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1. Full Text From Return of Information to Return of Value: Ethical Considerations when Sharing Individual-Level Research Data
by Nebeker, C and Leow, AD and Moore, RC
JOURNAL OF ALZHEIMERS DISEASE, ISSN 1387-2877, 2019, Volume 71, Issue 4, pp. 1081 - 1088
The implementation of digital health technologies into research studies for Alzheimer's disease and other clinical populations is on the rise. Digital tools... 
digital medicine | return of results | disclosure | information dissemination | informed consent | mobile health | patient rights | privacy | research ethics | NEUROSCIENCES | Cognitive dysfunction | Medical research | Community participation | Multidimensional methods | Electronic medical records | Ethics | Community involvement | Researchers | Ethical standards | Research methodology | Informed consent | Protocol (computers) | Electronic health records | Research methods
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2. Full Text Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: An MRI study of 676 AD, MCI, and normal subjects
by Hua, Xue and Leow, Alex D and Parikshak, Neelroop and Lee, Suh and Chiang, Ming-Chang and Toga, Arthur W and Jack, Clifford R and Weiner, Michael W and Thompson, Paul M and Alzheimer's Dis Neuroimaging Initi and Alzheimer's Disease Neuroimaging Initiative
NeuroImage, ISSN 1053-8119, 11/2008, Volume 43, Issue 3, pp. 458 - 469
In one of the largest brain MRI studies to date, we used tensor-based morphometry (TBM) to create 3D maps of structural atrophy in 676 subjects with... 
BRAIN ATROPHY | GRAY-MATTER LOSS | HIPPOCAMPAL ATROPHY | E EPSILON-4 ALLELE | TEMPORAL-LOBE ATROPHY | MILD COGNITIVE IMPAIRMENT | APOLIPOPROTEIN-E GENOTYPE | NEUROSCIENCES | NEUROIMAGING | VOXEL-BASED MORPHOMETRY | DEMENTIA RATING CDR | LONGITUDINAL MRI | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Neuropsychological Tests | Magnetic Resonance Imaging | Apolipoprotein E4 - genetics | Humans | Brain - pathology | Aged | Brain Mapping - methods | Image Processing, Computer-Assisted - methods | Alzheimer Disease - genetics | Disease Progression | Alzheimer Disease - pathology | Medical colleges | Medical research | Neurosciences | Magnetic resonance imaging | Medicine, Experimental | Alzheimer's disease | Telecommunications services industry | Communications industry | Studies | Alzheimers disease | Pharmaceutical industry | Dementia | Neuroimaging | Apolipoprotein E4 | Temporal lobe | Compression | Image processing | Neurodegenerative diseases | Memory | biomarkers | Brain mapping | Cognitive ability | Atrophy | Dementia disorders | Gene mapping | Morphometry | Age | Hippocampus | Geriatrics
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3. Full Text A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
by April J. Ho and Jason L. Stein and Xue Hua and Suh Lee and Derrek P. Hibar and Alex D. Leow and Ivo D. Dinov and Arthur W. Toga and Andrew J. Saykin and Li Shen and Tatiana Foroud and Nathan Pankratz and Matthew J. Huentelman and David W. Craig and Jill D. Gerber and April N. Allen and Jason J. Corneveaux and Dietrich A. Stephan and Charles S. DeCarli and Bryan M. DeChairo and Steven G. Potkin and Clifford R. Jack and Michael W. Weiner and Cyrus A. Raji and Oscar L. Lopez and James T. Becker and Owen T. Carmichael and Paul M. Thompson and the Alzheimer's Disease Neuroimaging Initiative and Marcus E. Raichle and Alzheimer's Dis Neuroimaging and Alzheimer's Disease Neuroimaging Initiative and the Alzheimer's Disease Neuroimaging Initiative
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2010, Volume 107, Issue 18, pp. 8404 - 8409
A recently identified variant within the fat mass and obesity-associated (FTO) gene is carried by 46% of Western Europeans and is associated with an ∼1.2 kg... 
Neuroimaging | Body mass index | Obesity | Frontal lobe | Alleles | Medical genetics | Alzheimers disease | Older adults | White matter | Genotypes | Tensor-based morphometry | Alzheimer's disease neuroimaging initiative | Brain structure | tensor-based morphometry | ATROPHY | body mass index | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | FUSED TOES FT | MILD COGNITIVE IMPAIRMENT | ADULT OBESITY | Alzheimer's Disease Neuroimaging Initiative | BODY-MASS INDEX | PHYSICAL-ACTIVITY | MATTER HYPERINTENSITY VOLUME | brain structure | obesity | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease | Brain - anatomy & histology | Humans | Risk Factors | Organ Size | Alpha-Ketoglutarate-Dependent Dioxygenase FTO | Obesity - genetics | Brain - metabolism | Proteins - genetics | Magnetic Resonance Imaging | Aged | Imaging, Three-Dimensional | Allelomorphism | Brain | Physiological aspects | Genetic aspects | Research | Health aspects | Biological Sciences
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4. Full Text Differentiating weight-restored anorexia nervosa and body dysmorphic disorder using neuroimaging and psychometric markers
by Vaughn, DA and Kerr, WT and Moody, TD and Cheng, GK and Morfini, F and Zhang, AF and Leow, AD and Strober, MA and Cohen, MS and Feusner, JD
PLOS ONE, ISSN 1932-6203, 05/2019, Volume 14, Issue 5, p. e0213974
Anorexia nervosa (AN) and body dysmorphic disorder (BDD) are potentially life-threatening conditions whose partially overlapping phenomenology distorted... 
MORTALITY | IMAGE | COGNITIVE-BEHAVIORAL THERAPY | MULTIDISCIPLINARY SCIENCES | FUNCTIONAL CONNECTIVITY | RELIABILITY | EATING-DISORDERS | CLINICAL-FEATURES | PREVALENCE | SCALE | COMORBIDITY | Neuroimaging | Usage | Analysis | Diagnosis | Research | Anorexia nervosa | Body dysmorphic disorder | Prevalence studies (Epidemiology) | Anorexia | Neurosciences | Nuclear magnetic resonance--NMR | Mental disorders | Visual stimuli | Nervous system | Mental depression | Phenomenology | Functional magnetic resonance imaging | Anxiety | Behavior | Signs and symptoms | Medical imaging | Mortality | Eating disorders | Graph theory | Substantia alba | Weight | Model accuracy | Medicine | Neurology | Learning algorithms | Tensors | Cognition & reasoning | Magnetic resonance imaging | Neural networks | Machine learning | Connectivity | Adults | Diagnostic systems | Psychiatry | Nuclear magnetic resonance | NMR
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5. Full Text Voxelwise genome-wide association study (vGWAS)
by Stein, Jason L and Hua, Xue and Lee, Suh and Ho, April J and Leow, Alex D and Toga, Arthur W and Saykin, Andrew J and Shen, Li and Foroud, Tatiana and Pankratz, Nathan and Huentelman, Matthew J and Craig, David W and Gerber, Jill D and Allen, April N and Corneveaux, Jason J and DeChairo, Bryan M and Potkin, Steven G and Weiner, Michael W and M. Thompson, Paul and Alzheimers Dis Neuroimaging Initia and Alzheimer's Disease Neuroimaging Initiative
NeuroImage, ISSN 1053-8119, 11/2010, Volume 53, Issue 3, pp. 1160 - 1174
The structure of the human brain is highly heritable, and is thought to be influenced by many common genetic variants, many of which are currently unknown.... 
AUTISTIC-LIKE PHENOTYPES | ALZHEIMERS-DISEASE | LITHIUM-TREATED PATIENTS | MILD COGNITIVE IMPAIRMENT | NEUROSCIENCES | NEUROIMAGING | CA2+-DEPENDENT ACTIVATOR | FALSE DISCOVERY RATE | BRAIN STRUCTURE | TENSOR-BASED MORPHOMETRY | GENETIC INFLUENCES | COMPLEX TRAITS | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Brain | Quantitative Trait, Heritable | Humans | Image Interpretation, Computer-Assisted | Genotype | Male | Cognition Disorders - genetics | Magnetic Resonance Imaging | Female | Aged | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Genome-Wide Association Study - methods | Medical colleges | Neurosciences | Genomics | Genomes | Alzheimer's disease | Studies | Medical imaging | Mental disorders | Genes | Influence | Statistical methods | Mitochondrial DNA | Health risk assessment | Age
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6. Full Text 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry
by Hua, Xue and Leow, Alex D and Lee, Suh and Klunder, Andrea D and Toga, Arthur W and Lepore, Natasha and Chou, Yi-Yu and Brun, Caroline and Chiang, Ming-Chang and Barysheva, Marina and Jack, Clifford R and Bernstein, Matt A and Britson, Paula J and Ward, Chadwick P and Whitwell, Jennifer L and Borowski, Bret and Fleisher, Adam S and Fox, Nick C and Boyes, Richard G and Barnes, Josephine and Harvey, Danielle and Kornak, John and Schuff, Norbert and Boreta, Lauren and Alexander, Gene E and Weiner, Michael W and Thompson, Paul M and the Alzheimer's Disease Neuroimaging Initiative and Alzheimer's Dis Neuroimaging Initi and Alzheimer's Disease Neuroimaging Initiative
Neuroimage, ISSN 1053-8119, 2008, Volume 41, Issue 1, pp. 19 - 34
Tensor-based morphometry (TBM) creates three-dimensional maps of disease-related differences in brain structure, based on nonlinearly registering brain MRI... 
GRAY-MATTER LOSS | HIPPOCAMPAL ATROPHY | DEFORMATION-BASED MORPHOMETRY | NEUROSCIENCES | NEUROIMAGING | STRUCTURAL MR-IMAGES | VOXEL-BASED MORPHOMETRY | FALSE DISCOVERY RATE | CARDIOVASCULAR HEALTH | PATTERN-CLASSIFICATION | REGIONAL SPATIAL NORMALIZATION | EARLY-ONSET | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Humans | Middle Aged | Cognition Disorders - pathology | Male | Alzheimer Disease - pathology | Atrophy | Neuropsychological Tests | Magnetic Resonance Imaging | Psychiatric Status Rating Scales | Algorithms | Image Processing, Computer-Assisted | Aged, 80 and over | Brain - pathology | Brain Mapping | Female | Aged | Alzheimer Disease - psychology | Cognition Disorders - psychology | Brain | Alzheimer's disease | Studies | Medical imaging | Biomedical research | Brain research | Cognition & reasoning | Cognitive ability | Clinical trials | Behavior | Alzheimers disease | Dementia | Neuroimaging | Temporal lobe | Compression | Neurodegenerative diseases | Brain mapping | Cerebrospinal fluid | Statistics | Maps | Magnetic resonance imaging | Dementia disorders | Morphometry | Hippocampus | Geriatrics
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7. Full Text Unbiased tensor-based morphometry: Improved robustness and sample size estimates for Alzheimer's disease clinical trials
by Hua, Xue and Hibar, Derrek P and Ching, Christopher R.K and Boyle, Christina P and Rajagopalan, Priya and Gutman, Boris A and Leow, Alex D and Toga, Arthur W and Jack, Clifford R and Harvey, Danielle and Weiner, Michael W and Thompson, Paul M and Alzheimer's Dis Neuroimaging Initi and Alzheimer's Disease Neuroimaging Initiative
NeuroImage, ISSN 1053-8119, 02/2013, Volume 66, pp. 648 - 661
Various neuroimaging measures are being evaluated for tracking Alzheimer's disease (AD) progression in therapeutic trials, including measures of structural... 
ADNI | Aging | Tensor-based morphometry | Mild cognitive impairment | Alzheimer's disease | Drug trial | ALLELE | MYELIN BREAKDOWN | BIOMARKER | NEUROSCIENCES | NEUROIMAGING | VOXEL-BASED MORPHOMETRY | HIPPOCAMPAL VOLUME | MR-IMAGES | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | IMAGE REGISTRATION | BRAIN | PROGRESSION | Data Interpretation, Statistical | Prospective Studies | Humans | Male | Clinical Trials as Topic | Cognitive Dysfunction - pathology | Alzheimer Disease - pathology | Atrophy | Diffusion Tensor Imaging - methods | Apolipoproteins E - genetics | Brain - pathology | Diffusion Tensor Imaging - instrumentation | Female | Research Design - standards | Aged | Alzheimer Disease - genetics | Medical research | Clinical trials | Medicine, Experimental | Diagnostic imaging | Drug therapy | Apolipoproteins | Health care | Discriminant analysis | Medical imaging | Bias | Biomarkers | Software | Alzheimers disease | Estimates | Methods
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8. Full Text Three-Dimensional Brain Growth Abnormalities in Childhood-Onset Schizophrenia Visualized by Using Tensor-Based Morphometry
by Nitin Gogtay and Allen Lu and Alex D. Leow and Andrea D. Klunder and Agatha D. Lee and Alex Chavez and Deanna Greenstein and Jay N. Giedd and Arthur W. Toga and Judith L. Rapoport and Paul M. Thompson
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2008, Volume 105, Issue 41, pp. 15979 - 15984
Earlier studies revealed progressive cortical gray matter (GM) loss in childhood-onset schizophrenia (COS) across both lateral and medial surfaces of the... 
Child psychiatry | Developmental biology | Imaging | Cerebral hemispheres | Schizophrenia | P values | Childhood schizophrenia | Parietal lobe | White matter | Symptoms | Development | MRI | development | MULTIDISCIPLINARY SCIENCES | PATTERNS | ADOLESCENCE | imaging | CORTICAL DEVELOPMENT | DEFORMATION | white matter | CONNECTIVITY | DISORDER | WHITE-MATTER ABNORMALITIES | DEFICITS | EXPRESSION | Magnetic Resonance Imaging | Nerve Fibers, Unmyelinated - pathology | Schizophrenia, Childhood - pathology | Humans | Adolescent | Cerebral Cortex - pathology | Brain - pathology | Brain Mapping | Brain - abnormalities | Brain - growth & development | Child | Case-Control Studies | Diagnosis | Magnetic resonance imaging | Methods | Schizophrenia in children | Biological Sciences
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9. Full Text The significance of negative correlations in brain connectivity
by Zhan, Liang and Jenkins, Lisanne M and Wolfson, Ouri E and GadElkarim, Johnson Jonaris and Nocito, Kevin and Thompson, Paul M and Ajilore, Olusola A and Chung, Moo K and Leow, Alex D
Journal of Comparative Neurology, ISSN 0021-9967, 10/2017, Volume 525, Issue 15, pp. 3251 - 3265
Understanding the modularity of functional magnetic resonance imaging (fMRI)–derived brain networks or “connectomes” can inform the study of brain function... 
Human Connectome Project | resting state | modularity | F1000 | RRID: SCR_005361 | negative correlations | functional connectome | RRID: SCR_006942 | FUNCTIONAL CONNECTIVITY | AUTOBIOGRAPHICAL MEMORY | NETWORKS | NEUROSCIENCES | RETRIEVAL | EXPERIENCES | COMMUNITY STRUCTURE | CONNECTOME | ZOOLOGY | SEX-DIFFERENCES | GENDER-DIFFERENCES | Brain - diagnostic imaging | Cerebrovascular Circulation - physiology | Humans | Magnetic Resonance Imaging - methods | Male | Sex Characteristics | Brain - physiology | Neural Pathways - physiology | Oxygen - blood | Rest | Computer Simulation | Neural Pathways - diagnostic imaging | Connectome - methods | Female | Models, Neurological | Neurosciences | Algorithms | Neuroimaging | Brain | Correlation | Brain architecture | Computational neuroscience | Brain mapping | Sex differences | Nervous system | Modularity | Modular structures | Optimization | Nodes | Datasets | Magnetic resonance imaging | Neural networks | Data sets | Computer applications | Gender aspects | Functional magnetic resonance imaging | Ising model | Software
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