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1. Biomarkers of the Tumor Microenvironment
: Basic Studies and Practical Applications
by Akslen, Lars A and Watnick, Randolph S and SpringerLink (Online service)
2017, ISBN 9783319391458
This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms... 
Medicine | Pathology | Cancer research
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2. Full Text Deblender: A semi-/unsupervised multi-operational computational method for complete deconvolution of expression data from heterogeneous samples
by Dimitrakopoulou, Konstantina and Wik, Elisabeth and Akslen, Lars A and Jonassen, Inge
BMC Bioinformatics, ISSN 1471-2105, 11/2018, Volume 19, Issue 1, pp. 408 - 408
BackgroundTowards discovering robust cancer biomarkers, it is imperative to unravel the cellular heterogeneity of patient samples and comprehend the... 
Cellular heterogeneity | Deconvolution | Model selection | Matrix factorization | Clustering | Gene expression | Particle swarm | Quadratic programming | TISSUE SAMPLES | BIOCHEMICAL RESEARCH METHODS | TUMOR | PATTERNS | CANCER | TRANSCRIPTOMES | RNA-SEQ | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MATHEMATICAL & COMPUTATIONAL BIOLOGY | GENE-EXPRESSION | NONNEGATIVE MATRIX FACTORIZATION | MICRODISSECTION | Computational Biology - methods | Algorithms | Gene Expression - genetics | Humans | Research | Matrix decomposition | Analysis | Medical research | State of the art | Heterogeneity | Computation | Data sets | Computer applications | Biomarkers | Bioindicators | Bioinformatics | Cancer | Index Medicus
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3. Full Text Lack of estrogen receptor-α is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma
by Wik, Elisabeth and Ræder, Maria B and Krakstad, Camilla and Trovik, Jone and Birkeland, Even and Hoivik, Erling A and Mjos, Siv and Werner, Henrica M.J and Mannelqvist, Monica and Stefansson, Ingunn M and Oyan, Anne M and Kalland, Karl H and Akslen, Lars A and Salvesen, Helga B
Clinical Cancer Research, ISSN 1078-0432, 03/2013, Volume 19, Issue 5, pp. 1094 - 1105
Purpose: We hypothesized that estrogen receptor-alpha (ER-alpha) status in endometrial carcinomas, associated with poor prognosis, is reflected in... 
PROGNOSTIC IMPACT | ONCOLOGY | RECURRENT | PATHWAY | VASCULAR INVASION | CATENIN | TARGETS | E-CADHERIN | EXPRESSION | CANCER | CLINICAL-SIGNIFICANCE | Prognosis | Prospective Studies | Follow-Up Studies | Oligonucleotide Array Sequence Analysis | Endometrial Neoplasms - mortality | Humans | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Endometrial Neoplasms - genetics | Epithelial-Mesenchymal Transition | Estrogen Receptor alpha - metabolism | Female | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | Signal Transduction | RNA, Messenger - genetics | Survival Rate | Reverse Transcriptase Polymerase Chain Reaction | Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases | Estrogen Receptor alpha - genetics | Polymorphism, Single Nucleotide - genetics | Endometrial Neoplasms - pathology | Aged | Biomarkers, Tumor - genetics | Neoplasm Staging | Index Medicus
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4. Full Text Two-view digital breast tomosynthesis versus digital mammography in a population-based breast cancer screening programme (To-Be): a randomised, controlled trial
by Hofvind, Solveig and Holen, Åsne S and Aase, Hildegunn S and Houssami, Nehmat and Sebuødegård, Sofie and Moger, Tron A and Haldorsen, Ingfrid S and Akslen, Lars A
The Lancet Oncology, ISSN 1470-2045, 06/2019, Volume 20, Issue 6, pp. 795 - 805
Digital breast tomosynthesis is an advancement of mammography, and has the potential to overcome limitations of standard digital mammography. This study aimed... 
INTERNATIONAL EXPERT CONSENSUS | CLINICAL-PERFORMANCE | PRIMARY THERAPY | EXPERIENCE | ONCOLOGY | Breast cancer | Mammography | Diagnosis | Analysis | Cancer
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5. Full Text Quantifying tumour vascularity in non-luminal breast cancers
by Kraby, Maria Ryssdal and Opdahl, Signe and Akslen, Lars A and Bofin, Anna M
Journal of Clinical Pathology, ISSN 0021-9746, 09/2017, Volume 70, Issue 9, pp. 766 - 774
AimsMicrovessel density (MVD), proliferating MVD (pMVD) and vascular proliferation index (VPI) are methods used to quantify tumour vascularity in... 
Angiogenesis | breast cancer | immunohistochemistry | breast pathology | SURVIVAL | SUBTYPES | MARKER | ANGIOGENIC SWITCH | IN-VIVO | GROWTH | REPRODUCTIVE FACTORS | PATTERNS | MICROVESSEL DENSITY | PROLIFERATION | PATHOLOGY | Immunohistochemistry | Predictive Value of Tests | Prognosis | Humans | Middle Aged | Neovascularization, Pathologic | Carcinoma - mortality | Microvessels - pathology | Carcinoma - chemistry | Breast Neoplasms - chemistry | Aged, 80 and over | Female | Registries | Carcinoma - pathology | von Willebrand Factor - analysis | Biomarkers, Tumor - analysis | Risk Factors | Breast Neoplasms - blood supply | Phenotype | Ki-67 Antigen - analysis | Breast Neoplasms - pathology | Breast Neoplasms - mortality | Aged | Carcinoma - blood supply | Receptor, ErbB-2 - analysis | Microvessels - chemistry | Care and treatment | Breast cancer | Enzymes | Gene expression | Cancer therapies | Pathology | Genotype & phenotype | Cell growth | Epidermal growth factor | Womens health | Medical prognosis | Rodents | Tumors | Index Medicus | Abridged Index Medicus
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6. Full Text Abstract 4329: Expression of serpin B2, neuroserpin and L1CAM in association with metastasis and survival in non-small cell lung cancer
by Ramnefjell, Maria and Helgeland, Lars and Akslen, Lars A
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 4329 - 4329
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7. Full Text Impact of pre-diagnostic triglycerides and HDL-cholesterol on breast cancer recurrence and survival by breast cancer subtypes
by Lofterød, Trygve and Mortensen, Elin S and Nalwoga, Hawa and Wilsgaard, Tom and Frydenberg, Hanne and Risberg, Terje and Eggen, Anne Elise and McTiernan, Anne and Aziz, Sura and Wist, Erik A and Stensvold, Andreas and Reitan, Jon B and Akslen, Lars A and Thune, Inger
BMC Cancer, ISSN 1471-2407, 06/2018, Volume 18, Issue 1, pp. 654 - 654
Background: High triglycerides and low levels of high density lipoprotein (HDL)-cholesterol are observed to promote tumor growth. However, whether breast... 
Lipids | Breast cancer | Molecular subtype | Survival | Triple negative breast cancer | POPULATION | PROTEIN | RISK | DENSITY-LIPOPROTEIN-CHOLESTEROL | METABOLISM | ONCOLOGY | INFLAMMATION | BODY-MASS INDEX | OUTCOMES | ASSOCIATION | EXPRESSION | Prognosis | Humans | Middle Aged | Risk Factors | Proportional Hazards Models | Neoplasm Recurrence, Local - mortality | Neoplasm Recurrence, Local - pathology | Breast Neoplasms - pathology | Triglycerides - blood | Breast Neoplasms - blood | Cholesterol, HDL - blood | Adult | Breast Neoplasms - mortality | Female | Aged | Neoplasm Recurrence, Local - blood | Relapse | Cholesterol, HDL | Analysis | Triglycerides | Research | Health aspects | Cancer | Index Medicus | VDP | Oncology: 762 | Klinisk medisinske fag: 750 | Onkologi: 762 | Medisinske Fag: 700 | Clinical medical disciplines: 750 | Medical disciplines: 700
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8. Full Text Prognostic impact and concordance of TERT promoter mutation and protein expression in matched primary and metastatic cutaneous melanoma
by Hugdahl, Emilia and Kalvenes, May Britt and Mannelqvist, Monica and Ladstein, Rita G and Akslen, Lars A
British Journal of Cancer, ISSN 0007-0920, 01/2018, Volume 118, Issue 1, pp. 98 - 105
Background: TERT promoter mutations are frequent in melanoma. Here we analysed the concordance and prognostic impact of TERT mutation and telomerase reverse... 
metastases | intra-tumoural discordance | TERT promoter mutation | nodular melanoma | inter-tumoural discordance | prognosis | TERT protein expression | CHROMATIN | TELOMERASE | TISSUE MICROARRAYS | CANCER | FEATURES | ONCOLOGY | Melanoma - metabolism | Promoter Regions, Genetic | Prognosis | Tissue Array Analysis | Humans | Male | Sequence Analysis, DNA | Skin Neoplasms - metabolism | Neoplasm Metastasis | Telomerase - genetics | Melanoma - genetics | Skin Neoplasms - genetics | Survival Analysis | Female | Telomerase - metabolism | Aged | Mutation | Immunohistochemistry | Sequences | RNA-directed DNA polymerase | Telomerase reverse transcriptase | Melanoma | Metastasis | Survival | Metastases | Proteins | Protein expression | Telomerase | Tumors | Index Medicus | Molecular Diagnostics
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9. Full Text Characterization of FGD5 Expression in Primary Breast Cancers and Lymph Node Metastases
by Valla, Marit and Mjønes, Patricia G and Engstrøm, Monica J and Ytterhus, Borgny and Bordin, Diana L and van Loon, Barbara and Akslen, Lars A and Vatten, Lars J and Opdahl, Signe and Bofin, Anna M
Journal of Histochemistry & Cytochemistry, ISSN 0022-1554, 11/2018, Volume 66, Issue 11, pp. 787 - 799
Faciogenital dysplasia 5 (FGD5) amplification drives tumor cell proliferation, and is present in 9.5% of breast cancers. We describe FGD5 expression, assess... 
prognosis | breast neoplasms | cohort study | MOLECULAR SUBTYPES | GUANINE-NUCLEOTIDE EXCHANGE | CELL BIOLOGY | BASAL EPITHELIAL PHENOTYPE | ONCOGENE | MESSENGER-RNA | RECOMMENDATIONS | GENE-EXPRESSION | CDC42 GTPASES | GROWTH-FACTOR | RHO-GTPASES
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10. Full Text Melanoma prone families with CDK4 germline mutation: Phenotypic profile and associations with MC1R variants
by Puntervoll, Hanne Eknes and Yang, Xiaohong R and Vetti, Hildegunn Hoøberg and Bachmann, Ingeborg M and Avril, Marie Françoise and Benfodda, Meriem and Catricalá, Caterina and Dalle, Stéphane and Duval-Modeste, Anne B and Ghiorzo, Paola and Grammatico, Paola and Harland, Mark and Hayward, Nicholas K and Hu, Hui-Han and Jouary, Thomas and Martin-Denavit, Tanguy and Ozola, Aija and Palmer, Jane M and Pastorino, Lorenza and Pjanova, Dace and Soufir, Nadem and Steine, Solrun J and Stratigos, Alexander J and Thomas, Luc and Tinat, Julie and Tsao, Hensin and Veinalde, Ruta and Tucker, Margaret A and Paillerets, Brigitte Bressac-de and Newton-Bishop, Julia A and Goldstein, Alisa M and Akslen, Lars A and Molven, Anders
Journal of Medical Genetics, ISSN 0022-2593, 2013, Volume 50, Issue 4, pp. 264 - 270
CDKN2A and CDK4 are high risk susceptibility genes for cutaneous malignant melanoma. Melanoma families with CDKN2A germline mutations have been extensively... 
Skin Neoplasms - pathology | Exons | Cyclin-Dependent Kinase 4 - genetics | Hair Color - genetics | Humans | Middle Aged | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Male | Melanoma - pathology | Phenotype | Melanoma - genetics | Skin Neoplasms - genetics | Germ-Line Mutation | Adult | Female | Genetic aspects | Research | Gene mutations | Melanoma | Index Medicus | Cancer: dermatological | counselling | Molecular genetics | Cancer Genetics | 1506 | Genetic screening
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11. Full Text Integrated genome-wide DMA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas
by Etemadmoghadam, Dariush and Defazio, Anna and Beroukhim, Rameen and Mermel, Craig and George, Joshy and Getz, Gad and Tothiil, Richard and Okamoto, Aikou and Raeder, Maria B and Harnett, Paul and Lade, Stephen and Akslen, Lars A and Tinker, Anna V and Locandro, Bianca and Aisop, Kathryn and Chiew, Yoke-Eng and Traficante, Nadia and Fereday, Sian and Johnson, Daryl and Fox, Stephen and Sellers, William and Urashima, Mitsuyoshi and Salvesen, Helga B and Meyerson, Matthew and Bowtell, David
Clinical Cancer Research, ISSN 1078-0432, 02/2009, Volume 15, Issue 4, pp. 1417 - 1427
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12. Full Text Biomarkers of the Tumor Microenvironment
: Basic Studies and Practical Applications
by Akslen, Lars A and Watnick, Randolph S
08/2017, 1st ed. 2017, ISBN 9783319391458, 537
This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms... 
Tumors | Oncology | Medicine & Public Health | Pathology | Cancer Research | Pathology, Cellular | Tumor markers
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13. Full Text Importance of P-Cadherin, β-Catenin, and Wnt5a/Frizzled for Progression of Melanocytic Tumors and Prognosis in Cutaneous Melanoma
by Ingeborg M. Bachmann and Oddbjørn Straume and Hanne E. Puntervoll and May Britt Kalvenes and Lars A. Akslen
Clinical Cancer Research, ISSN 1078-0432, 12/2005, Volume 11, Issue 24, pp. 8606 - 8614
Purpose: It has been proposed that melanoma cells shift from E-cadherin to N-cadherin expression during tumor development, and recent gene profiling has shown... 
β-catenin | Wnt5a | survival | nevi | melanoma | cadherins | Frizzled | NODULAR MELANOMAS | PHASE MELANOMAS | BREAST-CARCINOMA | ONCOLOGY | PROTEIN EXPRESSION | TISSUE MICROARRAYS | FIBROBLAST-GROWTH-FACTOR | MALIGNANT-MELANOMA | EXPRESSION PATTERN | HUMAN CANCER | N-CADHERIN | Immunohistochemistry | Up-Regulation | Melanoma - diagnosis | Cell Proliferation | Prognosis | Cadherins - metabolism | beta Catenin - analysis | Humans | Cytoplasm - metabolism | Wnt-5a Protein | Wnt Proteins - metabolism | Neovascularization, Pathologic - pathology | Cell Membrane - chemistry | Cell Nucleus - metabolism | Skin Neoplasms - mortality | Melanocytes - pathology | Proto-Oncogene Proteins - analysis | Skin Neoplasms - diagnosis | Biomarkers, Tumor - metabolism | Cell Membrane - metabolism | Cytoplasm - chemistry | Frizzled Receptors | Proto-Oncogene Proteins - metabolism | Skin Neoplasms - pathology | Neovascularization, Pathologic - diagnosis | Nevus - diagnosis | Biomarkers, Tumor - analysis | Down-Regulation | Receptors, G-Protein-Coupled | Cadherins - analysis | Receptors, Neurotransmitter - analysis | Melanoma - pathology | Wnt Proteins - analysis | beta Catenin - metabolism | Disease Progression | Nevus - pathology | Cell Nucleus - chemistry | Receptors, Neurotransmitter - metabolism | Melanoma - mortality | Index Medicus
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14. Full Text Abstract 4207: Secreted proteins from breast cancer cell lines as a source of cancer biomarkers
by Birkeland, Even and Mannelqvist, Monica and Akslen, Lars Andreas
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. 4207 - 4207
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15. Full Text Abstract CT066: Dendritic cell based cryoimmunotherapy associates with clinical variables and changes in T-cell receptor expression in a prospective phase I trial of metastatic castration resistant prostate cancer
by Thomsen, Liv Cecilie V and Honorè, Alfred and Almås, Bjarte and Reisæter, Lars A and Frugård, Jannicke and Kristoffersen, Einar K and Melve, Guro and Haslerud, Torjan and Rørvik, Jarle and Biermann, Martin and Helle, Svein Inge and Kvalheim, Gunnar and Azeem, Waqas and Olsen, Jan Roger and Halvorsen, Ole Johan and Akslen, Lars and Bahn, Duke K and Pantel, Klaus and Riethdorf, Sabine and Ragde, Haakon and Gjertsen, Bjørn Tore and Øyan, Anne M and Kalland, Karl-Henning and Beisland, Christian
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. CT066 - CT066
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16. Full Text Abstract B03: The predictive value of microvessel density, vascular proliferation index and markers of VEGF associated angiogenesis in patients with metastatic melanoma treated with bevacizumab monotherapy
by Schuster, Cornelia and Akslen, Lars A and Straume, Oddbjørn
Molecular Cancer Therapeutics, ISSN 1535-7163, 12/2015, Volume 14, Issue 12 Supplement 1, pp. B03 - B03
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17. Full Text TMPRSS2:ERG fusion transcripts in urine from prostate cancer patients correlate with a less favorable prognosis
by ROSTAD, KARI and HELLWINKEL, OLAF J. C and HAUKAAS, SVEIN A and HALVORSEN, OLE J and OYAN, ANNE M and HAESE, ALEXANDER and BUDAUS, LARS and ALBRECHT, HEIKO and AKSLEN, LARS A and SCHLOMM, THORSTEN and KALLAND, KARL-HENNING
Apmis, ISSN 0903-4641, 08/2009, Volume 117, Issue 8, pp. 575 - 582
Rostad K, Hellwinkel OJC, Haukaas SA, Halvorsen OJ, Øyan AM, Haese A, Budäus L, Albrecht H, Akslen LA, Schlomm T, Kalland K-H. TMPRSS2:ERG fusion transcripts... 
TMPRSS2 | urine screening | ERG, gene fusion | Prostate cancer | Urine screening | CELLS | MICROBIOLOGY | IMMUNOLOGY | PATHOLOGY | HETEROGENEITY | GENE FUSIONS | IN-VITRO | gene fusion | FREQUENCY | ERG | EXPRESSION | Prognosis | Exons | Humans | Middle Aged | Molecular Sequence Data | Male | RNA, Neoplasm - urine | Prostatic Neoplasms - diagnosis | Prostatic Neoplasms - genetics | Prostatic Neoplasms - urine | Biomarkers, Tumor - urine | Oncogene Proteins, Fusion - genetics | Prostate-Specific Antigen - urine | Base Sequence | Sensitivity and Specificity | Cell Line, Tumor | Transcription, Genetic | Aged | Biomarkers, Tumor - genetics | Protein Isoforms - genetics | Cancer patients | Analysis | Index Medicus
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18. Full Text The Prognostic Implication of the Basal-Like (Cyclin E high/p27low/p53 +/Glomeruloid-Microvascular-Proliferation+) Phenotype of BRCA1-Related Breast Cancer
by Foulkes, William D and Brunet, Jean-Sébastien and Stefansson, Ingunn M and Straume, Oddbjørn and Chappuis, Pierre O and Bégin, Louis R and Hamel, Nancy and Goffin, John R and Wong, Nora and Trudel, Michel and Kapusta, Linda and Porter, Peggy and Akslen, Lars A
Cancer Research, ISSN 0008-5472, 02/2004, Volume 64, Issue 3, pp. 830 - 835
Previous studies have shown that BRCA1-related breast cancers are often high-grade tumors that do not express estrogen receptors, HER2, p27(Kip1), or cyclin... 
Prognosis | Tumor Suppressor Protein p53 - biosynthesis | Humans | Middle Aged | Cyclin E - genetics | Tumor Suppressor Protein p53 - genetics | Breast Neoplasms - metabolism | Keratins - biosynthesis | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Adult | Female | Genes, BRCA1 | Proportional Hazards Models | Survival Rate | Cell Cycle Proteins - biosynthesis | Breast Neoplasms - blood supply | Cyclin-Dependent Kinase Inhibitor p27 | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Cyclin E - biosynthesis | Aged | Mutation | Keratins - genetics | Tumor Suppressor Proteins - biosynthesis | Index Medicus
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19. Full Text Microvascular proliferation in luminal Aand basal-like breast cancer subtypes
by Kraby, Maria Ryssdal and Krüger, Kristi and Opdahl, Signe and Vatten, Lars Johan and Akslen, Lars A and Bofin, Anna M
ISSN 0021-9746, 2015
Aims: The aims of this study were to examine microvessel density (MVD), proliferating MVD (pMVD) and Vascular Proliferation Index (VPI) in basal-like phenotype... 
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20. Full Text Trends in Diagnostics, Surgical Treatment, and Prognostic Factors for Outcomes in Medullary Thyroid Carcinoma in Norway: A Nationwide Population-Based Study
by Opsahl, Else Marie and Akslen, Lars Andreas and Schlichting, Ellen and Aas, Turid and Brauckhoff, Katrin and Hagen, Anne Irene and Rosenlund, Alf Frimann and Sigstad, Eva and Grøholt, Krystyna K and Mæhle, Lovise and Engebretsen, Lars Fredrik and Jørgensen, Lars H and Varhaug, Jan Erik and Bjøro, Trine
European Thyroid Journal, ISSN 2235-0640, 01/2019, Volume 8, Issue 1, pp. 31 - 40
Background: Medullary thyroid carcinoma (MTC) is rare. Nationwide population-based studies are important to evaluate its clinical course. Objectives: To... 
Clinical Thyroidology / Original Paper | Pathology | Trends | Diagnostics | Outcome | Surgery | Medullary thyroid carcinoma | SURVIVAL | MANAGEMENT | SERUM CALCITONIN | REOPERATION | COMPARTMENT | CANCER | RET PROTOONCOGENE | ENDOCRINOLOGY & METABOLISM | EXPERIENCE | CURE | MUTATIONS | Clinical Thyroidology | Original Paper
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