hu and Petrucelli, Leonard and Wolozin, Benjamin
Cell Reports, ISSN 2211-1247, 05/2016, Volume 15, Issue 7, pp. 1455 - 1466
Dendritic mislocalization of microtubule associated protein tau is a hallmark of tauopathies, but the role of dendritic tau is unknown. We now report that tau... 
ALZHEIMERS-DISEASE | TDP-43 | PHASE-TRANSITION | NEURODEGENERATION | AMYOTROPHIC-LATERAL-SCLEROSIS | MUTATIONS | DOMAINS | STRESS GRANULES | AGGREGATION | AMYLOID-BETA OLIGOMERS | CELL BIOLOGY | Dendrites - drug effects | Dendrites - metabolism | Cytoplasmic Granules - drug effects | Mice, Inbred C57BL | tau Proteins - toxicity | Solubility | tau Proteins - metabolism | Protein Transport - drug effects | Brain - metabolism | Tauopathies - metabolism | Animals | Protein Folding - drug effects | Cytoplasmic Granules - metabolism | Protein Binding - drug effects | Protein Stability - drug effects | Protein Kinase Inhibitors - pharmacology | Protein Synthesis Inhibitors - pharmacology | T-Cell Intracellular Antigen-1 | Proteome - metabolism | Tauopathies - physiopathology | RNA-Binding Proteins - metabolism
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13. Full Text Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation
by Abisambra, Jose F and Jinwal, Umesh K and Blair, Laura J and O'Leary III, John C and Li, Qingyou and Brady, Sarah and Wang, Li and Guidi, Chantal E and Zhang, Bo and Nordhues, Bryce A and Cockman, Matthew and Suntharalingham, Amirthaa and Li, Pengfei and Jin, Ying and Atkins, Christopher A and Dickey, Chad A
Journal of Neuroscience, ISSN 0270-6474, 05/2013, Volume 33, Issue 22, pp. 9498 - 9507
In Alzheimer's disease (AD), the mechanisms of neuronal loss remain largely unknown. Although tau pathology is closely correlated with neuronal loss, how its... 
NEURON LOSS | NEUROFIBRILLARY TANGLES | INCLUSION-BODY MYOPATHY | ALZHEIMERS-DISEASE | ER STRESS | DIFFERENTIAL ACTIVATION | UBIQUITIN | FRONTOTEMPORAL DEMENTIA | NEUROSCIENCES | TRANSGENIC MICE | PARKINSONS-DISEASE | Immunohistochemistry | Microsomes - metabolism | Data Interpretation, Statistical | eIF-2 Kinase - metabolism | Humans | Cells, Cultured | Endoplasmic Reticulum - physiology | Ubiquitin - metabolism | tau Proteins - metabolism | Male | CD3 Complex - metabolism | Blotting, Western | Alzheimer Disease - pathology | Animals | Alzheimer Disease - metabolism | Brain - ultrastructure | Brain - pathology | Female | Brain Chemistry | Mice | Unfolded Protein Response - physiology | Endoplasmic Reticulum Stress - physiology
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