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Trends in Biochemical Sciences, ISSN 0968-0004, 09/2018, Volume 43, Issue 9, p. 668
Macrolide antibiotics inhibit protein synthesis by targeting the bacterial ribosome. They bind at the nascent peptide exit tunnel and partially occlude it.... 
Translation | Peptides | Macrolide antibiotics | Amino acid sequence | Protein biosynthesis | Ribonucleic acid--RNA | Gene expression | Drug development | Modulators | Proteins | Antibiotics | Protein synthesis | Plugs
Journal Article
Annual Review of Microbiology, ISSN 0066-4227, 01/2018, Volume 72, p. 185
The ribosome is a major antibiotic target. Many types of inhibitors can stop cells from growing by binding at functional centers of the ribosome and... 
Proteins | Translation | Inhibitors | Antibiotics | RNA-protein interactions | tRNA | Protein synthesis | Protein biosynthesis | mRNA | Ribonucleic acid--RNA | Drug resistance | Substrates
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 12/2011, Volume 1241, Issue 1, pp. 33 - 47
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17152 - 17157
Differences between the structures of bacterial, archaeal, and eukaryotic ribosomes account for the selective action of antibiotics. Even minor variations in... 
Ketolides | Antibiotics | Macrolides | Drug interactions | Ribosomes | Bacteria | Nucleotides | Electron density | Genetic mutation | Binding sites | Ribosome structure | Chloramphenicol | Telithromycin | Erythromycin | Clindamycin | PROTEIN | BACTERIAL RIBOSOME | RNA GENE | MULTIDISCIPLINARY SCIENCES | telithromycin | RESISTANCE MUTATIONS | CONFERRING RESISTANCE | erythromycin | DOMAIN-II | BINDING-SITE | chloramphenicol | MACROLIDE ANTIBIOTICS | ribosome structure | clindamycin | PLEUROMUTILINS | Haloarcula marismortui - genetics | Haloarcula marismortui - metabolism | Chloramphenicol - chemistry | Erythromycin - metabolism | Molecular Sequence Data | Ribosomes - metabolism | Deinococcus - metabolism | Deinococcus - genetics | Haloarcula marismortui - chemistry | X-Ray Diffraction | Anti-Bacterial Agents - chemistry | Base Sequence | Escherichia coli - metabolism | Ketolides - metabolism | Deinococcus - chemistry | Molecular Structure | Clindamycin - chemistry | Peptidyl Transferases - metabolism | Clindamycin - metabolism | Peptidyl Transferases - chemistry | Ribosomes - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli - chemistry | RNA, Ribosomal, 23S - chemistry | Erythromycin - chemistry | Escherichia coli - genetics | Ketolides - chemistry | RNA, Ribosomal, 23S - metabolism | Chloramphenicol - metabolism | Escherichia coli | Crystals | Genetic aspects | Research | Properties | Structure | Observations | Peptidyl transferases | Drugs | lincosamides | Pathogens | rRNA | rRNA 23S | Data processing | Ribosomal subunits | Ionizing radiation | Peptidyltransferase | Crystal structure | Tunnels | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2017, Volume 114, Issue 52, p. 13673
Antibiotics can cause dormancy (bacteriostasis) or induce death (cidality) of the targeted bacteria. The bactericidal capacity is one of the most important... 
Translation | rRNA | Macrolide antibiotics | Nucleotides | Gene expression | Antibacterial agents | Cells | Critical components | Mode of action | Dormancy | Antibiotics | Ribonucleic acids | Aromatic compounds | Cell death | Bacteriostasis | Downtime | Bacteria | Kinetics | Mutation | Binding sites | Apoptosis
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2016, Volume 113, Issue 43, pp. 12150 - 12155
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 02/2019, Volume 10, Issue 1, pp. 930 - 13
Ribo-T is an engineered ribosome whose small and large subunits are tethered together by linking 16S rRNA and 23S rRNA in a single molecule. Although Ribo-T... 
PLATFORM | NUCLEOTIDES | METHYLATION | BACTERIAL RIBOSOME | BIOGENESIS | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | TRANSFER-RNA | TRANSLATION | DOMAINS | REVEALS | Cell proliferation | Post-transcription | Translation | rRNA 16S | Profiling | rRNA 23S | Ribosomes | Tethering | Lymphocytes T | Intermediates | Proteins | Cell growth | Ribosomal proteins | Lymphocytes | Translation elongation | Occupancy | Translation termination | Codons | Assembly | Elongation
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2014, Volume 111, Issue 27, pp. 9804 - 9809
Translation arrest directed by nascent peptides and small cofactors controls expression of important bacterial and eukaryotic genes, including antibiotic... 
Antibiotics | Active sites |