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science & technology (11) 11
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research article (3) 3
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1. Full Text Polymorphisms within the C-Reactive Protein (CRP) Promoter Region Are Associated with Plasma CRP Levels
by Carlson, Christopher S and Aldred, Shelley Force and Lee, Philip K and Tracy, Russell P and Schwartz, Stephen M and Rieder, Mark and Liu, Kiang and Williams, O. Dale and Iribarren, Carlos and Lewis, E. Cora and Fornage, Myriam and Boerwinkle, Eric and Gross, Myron and Jaquish, Cashell and Nickerson, Deborah A and Myers, Richard M and Siscovick, David S and Reiner, Alexander P
American journal of human genetics, ISSN 0002-9297, 2005, Volume 77, Issue 1, pp. 64 - 77
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | General aspects. Genetic counseling | Biological and medical sciences | Medical sciences | Medical genetics | Haplotypes | Promoter Regions, Genetic | C-Reactive Protein - metabolism | Base Sequence | Gene Frequency | Humans | Adolescent | Female | Male | C-Reactive Protein - genetics | Polymorphism, Single Nucleotide | Polymorphism, Genetic | Genetic aspects | C-reactive protein | Research | Genetic polymorphisms | Human genetics | Blood proteins | Proteins | Plasma | Genetics | Cardiovascular disease | Polymorphism | Index Medicus
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2. Full Text Functional analysis of transcription factor binding sites in human promoters
by Whiteld, Troy W and Wang, Jie and Collins, Patrick J and Partridge, E Christopher and Aldred, Shelley F and Trinklein, Nathan D and Myers, Richard M and Weng, Zhiping
Genome biology, ISSN 1474-760X, 09/2012, Volume 13, Issue 9, pp. R50 - R50
Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Transcription Factors - metabolism | Cell Line | Promoter Regions, Genetic | Nucleotide Motifs | Humans | Transcription Initiation Site | YY1 Transcription Factor - metabolism | Genome, Human | Binding Sites | Index Medicus | Research
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3. Full Text An abundance of bidirectional promoters in the human genome
by Trinklein, Nathan D and Force Aldred, Shelley and Hartman, Sara J and Schroeder, Diane I and Otillar, Robert P and Myers, Richard M
Genome research, ISSN 1088-9051, 01/2004, Volume 14, Issue 1, pp. 62 - 66
Biochemistry & Molecular Biology | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Cell Line | Embryo, Mammalian | Gene Expression Regulation - genetics | Humans | DNA Repair - physiology | Genes - genetics | DNA Repair - genetics | Promoter Regions, Genetic - genetics | Genes - physiology | Animals | Promoter Regions, Genetic - physiology | Cell Line, Tumor | Mice | HeLa Cells | Transcription, Genetic - genetics | Genome | Genome, Human | Sequence Analysis, DNA - methods | Fibroblasts - chemistry | Fibroblasts - metabolism | Genetic research | Promoters (Genetics) | Genetic transcription | Research | Human genome | Index Medicus | Letters
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4. Full Text Two-tiered approach identifies a network of cancer and liver disease-related genes regulated by miR-122
by Boutz, Daniel R and Collins, Patrick J and Suresh, Uthra and Lu, Mingzhu and Ramírez, Cristina M and Fernández-Hernando, Carlos and Huang, Yufei and Abreu, Raquel De Sousa and Le, Shu-Yun and Shapiro, Bruce A and Liu, Angela M and Luk, John M and Aldred, Shelley Force and Trinklein, Nathan D and Marcotte, Edward M and Penalva, Luiz O. F
The Journal of biological chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 20, pp. 18066 - 18078
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Liver Neoplasms - genetics | Neoplasm Proteins - biosynthesis | Genes, Neoplasm | Humans | MicroRNAs - metabolism | RNA, Neoplasm - metabolism | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - metabolism | RNA, Neoplasm - genetics | MicroRNAs - genetics | Neoplasm Proteins - genetics | Carcinoma, Hepatocellular - metabolism | Index Medicus | Genomics and Proteomics | Gene Regulation | Liver Metabolism | MicroRNA | Liver | miR-122 | Proteomics | Mass Spectrometry (MS) | Cellular Regulation
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5. Full Text A functional analysis of the CREB signaling pathway using HaloCHIP-chip and high throughput reporter assays
by Hartzell, Danette D and Trinklein, Nathan D and Mendez, Jacqui and Murphy, Nancy and Aldred, Shelley F and Wood, Keith and Urh, Marjeta
BMC genomics, ISSN 1471-2164, 10/2009, Volume 10, Issue 1, pp. 497 - 497
Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Oligonucleotide Array Sequence Analysis | Signal Transduction | Genomics | Humans | Transcriptional Activation | Genes, Reporter - genetics | DNA - metabolism | Promoter Regions, Genetic - genetics | Luciferases - genetics | Cyclic AMP Response Element-Binding Protein - genetics | High-Throughput Screening Assays | Cyclic AMP Response Element-Binding Protein - metabolism | HeLa Cells | Binding Sites | Usage | Transcription factors | DNA microarrays | Physiological aspects | Cellular signal transduction | Genetic aspects | Research | Genetic regulation | Index Medicus
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6. Full Text Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
by Birney, Ewan and Dutta, Anindya and Guigó, Roderic and Margulies, Elliott H and Snyder, Michael and Taylor, Christopher M and Asthana, Saurabh and Andrews, Robert M and Carter, Nigel P and Giresi, Paul G and Hawrylycz, Michael and James, Keith D and Johnson, Ericka M and Karnani, Neerja and Lee, Kirsten and Vetrie, David and Wilcox, Sarah and Tullius, Thomas D and Crawford, Gregory E and Dunham, Ian and Reymond, Alexandre and Zheng, Deyou and Frankish, Adam and Hofacker, Ivo L and Baertsch, Robert and Dike, Sujit and Hirsch, Heather A and Holroyd, Nancy and Taylor, Ruth and Matthews, Nicholas and Thomas, Daryl J and Bell, Ian and Zhao, Xiaodong and Brent, Michael and Pachter, Lior and Choo, Siew Woh and Choo, Chiou Yu and Ucla, Catherine and Brown, James B and Patel, Sandeep and Tammana, Hari and Wu, Jiaqian and Lian, Jin and Newburger, Peter and Bickel, Peter and Myers, Richard M and Stadler, Peter F and Lowe, Todd M and Wei, Chia-Lin and Ruan, Yijun and Gerstein, Mark and Fu, Yutao and Karaöz, Ulaş and Taylor, James and Hou, Minmei and Montoya-Burgos, Juan I and Löytynoja, Ari and Whelan, Simon and Huang, Haiyan and Zhang, Nancy R and Holmes, Ian and Rosenbloom, Kate and Kent, W. James and Stone, Eric A and Sidow, Arend and Zhang, Zhengdong D and Barrera, Leah and Ameur, Adam and Bieda, Mark C and Yao, Fei and Lee, Charlie W.H and Zhu, Zhou and Squazzo, Sharon and Richmond, Todd A and Rada-Iglesias, Alvaro and Wallerman, Ola and Komorowski, Jan and Ellis, Peter D and Lin, Jane M and Hillman-Jackson, Jennifer and Smith, Kayla and Thakkapallayil, Archana and Barber, Galt and Bird, Christine P and Eyras, Eduardo and Zody, Michael C and Abecasis, Gonçalo R and Bouffard, Gerard G and Maskeri, Baishali and Park, Morgan and Young, Alice C and Blakesley, Robert W and Muzny, Donna M and Jiang, Huaiyang and Weinstock, George M and Gibbs, Richard A and Fulton, Robert and Lindblad-Toh, Kerstin and Koriabine, Maxim and Osoegawa, Kazutoyo and ENCODE Project Consortium and The ENCODE Project Consortium
Nature (London), ISSN 0028-0836, 06/2007, Volume 447, Issue 7146, pp. 799 - 816
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Medical research | Data analysis | Databases | Genomics | Deoxyribonucleic acid | Deoxyribonucleic acid--DNA
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7. Full Text When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions
by Bradbury, Andrew R. M and Trinklein, Nathan D and Thie, Holger and Wilkinson, Ian C and Tandon, Atul K and Anderson, Stephen and Bladen, Catherine L and Jones, Brittany and Aldred, Shelley Force and Bestagno, Marco and Burrone, Oscar and Maynard, Jennifer and Ferrara, Fortunato and Trimmer, James S and Görnemann, Janina and Glanville, Jacob and Wolf, Philipp and Frenzel, Andre and Wong, Julin and Koh, Xin Yu and Eng, Hui-Yan and Lane, David and Lefranc, Marie-Paule and Clark, Mike and Dübel, Stefan
mAbs, ISSN 1942-0862, 05/2018, Volume 10, Issue 4, pp. 539 - 546
specificity | hybridoma | recombinant antibodies | paratope | monoclonal antibodies | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Antibodies, Monoclonal - genetics | Animals | Antibody Specificity - immunology | Genes, Immunoglobulin Light Chain - genetics | Genes, Immunoglobulin Light Chain - immunology | Humans | Hybridomas - immunology | Genes, Immunoglobulin Heavy Chain - genetics | Antibody Specificity - genetics | Antibodies, Monoclonal - immunology | Genes, Immunoglobulin Heavy Chain - immunology
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8. Full Text Sequence-based discovery demonstrates that fixed light chain human transgenic rats produce a diverse repertoire of antigen-specific antibodies
by Harris, Katherine E and Aldred, Shelley Force and Davison, Laura M and Ogana, Heather Anne N and Boudreau, Andrew and Brüggemann, Marianne and Osborn, Michael and Ma, Biao and Buelow, Benjamin and Clarke, Starlynn C and Dang, Kevin H and Iyer, Suhasini and Jorgensen, Brett and Pham, Duy T and Pratap, Payal P and Rangaswamy, Udaya S and Schellenberger, Ute and van Schooten, Wim C and Ugamraj, Harshad S and Vafa, Omid and Buelow, Roland and Trinklein, Nathan D
Frontiers in immunology, ISSN 1664-3224, 04/2018, Volume 9, pp. 889 - 889
Somatic hypermutation | Antibody repertoire | Humanized rodent | Transgenic rodent | Monoclonal human antibodies | Deep sequencing | Rearranged light chain | Life Sciences & Biomedicine | Immunology | Science & Technology | Rats, Transgenic | Genes, Immunoglobulin Light Chain - genetics | Germinal Center - immunology | Rats | Antibodies, Monoclonal - therapeutic use | Drug Discovery - methods | Rats, Sprague-Dawley | Antigens - administration & dosage | Antibodies, Monoclonal - genetics | Immunoglobulin kappa-Chains - genetics | Animals | B-Lymphocytes - immunology | Immunoglobulin kappa-Chains - immunology | Genes, Immunoglobulin Heavy Chain - genetics | Antigens - immunology | Models, Animal | High-Throughput Nucleotide Sequencing | Germinal Center - cytology | Immunoglobulin Heavy Chains - immunology | Antibodies, Monoclonal - immunology | Immunoglobulin Heavy Chains - genetics | Usage | Genetic variation | Rattus | Monoclonal antibodies | Research | High-throughput screening (Biochemical assaying) | rearranged light chain | somatic hypermutation | monoclonal human antibodies | deep sequencing | transgenic rodent | antibody repertoire
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