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index medicus (10) 10
apoptosis (9) 9
humans (8) 8
antineoplastic agents - pharmacology (7) 7
cell death (7) 7
proteins (7) 7
apoptosis - drug effects (6) 6
cancer (5) 5
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oncology (5) 5
activation (4) 4
animals (4) 4
biochemistry (4) 4
dose-response relationship, drug (4) 4
oligopeptides - pharmacology (4) 4
smac (4) 4
antineoplastic combined chemotherapy protocols - pharmacology (3) 3
biochemistry & molecular biology (3) 3
caspases - metabolism (3) 3
cell survival - drug effects (3) 3
diablo protein (3) 3
drug synergism (3) 3
enzyme activation (3) 3
iap proteins (3) 3
kinases (3) 3
mice (3) 3
rna interference (3) 3
structural basis (3) 3
time factors (3) 3
transfection (3) 3
x-linked inhibitor of apoptosis protein - chemistry (3) 3
x-linked inhibitor of apoptosis protein - metabolism (3) 3
xiap (3) 3
alpha-dependent apoptosis (2) 2
analysis (2) 2
antineoplastic agents - administration & dosage (2) 2
antineoplastic agents - chemistry (2) 2
apoptosis protein xiap (2) 2
bardoxolone methyl (2) 2
biomimetics (2) 2
bortezomib (2) 2
cancer therapies (2) 2
cancer-cells (2) 2
carcinoma, hepatocellular - metabolism (2) 2
caspase (2) 2
caspase 3 - metabolism (2) 2
caspase 7 - chemistry (2) 2
caspase inhibitors - pharmacology (2) 2
caspase-3 (2) 2
cell death - drug effects (2) 2
cell-death (2) 2
chemotherapy (2) 2
disease models, animal (2) 2
drug-induced apoptosis (2) 2
free radical scavengers - pharmacology (2) 2
hematology, oncology and palliative medicine (2) 2
iap (2) 2
iap protein (2) 2
iaps (2) 2
immunoglobulins (2) 2
in-vitro (2) 2
inhibition (2) 2
inhibitor of apoptosis proteins - metabolism (2) 2
inhibitors (2) 2
intracellular signaling peptides and proteins - pharmacology (2) 2
leukemia (2) 2
ligands (2) 2
liver neoplasms - metabolism (2) 2
lymphocytes b (2) 2
lymphoma (2) 2
lymphomas (2) 2
mechanism (2) 2
medical prognosis (2) 2
mitochondria (2) 2
mitochondrial proteins - metabolism (2) 2
mitochondrial proteins - pharmacology (2) 2
necroptosis (2) 2
nf-κb protein (2) 2
nuclear pore complex proteins - genetics (2) 2
nuclear pore complex proteins - metabolism (2) 2
oleanolic acid - pharmacology (2) 2
peptides (2) 2
phosphorylation (2) 2
protein structure, tertiary (2) 2
reactive oxygen species - metabolism (2) 2
recombinant fusion proteins - chemistry (2) 2
rna-binding proteins - genetics (2) 2
rna-binding proteins - metabolism (2) 2
signal transduction - drug effects (2) 2
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tumor necrosis factor-alpha - metabolism (2) 2
tumors (2) 2
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Apoptosis - An International Journal on Programmed Cell Death, ISSN 1360-8185, 04/2019, Volume 24, Issue 3-4, p. 269
Smac mimetics that deplete cellular inhibitor of apoptosis (cIAP) proteins have been shown to activate Nuclear Factor-kappa B (NF-I*B). Here, we report that... 
Proteins | Apoptosis
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 39, pp. 41522 - 41534
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 380, Issue 1, pp. 31 - 38
Highlights • BV6 triggers necroptosis in apoptosis resistant pancreatic cancer cells • Auto-/paracrine TNF〈loop is required for BV6-induced necroptosis •... 
Hematology, Oncology and Palliative Medicine | IAP proteins | Smac mimetic | Pancreatic carcinoma | Necroptosis | Cell death | CANCER-CELLS | PROGRAMMED NECROSIS | MYELOID-LEUKEMIA CELLS | DEATH PATHWAYS | TUMOR-NECROSIS-FACTOR | ONCOLOGY | XIAP INHIBITORS | ALPHA-DEPENDENT APOPTOSIS | TRAIL-INDUCED APOPTOSIS | TNF-ALPHA | THERAPEUTIC EXPLOITATION | Intracellular Signaling Peptides and Proteins - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | RNA-Binding Proteins - genetics | Caspase Inhibitors - pharmacology | Apoptosis - drug effects | Humans | Autocrine Communication - drug effects | Receptors, Tumor Necrosis Factor, Type I - metabolism | Necrosis | Dose-Response Relationship, Drug | Nuclear Pore Complex Proteins - genetics | Pancreatic Neoplasms - drug therapy | Caspases - metabolism | Transfection | RNA Interference | Time Factors | Amino Acid Chloromethyl Ketones - pharmacology | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Jurkat Cells | MAP Kinase Kinase Kinases - genetics | Nuclear Pore Complex Proteins - metabolism | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - enzymology | Pancreatic Neoplasms - genetics | MAP Kinase Kinase Kinases - metabolism | Receptors, Tumor Necrosis Factor, Type I - genetics | Biological Mimicry | Mitochondrial Proteins - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Signal Transduction - drug effects | Paracrine Communication - drug effects | Enzyme Activation | Oligopeptides - pharmacology | RNA-Binding Proteins - metabolism | Pancreatic cancer | Proteins | Immunoglobulins | Conflicts of interest | Ligands | Protein expression | Gene expression | Experiments | Apoptosis | Cancer
Journal Article
Apoptosis, ISSN 1360-8185, 2019, Volume 24, Issue 3-4, pp. 269 - 277
Smac mimetics that deplete cellular inhibitor of apoptosis (cIAP) proteins have been shown to activate Nuclear Factor-kappa B (NF-κB). Here, we report that... 
NF-κB | Smac | Cell death | Tunicamycin | Apoptosis | Proteins | NF-κB protein | DIABLO protein | Restoration | Activation | Exposure | Inhibition | Kinases | Mcl-1 protein | Cancer
Journal Article
Cancer Letters, ISSN 0304-3835, 2015, Volume 365, Issue 1, pp. 47 - 56
Highlights • Synthetic lethal interaction of Smac mimetic and oleanolic acid in hepatocellular carcinoma. • Cell death caused by combination treatment is... 
Hematology, Oncology and Palliative Medicine | IAP proteins | Smac | Cell death | Cancer | LIVER-TRANSPLANTATION | PANCREATIC-CANCER | DEPENDENT APOPTOSIS | DRUG-INDUCED APOPTOSIS | URSOLIC ACID | THERAPY | ONCOLOGY | BARDOXOLONE METHYL | IN-VIVO | INHIBITORS | ENDONUCLEASE-G | Free Radical Scavengers - pharmacology | Intracellular Signaling Peptides and Proteins - pharmacology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Oleanolic Acid - pharmacology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Transfection | Biomimetics | RNA Interference | Time Factors | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - pathology | Cell Survival - drug effects | Liver Neoplasms - genetics | Chick Embryo | Hep G2 Cells | Drug Synergism | Mitochondrial Proteins - pharmacology | Animals | Tumor Burden - drug effects | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Enzyme Activation | Oligopeptides - pharmacology | Carcinoma, Hepatocellular - metabolism | Biochemistry | Hepatoma | Proteins | Cysteine | Liver diseases | Analysis | Hepatitis C | Health aspects | Studies | Liver cancer | Chemotherapy | Medical prognosis | Clinical trials | Colonies & territories | Cytotoxicity | Ligands | Apoptosis | Index Medicus
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 10/2016, Volume 118, pp. 9 - 17
The lack of effective chemotherapies in hepatocellular carcinoma (HCC) is still an unsolved problem and underlines the need for new strategies in liver cancer... 
Redox | Hepatocellular carcinoma | Cell death | Sorafenib | ROS | Oleanolic acid | CANCER-CELLS | SOLID TUMORS | INDUCED APOPTOSIS | HEPATOCARCINOGENESIS | URSOLIC ACID | IN-VITRO | PHARMACOKINETICS | PATHWAY | BARDOXOLONE METHYL | FERROPTOSIS | PHARMACOLOGY & PHARMACY | Caspase 7 - metabolism | Free Radical Scavengers - pharmacology | Niacinamide - analogs & derivatives | Caspase Inhibitors - pharmacology | Niacinamide - antagonists & inhibitors | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Caspase 3 - chemistry | Caspase 7 - chemistry | Humans | Caspase 3 - metabolism | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Oleanolic Acid - pharmacology | Reactive Oxygen Species - agonists | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Proteolysis - drug effects | Carcinoma, Hepatocellular - drug therapy | Antineoplastic Agents - adverse effects | Phenylurea Compounds - adverse effects | Oleanolic Acid - adverse effects | Antineoplastic Agents - pharmacology | Cell Death - drug effects | DNA Fragmentation - drug effects | Biomarkers - metabolism | Cell Survival - drug effects | Liver Neoplasms - drug therapy | Niacinamide - adverse effects | Antineoplastic Combined Chemotherapy Protocols - antagonists & inhibitors | Antineoplastic Agents - chemistry | Enzyme Activation - drug effects | Oleanolic Acid - antagonists & inhibitors | Drug Synergism | Phenylurea Compounds - antagonists & inhibitors | Reactive Oxygen Species - antagonists & inhibitors | Liver Neoplasms - metabolism | Cell Line, Tumor | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Oxidative Stress - drug effects | Carcinoma, Hepatocellular - metabolism | Antimitotic agents | Biochemistry | Antineoplastic agents
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2013, Volume 12, Issue 12, pp. 2735 - 2747
Journal Article
EMBO Molecular Medicine, ISSN 1757-4676, 08/2016, Volume 8, Issue 8, pp. 851 - 862
Journal Article
Neoplasia (New York, N.Y.), ISSN 1522-8002, 12/2011, Volume 13, Issue 12, pp. 1162 - 1170
Defects in apoptosis contribute to treatment resistance and poor outcome of pancreatic cancer, calling for novel therapeutic strategies. Here, we provide the... 
Journal Article
FRONTIERS IN PEDIATRICS, ISSN 2296-2360, 2014, Volume 2, p. 75
Allogeneic hematopoietic stem cell transplantation (HSCT) is an established treatment option for high-risk hematological malignancies, and may also be offered... 
leukemia | CIK cells | PEDIATRICS | tumors | BV6 | cellular therapy | Leukemia
Journal Article
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