Atherosclerosis, ISSN 0021-9150, 2015, Volume 245, pp. 62 - 70
Abstract Background Multiple loci have been identified for coronary artery disease (CAD) by genome-wide association studies (GWAS), but no such studies on CAD...
Cardiovascular | Myocardial infarction | Haplotypes | CDKN2A/B | CXCL12 | KCNE2 | Genome-wide association | Heritability | Coronary artery disease | DOUBLECORTIN | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | LINEAR MIXED MODELS | VARIANTS | RISK | POLYMORPHISMS | GENE | PERIPHERAL VASCULAR DISEASE | MUTATIONS | CORONARY-HEART-DISEASE | FIBRINOGEN | Myocardial Infarction - genetics | Genetic Predisposition to Disease | Myocardial Infarction - epidemiology | Coronary Artery Disease - metabolism | Humans | Middle Aged | Risk Factors | Genotype | Male | Myocardial Infarction - metabolism | Incidence | Coronary Artery Disease - genetics | Female | Genome-Wide Association Study - methods | Saudi Arabia - epidemiology | Medical research | Genomics | Medicine, Experimental | Genetic research | Disease susceptibility | Genetic aspects | Coronary heart disease | Single nucleotide polymorphisms
Cardiovascular | Myocardial infarction | Haplotypes | CDKN2A/B | CXCL12 | KCNE2 | Genome-wide association | Heritability | Coronary artery disease | DOUBLECORTIN | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | LINEAR MIXED MODELS | VARIANTS | RISK | POLYMORPHISMS | GENE | PERIPHERAL VASCULAR DISEASE | MUTATIONS | CORONARY-HEART-DISEASE | FIBRINOGEN | Myocardial Infarction - genetics | Genetic Predisposition to Disease | Myocardial Infarction - epidemiology | Coronary Artery Disease - metabolism | Humans | Middle Aged | Risk Factors | Genotype | Male | Myocardial Infarction - metabolism | Incidence | Coronary Artery Disease - genetics | Female | Genome-Wide Association Study - methods | Saudi Arabia - epidemiology | Medical research | Genomics | Medicine, Experimental | Genetic research | Disease susceptibility | Genetic aspects | Coronary heart disease | Single nucleotide polymorphisms
Journal Article
BMC Cardiovascular Disorders, ISSN 1471-2261, 03/2013, Volume 13, Issue 1, pp. 17 - 17
Background: Angiotensinogen (AGT) constitutes a central component of the renin-angiotensin system that controls the systemic blood pressure and several other...
Obesity | Pleiotropy | Primary hypertension | Gene-disease interactions | Angiotensinogen polymorphism | Type 2 diabetes mellitus | Coronary artery disease | SYSTEM | HONG-KONG CHINESE | LARGE ANGIOGRAPHIC COHORT | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | LINKAGE PHASE | M235T POLYMORPHISM | VARIANT | HEART-DISEASE | ESSENTIAL-HYPERTENSION | CORONARY-ARTERY-DISEASE | Haplotypes | Oligonucleotide Array Sequence Analysis | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Male | Obesity - genetics | Case-Control Studies | Diabetes Mellitus, Type 2 - ethnology | DNA Mutational Analysis | Female | Hypertension - genetics | Odds Ratio | Real-Time Polymerase Chain Reaction | Saudi Arabia - epidemiology | Genetic Linkage | Genetic Predisposition to Disease | Risk Assessment | Gene Frequency | Risk Factors | Obesity - ethnology | Logistic Models | Chi-Square Distribution | Coronary Artery Disease - ethnology | Angiotensinogen - genetics | Coronary Angiography | Coronary Artery Disease - diagnostic imaging | Phenotype | Hypertension - ethnology | Coronary Artery Disease - genetics | Arabs - genetics | Polymorphism, Single Nucleotide | Hypertension | Type 2 diabetes | DNA microarrays | Atherosclerosis | Detectors | Angiotensin | Genetic aspects | Coronary heart disease | Risk factors | Biotechnology industry | Genetic polymorphisms | Heart attacks | Statistical analysis | Cardiovascular disease | Low density lipoprotein | Patients | Proteins | Studies | Coronary vessels | Population | Diabetes | Autoimmune diseases
Obesity | Pleiotropy | Primary hypertension | Gene-disease interactions | Angiotensinogen polymorphism | Type 2 diabetes mellitus | Coronary artery disease | SYSTEM | HONG-KONG CHINESE | LARGE ANGIOGRAPHIC COHORT | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | LINKAGE PHASE | M235T POLYMORPHISM | VARIANT | HEART-DISEASE | ESSENTIAL-HYPERTENSION | CORONARY-ARTERY-DISEASE | Haplotypes | Oligonucleotide Array Sequence Analysis | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Male | Obesity - genetics | Case-Control Studies | Diabetes Mellitus, Type 2 - ethnology | DNA Mutational Analysis | Female | Hypertension - genetics | Odds Ratio | Real-Time Polymerase Chain Reaction | Saudi Arabia - epidemiology | Genetic Linkage | Genetic Predisposition to Disease | Risk Assessment | Gene Frequency | Risk Factors | Obesity - ethnology | Logistic Models | Chi-Square Distribution | Coronary Artery Disease - ethnology | Angiotensinogen - genetics | Coronary Angiography | Coronary Artery Disease - diagnostic imaging | Phenotype | Hypertension - ethnology | Coronary Artery Disease - genetics | Arabs - genetics | Polymorphism, Single Nucleotide | Hypertension | Type 2 diabetes | DNA microarrays | Atherosclerosis | Detectors | Angiotensin | Genetic aspects | Coronary heart disease | Risk factors | Biotechnology industry | Genetic polymorphisms | Heart attacks | Statistical analysis | Cardiovascular disease | Low density lipoprotein | Patients | Proteins | Studies | Coronary vessels | Population | Diabetes | Autoimmune diseases
Journal Article
Disease Markers, ISSN 0278-0240, 2014, Volume 2014, pp. 291419 - 10
We examined the role of hepatic nuclear factor-1 alpha (HNF1 alpha) gene polymorphism on coronary artery disease (CAD) traits in 4631 Saudi angiographed...
C-REACTIVE PROTEIN | YOUNG-ADULTS | MEDICINE, RESEARCH & EXPERIMENTAL | VARIANTS | LINKAGE PHASE | RISK | PREVALENCE | PATHOLOGY | HNF1A GENE | HEPATOCYTE NUCLEAR FACTOR-1-ALPHA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | EXPRESSION | CORONARY-ARTERY-DISEASE | Dyslipidemias - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Male | Genetic Loci | Case-Control Studies | Coronary Artery Disease - genetics | Female | Polymorphism, Single Nucleotide | Hypertension - genetics | Chromosomes, Human, Pair 12 - genetics | Hypertension | Type 2 diabetes | Quantitative trait loci | Dyslipidemias | Genetic aspects | Health aspects | Chromosomes | Heart attack | Risk factors
C-REACTIVE PROTEIN | YOUNG-ADULTS | MEDICINE, RESEARCH & EXPERIMENTAL | VARIANTS | LINKAGE PHASE | RISK | PREVALENCE | PATHOLOGY | HNF1A GENE | HEPATOCYTE NUCLEAR FACTOR-1-ALPHA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | EXPRESSION | CORONARY-ARTERY-DISEASE | Dyslipidemias - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Male | Genetic Loci | Case-Control Studies | Coronary Artery Disease - genetics | Female | Polymorphism, Single Nucleotide | Hypertension - genetics | Chromosomes, Human, Pair 12 - genetics | Hypertension | Type 2 diabetes | Quantitative trait loci | Dyslipidemias | Genetic aspects | Health aspects | Chromosomes | Heart attack | Risk factors
Journal Article
BMC medical genetics, ISSN 1471-2350, 12/2013, Volume 14, Issue 1, pp. 127 - 127
Background: Adiponectin Q is a hormone that modulates several metabolic processes and contributes to the suppression of biochemical pathways leading to...
Haplotypes | Adiponectin 3′-utranslated region | Metabolic syndrome | Atherosclerosis | SYSTEMATIC ANALYSIS | POPULATION | DISEASE-ASSOCIATED VARIANTS | Adiponectin 3 '-utranslated region | LINKAGE PHASE | CLASSIFICATION | DIABETES-MELLITUS | ADIPOQ GENE | GENETICS & HEREDITY | ASSOCIATION | SINGLE-NUCLEOTIDE POLYMORPHISMS | CORONARY-ARTERY-DISEASE | Genetic Predisposition to Disease | Lipoproteins, HDL - genetics | Genetic Association Studies | Atherosclerosis - genetics | Humans | Middle Aged | Logistic Models | Male | Cardiovascular Diseases - genetics | Case-Control Studies | Saudi Arabia | Haplotypes - genetics | Metabolic Syndrome - genetics | Adiponectin - genetics | Coronary Artery Disease - genetics | Arabs - genetics | Female | 3' Untranslated Regions | Genetic Linkage | Adipose tissues | Physiological aspects | Genetic aspects | Disease susceptibility | Research | Risk factors | Hypertension | Heart attacks | Statistical analysis | Cardiovascular disease | Federal regulation | Studies | Body mass index | Hospitals | Coronary vessels | Insulin resistance | Population | Gene loci | Diabetes
Haplotypes | Adiponectin 3′-utranslated region | Metabolic syndrome | Atherosclerosis | SYSTEMATIC ANALYSIS | POPULATION | DISEASE-ASSOCIATED VARIANTS | Adiponectin 3 '-utranslated region | LINKAGE PHASE | CLASSIFICATION | DIABETES-MELLITUS | ADIPOQ GENE | GENETICS & HEREDITY | ASSOCIATION | SINGLE-NUCLEOTIDE POLYMORPHISMS | CORONARY-ARTERY-DISEASE | Genetic Predisposition to Disease | Lipoproteins, HDL - genetics | Genetic Association Studies | Atherosclerosis - genetics | Humans | Middle Aged | Logistic Models | Male | Cardiovascular Diseases - genetics | Case-Control Studies | Saudi Arabia | Haplotypes - genetics | Metabolic Syndrome - genetics | Adiponectin - genetics | Coronary Artery Disease - genetics | Arabs - genetics | Female | 3' Untranslated Regions | Genetic Linkage | Adipose tissues | Physiological aspects | Genetic aspects | Disease susceptibility | Research | Risk factors | Hypertension | Heart attacks | Statistical analysis | Cardiovascular disease | Federal regulation | Studies | Body mass index | Hospitals | Coronary vessels | Insulin resistance | Population | Gene loci | Diabetes
Journal Article
Human Genomics, ISSN 1473-9542, 2013, Volume 7, Issue 1, pp. 15 - 15
Background: The muscle Ras (MRAS) gene resides on chromosome 3q22.3 and encodes a member of the membrane-associated Ras small GTPase proteins, which function...
Obesity | Linkage | Hypertriglyceridaemia | Dyslipidaemia | Hypercholesterolaemia | Coronary artery disease | Haplotype | MRAS gene polymorphism | ACTIVATION | PROTEIN | LINKAGE PHASE | CONSTITUTIVELY ACTIVE MUTANT | M-RAS/R-RAS3 | INDUCTION | PATHWAY | M-RAS | GENETICS & HEREDITY | HITCHHIKING | EXPRESSION | Dyslipidemias - genetics | ras Proteins - genetics | Genetic Predisposition to Disease | Genetic Association Studies | Humans | Middle Aged | Genetic Loci - genetics | Linkage Disequilibrium - genetics | Male | Cholesterol, HDL - genetics | Obesity - genetics | Haplotypes - genetics | Homozygote | Coronary Artery Disease - genetics | Polymorphism, Single Nucleotide - genetics | Female | Heterozygote | Hypercholesterolemia - genetics | Chromosomes, Human, Pair 3 - genetics
Obesity | Linkage | Hypertriglyceridaemia | Dyslipidaemia | Hypercholesterolaemia | Coronary artery disease | Haplotype | MRAS gene polymorphism | ACTIVATION | PROTEIN | LINKAGE PHASE | CONSTITUTIVELY ACTIVE MUTANT | M-RAS/R-RAS3 | INDUCTION | PATHWAY | M-RAS | GENETICS & HEREDITY | HITCHHIKING | EXPRESSION | Dyslipidemias - genetics | ras Proteins - genetics | Genetic Predisposition to Disease | Genetic Association Studies | Humans | Middle Aged | Genetic Loci - genetics | Linkage Disequilibrium - genetics | Male | Cholesterol, HDL - genetics | Obesity - genetics | Haplotypes - genetics | Homozygote | Coronary Artery Disease - genetics | Polymorphism, Single Nucleotide - genetics | Female | Heterozygote | Hypercholesterolemia - genetics | Chromosomes, Human, Pair 3 - genetics
Journal Article
Data in Brief, ISSN 2352-3409, 06/2016, Volume 7, Issue C, pp. 172 - 176
The data shows results acquired in a large cohort of 5668 ethnic Arabs involved in a common variants association study for coronary artery disease (CAD) and...
Journal Article
International Journal of Cardiology, ISSN 0167-5273, 2015, Volume 186, pp. 77 - 89
Abstract Background The molecular mechanisms underlying the geometrical changes of the left ventricle during the progression to heart failure and recovery are...
Cardiovascular | Aortic banding | Pressure overload | Cardiokines | Matrixins | SOLUBLE CD40 LIGAND | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | CARDIAC MYOCYTES | MUSCLE CELLS | WALL STRESS | IN-VITRO | PRESSURE-OVERLOAD HYPERTROPHY | EXTRACELLULAR-MATRIX | LEFT-VENTRICULAR MASS | DYSFUNCTION | Matrix Metalloproteinases - genetics | Sheep, Domestic | Gene Expression Regulation | Heart Failure - physiopathology | Heart Failure - genetics | Immunoblotting | Heart Failure - metabolism | Disease Progression | RNA - genetics | Ventricular Remodeling | Animals | Recovery of Function - physiology | Sheep | Cytokines - genetics | Real-Time Polymerase Chain Reaction | Cytokines - biosynthesis | Disease Models, Animal | Matrix Metalloproteinases - biosynthesis | Heart failure
Cardiovascular | Aortic banding | Pressure overload | Cardiokines | Matrixins | SOLUBLE CD40 LIGAND | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | CARDIAC MYOCYTES | MUSCLE CELLS | WALL STRESS | IN-VITRO | PRESSURE-OVERLOAD HYPERTROPHY | EXTRACELLULAR-MATRIX | LEFT-VENTRICULAR MASS | DYSFUNCTION | Matrix Metalloproteinases - genetics | Sheep, Domestic | Gene Expression Regulation | Heart Failure - physiopathology | Heart Failure - genetics | Immunoblotting | Heart Failure - metabolism | Disease Progression | RNA - genetics | Ventricular Remodeling | Animals | Recovery of Function - physiology | Sheep | Cytokines - genetics | Real-Time Polymerase Chain Reaction | Cytokines - biosynthesis | Disease Models, Animal | Matrix Metalloproteinases - biosynthesis | Heart failure
Journal Article
Annals of Human Genetics, ISSN 0003-4800, 09/2009, Volume 73, Issue 5, pp. 475 - 483
Journal Article
Annals of Human Genetics, ISSN 0003-4800, 09/2009, Volume 73, Issue 5, pp. 475 - 483
Summary The role of the KIAA0391 and PSMA6 genes in predisposing individuals to disease is still not fully understood. We evaluated by molecular beacon-based...
Myocardial infarction | coronary artery disease | PSMA6 | haplotype | single nucleotide polymorphism | KIAA0391 | Single nucleotide polymorphism | Coronary artery disease | Haplotype | PROTEASOME PATHWAY | CHROMOSOME-2 | SUSCEPTIBILITY | ATHEROSCLEROSIS | RISK | POLYMORPHISM | IDENTIFICATION | JAPANESE POPULATION | GENETICS & HEREDITY | GENOMEWIDE LINKAGE | ASSOCIATION | Haplotypes | Myocardial Infarction - genetics | Humans | Middle Aged | Genotype | Male | Case-Control Studies | Proteasome Endopeptidase Complex - genetics | Ribonuclease P - genetics | Coronary Artery Disease - genetics | Female | Polymorphism, Single Nucleotide | Chromosomes, Human, Pair 14 - genetics | Analysis | Genetic research | Genetic aspects | Explosives | Disease susceptibility | Risk factors | Heart attack
Myocardial infarction | coronary artery disease | PSMA6 | haplotype | single nucleotide polymorphism | KIAA0391 | Single nucleotide polymorphism | Coronary artery disease | Haplotype | PROTEASOME PATHWAY | CHROMOSOME-2 | SUSCEPTIBILITY | ATHEROSCLEROSIS | RISK | POLYMORPHISM | IDENTIFICATION | JAPANESE POPULATION | GENETICS & HEREDITY | GENOMEWIDE LINKAGE | ASSOCIATION | Haplotypes | Myocardial Infarction - genetics | Humans | Middle Aged | Genotype | Male | Case-Control Studies | Proteasome Endopeptidase Complex - genetics | Ribonuclease P - genetics | Coronary Artery Disease - genetics | Female | Polymorphism, Single Nucleotide | Chromosomes, Human, Pair 14 - genetics | Analysis | Genetic research | Genetic aspects | Explosives | Disease susceptibility | Risk factors | Heart attack
Journal Article
International Journal of Diabetes Mellitus, ISSN 1877-5934, 04/2009, Volume 1, Issue 1, pp. 16 - 21
Background: Heterogeneous familial hypercholesterolemia (HFH) partly underlies polymorphic changes in the low-density lipoprotein receptor (LDLR),...
Apolipoprotein B | Low HDL-cholesterol levels | Low density lipoprotein receptor | Protein convertase subtilisin/kexin type 9 | Early CAD onset | Heterozygous familial hyperlipidemia | Haplotype | Autosomal dominant hypercholesterolemia
Apolipoprotein B | Low HDL-cholesterol levels | Low density lipoprotein receptor | Protein convertase subtilisin/kexin type 9 | Early CAD onset | Heterozygous familial hyperlipidemia | Haplotype | Autosomal dominant hypercholesterolemia
Journal Article
Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery, ISSN 1556-9845, 2006, Volume 1, Issue 4, p. 200
Journal Article
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