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Molecular & Cellular Oncology, ISSN 2372-3556, 09/2019, Volume 6, Issue 5, pp. 1 - 3
Gasdermin proteins have been extensively characterized for their ability to form necrotic pores in the plasma membrane, however, their interactions with other... 
GSDMD | pyroptosis | mitochondria | inflammasome | Gasdermin | apoptosis | cytochrome c | GSDME | DFNA5 | caspase-3
Journal Article
Nature Communications, ISSN 2041-1723, 01/2017, Volume 8, Issue 1, pp. 14128 - 14128
Apoptosis is a genetically regulated cell suicide programme mediated by activation of the effector caspases 3, 6 and 7. If apoptotic cells are not scavenged,... 
GSDMD | MEMBRANE ATTACK | GASDERMIN D | NECROSIS | GENE | MECHANISM | MULTIDISCIPLINARY SCIENCES | NLRP3 INFLAMMASOME ACTIVATION | GENOME-WIDE | PORE FORMATION | PYROPTOSIS | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 07/2009, Volume 183, Issue 2, pp. 787 - 791
The IL-1 family cytokines are regulated on transcriptional and posttranscriptional levels. Pattern recognition and cytokine receptors control pro-IL-1 beta... 
ASC | IMMUNOLOGY | CASPASE-1 ACTIVATION | NALP3 INFLAMMASOME | CELL-DEATH
Journal Article
Journal of Clinical Immunology, ISSN 0271-9142, 9/2010, Volume 30, Issue 5, pp. 693 - 702
Infection with Listeria monocytogenes can cause meningitis and septicemia in newborn, elderly, or immunocompromised individuals. Pregnant women are... 
Medical Microbiology | pyroptosis | Biomedicine | Immunology | AIM2 | innate immunity | inflammasome | Listeria monocytogenes | Internal Medicine | Infectious Diseases | NLRs | caspase-1 | PHAGOSOME MATURATION | FLAGELLIN | MURINE MACROPHAGES | BONE-MARROW | IMMUNOLOGY | IPAF | CYTOPLASMIC DNA | CELL-DEATH | PATTERN-RECOGNITION | IMMUNE-RESPONSES | INFECTION | DNA, Bacterial - pharmacology | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Listeria monocytogenes - immunology | Interleukin-1beta - metabolism | Flagellin - genetics | Listeriosis - immunology | Protein Multimerization - genetics | Apoptosis Regulatory Proteins - genetics | Nuclear Proteins - genetics | Macrophages - immunology | DNA-Binding Proteins | Calcium-Binding Proteins - metabolism | Flagellin - immunology | Listeriosis - metabolism | Macrophages - pathology | Listeriosis - genetics | Interleukin-1beta - immunology | Nuclear Proteins - metabolism | Enzyme Activation - drug effects | Mutation - genetics | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Carrier Proteins - genetics | Listeria monocytogenes - pathogenicity | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Inflammasomes - immunology | Listeria monocytogenes - genetics | Mice | Enzyme Activation - genetics | Cell Line, Transformed | Protein Multimerization - drug effects | Calcium-Binding Proteins - genetics | Oligomers | Meningitis | Macrophages | Pregnant women | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 385 - 393
Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1... 
PHAGOSOMAL ESCAPE | ACTIVATION | CASPASE-1 | ASC PYROPTOSOME | IMMUNOLOGY | NF-KAPPA-B | PATHOGEN RECOGNITION | NALP3 INFLAMMASOME | CYTOPLASMIC DNA | CELL-DEATH | PYRIN | L-Lactate Dehydrogenase - metabolism | Tularemia - metabolism | Humans | Protein Multimerization | Tularemia - genetics | Caspase 1 - metabolism | Multiprotein Complexes - genetics | Caspase 1 - immunology | Interleukin-1beta - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Multiprotein Complexes - metabolism | L-Lactate Dehydrogenase - immunology | Tularemia - immunology | Calcium Signaling - immunology | Interleukin-1beta - biosynthesis | Nuclear Proteins - genetics | Macrophages - immunology | DNA-Binding Proteins | Interferon Regulatory Factor-3 - immunology | Francisella tularensis - immunology | Macrophages - pathology | Cells, Cultured | Interleukin-1beta - immunology | Nuclear Proteins - metabolism | Immunity, Innate | Nuclear Proteins - immunology | Mice, Knockout | Macrophages - metabolism | Animals | L-Lactate Dehydrogenase - genetics | Caspase 1 - genetics | Interferon Regulatory Factor-3 - metabolism | Francisella tularensis - pathogenicity | Mice | Multiprotein Complexes - immunology | Interleukins | Bacterial proteins | Tularemia | Physiological aspects | Causes of | Genetic aspects | Research | Health aspects | Francisella tularensis | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 06/2015, Volume 6, Issue 1, pp. 7515 - 7515
Journal Article
Cell, ISSN 0092-8674, 2001, Volume 104, Issue 5, pp. 769 - 780
The inhibitor of apoptosis (IAP) proteins suppress cell death by inhibiting the catalytic activity of caspases. Here we present the crystal structure of... 
Journal Article
Journal Article