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Journal of Clinical Investigation, ISSN 0021-9738, 11/2018, Volume 128, Issue 11, pp. 5137 - 5149
Despite the success of immune checkpoint blockade against melanoma, many "cold" tumors like prostate cancer remain unresponsive. We found that hypoxic zones... 
MEDICINE, RESEARCH & EXPERIMENTAL | MELANOMA | THERAPY | TRANSGENIC ADENOCARCINOMA | MOUSE | REGULATORY T | ANTITUMOR IMMUNITY | SUPPRESSOR-CELLS | BLOCKADE | TUMOR MICROENVIRONMENT | IPILIMUMAB | Adenocarcinoma - pathology | Cell Hypoxia - immunology | Phosphoramide Mustards - pharmacology | Neoplasm Proteins - immunology | Male | Prostatic Neoplasms - immunology | Prostatic Neoplasms - therapy | Neoplasms, Experimental - pathology | Prostatic Neoplasms - genetics | Immunotherapy | Neoplasms, Experimental - immunology | Neoplasms, Experimental - genetics | Adenocarcinoma - genetics | T-Lymphocytes - pathology | Neoplasm Proteins - genetics | Prostatic Neoplasms - pathology | Nitroimidazoles - pharmacology | Neoplasms, Experimental - therapy | Mice, Knockout | Animals | Adenocarcinoma - therapy | Cell Line, Tumor | T-Lymphocytes - immunology | Mice | Cell Hypoxia - genetics | Usage | Care and treatment | Reorganization and restructuring | Research | T cells | Health aspects | Prostate cancer | Adenocarcinoma | PD-1 protein | Clinical trials | Lymphocytes T | Metastasis | Cell density | Metastases | Recruitment | Angiogenesis | CTLA-4 protein | Cell growth | Lymphocytes | Transgenic animals | Movement disorders | Spleen | Cytokines | Transgenic mice | Melanoma | Metabolism | Immune checkpoint | Medical prognosis | Hypoxia | Immunofluorescence | Prostate | Neuroendocrine tumors | Apoptosis | Tumors
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 03/2018, Volume 24, Issue 5, pp. 1138 - 1151
Purpose: Agonist antibodies targeting the T-cell costimulatory receptor 4-1BB (CD137) are among the most effective immunotherapeutic agents across preclinical... 
ONCOLOGY | CHEMOKINES | REGULATORY T-CELLS | IL-27 | MONOCLONAL-ANTIBODY | CANCER-IMMUNOTHERAPY | BLOCKADE | COMBINATION | TUMORS | EXPRESSION | LYMPHOCYTES | Antineoplastic Agents, Immunological - administration & dosage | Liver - pathology | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Skin Neoplasms - drug therapy | Receptors, CCR2 - immunology | Humans | Melanoma, Experimental - drug therapy | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Cell Line, Tumor - transplantation | Interleukins - metabolism | Receptors, CCR2 - antagonists & inhibitors | Signal Transduction - immunology | Liver - immunology | Melanoma, Experimental - immunology | Liver - drug effects | Myeloid Cells - immunology | Interleukins - immunology | CD8-Positive T-Lymphocytes - metabolism | Myeloid Cells - drug effects | Tumor Necrosis Factor Receptor Superfamily, Member 9 - agonists | Chemical and Drug Induced Liver Injury - pathology | Drug Evaluation, Preclinical | Chemical and Drug Induced Liver Injury - etiology | Skin Neoplasms - pathology | Tumor Microenvironment - drug effects | Skin Neoplasms - immunology | Mice, Inbred C57BL | Melanoma, Experimental - pathology | CTLA-4 Antigen - immunology | Chemical and Drug Induced Liver Injury - immunology | Mice, Knockout | Tumor Microenvironment - immunology | Antineoplastic Agents, Immunological - adverse effects | Animals | Signal Transduction - drug effects | CD8-Positive T-Lymphocytes - drug effects | Myeloid Cells - metabolism | Liver - cytology | Mice | CD8-Positive T-Lymphocytes - immunology | CTLA-4 Antigen - antagonists & inhibitors | CC chemokine receptors | Flow cytometry | Animal models | PD-1 protein | Toxicity | CD8 antigen | Liver | Transaminase | Interleukin | Kupffer cells | Antibodies | Lymphocytes T | Activation | Immunity | Hepatitis | Elevation | Cell activation | CTLA-4 protein | CCR2 protein | Lymphocytes | Rodents | Foxp3 protein | Hepatotoxicity | Immunoglobulins | Myeloid cells | CD137 antigen | Cytokines | Immunoregulation | Melanoma | Cytometry | Monocytes | Immune checkpoint | Hepatocytes | Experimental design | Chemokines | Monocyte chemoattractant protein 1 | Cancer | 4-1BB | Interleukin-27 | CTLA-4 | immunotherapy | CCR2
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 629 - 629
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 1700 - 1700
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2019, Volume 29, Issue 20, p. 126640
Activation of the stimulator of interferon genes (STING) pathway by both exogenous and endogenous cytosolic DNA results in the production of interferon beta... 
Phosphorothioate esters | Immune response | STING agonists | Cyclic dinucleotide | T-cell priming | DNA SENSOR | CYCLIC GMP-AMP | ACTIVATION | DESIGN | CHEMISTRY, MEDICINAL | C-DI-GMP | CHEMISTRY, ORGANIC | 2ND-MESSENGER | DINUCLEOTIDE | LIGAND
Journal Article
The Spectator, ISSN 1189-9417, 02/1997
We've come a long way, thanks to pioneers like [Casey Miller] and [Kate Swift]. Editors and TV producers came to recognize that while attitudes about women... 
Newspaper Article
by Denning, Chris and Mitrophanous, Kyriacos and Waddington, Simon and Buckley, Suzanne and Karda, Rajvinder and McKay, Tristan and Shantikumar, Saran and Meloni, Marco and Emanueli, Costanza and Berry, Martin and Logan, Ann and Leadbeater, Wendy and Scheven, Ben and Broadstock, Martin and Yáñez-Muñoz, Rafael J and Mandegar, Mohammad and Khoja, Suhail and Cowley, Sally and Mukherjee, Sayandip and Blundell, Michael and Blundell, Michael and Thrasher, Adrian and Thrasher, Adrian and James, William and Monaco, Zoia and Baker, Andrew and Wong, Suet Ping and Abdul-Razak, Hayder H and Rocca, Céline and Howe, Steven J and Alonso-Ferrero, María Eugenia and Gabriel, Richard and Bartholomae, Cynthia C and Gan, Chih Hao Victor and Garin, Marina and Molina-Estévez, Francisco Javier and Roberts, Alison C and Blundell, Michael and Güenechea, Guillermo and Holmes, Michael C and Gregory, Philip D and Kinnon, Christine and von Kalle, Christof and Schmidt, Manfred and Schmidt, Manfred and Bueren, Juan A and Thrasher, Adrian J and Heeroma, Joost and Mantoan, Laura and Wykes, Robert and Kaetzel, Dennis and Chabrol, Elodie and Schorge, Stephanie and Walker, Matthew and Ellison, Stuart and Trabalza, Antonio and Tisato, Veronica and Pazarentzos, Evangelos and Lee, Shirley and Papadaki, Vasiliki and Goniotaki, Despoina and Morgan, Sarah and Mirzaei, Nazanin and Mazarakis, Nicholas and Matsa, Elena and Kriston-Vizi, Janos and Leja, Thomas and Amisten, Stefan and Kolker, Ljudmila and Mioulane, Maxime and Vauchez, Karine and Aranyi, Tamas and Ketteler, Robin and Schneider, Michael and Denning, Chris and Harding, Sian and Zhan, Hong and Farzaneh, Farzin and Farzaneh, Farzin and Gilmour, Kimberly and Gilmour, Kimberly and Chan, Lucas and Chan, Lucas and McNicol, Anne-Marie and Xu-Bayford, Jin Hua and Adams, Stuart and Bhalla, Joti and Swift, Sue and Swift, Sue and Fehse, Boris and Baum, Christopher and Veys, Paul and Thrasher, Adrian and Thrasher, Adrian and Thrasher, Adrian and Thrasher, Adrian and Thrasher, Adrian and Thrasher, Adrian and Gaspar, H Bobby and Qasim, Waseem and ...
Human Gene Therapy, ISSN 1043-0342, 05/2013, Volume 24, Issue 5, pp. A1 - A42
Journal Article
by Ager, Casey and Reilley, Matthew and Nicholas, Courtney and Bartkowiak, Todd and Jaiswal, Ashvin and Curran, Michael and Albershardt, Tina C and Bajaj, Anshika and Archer, Jacob F and Reeves, Rebecca S and Ngo, Lisa Y and Berglund, Peter and ter Meulen, Jan and Denis, Caroline and Ghadially, Hormas and Arnoux, Thomas and Chanuc, Fabien and Fuseri, Nicolas and Wilkinson, Robert W and Wagtmann, Nicolai and Morel, Yannis and Andre, Pascale and Atkins, Michael B and Carlino, Matteo S and Ribas, Antoni and Thompson, John A and Choueiri, Toni K and Hodi, F. Stephen and Hwu, Wen-Jen and McDermott, David F and Atkinson, Victoria and Cebon, Jonathan S and Fitzharris, Bernie and Jameson, Michael B and McNeil, Catriona and Hill, Andrew G and Mangin, Eric and Ahamadi, Malidi and van Vugt, Marianne and van Zutphen, Mariëlle and Ibrahim, Nageatte and Long, Georgina V and Gartrell, Robyn and Blake, Zoe and Simoes, Ines and Fu, Yichun and Saito, Takuro and Qian, Yingzhi and Lu, Yan and Saenger, Yvonne M and Budhu, Sadna and De Henau, Olivier and Zappasodi, Roberta and Schlunegger, Kyle and Freimark, Bruce and Hutchins, Jeff and Barker, Christopher A and Wolchok, Jedd D and Merghoub, Taha and Burova, Elena and Allbritton, Omaira and Hong, Peter and Dai, Jie and Pei, Jerry and Liu, Matt and Kantrowitz, Joel and Lai, Venus and Poueymirou, William and MacDonald, Douglas and Ioffe, Ella and Mohrs, Markus and Olson, William and Thurston, Gavin and Capasso, Cristian and Frascaro, Federica and Carpi, Sara and Tähtinen, Siri and Feola, Sara and Fusciello, Manlio and Peltonen, Karita and Martins, Beatriz and Sjöberg, Madeleine and Pesonen, Sari and Ranki, Tuuli and Kyruk, Lukasz and Ylösmäki, Erkko and Cerullo, Vincenzo and Cerignoli, Fabio and Xi, Biao and Guenther, Garret and Yu, Naichen and Muir, Lincoln and Zhao, Leyna and Abassi, Yama and Cervera-Carrascón, Víctor and Siurala, Mikko and Santos, João and Havunen, Riikka and Parviainen, Suvi and Hemminki, Akseli and ...
Journal for ImmunoTherapy of Cancer, ISSN 2051-1426, 11/2016, Volume 4, Issue S1
Journal Article
by Lundqvist, Andreas and van Hoef, Vincent and Zhang, Xiaonan and Wennerberg, Erik and Lorent, Julie and Witt, Kristina and Sanz, Laia Masvidal and Liang, Shuo and Murray, Shannon and Larsson, Ola and Kiessling, Rolf and Mao, Yumeng and Sidhom, John-William and Bessell, Catherine A and Havel, Jonathan and Schneck, Jonathan and Chan, Timothy A and Sachsenmeier, Eliot and Woods, David and Berglund, Anders and Ramakrishnan, Rupal and Sodre, Andressa and Weber, Jeffrey and Zappasodi, Roberta and Li, Yanyun and Qi, Jingjing and Wong, Philip and Sirard, Cynthia and Postow, Michael and Newman, Walter and Koon, Henry and Velcheti, Vamsidhar and Callahan, Margaret K and Wolchok, Jedd D and Merghoub, Taha and Lum, Lawrence G and Choi, Minsig and Thakur, Archana and Deol, Abhinav and Dyson, Gregory and Shields, Anthony and Haymaker, Cara and Uemura, Marc and Murthy, Ravi and James, Marihella and Wang, Daqing and Brevard, Julie and Monaghan, Catherine and Swann, Suzanne and Geib, James and Cornfeld, Mark and Chunduru, Srinivas and Agrawal, Sudhir and Yee, Cassian and Wargo, Jennifer and Patel, Sapna P and Amaria, Rodabe and Tawbi, Hussein and Glitza, Isabella and Woodman, Scott and Hwu, Wen-Jen and Davies, Michael A and Hwu, Patrick and Overwijk, Willem W and Bernatchez, Chantale and Diab, Adi and Massarelli, Erminia and Segal, Neil H and Ribrag, Vincent and Melero, Ignacio and Gangadhar, Tara C and Urba, Walter and Schadendorf, Dirk and Ferris, Robert L and Houot, Roch and Morschhauser, Franck and Logan, Theodore and Luke, Jason J and Sharfman, William and Barlesi, Fabrice and Ott, Patrick A and Mansi, Laura and Kummar, Shivaani and Salles, Gilles and Carpio, Cecilia and Meier, Roland and Krishnan, Suba and McDonald, Dan and Maurer, Matthew and Gu, Xuemin and Neely, Jaclyn and Suryawanshi, Satyendra and Levy, Ronald and Khushalani, Nikhil and Wu, Jennifer and Zhang, Jinyu and Basher, Fahmin and Rubinstein, Mark and Bucsek, Mark and Qiao, Guanxi and ...
Journal for ImmunoTherapy of Cancer, ISSN 2051-1426, 11/2016, Volume 4, Issue S1
Journal Article
Proceedings of the Geologists¿ Association, ISSN 0016-7878, 1971, Volume 82, Issue 4, pp. 393,IN1 - 401,IN4
Specimens are described and figured from loose sandstone blocks found at various localities in East Anglia. They are shown to belong to genera with Russian... 
Journal Article
Journal of hand therapy : official journal of the American Society of Hand Therapists, ISSN 0894-1130, 08/2019
Proprioception encompasses the submodalities of joint position sense (JPS), kinesthesia, sense of force, and velocity. Owing to the vast mobility of the... 
Journal Article
1993, 3rd ed. --, ISBN 9780471938088, xiv, 151
Book
BMC Microbiology, ISSN 1471-2180, 2012, Volume 12, Issue 1, pp. 113 - 113
Background: The routinely used microbiological diagnosis of ventilator associated pneumonia (VAP) is time consuming and often requires invasive methods for... 
Multibed sorption tubes | Adsorptive enrichment | Breath analysis | Volatile organic compounds (VOCs) | In vitro headspace sampling | Pseudomonas aeruginosa | Volatile metabolites | Staphylococcus aureus | Gas chromatography mass spectrometry (GCMS) | ASPERGILLUS-FUMIGATUS | METHYLERYTHRITOL PHOSPHATE-PATHWAY | Volatile metabolites Staphylococcus aureus | SOLID-PHASE MICROEXTRACTION | MICROBIOLOGY | Breath analysis In vitro headspace sampling | ELECTRONIC NOSE | LUNG-CANCER | IN-VITRO | GAS-CHROMATOGRAPHY | ORGANIC-COMPOUNDS | CHROMATOGRAPHY-MASS SPECTROMETRY | NOSOCOMIAL PNEUMONIA | Gas Chromatography-Mass Spectrometry | Lung Diseases - diagnosis | Lung Diseases - microbiology | Humans | Middle Aged | Breath Tests | Volatile Organic Compounds - analysis | Male | Young Adult | Staphylococcus aureus - classification | Pseudomonas aeruginosa - metabolism | Aged, 80 and over | Adult | Female | Aged | Bacterial Infections - diagnosis | Pseudomonas aeruginosa - classification | Bacterial Infections - microbiology | Staphylococcus aureus - metabolism | Physiological aspects | Research | Metabolites | Health aspects | Sulfur compounds | Pneumonia | Bacterial infections | Microbiology | Bacterial pneumonia | Staphylococcus aureus infections | Esters | Aldehydes | Volatile organic compounds | Analysis | Bacteria | Mass spectrometry | Organic compounds | Medical research | Cell culture | Thoracic surgery | Intensive care | Statistical analysis | Disease | Mortality | Cystic fibrosis | Experiments | Chromatography | Manuscripts | Studies | Tuberculosis | Chronic obstructive pulmonary disease | Standard deviation
Journal Article
1981, 2d ed. --, xiv, 122 p., [10] leaves of plates
Book
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