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1. Full Text Functional and Evolutionary Insights from the Genomes of Three Parasitoid Nasonia Species
by Werren, John H and Richards, Stephen and Desjardins, Christopher A and Niehuis, Oliver and Gadau, Juergen and Colbourne, John K and Beukeboom, Leo W and Desplan, Claude and Elsik, Christine G and Grimmelikhuijzen, Cornelis J. P and Kitts, Paul and Lynch, Jeremy A and Murphy, Terence and Oliveira, Deodoro C. S. G and Smith, Christopher D and van de Zande, Louis and Worley, Kim C and Zdobnov, Evgeny M and Aerts, Maarten and Albert, Stefan and Anaya, Victor H and Anzola, Juan M and Barchuk, Angel R and Behura, Susanta K and Bera, Agata N and Berenbaum, May R and Bertossa, Rinaldo C and Bitondi, Marcia M. G and Bordenstein, Seth R and Bork, Peer and Bornberg-Bauer, Erich and Brunain, Marleen and Cazzamali, Giuseppe and Chaboub, Lesley and Chacko, Joseph and Chavez, Dean and Childers, Christopher P and Choi, Jeong-Hyeon and Clark, Michael E and Claudianos, Charles and Clinton, Rochelle A and Cree, Anew G and Cristino, Alexane S and Dang, Phat M and Darby, Alistair C and de Graaf, Dirk C and Devreese, Bart and Dinh, Huyen H and Edwards, Rachel and Elango, Navin and Elhaik, Eran and Ermolaeva, Olga and Evans, Jay D and Foret, Sylvain and Fowler, Gerald R and Gerlach, Daniel and Gibson, Joshua D and Gilbert, Donald G and Graur, Dan and Grunder, Stefan and Hagen, Darren E and Han, Yi and Hauser, Frank and Hultmark, Dan and Hunter, Henry C and Jhangian, Shalini N and Jiang, Huaiyang and Johnson, Reed M and Jones, Anew K and Junier, Thomas and Kadowaki, Tatsuhiko and Kamping, Albert and Kapustin, Yuri and Kechavarzi, Bobak and Kim, Jaebum and Kim, Jay and Kiryutin, Boris and Koevoets, Tosca and Kovar, Christie L and Kriventseva, Evgenia V and Kucharski, Robert and Lee, Heewook and Lee, Sana L and Lees, Kristin and Lewis, Lora R and Loehlin, David W and Logsdon, John M and Lopez, Jacqueline A and Lozado, Ryan J and Maglott, Donna and Maleszka, Ryszard and Mayampurath, Anoop and Mazur, Danielle J and McClure, Marcella A and Moore, Anew D and Morgan, Margaret B and Muller, Jean and Munoz-Torres, Monica C and Muzny, Donna M and Nazareth, Lynne V and ... and Nasonia Genome Working Grp and Nasonia Genome Working Group and The Nasonia Genome Working Group
Science (American Association for the Advancement of Science), ISSN 0036-8075, 1/2010, Volume 327, Issue 5963, pp. 343 - 348
Parasitoids | Venoms | Wolbachia | Medical genetics | Evolutionary genetics | Reports | Genomes | Biology | Insect genomes | Insect genetics | Research universities | HYMENOPTERA | VITRIPENNIS | SOCIAL INSECTS | DNA METHYLATION | APIS-MELLIFERA | GENES | PTEROMALIDAE | HONEYBEE | WASP NASONIA | DROSOPHILA | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Animals | Biological evolution | Cytogenetics | Biological and medical sciences | Genetics of eukaryotes. Biological and molecular evolution | Invertebrata | Molecular Sequence Data | Male | Wasps - genetics | Genetic Variation | DNA Methylation | Wolbachia - genetics | Wasp Venoms - chemistry | Arthropods - parasitology | Recombination, Genetic | Genetic Speciation | Wasp Venoms - toxicity | Female | Wasps - physiology | Genome, Insect | Host-Parasite Interactions | Insect Proteins - metabolism | Insect Viruses - genetics | Genes, Insect | Insect Proteins - genetics | Gene Transfer, Horizontal | Insecta - genetics | Sequence Analysis, DNA | DNA Transposable Elements | Biological Evolution | Quantitative Trait Loci | Developmental genetics | Genetic aspects | Research | Nucleotide sequencing | Wasps | Agricultural pests | Methods | Animal populations | Parasites | Insects | Evolutionary biology | Genomics | Index Medicus
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2. Full Text Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC
by Socinski, Mark A and Jotte, Robert M and Cappuzzo, Federico and Orlandi, Francisco and Stroyakovskiy, Daniil and Nogami, Naoyuki and Rodríguez-Abreu, Delvys and Moro-Sibilot, Denis and Thomas, Christian A and Barlesi, Fabrice and Finley, Gene and Kelsch, Claudia and Lee, Anthony and Coleman, Shelley and Deng, Yu and Shen, Yijing and Kowanetz, Marcin and Lopez-Chavez, Ariel and Sandler, Alan and Reck, Martin and IMpower150 Study Grp and IMpower150 Study Group
The New England journal of medicine, ISSN 0028-4793, 06/2018, Volume 378, Issue 24, pp. 2288 - 2301
PHASE-III TRIAL | CELLS | MULTICENTER | THERAPY | BEVACIZUMAB | ANTIBODY | OPEN-LABEL | CANCER | DOCETAXEL | CHEMOTHERAPY | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Lung Neoplasms - drug therapy | Lung Neoplasms - mortality | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Lung Neoplasms - pathology | Male | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - secondary | Anaplastic Lymphoma Kinase | Neoplasm Metastasis - drug therapy | Immunotherapy | Female | Paclitaxel - administration & dosage | Bevacizumab - administration & dosage | Carcinoma, Non-Small-Cell Lung - genetics | Carboplatin - administration & dosage | Carcinoma, Non-Small-Cell Lung - mortality | Genes, erbB-1 | B7-H1 Antigen - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - genetics | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Lung cancer, Non-small cell | Drug therapy | Research | Epidermal growth factor receptors | Liver | Non-small cell lung carcinoma | Oncology | Lymphocytes T | Metastasis | Cancer therapies | Patients | Bevacizumab | Metastases | Immunosuppression | Chemotherapy | Motivation | Medical prognosis | PD-L1 protein | Paclitaxel | Carboplatin | Population | Death | Vascular endothelial growth factor | Genotypes | Apoptosis | Tumors | Index Medicus | Abridged Index Medicus
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3. Full Text The Genome of Black Cottonwood, Populus trichocarpa (Torr. & Gray)
by G. A. Tuskan and S. DiFazio and S. Jansson and J. Bohlmann and I. Grigoriev and U. Hellsten and N. Putnam and S. Ralph and S. Rombauts and A. Salamov and J. Schein and L. Sterck and A. Aerts and R. R. Bhalerao and R. P. Bhalerao and D. Blaudez and W. Boerjan and A. Brun and A. Brunner and V. Busov and M. Campbell and J. Carlson and M. Chalot and J. Chapman and G.-L. Chen and D. Cooper and P. M. Coutinho and J. Couturier and S. Covert and Q. Cronk and R. Cunningham and J. Davis and S. Degroeve and A. Déjardin and C. dePamphilis and J. Detter and B. Dirks and I. Dubchak and S. Duplessis and J. Ehlting and B. Ellis and K. Gendler and D. Goodstein and M. Gribskov and J. Grimwood and A. Groover and L. Gunter and B. Hamberger and B. Heinze and Y. Helariutta and B. Henrissat and D. Holligan and R. Holt and W. Huang and N. Islam-Faridi and S. Jones and M. Jones-Rhoades and R. Jorgensen and C. Joshi and J. Kangasjärvi and J. Karlsson and C. Kelleher and R. Kirkpatrick and M. Kirst and A. Kohler and U. Kalluri and F. Larimer and J. Leebens-Mack and J.-C. Leplé and P. Locascio and Y. Lou and S. Lucas and F. Martin and B. Montanini and C. Napoli and D. R. Nelson and C. Nelson and K. Nieminen and O. Nilsson and V. Pereda and G. Peter and R. Philippe and G. Pilate and A. Poliakov and J. Razumovskaya and P. Richardson and C. Rinaldi and K. Ritland and P. Rouzé and D. Ryaboy and J. Schmutz and J. Schrader and B. Segerman and H. Shin and A. Siddiqui and F. Sterky and A. Terry and C.-J. Tsai and E. Uberbacher and P. Unneberg and ... and Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Science (American Association for the Advancement of Science), ISSN 0036-8075, 9/2006, Volume 313, Issue 5793, pp. 1596 - 1604
Enzymes | Disease resistance | MicroRNA | Genes | Genomics | Genomes | Biology | Biosynthesis | Research Articles | Chromosomes | Forest genetics | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Genetics and breeding of economic plants | Agronomy. Soil science and plant productions | Gene Duplication | Protein Structure, Tertiary | Gene Expression | Oligonucleotide Array Sequence Analysis | Genes, Plant | Computational Biology | Chromosome Mapping | Populus - genetics | RNA, Plant - analysis | Genome, Plant | Phylogeny | Sequence Analysis, DNA | Arabidopsis - genetics | Plant Proteins - genetics | Plant Proteins - chemistry | Populus - metabolism | RNA, Untranslated - analysis | Populus - growth & development | Polymorphism, Single Nucleotide | Evolution, Molecular | Expressed Sequence Tags | Cytokinins | Chromosome mapping | Cottonwood | Plant genetics | Genetic aspects | Research | Properties | Observations | Gene expression | Methods | Trees | Proteins | Index Medicus | Life Sciences | Cellular Biology | METABOLITES | BASIC BIOLOGICAL SCIENCES | COTTONWOODS | MERISTEMS | NUCLEOTIDES | TRANSPORT | BIOSYNTHESIS | GENETIC MAPPING | GENES | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | ARABIDOPSIS | PROTEINS | DISEASE RESISTANCE
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4. Full Text Cytosolic glucosylceramide regulates endolysosomal function in Niemann-Pick type C disease
by Wheeler, Simon and Haberkant, Per and Bhardwaj, Meenakshi and Tongue, Paige and Ferraz, Maria J and Halter, David and Sprong, Hein and Schmid, Ralf and Aerts, Johannes M.F.G and Sullo, Nikol and Sillence, Dan J
Neurobiology of disease, ISSN 0969-9961, 07/2019, Volume 127, pp. 242 - 252
Sphingolipid | Neurodegenerative disease | Endocytosis | Glycolipids | Lysosomal acidification | GBA2 | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Lysosomes - drug effects | Niemann-Pick C1 Protein - antagonists & inhibitors | Humans | Cytosol - drug effects | Androstenes - pharmacology | Endosomes - metabolism | Niemann-Pick Disease, Type C - metabolism | Animals | Lysosomes - metabolism | Fibroblasts - drug effects | Endosomes - drug effects | Cytosol - metabolism | Mice | Glucosylceramides - metabolism | Fibroblasts - metabolism | Membrane lipids | Nervous system diseases | Plant lipids | Analysis | Cells | Index Medicus
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5. Full Text Iminosugar-based inhibitors of glucosylceramide synthase prolong survival but paradoxically increase brain glucosylceramide levels in Niemann–Pick C mice
by Nietupski, Jennifer B and Pacheco, Joshua J and Chuang, Wei-Lien and Maratea, Kimberly and Li, Lingyun and Foley, Joseph and Ashe, Karen M and Cooper, Christopher G.F and Aerts, Johannes M.F.G and Copeland, Diane P and Scheule, Ronald K and Cheng, Seng H and Marshall, John
Molecular genetics and metabolism, ISSN 1096-7192, 04/2012, Volume 105, Issue 4, pp. 621 - 628
Glucosylceramide | GBA2 gene | Niemann–Pick type C disease | Lysosomal storage disease | Glucosylceramide synthase | Substrate reduction therapy | Niemann-Pick type C disease | Endocrinology & Metabolism | Genetics & Heredity | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Glucosyltransferases - antagonists & inhibitors | Niemann-Pick Disease, Type C - drug therapy | Brain - cytology | Niemann-Pick Disease, Type C - enzymology | Liver - metabolism | Imino Sugars - therapeutic use | Survival Rate | Enzyme Inhibitors - therapeutic use | Mice, Knockout | Brain - drug effects | Brain - metabolism | Drug Synergism | Animals | Liver - drug effects | Glycosphingolipids - metabolism | Niemann-Pick Disease, Type C - mortality | Liver - cytology | Mice | Mice, Inbred BALB C | Glucosylceramides - metabolism | Disease Models, Animal | Lipids | Analysis | Niemann-Pick disease | Spleen | Brain | Neurodegenerative diseases | Liver | Central nervous system | endosomes | Inflammation | Longevity | Survival | Cholesterol | Ceramide glucosyltransferase | Glycosphingolipids | Glycolipids | sphingomyelin | Glucosylceramidase | Npc1 protein | Mutation | Gangliosides | Index Medicus
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6. Full Text Temperature sensitivity of peatland C and N cycling: Does substrate supply play a role?
by Weedon, James T and Aerts, Rien and Kowalchuk, George A and van Logtestijn, Richard and Andringa, Dave and van Bodegom, Peter M
Soil biology & biochemistry, ISSN 0038-0717, 06/2013, Volume 61, pp. 109 - 120
Soil enzymes | Sub-arctic peatlands | Global change | Seasonal dynamics | qPCR | Respiration | Microbial community structure | Nitrogen cycling | national | QPCR | Soil Science | Agriculture | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Biochemistry and biology | Physics, chemistry, biochemistry and biology of agricultural and forest soils | Biological and medical sciences | Soil science | Chemical, physicochemical, biochemical and biological properties | Agronomy. Soil science and plant productions | Enzymes | Soils | Carbon content | Ecosystems | Analysis | Global warming | Peat | Peat-bogs
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