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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2017, Volume 114, Issue 45, pp. E9549 - E9558
Journal Article
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7381, pp. 365 - 370
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2008, Volume 105, Issue 36, pp. 13292 - 13297
Journal Article
PLoS Computational Biology, ISSN 1553-734X, 01/2012, Volume 8, Issue 1, p. e1002341
Journal Article
Cancer Letters, ISSN 0304-3835, 2017, Volume 397, pp. 23 - 32
Abstract Mast cells (MCs) constitute an important part of the tumor microenvironment (TME). However, their underlying mechanisms of activation within the TME... 
Hematology, Oncology and Palliative Medicine | Adenosine | Mast cells | Tumor microenvironment | Adenosine A3 receptor | PANCREATIC DUCTAL ADENOCARCINOMA | SOLID TUMORS | T-CELL | MICROENVIRONMENT | ONCOLOGY | INFLAMMATION | GROWTH | TUMOR-ASSOCIATED MACROPHAGES | TNF-ALPHA | POLARIZATION | SECRETORY GRANULES | Phosphorylation | Pancreatic Neoplasms - metabolism | Humans | Lung Neoplasms - metabolism | Tumor Microenvironment | Lung Neoplasms - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Transfection | RNA Interference | Time Factors | Receptor, Adenosine A3 - metabolism | Mast Cells - metabolism | Cell Membrane - metabolism | Interleukin-8 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Lung Neoplasms - genetics | A549 Cells | Autocrine Communication | Paracrine Communication | Signal Transduction | Pancreatic Neoplasms - pathology | Pancreatic Neoplasms - genetics | Mast Cells - pathology | Adenosine - metabolism | Receptor, Adenosine A3 - genetics | Enzyme Activation | Interleukins | Developmental biology | Phosphotransferases | Cancer cells | Cancer | Enzymes | Pancreatic cancer | Membranes | Laboratories | Crosstalk | Interleukin | Paracrine signalling | AKT protein | Activation | Kinases | Cell activation | Down-regulation | CD73 antigen | Autocrine signalling | Interleukin 8 | Cytokines | Secretion | Extracellular signal-regulated kinase | Allergies | 1-Phosphatidylinositol 3-kinase | Stem cells | Ligands | Chemokines | Tumors
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2017, Volume 114, Issue 45, p. E9549
Insight regarding how diverse enzymatic functions and reactions have evolved from ancestral scaffolds is fundamental to understanding chemical and evolutionary... 
Enzymes | Biotechnology | Structural design | Divergence | Biological evolution | Nitroreductase | Chemical reactions | Structural engineering | Phylogeny | Subgroups | Redesign | Computer programs | Exploitation | Proteins | Molecules | Specialization | Flavin mononucleotide | Flavin | Computer applications | Phylogenetics | Evolution | Scaffolds | Structure-function relationships
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2017, Volume 1446, pp. 111 - 132
The Gene Ontology (GO) (Ashburner et al., Nat Genet 25(1):25-29, 2000) is a powerful tool in the informatics arsenal of methods for evaluating annotations in a... 
Evidence of function | Catalytic function | Misannotation | Enzyme | Computational Biology - methods | Animals | Enzymes - classification | Databases, Protein | Enzymes - genetics | Humans | Molecular Sequence Annotation - methods | Enzymes - metabolism | Gene Ontology
Journal Article
Journal Article
PLoS Computational Biology, ISSN 1553-7358, 01/2012, Volume 8, Issue 1
Journal Article
Biochemistry, ISSN 0006-2960, 06/2019, Volume 58, Issue 22, pp. 2617 - 2627
A 4-oxalocrotonate tautomerase (4-OT) trimer has been isolated from Burkholderia lata, and a kinetic, mechanistic, and structural analysis has been performed.... 
Journal Article
Cell, ISSN 0092-8674, 10/2015, Volume 163, Issue 3, pp. 535 - 537
Using mutation libraries and deep sequencing, Aakre et al. study the evolution of protein-protein interactions using a toxin-antitoxin model. The results... 
NETWORK | SELECTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Mesorhizobium - metabolism | Evolution, Molecular | Protein Interaction Maps | Proteins | Biological products | Analysis | Protein-protein interactions | Enzymes
Journal Article
Journal Article