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1. Full Text Autophagy as a mechanism of Apo2L/TRAIL resistance
by Sharma, Arishya and Almasan, Alexandru
Cancer biology & therapy, ISSN 1538-4047, 09/2018, Volume 19, Issue 9, pp. 755 - 762
prostate cancer | autophagy | flux | p62/SQSTM1 | Apo2L/TRAIL | autophagosome | Apoptosis | Life Sciences & Biomedicine | Oncology | Science & Technology | Index Medicus
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2. Full Text USP14 Regulates DNA Damage Response and Is a Target for Radiosensitization in Non-Small Cell Lung Cancer
by Sharma, Arishya and Almasan, Alexandru
International journal of molecular sciences, ISSN 1422-0067, 09/2020, Volume 21, Issue 17, p. 6383
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Ubiquitin | Biotechnology | Chromatin | Protein kinase C | Ubiquitin-specific proteinase | DNA damage | Lung cancer | Homologous recombination | Homology | Cancer therapies | Recruitment | Proteins | Ionizing radiation | Radiosensitization | Cell cycle | Repair | Deoxyribonucleic acid--DNA | Enzymes | Small cell lung carcinoma | BRCA1 protein | Non-small cell lung carcinoma | Radiation therapy | Gene expression | Double-strand break repair | Survival | Survival analysis | DNA-dependent protein kinase | Medical prognosis | Non-homologous end joining | Proteasomes | Protein expression | Apoptosis | Index Medicus | USP14 | NSCLC | non-homologous end-joining | homologous recombination | radiosensitization
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3. Full Text Targeting BCL-2 in B-cell malignancies and overcoming therapeutic resistance
by Kapoor, Isha and Bodo, Juraj and Hill, Brian T and Hsi, Eric D and Almasan, Alexandru
Cell death & disease, ISSN 2041-4889, 11/2020, Volume 11, Issue 11, pp. 941 - 941
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Chronic lymphatic leukemia | Bcl-2 protein | Transcription | Myeloid leukemia | Leukemia | Lymphatic leukemia | Drug resistance | Lymphoma | Mcl-1 protein | Proteins | Mitochondria | Reviews | Bcl-x protein | Lymphocytes B | Epigenetics | Tumorigenesis | Acute myeloid leukemia | Apoptosis | Index Medicus
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4. Full Text USP14 is a deubiquitinase for Ku70 and critical determinant of non-homologous end joining repair in autophagy and PTEN-deficient cells
by Sharma, Arishya and Alswillah, Turkeya and Kapoor, Isha and Debjani, Pal and Willard, Belinda and Summers, Matthew K and Gong, Zihua and Almasan, Alexandru
Nucleic acids research, ISSN 0305-1048, 01/2020, Volume 48, Issue 2, pp. 736 - 747
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | PTEN Phosphohydrolase - genetics | PTEN Phosphohydrolase - deficiency | Tumor Suppressor p53-Binding Protein 1 - genetics | Autophagy - radiation effects | DNA End-Joining Repair - radiation effects | Humans | DNA Repair - radiation effects | Signal Transduction - genetics | Ubiquitin Thiolesterase - genetics | Proto-Oncogene Proteins c-akt - genetics | DNA Breaks, Double-Stranded - radiation effects | Ku Autoantigen - genetics | Chromatin - radiation effects | HEK293 Cells | Signal Transduction - radiation effects | Ataxia Telangiectasia Mutated Proteins - genetics | Chromatin - genetics | DNA Damage - radiation effects | Radiation, Ionizing | Index Medicus | Genome Integrity, Repair and
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5. Full Text Abstract 4265: Computational models of the role of base excision repair in sensitization of cancer cells to 5-fluorodeoxyuridine
by Qian, Mengdi and Almasan, Alexandru and Gürkan-Çavusoglu, Evren
Cancer research (Chicago, Ill.), ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 4265 - 4265
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6. Full Text Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress
by Singh, Kamini and Matsuyama, Shigemi and Drazba, Judith A and Almasan, Alexandru
Autophagy, ISSN 1554-8627, 02/2012, Volume 8, Issue 2, pp. 236 - 251
senescence | AMPK | autophagy | Ulk1 | p18-Cyclin E | DNA damage | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Senescence | P18-Cyclin E | ULK1 | Autophagy | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Cell Line | Microscopy, Electron, Scanning | Peptide Fragments - metabolism | Antigens, Nuclear - metabolism | Humans | Stress, Physiological | Cytoplasm - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | DNA-Binding Proteins - metabolism | Animals | Ku Autoantigen | Cellular Senescence | Proteolysis | Adenylate Kinase - metabolism | Cyclin E - metabolism | DNA Damage | Enzyme Activation | Apoptosis | Index Medicus | Basic Research Paper
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7. Full Text Abstract 4533:In silicoanalysis of enhanced radiosensitivity in radiation treatment combined with androgen deprivation therapy for prostate cancer
by Qian, Mengdi and Almasan, Alexandru and Gürkan-Çavusoglu, Evren
Cancer research (Chicago, Ill.), ISSN 0008-5472, 07/2017, Volume 77, Issue 13 Supplement, pp. 4533 - 4533
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8. Full Text Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy
by Almasan, Alexandru and Ashkenazi, Avi
Cytokine & growth factor reviews, ISSN 1359-6101, 2003, Volume 14, Issue 3, pp. 337 - 348
Caspases | Apo2L/TRAIL | Death receptors | Interferons | Apoptosis | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Proto-Oncogene Proteins c-bcl-2 - physiology | Humans | Tumor Necrosis Factor-alpha - genetics | Receptors, TNF-Related Apoptosis-Inducing Ligand | Receptors, Tumor Necrosis Factor - physiology | Membrane Glycoproteins - physiology | Neoplasms - therapy | TNF-Related Apoptosis-Inducing Ligand | X-Linked Inhibitor of Apoptosis Protein | Carrier Proteins - physiology | Proteins - physiology | Virus Diseases - immunology | Signal Transduction | Intracellular Signaling Peptides and Proteins | Membrane Glycoproteins - genetics | Animals | Apoptosis Regulatory Proteins | Models, Biological | Neoplasms - immunology | NF-kappa B - physiology | Tumor Necrosis Factor-alpha - physiology | CASP8 and FADD-Like Apoptosis Regulating Protein | Interferons - physiology | Mice | Apoptosis - physiology | Index Medicus
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9. Full Text Development of venetoclax for therapy of lymphoid malignancies
by Zhu, Huayuan and Almasan, Alexandru
Drug design, development and therapy, ISSN 1177-8881, 03/2017, Volume 11, pp. 685 - 694
BCL-2 | Chronic lymphocytic leukemia | BCL-xL | MCL-1 | Venetoclax | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Sulfonamides - chemical synthesis | Sulfonamides - chemistry | Sulfonamides - therapeutic use | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Antineoplastic Agents - chemical synthesis | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Humans | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - chemistry | Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis | Lymphoma, B-Cell - drug therapy | Drug therapy | Lymphatic diseases | Therapy | Bcl-2 protein | Pathogenesis | Leukemia | Multiple myeloma | Clinical trials | Cytotoxicity | Homology | Kinases | Cancer therapies | Proteins | Bcl-x protein | Clonal deletion | Medical research | Chronic lymphatic leukemia | Therapeutic applications | Tumor cells | Cloning | Cyclin-dependent kinases | Lymphatic leukemia | Lymphoma | Patients | Mcl-1 protein | Gene amplification | Lymphocytes B | Apoptosis | B-cell lymphoma | Index Medicus | Bcl-2 | Mcl-1 | Bcl-xL | chronic lymphocytic leukemia | venetoclax
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10. Full Text Abstract 2707: Quantitative analysis of the role of androgen receptor in radiation treatment for prostate cancer
by Qian, Mengdi and Almasan, Alexandru and Gurkan-Cavusoglu, Evren
Cancer research (Chicago, Ill.), ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 2707 - 2707
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11. Full Text Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression
by Flynn, Alyssa La Belle and Calhoun, Benjamin C and Sharma, Arishya and Chang, Jenny C and Almasan, Alexandru and Schiemann, William P
Nature communications, ISSN 2041-1723, 08/2019, Volume 10, Issue 1, pp. 3668 - 15
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Autophagy-Related Protein 7 - metabolism | Humans | Cell Self Renewal | Neoplasm Metastasis | Animals | Breast Neoplasms - genetics | Phosphofructokinase-2 - metabolism | Neoplastic Stem Cells - metabolism | Breast Neoplasms - pathology | Ubiquitin-Conjugating Enzymes - metabolism | Cell Line, Tumor | Female | Mice | Autophagy - genetics | Autophagy-Related Proteins - metabolism | Sequestosome-1 Protein - metabolism | Activation | Breast cancer | Metastasis | Kinases | Gene expression | Autophagy | Fructose | Metastases | Dormancy | Depletion | DNA microarrays | Stem cells | Disruption | Lesions | 6-Phosphofructo-2-kinase | Phagocytosis | Index Medicus
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12. Full Text Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation
by Zhang, Fan and Lou, Lihong and Peng, Bo and Song, Xiaotian and Reizes, Ofer and Almasan, Alexandru and Gong, Zihua
Cancer research (Chicago, Ill.), ISSN 0008-5472, 03/2020, Volume 80, Issue 5, pp. 999 - 1010
Life Sciences & Biomedicine | Oncology | Science & Technology | Index Medicus
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