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by George, J and Lim, J.S and Jang, S.J and Cun, Y.P and Ozretic, L and Kong, G and Leenders, F and Lu, X and Fernandez-Cuesta, L and Bosco, G and Muller, C and Dahmen, I and Jahchan, N.S and Park, K.S and Yang, D and Karnezis, A.N and Vaka, D and Torres, A and Wang, M.S and Korbel, J.O and Menon, R and Chun, S.M and Kim, D and Wilkerson, M and Hayes, N and Engelmann, D and Putzer, B and Bos, M and Michels, S and Vlasic, I and Seidel, D and Pinther, B and Schaub, P and Becker, C and Altmuller, J and Yokota, J and Kohno, T and Iwakawa, R and Tsuta, K and Noguchi, M and Muley, T and Hoffmann, H and Schnabel, P.A and Petersen, I and Chen, Y and Soltermann, A and Tischler, V and Choi, C.M and Kim, Y.H and Massion, P.P and Zou, Y and Jovanovic, D and Kontic, M and Wright, G.M and Russell, P.A and Solomon, B and Koch, I and Lindner, M and Muscarella, L.A and la Torre, A and Field, J.K and Jakopovic, M and Knezevic, J and Castanos-Velez, E and Roz, L and Pastorino, U and Brustugun, O.T and Lund-Iversen, M and Thunnissen, E and Kohler, J and Schuler, M and Botling, J and Sandelin, M and Sanchez-Cespedes, M and Salvesen, H.B and Achter, V and Lang, U and Bogus, M and Schneider, P.M and Zander, T and Ansen, S and Hallek, M and Wolf, J and Vingron, M and Yatabe, Y and Travis, W.D and Nurnberg, P and Reinhardt, C and Perner, S and Heukamp, L and Buttner, R and Haas, S.A and Brambilla, E and Peifer, M and Sage, J and Thomas, R.K and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Lungmedicin och allergologi and Uppsala universitet and Institutionen för medicinska vetenskaper
Nature, ISSN 0028-0836, 2015, Volume 524, Issue 7563, pp. 47 - 53
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic... 
NEUROENDOCRINE TUMORS | PATHWAY | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | IN-VIVO | GENES | CYCLE ARREST | NOTCH | C-KIT | MUTATIONS | CARCINOMA | Neurosecretory Systems - pathology | Receptors, Notch - metabolism | Chromosome Breakpoints | Genomics | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Male | Receptors, Notch - genetics | Gene Expression Profiling | Tumor Suppressor Protein p53 - genetics | Small Cell Lung Carcinoma - metabolism | Tumor Suppressor Proteins - genetics | Neurosecretory Systems - metabolism | Female | Nuclear Proteins - genetics | Disease Models, Animal | Lung Neoplasms - genetics | Signal Transduction - genetics | Small Cell Lung Carcinoma - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Genome, Human - genetics | Small Cell Lung Carcinoma - pathology | Tumor Protein p73 | Animals | Cyclin D1 - genetics | Retinoblastoma Protein - genetics | Alleles | Cell Line, Tumor | Mice | Gene mutations | Analysis | Exome sequencing | Lung cancer, Small cell | Genetic aspects | Drug therapy | Cancer | Pathogenesis | Lung cancer | Genomes | Mutation | Kinases | Gene expression | Cancer therapies | Tumors | Clinical Medicine | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Cancer and Oncology | Klinisk medicin | Cancer och onkologi
Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7575, pp. 700 - 704
Journal Article
Nature Protocols, ISSN 1754-2189, 06/2018, Volume 13, Issue 6, pp. 1488 - 1501
The genomes of cancer cells constantly change during pathogenesis. This evolutionary process can lead to the emergence of drug-resistant mutations in subclonal... 
Cluster analysis | Copy number variations | Oncology, Experimental | Genetic research | Genetic aspects | Research | Methods | Cancer | Performance tests | Sequences | Populations | Computer simulation | Pathogenesis | Test procedures | Genomes | Clustering | Drug resistance | UNIX (operating system) | Computer applications | Mutation | Bioinformatics | Tumors
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 727 - 8
Journal Article
Nature communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 3518
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1048 - 13
Journal Article
Science, ISSN 0036-8075, 12/2018, Volume 362, Issue 6419, pp. 1165 - 1170
Journal Article