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Molecular Pharmacology, ISSN 0026-895X, 01/2008, Volume 73, Issue 1, pp. 157 - 169
We hypothesized that lacosamide modulates voltage-gated sodium channels (VGSCs) at clinical concentrations (32-100 μM). Lacosamide reduced spiking evoked in... 
CORTEX IN-VITRO | RAT HIPPOCAMPAL-NEURONS | PHENYTOIN | LAMOTRIGINE | NA+ CHANNELS | BLOCK | BINDING-SITE | CARBAMAZEPINE | PHARMACOLOGY & PHARMACY | BLASTOMA CELLS | ANTIEPILEPTIC DRUGS | Action Potentials | Animals | Cells, Cultured | Rats | Acetamides - pharmacology | Sodium Channels - drug effects | Anticonvulsants - pharmacology | Ion Channel Gating - drug effects
Journal Article
Journal Article
Journal Article
Gut, ISSN 0017-5749, 03/2018, Volume 67, Issue 3, pp. 562 - 573
ObjectiveOncolytic viruses (OVs) represent promising, proinflammatory cancer treatments. Here, we explored whether OV-induced innate immune responses could... 
CANCER IMMUNOBIOLOGY | HEPATITIS C | ANTIVIRAL THERAPY | IMMUNOTHERAPY | HEPATOCELLULAR CARCINOMA | HEPATOCELLULAR-CARCINOMA | THERAPY | REPLICATION | PROTEIN | HEPATITIS-C VIRUS | DENDRITIC CELLS | REACTIVATION | SURGICAL OUTCOMES | RECURRENCE | INFECTION | GASTROENTEROLOGY & HEPATOLOGY | Hepacivirus - immunology | Humans | Culture Media, Conditioned - pharmacology | Liver Neoplasms - therapy | Leukocytes, Mononuclear | Interleukins - metabolism | Liver - immunology | Burkitt Lymphoma - immunology | Reoviridae - immunology | Hepacivirus - physiology | Carcinoma, Hepatocellular - immunology | Burkitt Lymphoma - therapy | Liver Neoplasms - virology | Interferon-alpha - metabolism | Virus Replication - drug effects | Burkitt Lymphoma - virology | Liver Neoplasms - immunology | Carcinoma, Hepatocellular - virology | Immunity, Innate | Mice, SCID | Herpesvirus 4, Human | Oncolytic Virotherapy | Xenograft Model Antitumor Assays | Animals | Hepatocytes | Interferon-beta - metabolism | Oncolytic Viruses - immunology | Cell Line, Tumor | Carcinoma, Hepatocellular - therapy | Mice | Natural Killer T-Cells - immunology | Immune response | Transplants & implants | Cytokines | Viruses | Cytotoxicity | Hepatocellular carcinoma | Infections | Genomes | Inflammation | Patients | Cancer therapies | Lymphoma | Proteins | Liver cancer | Hepatitis | Medical prognosis | Immunotherapy | Oncolysis | Replication | Lymphomas | Interferon | Clinical medicine | Tumors | Hepatology | 1506
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2011, Volume 31, Issue 23, pp. 8669 - 8680
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2009, Volume 15, Issue 12, pp. 1392 - 1398
The cellular mechanisms underlying typical absence seizures, which characterize various idiopathic generalized epilepsies, are not fully understood, but... 
MEDICINE, RESEARCH & EXPERIMENTAL | GAMMA-HYDROXYBUTYRIC ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNAPTIC-TRANSMISSION | MECHANISMS | CELL BIOLOGY | SPIKE | WAVE | SEIZURES | THALAMUS | MOUSE MODEL | RAT-BRAIN | RECEPTORS
Journal Article
by Ross, Mark T and Grafham, Darren V and Coffey, Alison J and Scherer, Steven and McLay, Kirsten and Muzny, Donna and Platzer, Matthias and Howell, Gareth R and Burrows, Christine and Bird, Christine P and Prankish, Adam and Lovell, Frances L and Howe, Kevin L and Ashurst, Jennifer L and Fulton, Robert S and Sudbrak, Ralf and Wen, Gaiping and Jones, Matthew C and Hurles, Matthew E and Andrews, T. Daniel and Scott, Carol E and Searle, Stephen and Ramser, Juliane and Whittaker, Adam and Deadman, Rebecca and Carter, Nigel P and Hunt, Sarah E and Chen, Rui and Cree, Andrew and Gunaratne, Preethi and Havlak, Paul and Hodgson, Anne and Metzker, Michael L and Richards, Stephen and Scott, Graham and Steffen, David and Sodergren, Erica and Wheeler, David A and Worley, Kim C and Alnscough, Rachael and Ambrose, Kerrie D and Ansari-Lari, M. Ali and Aradhya, Swaroop and Ashwell, Robert I. S and Babbage, Anne K and Bagguley, Claire L and Ballabio, Andrea and Banerjee, Ruby and Barker, Gary E and Barlow, Karen F and Barrett, Ian P and Bates, Karen N and Beare, David M and Beasley, Helen and Beasley, Oliver and Beck, Alfred and Bethel, Graeme and Blechschmidt, Karin and Brady, Nicola and Bray-Allen, Sarah and Bridgeman, Anne M and Brown, Andrew J and Brown, Mary J and Bonnin, David and Bruford, Elspeth A and Buhay, Christian and Burch, Paula and Burford, Deborah and Burgess, Joanne and Burrill, Wayne and Burton, John and Bye, Jackie M and Carder, Carol and Carrel, Laura and Chako, Joseph and Chapman, Joanne C and Chavez, Dean and Chen, Ellson and Chen, Guan and Chen, Yuan and Chen, Zhijian and Chinault, Craig and Ciccodicola, Alfredo and Clark, Sue Y and Clarke, Graham and Clee, Chris M and Clegg, Sheila and Clerc-Blankenburg, Kerstin and Clifford, Karen and Cobley, Vicky and Cole, Charlotte G and Conquer, Jen S and Corby, Nicole and Connor, Richard E and David, Robert and Davies, Joy and Davis, Clay and Davis, John and Delgado, Oliver and DeShazo, Denise and ...
Nature, ISSN 0028-0836, 03/2005, Volume 434, Issue 7031, pp. 325 - 337
Journal Article