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Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 01/2012, Volume 22, Issue 1, pp. 296 - 299
The synthesis and biophysical evaluation of R and S-5\'-Me- alpha -l-LNA nucleoside phosphoramidites and modified oligo-2\'-deoxyribonucleotides is reported.... 
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2012, Volume 22, Issue 1, p. 296
Journal Article
Nucleic Acids Research, ISSN 1362-4962, 01/2010, Volume 38, Issue 20, pp. 7298 - 7307
A high-resolution solution structure of a stable 42-nt RNA dimeric construct has been derived based on a high number of NMR observables including nuclear... 
Protons | Solvents | Base pairs | Phages | Antisense | Data processing | siRNA | Nucleotides | N.M.R | Nuclear Overhauser effect | Ribose | Temperature effects | Phosphate | Double-stranded
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2011, Volume 21, Issue 1, p. 588
Journal Article
Journal Article
Chemical Communications, ISSN 1359-7345, 08/2012, Volume 48, Issue 66, pp. 8195 - 8197
Combining the structural elements of the second generation 2'-O-methoxyethyl (MOE) and locked nucleic acid (LNA) antisense oligonucleotide (AON) modifications... 
ACID LNA | NUCLEOSIDE ANALOGS | CRYSTAL-STRUCTURE | STABILITY | DUPLEXES | ANTISENSE OLIGONUCLEOTIDES | CHEMISTRY, MULTIDISCIPLINARY | Models, Molecular | DNA - chemistry | Nucleosides - chemistry | Oligoribonucleotides - chemistry | Deoxyribonucleases - chemistry | Antisense oligonucleotides
Journal Article
Journal Article
Biochemistry, ISSN 0006-2960, 1/2012, Volume 51, Issue 1, pp. 7 - 9
Locked nucleic acid (LNA) analogs with 2′,4′-bridged sugars show promise in antisense applications. S -5′-Me-LNA has high RNA affinity and modified... 
Journal Article
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 11/2010, Volume 38, Issue 20, pp. 7298 - 7307
Journal Article
Molecular Therapy - Nucleic Acids, ISSN 2162-2531, 2012, Volume 1, Issue 10, pp. e47 - e47
We report the structure activity relationships of short 14-mer phosphorothioate gapmer antisense oligonucleotides (ASOs) modified with α- -locked nucleic acid... 
gapmer | immune stimulation | oligonucleotides | α-L-LNA | hepatotoxicity | Oligonucleotides; α-l-LNA | Immune stimulation | Hepatotoxicity | Gapmer | MEDICINE, RESEARCH & EXPERIMENTAL | alpha-L-LNA | Original
Journal Article
FEBS Letters, ISSN 0014-5793, 2001, Volume 509, Issue 2, pp. 309 - 316
Journal Article
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