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1. Full Text Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
by Seow, Yiqi and Betts, Corinne and Wood, Matthew J A and Lakhal, Samira and Yin, HaiFang and Alvarez-Erviti, Lydia
Nature biotechnology, ISSN 1087-0156, 04/2011, Volume 29, Issue 4, pp. 341 - 345
Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | Fundamental and applied biological sciences. Psychology | Biotechnology | Biological and medical sciences | Miscellaneous | Health. Pharmaceutical industry | Industrial applications and implications. Economical aspects | Exosomes - metabolism | Amyloid Precursor Protein Secretases - genetics | Cell Line | Gene Transfer Techniques | Microglia - metabolism | Lysosomal-Associated Membrane Protein 2 - genetics | Mice, Inbred C57BL | Alzheimer Disease - therapy | Male | Aspartic Acid Endopeptidases - genetics | RNA, Messenger - metabolism | Gene Knockdown Techniques | Brain - metabolism | Rabies virus - metabolism | Animals | Peptides - metabolism | Proteins - metabolism | Membrane Proteins - metabolism | Mice | Neurons - metabolism | Genetic Vectors | RNA, Small Interfering - administration & dosage | Dendritic Cells - metabolism | Research | RNA | Membrane proteins | Brain | Gene therapy | Ribonucleic acid--RNA | Rodents | Index Medicus
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2. Full Text Systemic exosomal siRNA delivery reduced alpha‐synuclein aggregates in brains of transgenic mice
by Cooper, J. Mark and Wiklander, P.B. Oscar and Nordin, Joel Z and Al‐Shawi, Raya and Wood, Matthew J and Vithlani, Mansi and Schapira, Anthony H. V and Simons, J. Paul and El‐Andaloussi, Samir and Alvarez‐Erviti, Lydia
Movement disorders, ISSN 0885-3185, 10/2014, Volume 29, Issue 12, pp. 1476 - 1485
α‐Syn | siRNA | transgenic mice | RVG‐exosomes | RVG-exosomes | α-Syn | Transgenic mice | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Humans | RNA, Messenger - metabolism | Brain - metabolism | Transfection | Time Factors | Exosomes - physiology | Viral Proteins - administration & dosage | alpha-Synuclein - genetics | Peptide Fragments - genetics | Dendritic Cells - metabolism | Neuroblastoma - pathology | Glycoproteins - genetics | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Gene Expression Regulation - physiology | Viral Proteins - genetics | Mice, Transgenic | Mutation - genetics | Genetic Vectors - genetics | Glycoproteins - administration & dosage | Gene Expression Regulation - drug effects | Animals | Cell Line, Tumor | Mice | RNA, Small Interfering - administration & dosage | alpha-Synuclein - metabolism | Index Medicus | Medicin och hälsovetenskap
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3. Full Text Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting
by Wiklander, Oscar P. B and Nordin, Joel Z and O'Loughlin, Aisling and Gustafsson, Ylva and Corso, Giulia and Mäger, Imre and Vader, Pieter and Lee, Yi and Sork, Helena and Seow, Yiqi and Heldring, Nina and Alvarez-Erviti, Lydia and Smith, CI Edvard and Le Blanc, Katarina and Macchiarini, Paolo and Jungebluth, Philipp and Wood, Matthew J. A and Andaloussi, Samir EL
Journal of extracellular vesicles, ISSN 2001-3078, 01/2015, Volume 4, Issue 1, pp. 1 - n/a
biodistribution | extracellular vesicles | exosomes | tissue targeting | nanotechnology | drug delivery | microvesicles | Journal Article | Tissue targeting | Extracellular vesicles | Drug delivery | Microvesicles | Exosomes | Biodistribution | Nanotechnology | Medicine | Nanoparticles | Laboratories | Colleges & universities | Science | Nervous system | Physiology | Anatomy & physiology | Labeling | Medicin och hälsovetenskap
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4. Full Text Exosome-mediated delivery of siRNA in vitro and in vivo
by El-Andaloussi, Samir and Lee, Yi and Lakhal-Littleton, Samira and Li, Jinghuan and Seow, Yiqi and Gardiner, Chris and Alvarez-Erviti, Lydia and Sargent, Ian L and Wood, Matthew J.A
Nature protocols, ISSN 1754-2189, 2012, Volume 7, Issue 12, pp. 2112 - 2126
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biochemical Research Methods | Science & Technology | Brain - metabolism | Gene Transfer Techniques | RNA, Small Interfering - genetics | Animals | Transfection - methods | Gene Silencing | Exosomes - genetics | Mice | Genetic Vectors | RNA, Small Interfering - administration & dosage | Drugs | Drug delivery systems | RNA | Genetic engineering | Cell organelles | Research | Properties | Methods | Vehicles | Index Medicus | Medicin och hälsovetenskap
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5. Full Text Antimicrobial resistance and virulence of Pseudomonas spp. among healthy animals: concern about exolysin ExlA detection
by Ruiz-Roldan, Lidia and Rojo-Bezares, Beatriz and de Toro, Maria and Lopez, Maria and Toledano, Paula and Lozano, Carmen and Chichon, Gabriela and Alvarez-Erviti, Lydia and Torres, Carmen and Saenz, Yolanda
Scientific reports, ISSN 2045-2322, 07/2020, Volume 10, Issue 1, pp. 11667 - 11667
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Virulence Factors - genetics | Humans | Asymptomatic Diseases | Phylogeny | Feces - microbiology | Pseudomonas - drug effects | Bacterial Typing Techniques | Animals, Domestic - microbiology | Ducks - microbiology | Drug Resistance, Bacterial - genetics | Pseudomonas - genetics | Pseudomonas - classification | Ticks - microbiology | Cats | Genome, Bacterial | Bacterial Proteins - genetics | Pseudomonas - pathogenicity | Electrophoresis, Gel, Pulsed-Field | Pseudomonas Infections - microbiology | Sus scrofa - microbiology | Whole Genome Sequencing | Pets - microbiology | Sheep, Domestic - microbiology | Animals | Pseudomonas Infections - epidemiology | Spain - epidemiology | Dogs | Bacterial Proteins - metabolism | Virulence Factors - metabolism | Deer - microbiology | Virulence | Cytotoxicity | Antimicrobial agents | Genomes | Drug resistance | Pathogenicity | Phenazine | Plant diseases | Biofilms | Aztreonam | Pigments | Serotypes | Antimicrobial resistance | Strains (organisms) | Genotypes | Index Medicus
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6. Full Text Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology
by Izco, María and Blesa, Javier and Schleef, Martin and Schmeer, Marco and Porcari, Riccardo and Al-Shawi, Raya and Ellmerich, Stephan and de Toro, María and Gardiner, Chris and Seow, Yiqi and Reinares-Sebastian, Alejandro and Forcen, Raquel and Simons, J. Paul and Bellotti, Vittorio and Cooper, J. Mark and Alvarez-Erviti, Lydia
Molecular therapy, ISSN 1525-0016, 12/2019, Volume 27, Issue 12, pp. 2111 - 2122
gene therapy | shRNA minicircle | alpha-synuclein | exosomes | Parkinson’s disease | Parkinson's disease | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Basal ganglia | Dopamine | Disease | Peptides | Neurodegenerative diseases | Pathogenesis | Therapeutic applications | Transgenic mice | Central nervous system diseases | siRNA | Gene expression | Synuclein | Exosomes | Experiments | Studies | Proteins | Plasmids | Green fluorescent protein | Mutation | Movement disorders | Deoxyribonucleic acid--DNA | Dopamine receptors | Index Medicus | Original
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7. Full Text Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line
by Alvarez-Erviti, Lydia and Couch, Yvonne and Richardson, Jill and Cooper, J. Mark and Wood, Matthew J.A
Neuroscience research, ISSN 0168-0102, 04/2011, Volume 69, Issue 4, pp. 337 - 342
Inflammation | Parkinson's disease | BV-2 | Alpha-synuclein | Microglia | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Cell Line | Microglia - metabolism | Gene Expression | Humans | alpha-Synuclein - immunology | Inflammation - immunology | alpha-Synuclein - secretion | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Animals | Microglia - immunology | Neurons - secretion | Mice | Cytokines - biosynthesis | Culture Media, Conditioned - metabolism | Index Medicus
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8. Full Text The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation
by Couch, Yvonne and Alvarez-Erviti, Lydia and Sibson, Nicola R and Wood, Matthew J.A and Anthony, Daniel C
Journal of neuroinflammation, ISSN 1742-2094, 11/2011, Volume 8, Issue 1, pp. 166 - 166
Chemokine | Brain | Parkinson's | Cytokine | Inflammation | α-synuclein | Snca | Neurosciences | Immunology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Inflammation - pathology | Substantia Nigra - pathology | Amyloid beta-Peptides - pharmacology | alpha-Synuclein - immunology | Cell Death - immunology | Substantia Nigra - immunology | Lipopolysaccharides - immunology | Transcription Factor RelA - genetics | alpha-Synuclein - pharmacology | Serum Albumin - immunology | Microglia - immunology | Tumor Necrosis Factor-alpha - immunology | Transcription Factor RelA - immunology | Female | Cytokines - genetics | Cytokines - immunology | Microglia - cytology | Cell Line | Parkinson Disease - pathology | Microglia - drug effects | Parkinson Disease - immunology | Interleukin-1beta - immunology | Inflammation - immunology | Substantia Nigra - drug effects | Animals | Serum Albumin - pharmacology | Lipopolysaccharides - pharmacology | Mice | Index Medicus | cytokine | chemokine | inflammation | brain | SNCA
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9. Full Text IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model
by Piñeiro-Hermida, Sergio and López, Icíar P and Alfaro-Arnedo, Elvira and Torrens, Raquel and Iñiguez, María and Alvarez-Erviti, Lydia and Ruíz-Martínez, Carlos and Pichel, José G
Scientific reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 4290 - 13
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Tyrosine | Oxidative stress | Lung cancer | Lung diseases | Homeostasis | Leukocytes (neutrophilic) | Inflammation | Insulin-like growth factors | Permeability | Gene deletion | Macrophages | Insulin | Asthma | Bleomycin | Clonal deletion | Lungs | Down-regulation | Insulin-like growth factor I receptors | Fibrosis | Epigenetics | Bone marrow | Chronic obstructive pulmonary disease | Protein-tyrosine kinase | Cancer | Index Medicus
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10. Full Text Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
by Alvarez-Erviti, Lydia and Seow, Yiqi and Schapira, Anthony H and Gardiner, Chris and Sargent, Ian L and Wood, Matthew J.A and Cooper, J. Mark
Neurobiology of disease, ISSN 0969-9961, 2011, Volume 42, Issue 3, pp. 360 - 367
Neurology | Ammonium chloride | Lysosomal inhibition | Exosome | Bafilomycin A1 | Alpha-synuclein | Transmission | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Exosomes - metabolism | Immunohistochemistry | Cell Line | Cell Proliferation | Enzyme-Linked Immunosorbent Assay | Humans | Cells, Cultured | Blotting, Western | Lysosomes - metabolism | Statistics, Nonparametric | Neurons - metabolism | Parkinson Disease - metabolism | alpha-Synuclein - metabolism | Ammonium compounds | Disease transmission | Parkinson's disease | Ammonium paratungstate | Index Medicus
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11. Full Text Glial activation precedes alpha-synuclein pathology in a mouse model of Parkinson's disease
by Izco, Maria and Blesa, Javier and Verona, Guglielmo and Cooper, J Mark and Alvarez-Erviti, Lydia
Neuroscience research, 12/2020
Index Medicus
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12. Full Text Lesion of the centromedian thalamic nucleus in MPTP‐treated monkeys
by Lanciego, Jose L and Rodríguez‐Oroz, Maria C and Blesa, Francisco J and Alvarez‐Erviti, Lydia and Guridi, Jorge and Barroso‐Chinea, Pedro and Smith, Yoland and Obeso, Jose A
Movement disorders, ISSN 0885-3185, 04/2008, Volume 23, Issue 5, pp. 708 - 715
intralaminar thalamic nuclei | kainic acid lesion | Parkinson's disease | MPTP monkey model | Intralaminar thalamic nuclei | Kainic acid lesion | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Neurology | Biological and medical sciences | Anticonvulsants. Antiepileptics. Antiparkinson agents | Medical sciences | Neuropharmacology | Pharmacology. Drug treatments | Parkinsonian Disorders - physiopathology | Levodopa - therapeutic use | Intralaminar Thalamic Nuclei - pathology | Macaca fascicularis | Male | Parkinsonian Disorders - chemically induced | Stereotaxic Techniques | Animals | Parkinsonian Disorders - drug therapy | Levodopa - adverse effects | Functional Laterality - drug effects | Intralaminar Thalamic Nuclei - drug effects | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Kainic Acid - toxicity | Dyskinesia, Drug-Induced - diagnosis | Index Medicus | Parkinson’s disease
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