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Cellular Physiology and Biochemistry, ISSN 1015-8987, 07/2017, Volume 42, Issue 4, pp. 1366 - 1376
Background/Aims: Istaroxime is a validated inotropic Na+/K+ ATPase inhibitor currently in development for the treatment of various cardiac conditions. Recent... 
DU-145 prostate cancer cells | Orai1 | SOCE | FAK | Istaroxime | Migration | ELEVATED ORAI1 | OPERATED CA2+ ENTRY | PHYSIOLOGY | MEMBRANE ANDROGEN RECEPTORS | PRO-APOPTOTIC RESPONSES | CELL BIOLOGY | IN-VITRO | NA+/K+ ATPASE INHIBITOR | ACTIN REORGANIZATION | BREAST-TUMOR CELLS | RHABDOMYOSARCOMA CELLS | FOCAL ADHESION KINASE | Focal Adhesion Kinase 1 - genetics | Epithelial Cells - metabolism | Calcium Channels - metabolism | Calcium - metabolism | Epithelial Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Male | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Prostate - metabolism | Stromal Interaction Molecule 1 - genetics | Prostate - pathology | Fura-2 - chemistry | Prostate - drug effects | Etiocholanolone - pharmacology | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Calcium Channels - genetics | Focal Adhesion Kinase 1 - metabolism | ORAI1 Protein - metabolism | Fluorescent Dyes - chemistry | ORAI1 Protein - genetics | Signal Transduction | Etiocholanolone - analogs & derivatives | Epithelial Cells - pathology | Sodium Channel Blockers - pharmacology | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Cell Movement - drug effects | Stromal Interaction Molecule 1 - metabolism | ORAI1 Protein - antagonists & inhibitors | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Focal Adhesion Kinase 1 - antagonists & inhibitors | Stromal Interaction Molecule 1 - antagonists & inhibitors
Journal Article
Anti-Cancer Agents in Medicinal Chemistry, ISSN 1871-5206, 2014, Volume 14, Issue 5, pp. 762 - 770
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Cellular Physiology and Biochemistry, ISSN 1015-8987, 10/2014, Volume 34, Issue 4, pp. 1402 - 1412
Background/Aims: Functional membrane androgen receptors (mARs) have recently been described in colon tumor cells and tissues. Their activation by specific... 
Original Paper | c-Src | GSK-3beta | Actin | Beta-catenin | mARs | Colon tumors | Cyclin D1 | PHYSIOLOGY | PROTEIN-KINASE | TYROSINE KINASES | CELL BIOLOGY | GLYCOGEN-SYNTHASE KINASE-3-BETA | IN-VITRO | ACTIN REORGANIZATION | SIGNALING PATHWAY | COLORECTAL-CANCER | PROSTATE-CANCER CELLS | TESTOSTERONE RECEPTORS
Journal Article
Experimental Cell Research, ISSN 0014-4827, 2008, Volume 314, Issue 17, pp. 3162 - 3174
In this study we describe a novel Rho small GTPase dependent pathway that elicits apoptotic responses controlled by actin reorganization in hormone-sensitive... 
mAR activation | Rho-GTPase signaling | Prostate cancer | Actin dynamics | Apoptosis | LIM-KINASE | STEROID-HORMONES | PROGESTIN RECEPTOR | CELL BIOLOGY | IN-VITRO | GLUCOCORTICOID-RECEPTOR | ONCOLOGY | TESTOSTERONE RECEPTORS | FOCAL ADHESION KINASE | ACTIN CYTOSKELETON | NONGENOMIC ACTIONS | COFILIN PHOSPHORYLATION | Focal Adhesion Kinase 1 - genetics | Prostatic Neoplasms - metabolism | Humans | Receptors, Androgen - metabolism | Actins - metabolism | Male | cdc42 GTP-Binding Protein - metabolism | rhoA GTP-Binding Protein - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Testosterone - analogs & derivatives | rhoA GTP-Binding Protein - genetics | rhoB GTP-Binding Protein - metabolism | Lim Kinases - metabolism | Testosterone - metabolism | rho-Associated Kinases - metabolism | Amides - metabolism | rhoB GTP-Binding Protein - genetics | Destrin - metabolism | Focal Adhesion Kinase 1 - metabolism | Prostatic Neoplasms - pathology | Enzyme Inhibitors - metabolism | rho-Associated Kinases - genetics | Serum Albumin, Bovine - metabolism | Phosphatidylinositol 3-Kinases - genetics | Animals | Pyridines - metabolism | Receptors, Androgen - genetics | Cell Line, Tumor | Signal Transduction - physiology | Apoptosis - physiology | Enzyme Activation | rac1 GTP-Binding Protein - metabolism | Muscle proteins | Actin | Cancer cells | Signal transduction | Hormones | Cellular biology
Journal Article
by Ötünçtemur, Alper and Çakır, Süleyman Sami and Dursun, Murat and Polat, Emre Can and Somay, Adnan and Somay, Adnan and Özbay, Nurver and Özbay, Nurver and Çekmen, Mustafa and Lee, Ming Chak and Brooks, Andrew and Drummond, Malcolm and Lau, Howard and Patel, Manish and Wang, Audrey and Woo, Henry and Kim, Hyun Jin and Averch, Timothy D and Averch, Timothy D and Kim, Hyung and Yildirim, Ibrahim and Tapan, Serkan and Aydur, Emin and Tahmaz, Lutfu and Dayanc, Murat and Olweny, Ephrem O and Faddegon, Stephen and Faddegon, Stephen and Best, Sara L and Jackson, Neil and Wehner, Eleanor F and Tan, Yung K and Tan, Yung K and Zuzak, Karel J and Cadeddu, Jeffrey A and Cadeddu, Jeffrey A and Cadeddu, Jeffrey A and Tan, Yung Khan and Olweny, Ephrem O and Liu, Zhou Wei and Kapur, Payal and Faddegon, Steve and Yin, Gang and Cadeddu, Jeffrey and Park, Jane Hyeon and Castillo, Josefino Cortez and Morales Jr, Marcelino Lopeztan and Colli, Janet and Wang, Zijun and Keel, Christopher and Lee, Benjamin R and Dilli, Alper and Zengin, Kürşad and Yalçınkaya, Fatih and Yiğitbaşı, Orhan and Sertçelik, Memduh Nurettin and Arıdoğan, Ibrahim Atilla and Izol, Volkan and Acıkalın, Arbil and Abat, Deniz and Tuli, Abdullah and Bayazıt, Yıldırım and Resorlu, Berkan and Unsal, Ali and Saitz, Theodore and Grossman, Leah and Dorsey, Philip and Pedersen, Ditte and Lund, Martin and Marcussen, Niels and Lund, Lars and Graversen, Joseph A and Wikenheiser, Jamie and Kerkoutian, Susan and Abdelshehid, Corollos and Abdelshehid, Corollos and Alipanah, Reza and Quach, Stephen and Zarraga, Jerome P and Gerbatsch, Isabelle and Huang, Jiaoti and Landman, Jaime and Landman, Jaime and Kyriazis, Iason and Kagadis, George and Loudos, George and Kallidonis, Panagiotis and Kallidonis, Panagiotis and Georgiopoulos, Ioannis and Liourdi, Despoina and Apostolopoulos, Dimitris and Nikiforidis, George and Liatsikos, Evangelos and Liatsikos, Evangelos and Fishman, Andrew and Dorai, Thambi and Dorai, Thambi and Ding, Cheng and Haberle, Ines Batinic and Grasso, Michael and ...
Journal of Endourology, ISSN 0892-7790, 09/2012, Volume 26, Issue S1, pp. P1 - A572
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Oncotarget, ISSN 1949-2553, 04/2016, Volume 7, Issue 17, pp. 24415 - 24428
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