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ACS Chemical Biology, ISSN 1554-8929, 01/2013, Volume 8, Issue 1, pp. 96 - 104
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2000, Volume 346, Issue 3, pp. 561 - 576
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 09/2010, Volume 430, Issue 3, pp. 405 - 413
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2018, Volume 475, Issue 1, pp. 23 - 44
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2008, Volume 411, Issue 2, pp. 249 - 260
Journal Article
Science Translational Medicine, ISSN 1946-6234, 07/2018, Volume 10, Issue 451
Missense mutations in leucine-rich repeat kinase 2 (LRRK2) cause familial Parkinson's disease (PD). However, a potential role of wild-type LRRK2 in idiopathic... 
KINASE 2 LRRK2 | MEDICINE, RESEARCH & EXPERIMENTAL | INHIBITION | GENE | PHOSPHORYLATION | 14-3-3 BINDING | NEURODEGENERATION | ALPHA-SYNUCLEIN | MUTATIONS | NOX2 | CELL BIOLOGY | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 01/2019, Volume 116, Issue 5, pp. 1579 - 1584
Journal Article
EMBO JOURNAL, ISSN 0261-4189, 09/2016, Volume 35, Issue 17, pp. 1902 - 1922
We explore mechanisms that enable cancer cells to tolerate PI3K or Akt inhibitors. Prolonged treatment of breast cancer cells with PI3K or Akt inhibitors leads... 
PHOSPHOINOSITIDE 3-KINASE PATHWAY | IN-VIVO ROLE | protein kinase inhibitors | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT INHIBITOR | ANTITUMOR-ACTIVITY | PI3K and NDRG1 | PROTEIN-KINASE B | P70 S6 KINASE | CELL BIOLOGY | BREAST-CANCER | PHOSPHATIDYLINOSITOL 3-PHOSPHATE | CAENORHABDITIS-ELEGANS | PI3 KINASE | NanoString | SGK3 | mTORC2 | mTORC1 | signal transduction inhibitors
Journal Article
Nature, ISSN 0028-0836, 05/2013, Volume 497, Issue 7448, pp. 193 - 194
Intriguingly, the substratebinding region on FRB is also the binding site of the FKBP12-rapamycin complex. [...]the mechanism by which the FKBP12-rapamycin... 
Research | Structure | Protein kinases | Cytology | Crystals | Proteins | Enzymes | Phosphorylation | Cell division | Kinases | Crystal structure | Recruitment
Journal Article
ACS CHEMICAL BIOLOGY, ISSN 1554-8929, 05/2019, Volume 14, Issue 5, pp. 882 - 892
Inducing post-translational protein knockdown is an important approach to probe biology and validate drug targets. An efficient strategy to achieve this... 
TARGET | SYSTEM | COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEGRADATION | DEPLETION | PROTACS | INHIBITOR | DISCOVERY | E3 UBIQUITIN LIGASE | MOLECULES
Journal Article
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