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The EMBO Journal, ISSN 0261-4189, 01/2015, Volume 34, Issue 2, pp. 200 - 217
Hedgehog signaling is essential for tissue development and stemness, and its deregulation has been observed in many tumors. Aberrant activation of Hedgehog... 
interaction | Hedgehog | cancer | li1 | DNA | li inhibitors | Gli inhibitors | Gli1-DNA interaction | Cancer | CANCER-CELLS | STEM-CELLS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | HUMAN GLIOMA | CELL BIOLOGY | PATHWAY BLOCKADE | INHIBITION | GROWTH | SCORING FUNCTIONS | MEDULLOBLASTOMA | Embryo, Mammalian - drug effects | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Receptors, G-Protein-Coupled - metabolism | Isoflavones - pharmacology | Cerebellum - drug effects | Embryo, Mammalian - metabolism | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | Female | Glioblastoma - metabolism | Receptors, Cell Surface - physiology | Patched Receptors | DNA - drug effects | Fibroblasts - metabolism | Mutagenesis, Site-Directed | Cerebellum - metabolism | DNA - metabolism | Mice, SCID | Mutation - genetics | Kruppel-Like Transcription Factors - chemistry | Molecular Dynamics Simulation | Mice, Knockout | Animals | Embryonic Stem Cells - drug effects | Signal Transduction - drug effects | Embryo, Mammalian - cytology | Fibroblasts - drug effects | Glioblastoma - pathology | Cerebellum - cytology | Mice, Inbred NOD | Fibroblasts - cytology | Mice | Mice, Inbred BALB C | Zinc Finger Protein GLI1 | Glioblastoma - drug therapy | Kruppel-Like Transcription Factors - genetics | Medical research | Amino acids | Molecular biology | Deoxyribonucleic acid--DNA | Stem cells | Tumors | Index Medicus | Gli1–DNA interaction
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 2018, Volume 9, Issue 1, pp. 976 - 17
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 06/2016, Volume 15, Issue 6, pp. 1177 - 1189
Journal Article
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2018, Volume 156, pp. 554 - 562
Aberrant activation of the Hedgehog (Hh) pathway is responsible for the onset and progression of several malignancies. Small molecules able to block the... 
Gli inhibitors | Synergistic effects | Hedgehog inhibitors | Smo antagonists | Isoflavones | Cancer | CHEMISTRY, MEDICINAL | VISMODEGIB | PROLIFERATION | DISCOVERY | SIGNALING PATHWAY | BASAL-CELL CARCINOMA | PROSTATE-CANCER | GROWTH | RESISTANCE | MEDULLOBLASTOMA | MODULATION | Prevention | Gliomas | Analysis | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2014, Volume 57, Issue 15, pp. 6531 - 6552
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2015, Volume 58, Issue 15, pp. 5789 - 5807
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 10/2017, Volume 101, Issue 4, pp. 552 - 563
The Sonic Hedgehog (SHH) pathway is a key signaling pathway orchestrating embryonic development, mainly of the CNS and limbs. In vertebrates, SHH signaling is... 
polymicrogyria | developmental defects | hypomorphic variants | congenital ataxia | ciliopathies | SUFU | Joubert syndrome | Sonic Hedgehog | molar tooth sign | GLI3 | SHH | SIGNALING PATHWAY | GENETICS & HEREDITY | PLANAR CELL POLARITY | CEREBELLAR DEVELOPMENT | GLI PROTEINS | MUTATIONS | KIF7 | MEDULLOBLASTOMA | PHENOTYPIC SPECTRUM | PRIMARY CILIA | Abnormalities, Multiple - pathology | Skin - metabolism | Humans | Zinc Finger Protein Gli3 | Hedgehog Proteins - metabolism | Male | Bone Diseases, Developmental - genetics | Mutation, Missense | Cerebellum - abnormalities | Bone Diseases, Developmental - pathology | Gene Expression Regulation, Developmental | Kruppel-Like Transcription Factors - metabolism | Kidney Diseases, Cystic - genetics | Craniofacial Abnormalities - pathology | Female | Child | Abnormalities, Multiple - genetics | Craniofacial Abnormalities - genetics | Repressor Proteins - metabolism | Skin - pathology | Fibroblasts - metabolism | Repressor Proteins - chemistry | Signal Transduction | Cells, Cultured | Repressor Proteins - genetics | Eye Abnormalities - genetics | Fibroblasts - pathology | Genes, Recessive | Sequence Analysis, DNA | Cerebellum - pathology | Kidney Diseases, Cystic - pathology | Nerve Tissue Proteins - metabolism | Eye Abnormalities - pathology | Retina - abnormalities | Retina - pathology | Cohort Studies | Embryonic development | Usage | Gene mutations | Analysis | Nucleotide sequencing | Research | Diagnosis | Children | Health aspects | DNA sequencing | Index Medicus
Journal Article
ChemPlusChem, ISSN 2192-6506, 06/2015, Volume 80, Issue 6, pp. 938 - 943
The design and the preparation of a small library of 1,4‐diphenyl‐1,2,3‐triazole derivatives is reported, with the aim to obtain a new class of Hedgehog... 
docking | click chemistry | vismodegib | hedgehog pathway | cancer stem cells | CANCER-CELLS | CONFORMER GENERATION | VALIDATION | CHEMISTRY, MULTIDISCIPLINARY | BASAL-CELL CARCINOMA | RESISTANCE | INHIBITOR | HEDGEHOG SIGNALING PATHWAY | Triazoles | Stem cells
Journal Article