Journal of Clinical Immunology, ISSN 0271-9142, 1/2015, Volume 35, Issue 1, pp. 1 - 10
Tuberculosis (TB) is considered a major worldwide health problem with 10 million new cases diagnosed each year. Our understanding of TB immunology has become...
Medical Microbiology | Biomedicine | Immunology | Tuberculosis | inflammasome | Infectious Diseases | Internal Medicine | TLRs | C-REACTIVE PROTEIN | BACTERIAL-INFECTIONS | DENDRITIC CELLS | ANHIDROTIC ECTODERMAL DYSPLASIA | IMMUNOLOGY | PATHOGEN RECOGNITION | LONG PENTRAXIN PTX3 | TOLL-LIKE RECEPTORS | HOST-DEFENSE | PULMONARY TUBERCULOSIS | INNATE IMMUNITY | Reactive Oxygen Species - metabolism | Cytokines - metabolism | Humans | Mycobacterium tuberculosis - immunology | Tuberculosis - etiology | Immunity, Innate | Mycobacterium tuberculosis - pathogenicity | Tuberculosis - immunology | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Models, Immunological | Animals | C-Reactive Protein - metabolism | Inflammasomes - immunology | Mice | Serum Amyloid P-Component - metabolism | Toll-Like Receptors - metabolism | Tuberculosis - metabolism | Lectins | Immunotherapy | Key Review
Medical Microbiology | Biomedicine | Immunology | Tuberculosis | inflammasome | Infectious Diseases | Internal Medicine | TLRs | C-REACTIVE PROTEIN | BACTERIAL-INFECTIONS | DENDRITIC CELLS | ANHIDROTIC ECTODERMAL DYSPLASIA | IMMUNOLOGY | PATHOGEN RECOGNITION | LONG PENTRAXIN PTX3 | TOLL-LIKE RECEPTORS | HOST-DEFENSE | PULMONARY TUBERCULOSIS | INNATE IMMUNITY | Reactive Oxygen Species - metabolism | Cytokines - metabolism | Humans | Mycobacterium tuberculosis - immunology | Tuberculosis - etiology | Immunity, Innate | Mycobacterium tuberculosis - pathogenicity | Tuberculosis - immunology | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Models, Immunological | Animals | C-Reactive Protein - metabolism | Inflammasomes - immunology | Mice | Serum Amyloid P-Component - metabolism | Toll-Like Receptors - metabolism | Tuberculosis - metabolism | Lectins | Immunotherapy | Key Review
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2004, Volume 500, Issue 1, pp. 51 - 62
Glucocorticoids bind to and activate a cytoplasmic glucocorticoid receptor. The activated glucocorticoid receptor translocates into the nucleus and binds to...
Glucocorticoid resistance | Nuclear factor-κB | Histone acetylation/deacetylation | Asthma | histone acetylation/deacetylation | DNA-BINDING | BRONCHIAL BIOPSIES | REVERSIBLE ACETYLATION | nuclear factor-kappa B | RECEPTOR | asthma | glucocorticoid resistance | NECROSIS-FACTOR-ALPHA | TERMINAL KINASE | HISTONE DEACETYLASES | MESSENGER-RNA | PHARMACOLOGY & PHARMACY | C-JUN | NF-KAPPA-B | Transcription, Genetic - drug effects | Asthma - metabolism | Anti-Inflammatory Agents - pharmacology | Humans | Chromatin Assembly and Disassembly - genetics | NF-kappa B - metabolism | Asthma - drug therapy | Receptors, Glucocorticoid - agonists | Inflammation - metabolism | Animals | Inflammation - drug therapy | Glucocorticoids - pharmacology | Inflammation - genetics | Receptors, Glucocorticoid - physiology | Chromatin | Corticosteroids | Protease inhibitors | Proteases | Analysis | Genetic aspects | DNA binding proteins | Gene expression | Theophylline | Steroids
Glucocorticoid resistance | Nuclear factor-κB | Histone acetylation/deacetylation | Asthma | histone acetylation/deacetylation | DNA-BINDING | BRONCHIAL BIOPSIES | REVERSIBLE ACETYLATION | nuclear factor-kappa B | RECEPTOR | asthma | glucocorticoid resistance | NECROSIS-FACTOR-ALPHA | TERMINAL KINASE | HISTONE DEACETYLASES | MESSENGER-RNA | PHARMACOLOGY & PHARMACY | C-JUN | NF-KAPPA-B | Transcription, Genetic - drug effects | Asthma - metabolism | Anti-Inflammatory Agents - pharmacology | Humans | Chromatin Assembly and Disassembly - genetics | NF-kappa B - metabolism | Asthma - drug therapy | Receptors, Glucocorticoid - agonists | Inflammation - metabolism | Animals | Inflammation - drug therapy | Glucocorticoids - pharmacology | Inflammation - genetics | Receptors, Glucocorticoid - physiology | Chromatin | Corticosteroids | Protease inhibitors | Proteases | Analysis | Genetic aspects | DNA binding proteins | Gene expression | Theophylline | Steroids
Journal Article
83.
Full Text
Common Infections and Target Organs Associated with Chronic Granulomatous Disease in Iran
International Archives of Allergy and Immunology, ISSN 1018-2438, 05/2019, Volume 179, Issue 1, pp. 62 - 73
Recurrent severe bacterial and fungal infections are characteristic features of the rare genetic immunodeficiency disorder chronic granulomatous disease (CGD)....
Clinical Immunology – Review Article | DIAGNOSIS | Chronic granulomatous disease | PRIMARY IMMUNODEFICIENCY DISORDERS | MANAGEMENT | IMMUNOLOGY | NATIONAL REGISTRY | CHILDREN | Infection | INTERSTITIAL LUNG-DISEASE | Aspergillus | MYCOBACTERIA | ADULT PATIENT | GENE | ALLERGY | MUTATIONS
Clinical Immunology – Review Article | DIAGNOSIS | Chronic granulomatous disease | PRIMARY IMMUNODEFICIENCY DISORDERS | MANAGEMENT | IMMUNOLOGY | NATIONAL REGISTRY | CHILDREN | Infection | INTERSTITIAL LUNG-DISEASE | Aspergillus | MYCOBACTERIA | ADULT PATIENT | GENE | ALLERGY | MUTATIONS
Journal Article
PLoS computational biology, ISSN 1553-7358, 04/2019, Volume 15, Issue 4, p. e1006951
Crohn's disease and ulcerative colitis are driven by both common and distinct underlying mechanisms of pathobiology. Both diseases, exhibit heterogeneity...
BIOMARKERS | CROHNS-DISEASE | INTERLEUKIN-17 | SIGNATURES | ULCERATIVE-COLITIS | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | IBD | INNATE LYMPHOID-CELLS | INFLIXIMAB | EXPRESSION | PLASTICITY | Pathology | Inflammatory bowel diseases | Diagnosis | Analysis | Enrichment | Cluster analysis | Biomedical research | Medical services | Clinical trials | Identification | Lymphocytes T | Macrophages | Genotype & phenotype | Heterogeneity | Cell activation | Immunology | Pathways | Precision medicine | Lymphocytes | Intestine | Classification | Signatures | Supervision | Subpopulations | Research & development--R&D | Therapeutic applications | Medical treatment | Inflammation | Gene expression | Clustering | Patients | Quality of life | Crohns disease | Inflammatory bowel disease | Biopsy | Tumor necrosis factor | Biomarkers | Ulcerative colitis | Research & development | R&D
BIOMARKERS | CROHNS-DISEASE | INTERLEUKIN-17 | SIGNATURES | ULCERATIVE-COLITIS | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | IBD | INNATE LYMPHOID-CELLS | INFLIXIMAB | EXPRESSION | PLASTICITY | Pathology | Inflammatory bowel diseases | Diagnosis | Analysis | Enrichment | Cluster analysis | Biomedical research | Medical services | Clinical trials | Identification | Lymphocytes T | Macrophages | Genotype & phenotype | Heterogeneity | Cell activation | Immunology | Pathways | Precision medicine | Lymphocytes | Intestine | Classification | Signatures | Supervision | Subpopulations | Research & development--R&D | Therapeutic applications | Medical treatment | Inflammation | Gene expression | Clustering | Patients | Quality of life | Crohns disease | Inflammatory bowel disease | Biopsy | Tumor necrosis factor | Biomarkers | Ulcerative colitis | Research & development | R&D
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2015, Volume 290, Issue 14, pp. 9111 - 9121
Airway smooth muscle (ASM) mass is increased in asthma, and ASM cells from patients with asthma are hyperproliferative and release more IL-6 and CXCL8. The BET...
SELECTIVE-INHIBITION | CELLS | PROTEIN | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALVEOLAR MACROPHAGES | RAPID CHANGES | MECHANISMS | RELATIVE CORTICOSTEROID INSENSITIVITY | PAUSE RELEASE | EXPRESSION | Asthma - metabolism | Cytokines - metabolism | Humans | RNA, Messenger - genetics | Cell Proliferation - physiology | Cells, Cultured | Transforming Growth Factor beta - physiology | Trachea - metabolism | Cytokines - genetics | Gene Knockdown Techniques | Airway Smooth Muscle | Interleukin 6 (IL-6) | Cell Proliferation | CXCL8 | I-BET762 | JQ1 | SGCBD01 | Cell Biology | Asthma | Bromodomain-containing Protein 4 (BRD4) | Myc (c-Myc)
SELECTIVE-INHIBITION | CELLS | PROTEIN | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ALVEOLAR MACROPHAGES | RAPID CHANGES | MECHANISMS | RELATIVE CORTICOSTEROID INSENSITIVITY | PAUSE RELEASE | EXPRESSION | Asthma - metabolism | Cytokines - metabolism | Humans | RNA, Messenger - genetics | Cell Proliferation - physiology | Cells, Cultured | Transforming Growth Factor beta - physiology | Trachea - metabolism | Cytokines - genetics | Gene Knockdown Techniques | Airway Smooth Muscle | Interleukin 6 (IL-6) | Cell Proliferation | CXCL8 | I-BET762 | JQ1 | SGCBD01 | Cell Biology | Asthma | Bromodomain-containing Protein 4 (BRD4) | Myc (c-Myc)
Journal Article
Chest, ISSN 0012-3692, 06/2018, Volume 153, Issue 6, pp. 1424 - 1431
COPD is a leading cause of morbidity and mortality worldwide. Long-term cigarette smoking is the cause of > 90% of COPD cases in Westernized countries....
BALT | autoantibody | autoimmunity | ADCC | mAbs | AUTOANTIBODIES | LUNG | MECHANISMS | PATHOGENESIS | CELL-ACTIVATING FACTOR | RESPIRATORY SYSTEM | INFLAMMATION | DISEASE | IL-17 | MONOCLONAL-ANTIBODIES | T-CELLS | CRITICAL CARE MEDICINE | Autoimmunity | Lung diseases, Obstructive | Comorbidity | Patient outcomes | Causes of | Research | Health aspects | Smoking
BALT | autoantibody | autoimmunity | ADCC | mAbs | AUTOANTIBODIES | LUNG | MECHANISMS | PATHOGENESIS | CELL-ACTIVATING FACTOR | RESPIRATORY SYSTEM | INFLAMMATION | DISEASE | IL-17 | MONOCLONAL-ANTIBODIES | T-CELLS | CRITICAL CARE MEDICINE | Autoimmunity | Lung diseases, Obstructive | Comorbidity | Patient outcomes | Causes of | Research | Health aspects | Smoking
Journal Article
Clinical Science, ISSN 0143-5221, 2017, Volume 131, Issue 11, pp. 1147 - 1159
Airway remodelling is an important component of chronic obstructive pulmonary disease (COPD). Neutrophil gelatinase-associated lipocalin (NGAL) from...
EPITHELIAL-MESENCHYMAL TRANSITION | FIBROSIS | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | OXIDATIVE STRESS | INFLAMMATION | OZONE-EXPOSURE | ASTHMA | CIGARETTE-SMOKE | PERIPHERAL-BLOOD | EXPRESSION | Epithelial-Mesenchymal Transition - physiology | Humans | Middle Aged | Wnt Signaling Pathway - physiology | Epithelial-Mesenchymal Transition - drug effects | Pulmonary Disease, Chronic Obstructive - physiopathology | Pulmonary Disease, Chronic Obstructive - pathology | Basement Membrane - pathology | Inflammation Mediators - pharmacology | Bronchoalveolar Lavage Fluid - cytology | Lipocalin-2 - genetics | Lung - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Airway Remodeling - physiology | Bronchi - pathology | Neutrophils - metabolism | Disease Models, Animal | Lipocalin-2 - pharmacology | Lipocalin-2 - physiology | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | Ozone | Gene Expression Regulation - drug effects | Cell Movement - drug effects | Smoking - metabolism | Animals | Lipocalin-2 - metabolism | Wnt Signaling Pathway - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Aged | Cell Proliferation - drug effects
EPITHELIAL-MESENCHYMAL TRANSITION | FIBROSIS | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | OXIDATIVE STRESS | INFLAMMATION | OZONE-EXPOSURE | ASTHMA | CIGARETTE-SMOKE | PERIPHERAL-BLOOD | EXPRESSION | Epithelial-Mesenchymal Transition - physiology | Humans | Middle Aged | Wnt Signaling Pathway - physiology | Epithelial-Mesenchymal Transition - drug effects | Pulmonary Disease, Chronic Obstructive - physiopathology | Pulmonary Disease, Chronic Obstructive - pathology | Basement Membrane - pathology | Inflammation Mediators - pharmacology | Bronchoalveolar Lavage Fluid - cytology | Lipocalin-2 - genetics | Lung - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Airway Remodeling - physiology | Bronchi - pathology | Neutrophils - metabolism | Disease Models, Animal | Lipocalin-2 - pharmacology | Lipocalin-2 - physiology | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | Ozone | Gene Expression Regulation - drug effects | Cell Movement - drug effects | Smoking - metabolism | Animals | Lipocalin-2 - metabolism | Wnt Signaling Pathway - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Aged | Cell Proliferation - drug effects
Journal Article
Respiratory Research, ISSN 1465-9921, 11/2018, Volume 19, Issue 1, pp. 230 - 12
BackgroundMitochondrial damage leading to oxidant stress may play an important role in the pathogenesis of airflow obstruction and emphysema. NLPR3...
Mitochondrial ROS | Ozone | Lung inflammation | NLRP3 inflammasome | Emphysema | RESPIRATORY SYSTEM | INJURY | LEADS | RECEPTOR | DYSFUNCTION | STRESS | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Oxidative Stress - physiology | Emphysema - metabolism | Male | Ozone - toxicity | Ozone - administration & dosage | Animals | Pneumonia - chemically induced | Emphysema - chemically induced | Mice | Oxidative Stress - drug effects | Mitochondria - physiology | Pneumonia - metabolism | NLRP3 | Reactive oxygen species | Genetic aspects | Research | Lung diseases | Risk factors | Oxidative stress | Senescence | Pathogenesis | Smooth muscle | Mitochondrial DNA | Remodeling | Caspase-1 | Respiratory tract | Interleukin 6 | Proteins | Mitochondria | Bronchoalveolar lavage | Chronic obstructive pulmonary disease | Inhibition | Alveoli | Pathogens | Muscles | Bronchus | Caspase | Inflammation | Exposure | Gene expression | Cigarettes | IL-1β | Air flow | Inhibitors | Lungs | Electron transport | Laboratory animals
Mitochondrial ROS | Ozone | Lung inflammation | NLRP3 inflammasome | Emphysema | RESPIRATORY SYSTEM | INJURY | LEADS | RECEPTOR | DYSFUNCTION | STRESS | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Oxidative Stress - physiology | Emphysema - metabolism | Male | Ozone - toxicity | Ozone - administration & dosage | Animals | Pneumonia - chemically induced | Emphysema - chemically induced | Mice | Oxidative Stress - drug effects | Mitochondria - physiology | Pneumonia - metabolism | NLRP3 | Reactive oxygen species | Genetic aspects | Research | Lung diseases | Risk factors | Oxidative stress | Senescence | Pathogenesis | Smooth muscle | Mitochondrial DNA | Remodeling | Caspase-1 | Respiratory tract | Interleukin 6 | Proteins | Mitochondria | Bronchoalveolar lavage | Chronic obstructive pulmonary disease | Inhibition | Alveoli | Pathogens | Muscles | Bronchus | Caspase | Inflammation | Exposure | Gene expression | Cigarettes | IL-1β | Air flow | Inhibitors | Lungs | Electron transport | Laboratory animals
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 12/2002, Volume 110, Issue 6, pp. S261 - S268
β -Adrenergic receptor agonists and glucocorticoids are the two most effective treatments for asthma, and used in combination they are more effective than...
mitogen-activated protein kinase | Phosphorylation | gene induction | nuclear translocation | Mitogen-activated protein kinase | Gene induction | Nuclear translocation
mitogen-activated protein kinase | Phosphorylation | gene induction | nuclear translocation | Mitogen-activated protein kinase | Gene induction | Nuclear translocation
Journal Article
American journal of respiratory and critical care medicine, ISSN 1073-449X, 2017, Volume 195, Issue 4, pp. 443 - 455
Rationale: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. Objectives: Using transcriptomic profiling of airway...
Gene set variation analysis | T-helper type 2 | Corticosteroid insensitivity | Severe asthma | Exhaled nitric oxide | corticosteroid insensitivity | CELLS | OXIDATIVE STRESS | CLINICAL PHENOTYPES | INTERLEUKIN-5 | CLUSTER-ANALYSIS | RESPIRATORY SYSTEM | gene set variation analysis | INFLAMMATION | ALLERGIC-ASTHMA | severe asthma | exhaled nitric oxide | GENE-EXPRESSION | AIR-FLOW OBSTRUCTION | ATOPIC ASTHMA | CRITICAL CARE MEDICINE | Sputum - cytology | Humans | Middle Aged | Bronchoscopy - methods | Male | Th2 Cells - immunology | Adrenal Cortex Hormones - therapeutic use | Eosinophils - immunology | Sputum - immunology | Asthma - immunology | Adult | Female | Leukocyte Count | Bronchi - pathology | Severity of Illness Index | Biomarkers - analysis | Breath Tests | Adrenal Cortex Hormones - pharmacology | Gene Expression Profiling - methods | Th2 Cells - cytology | Inflammation | Asthma - drug therapy | Asthma - genetics | Gene Expression Profiling - instrumentation | Drug Resistance - genetics | Phenotype | Biopsy | Drug Resistance - immunology | Adrenal Cortex Hormones - immunology | Eosinophils - cytology | Asthma - pathology | Bronchoscopy - instrumentation | Cohort Studies | Index Medicus | Abridged Index Medicus
Gene set variation analysis | T-helper type 2 | Corticosteroid insensitivity | Severe asthma | Exhaled nitric oxide | corticosteroid insensitivity | CELLS | OXIDATIVE STRESS | CLINICAL PHENOTYPES | INTERLEUKIN-5 | CLUSTER-ANALYSIS | RESPIRATORY SYSTEM | gene set variation analysis | INFLAMMATION | ALLERGIC-ASTHMA | severe asthma | exhaled nitric oxide | GENE-EXPRESSION | AIR-FLOW OBSTRUCTION | ATOPIC ASTHMA | CRITICAL CARE MEDICINE | Sputum - cytology | Humans | Middle Aged | Bronchoscopy - methods | Male | Th2 Cells - immunology | Adrenal Cortex Hormones - therapeutic use | Eosinophils - immunology | Sputum - immunology | Asthma - immunology | Adult | Female | Leukocyte Count | Bronchi - pathology | Severity of Illness Index | Biomarkers - analysis | Breath Tests | Adrenal Cortex Hormones - pharmacology | Gene Expression Profiling - methods | Th2 Cells - cytology | Inflammation | Asthma - drug therapy | Asthma - genetics | Gene Expression Profiling - instrumentation | Drug Resistance - genetics | Phenotype | Biopsy | Drug Resistance - immunology | Adrenal Cortex Hormones - immunology | Eosinophils - cytology | Asthma - pathology | Bronchoscopy - instrumentation | Cohort Studies | Index Medicus | Abridged Index Medicus
Journal Article
Thorax, ISSN 0040-6376, 06/2011, Volume 66, Issue 6, pp. 521 - 527
BackgroundChronic obstructive pulmonary disease (COPD) is characterised by oxidative stress and increased risk of lung carcinoma. Oxidative stress causes DNA...
CELLS | OXIDATIVE STRESS | ACETYLATION | RESPIRATORY SYSTEM | DEPENDENT PROTEIN-KINASE | RISK | END | Smoking - adverse effects | Epithelial Cells - metabolism | Antigens, Nuclear - metabolism | Epithelial Cells - drug effects | Humans | Lung Neoplasms - metabolism | Middle Aged | Male | Bronchi - drug effects | DNA-Binding Proteins - metabolism | Lung Neoplasms - etiology | Bronchi - metabolism | Adult | Female | Pulmonary Disease, Chronic Obstructive - metabolism | Bronchi - cytology | Disease Models, Animal | Pulmonary Disease, Chronic Obstructive - genetics | Lung Neoplasms - genetics | Mice, Inbred C57BL | Cells, Cultured | Hydrogen Peroxide - pharmacology | Oxidative Stress - genetics | Pulmonary Disease, Chronic Obstructive - complications | Animals | Ku Autoantigen | DNA Repair | Aged | Mice | DNA Damage | Lung diseases, Obstructive | Care and treatment | DNA damage | Lung cancer | Causes of | Development and progression | Health aspects | DNA repair | Risk factors
CELLS | OXIDATIVE STRESS | ACETYLATION | RESPIRATORY SYSTEM | DEPENDENT PROTEIN-KINASE | RISK | END | Smoking - adverse effects | Epithelial Cells - metabolism | Antigens, Nuclear - metabolism | Epithelial Cells - drug effects | Humans | Lung Neoplasms - metabolism | Middle Aged | Male | Bronchi - drug effects | DNA-Binding Proteins - metabolism | Lung Neoplasms - etiology | Bronchi - metabolism | Adult | Female | Pulmonary Disease, Chronic Obstructive - metabolism | Bronchi - cytology | Disease Models, Animal | Pulmonary Disease, Chronic Obstructive - genetics | Lung Neoplasms - genetics | Mice, Inbred C57BL | Cells, Cultured | Hydrogen Peroxide - pharmacology | Oxidative Stress - genetics | Pulmonary Disease, Chronic Obstructive - complications | Animals | Ku Autoantigen | DNA Repair | Aged | Mice | DNA Damage | Lung diseases, Obstructive | Care and treatment | DNA damage | Lung cancer | Causes of | Development and progression | Health aspects | DNA repair | Risk factors
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 09/2004, Volume 200, Issue 5, pp. 689 - 695
Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease of the lungs with little or no response to glucocorticoids and a high...
Histone deacetylases | Steroid resistance | Interleukin-8 | Theophylline | COPD | steroid resistance | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | theophylline | ALPHA | KAPPA-B | IMMUNOLOGY | interleukin-8 | histone deacetylase | OBSTRUCTIVE PULMONARY-DISEASE | SMOKERS | GENE-EXPRESSION | ALVEOLAR MACROPHAGES | ASTHMA | ASSOCIATION | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Enzyme-Linked Immunosorbent Assay | Oxidative Stress | Glutathione - metabolism | Humans | Middle Aged | Lipopolysaccharides - metabolism | Bronchodilator Agents - pharmacology | Histone Deacetylases - metabolism | Male | Inflammation | Blotting, Western | Macrophages - metabolism | U937 Cells | Steroids - metabolism | Theophylline - pharmacology | Female | Aged | Interleukin-8 - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Hydroxamic Acids - pharmacology | Smoking | Brief Definitive Report
Histone deacetylases | Steroid resistance | Interleukin-8 | Theophylline | COPD | steroid resistance | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | theophylline | ALPHA | KAPPA-B | IMMUNOLOGY | interleukin-8 | histone deacetylase | OBSTRUCTIVE PULMONARY-DISEASE | SMOKERS | GENE-EXPRESSION | ALVEOLAR MACROPHAGES | ASTHMA | ASSOCIATION | Immunohistochemistry | Tumor Necrosis Factor-alpha - metabolism | Enzyme-Linked Immunosorbent Assay | Oxidative Stress | Glutathione - metabolism | Humans | Middle Aged | Lipopolysaccharides - metabolism | Bronchodilator Agents - pharmacology | Histone Deacetylases - metabolism | Male | Inflammation | Blotting, Western | Macrophages - metabolism | U937 Cells | Steroids - metabolism | Theophylline - pharmacology | Female | Aged | Interleukin-8 - metabolism | Pulmonary Disease, Chronic Obstructive - metabolism | Hydroxamic Acids - pharmacology | Smoking | Brief Definitive Report
Journal Article