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Inhibition of the mTOR pathway: A new mechanism of β cell toxicity induced by tacrolimus
American journal of transplantation, ISSN 1600-6135, 12/2019, Volume 19, Issue 12, pp. 3240 - 3249
molecular biology | murine | animal models | immunosuppressant ‐ mechanistic target of rapamycin (mTOR) | kidney transplantation/nephrology | tacrolimus | cellular biology | new onset/posttransplant | immunosuppressant ‐ calcineurin inhibitor | diabetes | basic (laboratory) research/science | Transplantation | Life Sciences & Biomedicine | Surgery | Science & Technology | Beta cells | TOR protein | Signal transduction | Immunoprecipitation | Tacrolimus | Transplants & implants | Toxicity | Fibrosarcoma | Rapamycin | Palmitic acid | Insulin | Index Medicus
Journal Article
The Journal of cell biology, ISSN 0021-9525, 9/2010, Volume 190, Issue 6, pp. 1023 - 1037
Aggregation | Quantification | Secretion | Neurons | Cell lines | Small interfering RNA | Cell aggregates | Parkinson disease | HeLa cells | Physiological regulation | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Parkinson Disease - pathology | rab1 GTP-Binding Proteins - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Phagosomes - metabolism | Secretory Vesicles - metabolism | alpha-Synuclein - secretion | Autophagy | Gene Knockdown Techniques | Protein Transport | Drosophila melanogaster - metabolism | Animals | Models, Biological | Cell Line, Tumor | Golgi Apparatus - metabolism | Membrane Proteins - metabolism | Mice | Parkinson Disease - metabolism | alpha-Synuclein - metabolism | Index Medicus
Journal Article
The EMBO journal, ISSN 0261-4189, 06/2018, Volume 37, Issue 11, p. n/a
cryptic exon | ALS | splicing | TDP‐43 | skiptic exon | TDP-43 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | RNA-Binding Proteins - genetics | Gene Expression Regulation - genetics | Alternative Splicing - genetics | Amyotrophic Lateral Sclerosis - genetics | Humans | Exons - genetics | DNA-Binding Proteins - genetics | Motor Neurons - pathology | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Animals | RNA Splicing - genetics | Mice | Mutation | Phenotypes | Splicing | Pathogenesis | Exons | Amyotrophic lateral sclerosis | Gene expression | Ribonucleic acid--RNA | Molecular chains | Mutants | Complexity | Proteins | RNA-binding protein | Motor neuron diseases | Neurodegeneration | Degeneration | RNA processing | Index Medicus | Neuroscience | RNA Biology | Molecular Biology of Disease
Journal Article
Mammalian genome, ISSN 0938-8990, 8/2019, Volume 30, Issue 7, pp. 173 - 191
Life Sciences | Human Genetics | Cell Biology | Animal Genetics and Genomics | Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Phenotype | Animals | Neurodegenerative Diseases - pathology | Neurodegenerative Diseases - physiopathology | Humans | Mice, Transgenic | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - therapy | Mice | Chimera | Disease Models, Animal | Precision Medicine | Stem cell research | Nervous system diseases | Huntington's chorea | Gene mutations | Analysis | Stem cells | Transplantation | Alzheimer's disease | Animal models | Parkinson's disease | Neurodegenerative diseases | Disease | Precision medicine | Movement disorders | Index Medicus
Journal Article
Nature genetics, ISSN 1061-4036, 07/2005, Volume 37, Issue 7, pp. 771 - 776
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Humans | Huntington Disease - pathology | Cercopithecus aethiops | Autophagy | PC12 Cells | Behavior, Animal | Adenylyl Imidodiphosphate - pharmacology | Mice, Mutant Strains | Inclusion Bodies - metabolism | Nuclear Proteins - genetics | Dyneins - metabolism | Adenine - analogs & derivatives | Rats | Adenine - pharmacology | Synucleins | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Animals | Brain - pathology | Huntington Disease - genetics | Dyneins - antagonists & inhibitors | Mice | Dyneins - genetics | Mutation | Proteasome Endopeptidase Complex - metabolism | COS Cells | Diptera | Crosses, Genetic | Physiological aspects | Genetic aspects | Research | Gene mutations | Health aspects | Dynein | Index Medicus
Journal Article
Disease models & mechanisms, ISSN 1754-8403, 01/2019, Volume 12, Issue 1, p. dmm037424
ALS | Transgenic | Amyotrophic lateral sclerosis | Gene targeted | ENU | Knock-in | Pathology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Gene Targeting | Animals | Amyotrophic Lateral Sclerosis - physiopathology | Amyotrophic Lateral Sclerosis - genetics | Mutagenesis - genetics | Mice, Transgenic | Mutation - genetics | Disease Models, Animal | Review
Journal Article
Mammalian genome, ISSN 0938-8990, 8/2011, Volume 22, Issue 7, pp. 420 - 448
Life Sciences | Anatomy | Zoology | Cell Biology | Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Superoxide Dismutase - genetics | Amyotrophic Lateral Sclerosis - therapy | Amyotrophic Lateral Sclerosis - genetics | Drosophila | Humans | Rats | Zebrafish | DNA-Binding Proteins - genetics | DNA-Binding Proteins - metabolism | Caenorhabditis elegans | Animals | Amyotrophic Lateral Sclerosis - metabolism | Dogs | Mice | Superoxide Dismutase-1 | Superoxide Dismutase - metabolism | Disease Models, Animal | Amyotrophic lateral sclerosis | Models | Superoxide | RNA | Protein binding | Index Medicus | Animal models | Motor neuron disease | Superoxide dismutase | Inflammation | Regulatory sequences | Mitochondria | DNA-binding protein | Protein folding | Excitotoxicity | Mutation | Axonal transport | Neurotrophins | RNA processing
Journal Article