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science & technology (32) 32
animals (29) 29
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1. Full Text Inhibition of the mTOR pathway: A new mechanism of β cell toxicity induced by tacrolimus
by Rodriguez‐Rodriguez, Ana Elena and Donate‐Correa, Javier and Rovira, Jordi and Cuesto, Germán and Luis‐Ravelo, Diego and Fernandes, Miguel X and Acevedo‐Arozena, Abraham and Diekmann, Fritz and Acebes, Angel and Torres, Armando and Porrini, Esteban
American journal of transplantation, ISSN 1600-6135, 12/2019, Volume 19, Issue 12, pp. 3240 - 3249
molecular biology | murine | animal models | immunosuppressant ‐ mechanistic target of rapamycin (mTOR) | kidney transplantation/nephrology | tacrolimus | cellular biology | new onset/posttransplant | immunosuppressant ‐ calcineurin inhibitor | diabetes | basic (laboratory) research/science | Transplantation | Life Sciences & Biomedicine | Surgery | Science & Technology | Beta cells | TOR protein | Signal transduction | Immunoprecipitation | Tacrolimus | Transplants & implants | Toxicity | Fibrosarcoma | Rapamycin | Palmitic acid | Insulin | Index Medicus
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2. Full Text α-Synuclein impairs macroautophagy: implications for Parkinson's disease
by Ashley R. Winslow and Chien-Wen Chen and Silvia Corrochano and Abraham Acevedo-Arozena and David E. Gordon and Andrew A. Peden and Maike Lichtenberg and Fiona M. Menzies and Brinda Ravikumar and Sara Imarisio and Steve Brown and Cahir J. O'Kane and David C. Rubinsztein
The Journal of cell biology, ISSN 0021-9525, 9/2010, Volume 190, Issue 6, pp. 1023 - 1037
Aggregation | Quantification | Secretion | Neurons | Cell lines | Small interfering RNA | Cell aggregates | Parkinson disease | HeLa cells | Physiological regulation | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Parkinson Disease - pathology | rab1 GTP-Binding Proteins - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Phagosomes - metabolism | Secretory Vesicles - metabolism | alpha-Synuclein - secretion | Autophagy | Gene Knockdown Techniques | Protein Transport | Drosophila melanogaster - metabolism | Animals | Models, Biological | Cell Line, Tumor | Golgi Apparatus - metabolism | Membrane Proteins - metabolism | Mice | Parkinson Disease - metabolism | alpha-Synuclein - metabolism | Index Medicus
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3. Full Text Mice with endogenous TDP‐43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis
by Fratta, Pietro and Sivakumar, Prasanth and Humphrey, Jack and Lo, Kitty and Ricketts, Thomas and Oliveira, Hugo and Brito‐Armas, Jose M and Kalmar, Bernadett and Ule, Agnieszka and Yu, Yichao and Birsa, Nicol and Bodo, Cristian and Collins, Toby and Conicella, Alexander E and Mejia Maza, Alan and Marrero‐Gagliardi, Alessandro and Stewart, Michelle and Mianne, Joffrey and Corrochano, Silvia and Emmett, Warren and Codner, Gemma and Groves, Michael and Fukumura, Ryutaro and Gondo, Yoichi and Lythgoe, Mark and Pauws, Erwin and Peskett, Emma and Stanier, Philip and Teboul, Lydia and Hallegger, Martina and Calvo, Andrea and Chiò, Adriano and Isaacs, Adrian M and Fawzi, Nicolas L and Wang, Eric and Housman, David E and Baralle, Francisco and Greensmith, Linda and Buratti, Emanuele and Plagnol, Vincent and Fisher, Elizabeth MC and Acevedo‐Arozena, Abraham
The EMBO journal, ISSN 0261-4189, 06/2018, Volume 37, Issue 11, p. n/a
cryptic exon | ALS | splicing | TDP‐43 | skiptic exon | TDP-43 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA-Binding Proteins - genetics | Gene Expression Regulation - genetics | Alternative Splicing - genetics | Amyotrophic Lateral Sclerosis - genetics | Humans | Exons - genetics | DNA-Binding Proteins - genetics | Motor Neurons - pathology | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Animals | RNA Splicing - genetics | Mice | Mutation | Phenotypes | Splicing | Pathogenesis | Exons | Amyotrophic lateral sclerosis | Gene expression | Ribonucleic acid--RNA | Molecular chains | Mutants | Complexity | Proteins | RNA-binding protein | Motor neuron diseases | Neurodegeneration | Degeneration | RNA processing | Index Medicus | Neuroscience | RNA Biology | Molecular Biology of Disease
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4. Full Text Uses for humanised mouse models in precision medicine for neurodegenerative disease
by Nair, Remya R and Corrochano, Silvia and Gasco, Samanta and Tibbit, Charlotte and Thompson, David and Maduro, Cheryl and Ali, Zeinab and Fratta, Pietro and Arozena, Abraham Acevedo and Cunningham, Thomas J and Fisher, Elizabeth M. C
Mammalian genome, ISSN 0938-8990, 8/2019, Volume 30, Issue 7, pp. 173 - 191
Life Sciences | Human Genetics | Cell Biology | Animal Genetics and Genomics | Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Phenotype | Animals | Neurodegenerative Diseases - pathology | Neurodegenerative Diseases - physiopathology | Humans | Mice, Transgenic | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - therapy | Mice | Chimera | Disease Models, Animal | Precision Medicine | Stem cell research | Nervous system diseases | Huntington's chorea | Gene mutations | Analysis | Stem cells | Transplantation | Alzheimer's disease | Animal models | Parkinson's disease | Neurodegenerative diseases | Disease | Precision medicine | Movement disorders | Index Medicus
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5. Full Text Dynein mutations impair autophagic clearance of aggregate-prone proteins
by Berger, Zdenek and Ravikumar, Brinda and Rubinsztein, David C and Imarisio, Sara and Acevedo-Arozena, Abraham and Brown, Steve D M and Vacher, Coralie and O'Kane, Cahir J
Nature genetics, ISSN 1061-4036, 07/2005, Volume 37, Issue 7, pp. 771 - 776
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Humans | Huntington Disease - pathology | Cercopithecus aethiops | Autophagy | PC12 Cells | Behavior, Animal | Adenylyl Imidodiphosphate - pharmacology | Mice, Mutant Strains | Inclusion Bodies - metabolism | Nuclear Proteins - genetics | Dyneins - metabolism | Adenine - analogs & derivatives | Rats | Adenine - pharmacology | Synucleins | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Animals | Brain - pathology | Huntington Disease - genetics | Dyneins - antagonists & inhibitors | Mice | Dyneins - genetics | Mutation | Proteasome Endopeptidase Complex - metabolism | COS Cells | Diptera | Crosses, Genetic | Physiological aspects | Genetic aspects | Research | Gene mutations | Health aspects | Dynein | Index Medicus
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6. Full Text Transgenic and physiological mouse models give insights into different aspects of amyotrophic lateral sclerosis
by De Giorgio, Francesca and Maduro, Cheryl and Maduro, Cheryl and Fisher, Elizabeth M.C and Fisher, Elizabeth M C and Acevedo-Arozena, Abraham and Acevedo-Arozena, Abraham
Disease models & mechanisms, ISSN 1754-8403, 01/2019, Volume 12, Issue 1, p. dmm037424
ALS | Transgenic | Amyotrophic lateral sclerosis | Gene targeted | ENU | Knock-in | Pathology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Gene Targeting | Animals | Amyotrophic Lateral Sclerosis - physiopathology | Amyotrophic Lateral Sclerosis - genetics | Mutagenesis - genetics | Mice, Transgenic | Mutation - genetics | Disease Models, Animal | Review
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7. Full Text SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments
by Joyce, Peter I and Fratta, Pietro and Fisher, Elizabeth M. C and Acevedo-Arozena, Abraham
Mammalian genome, ISSN 0938-8990, 8/2011, Volume 22, Issue 7, pp. 420 - 448
Life Sciences | Anatomy | Zoology | Cell Biology | Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Superoxide Dismutase - genetics | Amyotrophic Lateral Sclerosis - therapy | Amyotrophic Lateral Sclerosis - genetics | Drosophila | Humans | Rats | Zebrafish | DNA-Binding Proteins - genetics | DNA-Binding Proteins - metabolism | Caenorhabditis elegans | Animals | Amyotrophic Lateral Sclerosis - metabolism | Dogs | Mice | Superoxide Dismutase-1 | Superoxide Dismutase - metabolism | Disease Models, Animal | Amyotrophic lateral sclerosis | Models | Superoxide | RNA | Protein binding | Index Medicus | Animal models | Motor neuron disease | Superoxide dismutase | Inflammation | Regulatory sequences | Mitochondria | DNA-binding protein | Protein folding | Excitotoxicity | Mutation | Axonal transport | Neurotrophins | RNA processing
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