X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
structure-activity relationship (37) 37
humans (36) 36
animals (35) 35
index medicus (34) 34
chemistry, medicinal (33) 33
pharmacology & pharmacy (27) 27
rats (19) 19
derivatives (18) 18
male (17) 17
models, molecular (15) 15
biochemistry & molecular biology (14) 14
dose-response relationship, drug (12) 12
lipophilicity (12) 12
monoamine oxidase inhibitors - chemistry (12) 12
monoamine oxidase inhibitors - pharmacology (12) 12
biological evaluation (11) 11
cholinesterase inhibitors - chemistry (11) 11
cholinesterase inhibitors - pharmacology (11) 11
in vitro techniques (11) 11
alzheimer's disease (10) 10
cell line, tumor (10) 10
chemistry (10) 10
design (10) 10
inhibitors (10) 10
molecular structure (10) 10
analysis (9) 9
magnetic resonance spectroscopy (9) 9
alzheimers-disease (8) 8
chemistry, organic (8) 8
drug design (8) 8
monoamine oxidase - metabolism (8) 8
organic chemistry (8) 8
rats, wistar (8) 8
structure-activity relationships (8) 8
1,2,3,4-tetrahydroisoquinoline (7) 7
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (7) 7
1-methyl-4-phenylpyridinium (7) 7
binding sites (7) 7
coumarins - chemistry (7) 7
isoquinolines - pharmacology (7) 7
molecular conformation (7) 7
monoamine oxidase inhibitors - chemical synthesis (7) 7
parkinson's disease (7) 7
parkinsons-disease (7) 7
solubility (7) 7
acetylcholinesterase (6) 6
analogs (6) 6
binding (6) 6
cancer (6) 6
chemistry, physical (6) 6
cholinesterase inhibitors - chemical synthesis (6) 6
coumarins - pharmacology (6) 6
crystallography, x-ray (6) 6
heterocyclic compounds (6) 6
potent (6) 6
quantitative structure-activity relationship (6) 6
acetylcholinesterase - metabolism (5) 5
acyclic or carbocyclic compounds (5) 5
anticoagulants - pharmacology (5) 5
butyrylcholinesterase (5) 5
cell survival - drug effects (5) 5
chemical phenomena (5) 5
chemistry, multidisciplinary (5) 5
coumarins (5) 5
cytotoxicity (5) 5
discovery (5) 5
enzymes (5) 5
hydrogen-ion concentration (5) 5
kinetics (5) 5
ligands (5) 5
metallurgy (5) 5
mice (5) 5
molecular docking simulation (5) 5
neuroprotection (5) 5
neuroprotective agents - chemistry (5) 5
neuroprotective agents - pharmacology (5) 5
oxidation (5) 5
platelet aggregation - drug effects (5) 5
platelet aggregation inhibitors - pharmacology (5) 5
protein (5) 5
selective inhibitors (5) 5
structure–activity relationships (5) 5
water (5) 5
2h-chromen-2-one derivatives (4) 4
adult (4) 4
alkaloids (4) 4
alzheimer’s disease (4) 4
anticoagulants - chemistry (4) 4
brain (4) 4
brain - drug effects (4) 4
butyrylcholinesterase - metabolism (4) 4
catalytic domain (4) 4
cells, cultured (4) 4
chromatography, high pressure liquid (4) 4
complex-i (4) 4
coumarin (4) 4
coumarins - chemical synthesis (4) 4
derivatives thereof (4) 4
dogs (4) 4
drug discovery (4) 4
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 7, p. 1544
Journal Article
Journal of Separation Science, ISSN 1615-9306, 03/2018, Volume 41, Issue 6, pp. 1376 - 1384
The enantiomer separation of a number of racemic 7‐[(1‐alkylpiperidin‐3‐yl)methoxy]coumarin derivatives, some of which show outstanding in vitro multitarget... 
polysaccharides | chiral recognition | molecular docking | coumarins | linear free energy relationships | Coumarins | Nitriles | Polysaccharides | Enantiomers | Hydrogen | High performance liquid chromatography | Hydrogen bonds | Acetonitrile | Derivatives | Nitrogen dioxide | Coumarin | Free energy | Molecular docking
Journal Article
Molecules, ISSN 1420-3049, 03/2016, Volume 21, Issue 3, p. 362
The need for developing real disease-modifying drugs against neurodegenerative syndromes, particularly Alzheimer’s disease (AD), shifted research towards... 
cholinesterase inhibitors | Alzheimer’s disease | multi-target-directed ligands | MAO inhibitors | coumarins
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 07/2019, Volume 9, Issue 1, pp. 9884 - 10
The Gibsonian notion of affordance has been massively employed in cognitive sciences to characterize the tight interdependence between hand-related actions,... 
NEUROPSYCHOLOGY | SCALED INFORMATION | CORTEX | MULTIDISCIPLINARY SCIENCES | COMPONENTS | OBJECTS | ECONOMY | FULL | Locomotion | Exploration | Computer applications | Cognitive ability
Journal Article
Chemistry of Heterocyclic Compounds, ISSN 0009-3122, 03/2017, Volume 53, Issue 3, pp. 239 - 239
The impressive advances in the ability of organic and medicinal chemists to efficiently prepare libraries containing thousands of small organic molecules has... 
CHEMISTRY, ORGANIC | Heterocyclic compounds | Drug discovery
Journal Article
FUTURE MEDICINAL CHEMISTRY, ISSN 1756-8919, 10/2019, Volume 11, Issue 20, pp. 2735 - 2755
Pyrrolo[2,1-a]isoquinoline (PIq) is a nitrogen heterocyclic scaffold of diverse alkaloids endowed with several biological activities, including antiretroviral... 
synthesis | CHEMISTRY, MEDICINAL | DOMINO REACTIONS | drug design | alkaloids | BOND FORMATION | CASCADE | anticancer | structure-activity relationships | LAMELLARIN ALKALOIDS | INDOLIZINE | antiviral | 1,3-DIPOLAR CYCLOADDITION | REGIOSELECTIVE SYNTHESIS | BIOLOGICAL EVALUATION | pyrrolo[2,1-a]isoquinoline | pharmacophore | DERIVATIVES | EFFICIENT
Journal Article
ChemMedChem, ISSN 1860-7179, 08/2017, Volume 12, Issue 16, pp. 1349 - 1358
Acetylcholinesterase (AChE) inhibitors still comprise the majority of the marketed drugs for Alzheimer's disease (AD). The structural arrangement of the... 
dimerization | inhibitors | enzyme catalysis | Alzheimer's disease | coumarins | Coumarins - metabolism | Humans | Cholinesterase Inhibitors - chemistry | Protective Agents - metabolism | Coumarins - chemistry | Protective Agents - chemistry | Structure-Activity Relationship | Butyrylcholinesterase - chemistry | Cholinesterase Inhibitors - metabolism | Butyrylcholinesterase - metabolism | Protective Agents - pharmacology | Inhibitory Concentration 50 | Binding Sites | Dimerization | Cell Survival - drug effects | Catalytic Domain | Amyloid beta-Peptides - toxicity | Acetylcholinesterase - chemistry | Coumarins - pharmacology | Cholinesterase Inhibitors - pharmacology | Cell Line, Tumor | Ligands | Molecular Docking Simulation | Kinetics | Acetylcholinesterase - metabolism | COMPLEX | CHEMISTRY, MEDICINAL | PROTEIN | CRYSTAL-STRUCTURE | DOCKING | STRUCTURAL-ANALYSIS | HUMAN TRANSTHYRETIN | AMYLOIDOGENESIS | GENETIC ALGORITHM | FIBRIL FORMATION INHIBITORS | TTR | PHARMACOLOGY & PHARMACY | Coumarins | Enzyme inhibitors | Catalysis | Surface active agents | Enzyme kinetics | Biological properties | Linkages | Drugs | Neurodegenerative diseases | Fragments | Agglomeration | Catalytic activity | Binders | Acetylcholinesterase | Coumarin | Aliphatic compounds | Spacers | Fibrillogenesis | Inhibitors | Reaction kinetics | β-Amyloid | Inhibition | Alzheimers disease | Binding sites
Journal Article
ChemMedChem, ISSN 1860-7179, 08/2018, Volume 13, Issue 15, pp. 1588 - 1596
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2016, Volume 59, Issue 14, pp. 6791 - 6806
Journal Article
Journal of Pharmacy and Pharmacology, ISSN 0022-3573, 10/2015, Volume 67, Issue 10, p. 1380
The aim of this work is to investigate whether and how two newly synthesized 3,4,5-trimethoxygalloyl-containing compounds 1 and 3 interfere with the... 
Adenosine | Analysis | Muscle proteins | Mitogens | Protein kinases | Adenosine triphosphate | Tumors | Necrosis
Journal Article
JOURNAL OF PHYSICAL CHEMISTRY B, ISSN 1520-6106, 01/2020, Volume 124, Issue 1, pp. 28 - 37
Depending on the chemical scaffold, a bioactive species could reflect the interplay between ionization and tautomerism, which is often complicated by the... 
ACTIVATED ALKYNES | PH-METRIC LOG | PARTITION-COEFFICIENTS | TETRAHYDROPYRIDINE RING | CHEMISTRY, PHYSICAL | FREE-ENERGIES | CONFORMATION | DISSOCIATION-CONSTANTS | PK(A) | WATER | LIPOPHILICITY
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2015, Volume 58, Issue 14, pp. 5561 - 5578
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2019, Volume 161, pp. 292 - 309
Herein we envisaged the possibility of exploiting alkyl nitrates as precursors of alcohol-bearing dual inhibitors targeting acetylcholinesterase (AChE) and... 
Monoamine oxidase B | Multitargeting agents | Nitric oxide donor | Acetylcholinesterase | BUTYRYLCHOLINESTERASE | OXIDATIVE STRESS | DESIGN | CHEMISTRY, MEDICINAL | ALZHEIMERS-DISEASE | AMYLOID PLAQUES | CHOLINESTERASE-INHIBITORS | POTENT | 2H-CHROMEN-2-ONE DERIVATIVES | BIOLOGICAL EVALUATION | COUMARIN DERIVATIVES | Cell Survival - drug effects | Monoamine Oxidase Inhibitors - pharmacology | Neuroprotective Agents - chemistry | Humans | Molecular Conformation | Cholinesterase Inhibitors - chemistry | Hydrogen Peroxide - pharmacology | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Dose-Response Relationship, Drug | Nitrates - metabolism | Neuroprotective Agents - chemical synthesis | Neuroprotective Agents - pharmacology | Cholinesterase Inhibitors - pharmacology | Rotenone - antagonists & inhibitors | Rotenone - pharmacology | Cell Line, Tumor | Monoamine Oxidase Inhibitors - chemistry | Nitric Oxide - metabolism | Hydrogen Peroxide - antagonists & inhibitors | Acetylcholinesterase - metabolism | Monoamine Oxidase - metabolism | Oxidases | Phosphates | Nervous system diseases | Hydrogen peroxide | Nitrates | Permeability | Investigations | Alcohols | Dextran | Methyl aspartate | Metabolites | Nitric oxide | Fluorescein | Alzheimer's disease | High performance liquid chromatography | Index Medicus
Journal Article
ChemMedChem, ISSN 1860-7179, 08/2017, Volume 12, Issue 16, pp. 1380 - 1389
Journal Article
20.