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index medicus (51) 51
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1. Full Text Abstract 4265: Computational models of the role of base excision repair in sensitization of cancer cells to 5-fluorodeoxyuridine
by Qian, Mengdi and Almasan, Alexandru and Gürkan-Çavusoglu, Evren
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 4265 - 4265
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2. Full Text Abstract 4533:In silicoanalysis of enhanced radiosensitivity in radiation treatment combined with androgen deprivation therapy for prostate cancer
by Qian, Mengdi and Almasan, Alexandru and Gürkan-Çavusoglu, Evren
Cancer Research, ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 4533 - 4533
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3. Full Text Abstract 2707: Quantitative analysis of the role of androgen receptor in radiation treatment for prostate cancer
by Qian, Mengdi and Almasan, Alexandru and Gurkan-Cavusoglu, Evren
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 2707 - 2707
The purpose of this study is to quantitatively investigate the mechanism of androgen receptor (AR) and non-homologous end joining (NHEJ) interaction after and... 
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4. Full Text Caspase-3 Activation Is a Critical Determinant of Genotoxic Stress-Induced Apoptosis
by Choudhary, Gaurav S and Al-harbi, Sayer and Almasan, Alexandru
Methods in Molecular Biology, ISSN 1064-3745, 2015, Volume 1219, pp. 1 - 9
Apoptosis can be measured by number of methods by taking advantage of the morphological, biochemical, and molecular changes undergoing in a cell during this... 
Immunohistochemistry | Irradiation | Flow cytometry | Caspase-3 | PARP-1 | Apoptosis | Flow Cytometry - methods | Humans | Caspase 3 - metabolism | Immunoblotting - methods | Immunohistochemistry - methods | Animals | Fluorescein | Caspase 3 - analysis | Mice | DNA Damage | Enzyme Activation | Fluorescent Dyes | Index Medicus
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5. Full Text Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress
by Singh, Kamini and Matsuyama, Shigemi and Drazba, Judith A and Almasan, Alexandru
Autophagy, ISSN 1554-8627, 02/2012, Volume 8, Issue 2, pp. 236 - 251
Autophagy regulates cell survival and cell death upon various cellular stresses, yet the molecular signaling events involved are not well defined. Here, we... 
senescence | AMPK | autophagy | Ulk1 | p18-Cyclin E | DNA damage | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Senescence | P18-Cyclin E | ULK1 | Autophagy | KU70 | CELLS | CYCLIN-E | PROTEIN | PHOSPHORYLATION | CELLULAR SENESCENCE | CANCER | CELL BIOLOGY | MITOCHONDRIAL DYSFUNCTION | CYTOCHROME-C RELEASE | CASPASE ACTIVATION | Cell Line | Microscopy, Electron, Scanning | Peptide Fragments - metabolism | Antigens, Nuclear - metabolism | Humans | Stress, Physiological | Cytoplasm - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | DNA-Binding Proteins - metabolism | Animals | Ku Autoantigen | Cellular Senescence | Proteolysis | Adenylate Kinase - metabolism | Cyclin E - metabolism | DNA Damage | Enzyme Activation | Apoptosis | Index Medicus | Basic Research Paper
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6. Full Text Autophagy as a mechanism of Apo2L/TRAIL resistance
by Sharma, Arishya and Almasan, Alexandru
Cancer Biology & Therapy, ISSN 1538-4047, 09/2018, Volume 19, Issue 9, pp. 755 - 762
Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is unique to selectively induce apoptosis in tumor cells while sparing... 
prostate cancer | autophagy | flux | p62/SQSTM1 | Apo2L/TRAIL | autophagosome | Apoptosis | ACTIVATION | TRAIL | CANCER-CELL-DEATH | CRYSTAL-STRUCTURE | RECEPTOR 5 | p62 | TNF FAMILY | BREAST-CANCER | Apo2L | APOPTOSIS-INDUCING LIGAND | NECROSIS | ONCOLOGY | TRAIL-INDUCED APOPTOSIS | CASPASE-8 | SQSTM1
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7. Full Text Guidelines for the use and interpretation of assays for monitoring autophagy
by Klionsky, Daniel J and Abdalla, Fabio C and Abeliovich, Hagai and Abraham, Robert T and Acevedo-Arozena, Abraham and Adeli, Khosrow and Agholme, Lotta and Agnello, Maria and Agostinis, Patrizia and Aguirre-Ghiso, Julio A and Ahn, Hyung Jun and Ait-Mohamed, Ouardia and Ait-Si-Ali, Slimane and Akematsu, Takahiko and Akira, Shizuo and Al-Younes, Hesham M and Al-Zeer, Munir A and Albert, Matthew L and Albin, Roger L and Alegre-Abarrategui, Javier and Aleo, Maria Francesca and Alirezaei, Mehrdad and Almasan, Alexandru and Almonte-Becerril, Maylin and Amano, Atsuo and Amaravadi, Ravi K and Amarnath, Shoba and Amer, Amal O and Andrieu-Abadie, Nathalie and Anantharam, Vellareddy and Ann, David K and Anoopkumar-Dukie, Shailendra and Aoki, Hiroshi and Apostolova, Nadezda and Arancia, Giuseppe and Aris, John P and Asanuma, Katsuhiko and Asare, Nana Y.O and Ashida, Hisashi and Askanas, Valerie and Askew, David S and Auberger, Patrick and Baba, Misuzu and Backues, Steven K and Baehrecke, Eric H and Bahr, Ben A and Bai, Xue-Yuan and Bailly, Yannick and Baiocchi, Robert and Baldini, Giulia and Balduini, Walter and Ballabio, Andrea and Bamber, Bruce A and Bampton, Edward T.W and Juhász, Gábor and Bartholomew, Clinton R and Bassham, Diane C and Bast, Robert C and Batoko, Henri and Bay, Boon-Huat and Beau, Isabelle and Béchet, Daniel M and Begley, Thomas J and Behl, Christian and Behrends, Christian and Bekri, Soumeya and Bellaire, Bryan and Bendall, Linda J and Benetti, Luca and Berliocchi, Laura and Bernardi, Henri and Bernassola, Francesca and Besteiro, Sébastien and Bhatia-Kissova, Ingrid and Bi, Xiaoning and Biard-Piechaczyk, Martine and Blum, Janice S and Boise, Lawrence H and Bonaldo, Paolo and Boone, David L and Bornhauser, Beat C and Bortoluci, Karina R and Bossis, Ioannis and Bost, Frédéric and Bourquin, Jean-Pierre and Boya, Patricia and Boyer-Guittaut, Michaël and Bozhkov, Peter V and Brady, Nathan R and Brancolini, Claudio and Brech, Andreas and Brenman, Jay E and Brennand, Ana and Bresnick, Emery H and Brest, Patrick and Bridges, Dave and Bristol, Molly L and Brookes, Paul S and Brown, Eric J and Brumell, John H and ... and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Geriatrik and Institutionen för medicin och hälsa and Farmakologi and Experimentell patologi and Hälsouniversitetet and Cellbiologi
Autophagy, ISSN 1554-8627, 04/2012, Volume 8, Issue 4, pp. 445 - 544
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and... 
stress | vacuole | autolysosome | flux | LC3 | autophagosome | lysosome | phagophore | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Phagophore | Lysosome | Autolysosome | Flux | Autophagosome | Vacuole | Stress | ACTIVATED PROTEIN-KINASE | CHAPERONE-MEDIATED AUTOPHAGY | VACUOLE TARGETING PATHWAY | ENDOPLASMIC-RETICULUM STRESS | ISOLATED RAT HEPATOCYTES | STARVATION-INDUCED AUTOPHAGY | GLUCAGON-INDUCED AUTOPHAGY | CELL BIOLOGY | PROGRAMMED CELL-DEATH | BREAST-CANCER CELLS | BETAINE HOMOCYSTEINE METHYLTRANSFERASE | Biological Assay - methods | Animals | Autophagy - genetics | Models, Biological | Humans | Index Medicus | Life Sciences | Cellular Biology | Review | Medical and Health Sciences | Medicin och hälsovetenskap
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8. Full Text PARP Inhibition Sensitizes to Low Dose-Rate Radiation TMPRSS2-ERG Fusion Gene-Expressing and PTEN-Deficient Prostate Cancer Cells
by Chatterjee, Payel and Choudhary, Gaurav S and Sharma, Arishya and Singh, Kamini and Heston, Warren D and Ciezki, Jay and Klein, Eric A and Almasan, Alexandru
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e60408 - e60408
Exposure to genotoxic agents, such as irradiation produces DNA damage, the toxicity of which is augmented when the DNA repair is impaired. Poly (ADP-ribose)... 
CARCINOMA-CELLS | LYMPHOMA-CELLS | AG014699 | GENOTOXIC STRESS | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | HOMOLOGOUS RECOMBINATION | IONIZING-RADIATION | TUMORS | PROGRESSION | POLY(ADP-RIBOSE) POLYMERASE INHIBITOR | Transcriptional Regulator ERG | Cell Line | Cell Survival - drug effects | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - metabolism | Humans | Trans-Activators | Cellular Senescence - drug effects | Morpholines - pharmacology | PTEN Phosphohydrolase - metabolism | Male | Cell Survival - radiation effects | Recombinant Fusion Proteins | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | Cellular Senescence - radiation effects | Fluorescent Antibody Technique | Cell Line, Tumor | Indoles - pharmacology | Serine Endopeptidases | Chromones - pharmacology | DNA damage | Analysis | Genetic aspects | Research | DNA repair | Prostate cancer | Cancer | Cell culture | Protein kinase C | Radiosensitivity | Homologous recombination | Lung cancer | Genotoxicity | Radiation | Galactosidase | Phosphatase | ADP | Mimicry | Proteins | Fusion protein | Deoxyribonucleic acid--DNA | Sensitivity analysis | BRCA1 protein | Gene expression | Survival | Radiation dosage | ERG gene | Inhibitors | Irradiation | Sensitivity enhancement | Lymphomas | Mutation | Radiation damage | ETS protein | Senescence | Toxicity | Homology | Biology | Activation | Ribose | Rodents | Cell cycle | Brachytherapy | BRCA2 protein | Cell survival | Poly(ADP-ribose) polymerase | Breast cancer | Radiation therapy | Polymerase | Sensitivity | DNA-dependent protein kinase | Cell lines | Prostate | PTEN protein | Tumors | Apoptosis | Index Medicus | Deoxyribonucleic acid | DNA
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9. Full Text Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression
by Flynn, AL and Calhoun, BC and Sharma, A and Chang, JC and Almasan, A and Schiemann, WP
NATURE COMMUNICATIONS, ISSN 2041-1723, 08/2019, Volume 10, Issue 1, pp. 1 - 15
Breast cancer stem cells (BCSCs) are unique in their ability to undergo unlimited self-renewal, an essential process in breast cancer recurrence following... 
EPITHELIAL-MESENCHYMAL TRANSITION | GLYCOLYSIS | BREAST-CANCER CELLS | STEM-CELLS | MULTIDISCIPLINARY SCIENCES | GROWTH | MECHANISMS | FRUCTOSE 2,6-BISPHOSPHATE | CHLOROQUINE | CHEMOTHERAPY | PROGRESSION | Activation | Breast cancer | Metastasis | Kinases | Gene expression | Autophagy | Fructose | Metastases | Dormancy | Depletion | DNA microarrays | Stem cells | Breast | Disruption | Lesions | 6-Phosphofructo-2-kinase | Phagocytosis | Index Medicus
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10. Full Text Mcl-1 phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells
by Mazumder, Suparna and Choudhary, Gaurav S and Al-harbi, Sayer and Almasan, Alexandru
Cancer Research, ISSN 0008-5472, 06/2012, Volume 72, Issue 12, pp. 3069 - 3079
ABT-737 is a small molecule Bcl-2homology (BH)-3 domain mimetic that binds to the Bcl-2 family proteins Bcl-2 and Bcl-xL and is currently under investigation... 
MULTIPLE-MYELOMA | MITOCHONDRIAL APOPTOSIS | ONCOLOGY | CASPASE-MEDIATED CLEAVAGE | PROSTATE-CANCER | DOWN-REGULATION | CHRONIC LYMPHOCYTIC-LEUKEMIA | BH3 DOMAINS | BCL-2 FAMILY | UP-REGULATION | CANCER-THERAPY | Phosphorylation | Apoptosis - drug effects | Humans | Drug Resistance, Neoplasm | Proto-Oncogene Proteins c-bcl-2 - metabolism | Bcl-2-Like Protein 11 | Biphenyl Compounds - pharmacology | Nitrophenols - pharmacology | RNA Interference | Leukemia, B-Cell - drug therapy | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Leukemia, B-Cell - pathology | Sulfonamides - pharmacology | Piperazines - pharmacology | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Apoptosis Regulatory Proteins - metabolism | Gossypol - pharmacology | Pyrroles - pharmacology | Myeloid Cell Leukemia Sequence 1 Protein | Cell Line, Tumor | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | RNA, Small Interfering | Proto-Oncogene Proteins c-bcl-2 - genetics | Index Medicus | ABT-737 | Mcl-1 | gossypol | B-cell tumor | Noxa
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11. Full Text Autophagic flux determines cell death and survival in response to Apo2L/TRAIL (dulanermin)
by Singh, Kamini and Sharma, Arishya and Mir, Maria C and Drazba, Judith A and Heston, Warren D and Magi-Galluzzi, Cristina and Hansel, Donna and Rubin, Brian P and Klein, Eric A and Almasan, Alexandru
Molecular Cancer, ISSN 1476-4598, 03/2014, Volume 13, Issue 1, pp. 70 - 70
Background: Macroautophagy is a catabolic process that can mediate cell death or survival. Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing... 
Caspase-8 | Dulanermin | p62/SQSTM1 | Apo2L/TRAIL | Autophagy | Prostate cancer | APOPTOSIS | UBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYPOXIA | THERAPY | ONCOLOGY | PROSTATE-CANCER CELLS | ATG8 | LIGAND | STRESS | LC3 | Immunohistochemistry | Microscopy, Electron, Transmission | Prostatic Neoplasms - metabolism | Prostatic Neoplasms - pathology | Sequestosome-1 Protein | Tissue Array Analysis | Humans | Caspase 8 - metabolism | Immunoblotting | Male | Microscopy, Confocal | Flow Cytometry | TNF-Related Apoptosis-Inducing Ligand - pharmacology | Cell Line, Tumor | Adaptor Proteins, Signal Transducing - biosynthesis | Antineoplastic Agents - pharmacology | Drug Resistance, Neoplasm - physiology | Cell Survival - physiology | Biotechnology industry | Investigations | Proteins | Pathology | Colleges & universities | Ligands | Software | Experiments | Cancer therapies | Apoptosis | Index Medicus
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12. Full Text Interaction of a Cyclin E Fragment with Ku70 Regulates Bax-Mediated Apoptosis
by Suparna Mazumder and Dragos Plesca and Michael Kinter and Alexandru Almasan
Molecular and Cellular Biology, ISSN 0270-7306, 05/2007, Volume 27, Issue 9, pp. 3511 - 3520
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
HEMATOPOIETIC-CELLS | GENOTOXIC STRESS | PROAPOPTOTIC BAX | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | IN-VIVO | MITOCHONDRIAL DYSFUNCTION | CELL-CYCLE | CYTOCHROME-C RELEASE | BCL-2 FAMILY-MEMBERS | CASPASE ACTIVATION | CELL BIOLOGY | Cell Line | Peptide Fragments - metabolism | Caspase 9 - metabolism | Antigens, Nuclear - metabolism | Humans | bcl-2-Associated X Protein - metabolism | Caspase 2 - metabolism | DNA-Binding Proteins - genetics | Cyclin E - genetics | DNA-Binding Proteins - deficiency | Mice, Knockout | DNA-Binding Proteins - metabolism | Two-Hybrid System Techniques | Animals | Antigens, Nuclear - genetics | Ku Autoantigen | Protein Binding | Mice | Cyclin E - metabolism | Enzyme Activation | bcl-2-Associated X Protein - deficiency | Peptide Fragments - genetics | bcl-2-Associated X Protein - genetics | Apoptosis | Index Medicus
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13. Full Text Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis
by Mazumder, Suparna and Plesea, Dragos and Almasan, Alexandru
Methods in Molecular Biology, ISSN 1064-3745, 12/2007, Volume 414, pp. 13 - 21
Immunohistochemistry | Flow cytometry | Caspase-3 | PARP-1 | γ-irradiation | Apoptosis
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14. Full Text Surface levels of CD20 determine anti-CD20 antibodies mediated cell death in vitro
by Singh, Vijay and Gupta, Damodar and Arora, Rajesh and Tripathi, Rajendra Prashad and Almasan, Alexandru and Macklis, Roger M
PLoS ONE, ISSN 1932-6203, 11/2014, Volume 9, Issue 11, pp. e111113 - e111113
In Background: The sensitivity of human Burkitt's lymphoma cells to rituximab (Rtx) and tositumomab (Tst) was assessed on cells expressing different levels of... 
COMPLEMENT | TYROSINE PHOSPHORYLATION | INDUCED APOPTOSIS | RITUXIMAB | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | CHRONIC LYMPHOCYTIC-LEUKEMIA | NON-HODGKINS-LYMPHOMA | HUMAN B-CELLS | MONOCLONAL-ANTIBODIES | EXPRESSION | Gene Expression | Reactive Oxygen Species - metabolism | Humans | Rituximab | Immunophenotyping | Antigens, CD20 - metabolism | Membrane Potential, Mitochondrial - drug effects | Antigens, CD20 - genetics | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Membrane - metabolism | Cell Death - drug effects | Antibodies, Monoclonal, Murine-Derived - pharmacology | Cell Cycle - drug effects | Ionizing radiation | Cell death | Immunotherapy | Monoclonal antibodies | Lymphomas | Biochemistry | B cells | Nuclear medicine | Reactive oxygen species | Leukemia | Radiation | Cytotoxicity | Lipids | Kinases | Cancer therapies | Cell surface | Proteins | Mitochondria | Reaction kinetics | Membrane potential | Radiation effects | Immunoglobulins | γ Radiation | Effectiveness | Mortality | Lymphoma | Burkitt's lymphoma | Cell suspensions | Lymphocytes B | Resists | CD20 antigen | Irradiation | Kinetics | Tumors | Apoptosis | Index Medicus
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