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index medicus (14) 14
animals (9) 9
humans (7) 7
mice (7) 7
alpha-synuclein (6) 6
brain - metabolism (6) 6
parkinson's disease (6) 6
parkinsons-disease (6) 6
brain (5) 5
neurology (5) 5
neurosciences (5) 5
article (4) 4
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research (4) 4
alpha-synuclein - metabolism (3) 3
autolysosome (3) 3
biochemistry & molecular biology (3) 3
cell and molecular biology (3) 3
cell- och molekylärbiologi (3) 3
flux (3) 3
gene expression (3) 3
inflammation (3) 3
life sciences (3) 3
lysosome (3) 3
macroautophagy (3) 3
medical and health sciences (3) 3
medicin och hälsovetenskap (3) 3
mice, inbred c57bl (3) 3
nervous system (3) 3
phagophore (3) 3
rna (3) 3
rna, small interfering - administration & dosage (3) 3
stress (3) 3
vacuole (3) 3
activation (2) 2
alpha-synuclein - genetics (2) 2
alpha-synuclein - immunology (2) 2
anatomy & physiology (2) 2
animal diseases (2) 2
autophagosome (2) 2
autophagy (2) 2
autophagy - drug effects (2) 2
autophagy - physiology (2) 2
basic medicine (2) 2
blotting, western (2) 2
bone marrow (2) 2
brain - physiopathology (2) 2
cell biology (2) 2
chaperone-mediated autophagy (2) 2
corrigendum (2) 2
dendritic cells - metabolism (2) 2
dopamine - metabolism (2) 2
dopaminergic-neurons (2) 2
exosomes (2) 2
exosomes - metabolism (2) 2
female (2) 2
gene expression regulation - drug effects (2) 2
gene therapy (2) 2
gene transfer techniques (2) 2
genetic vectors (2) 2
genetics & heredity (2) 2
growth-factor (2) 2
homeostasis (2) 2
inflammation - immunology (2) 2
lc3 (2) 2
lewy bodies (2) 2
medical biotechnology, molecular biology, microbiology, biochemistry or biopharmacy (2) 2
medicinsk bioteknologi, molekylärbiologi, mikrobiologi, biokemi eller biofarmaci (2) 2
medicinska och farmaceutiska grundvetenskaper (2) 2
mice, transgenic (2) 2
microglia (2) 2
microglia - immunology (2) 2
microglia - metabolism (2) 2
nervous system diseases (2) 2
neurology. diseases of the nervous system (2) 2
neurons - metabolism (2) 2
oxidative stress (2) 2
parkinson disease - genetics (2) 2
parkinson disease - metabolism (2) 2
parkinson disease - pathology (2) 2
parkinson’s disease (2) 2
pathology (2) 2
phosphorylation (2) 2
proteins (2) 2
rna, messenger - metabolism (2) 2
statistics, nonparametric (2) 2
substantia-nigra (2) 2
time factors (2) 2
tnf-alpha (2) 2
0601 biochemistry and cell biology (1) 1
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (1) 1
abridged index medicus (1) 1
activated protein-kinase (1) 1
adaptor proteins, signal transducing - metabolism (1) 1
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alpha-synuclein - pharmacology (1) 1
alpha-synuclein - secretion (1) 1
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1. Full Text Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
by Seow, Yiqi and Betts, Corinne and Wood, Matthew J A and Lakhal, Samira and Yin, HaiFang and Alvarez-Erviti, Lydia
Nature Biotechnology, ISSN 1087-0156, 04/2011, Volume 29, Issue 4, pp. 341 - 345
To realize the therapeutic potential of RNA drugs, efficient, tissue-specific and nonimmunogenic delivery technologies must be developed. Here we show that... 
BACE1 | CELLS | GENE DELIVERY | RNA | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PERSPECTIVES | GROWTH | NEURONS | MICE | VECTORS | Exosomes - metabolism | Amyloid Precursor Protein Secretases - genetics | Cell Line | Gene Transfer Techniques | Microglia - metabolism | Lysosomal-Associated Membrane Protein 2 - genetics | Mice, Inbred C57BL | Alzheimer Disease - therapy | Male | Aspartic Acid Endopeptidases - genetics | RNA, Messenger - metabolism | Gene Knockdown Techniques | Brain - metabolism | Rabies virus - metabolism | Animals | Peptides - metabolism | Proteins - metabolism | Membrane Proteins - metabolism | Mice | Neurons - metabolism | Genetic Vectors | RNA, Small Interfering - administration & dosage | Dendritic Cells - metabolism | Research | Membrane proteins | Brain | Biotechnology | Gene therapy | Ribonucleic acid--RNA | Rodents | Index Medicus
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2. Full Text Systemic exosomal siRNA delivery reduced alpha‐synuclein aggregates in brains of transgenic mice
by Cooper, J. Mark and Wiklander, P.B. Oscar and Nordin, Joel Z and Al‐Shawi, Raya and Wood, Matthew J and Vithlani, Mansi and Schapira, Anthony H. V and Simons, J. Paul and El‐Andaloussi, Samir and Alvarez‐Erviti, Lydia
Movement Disorders, ISSN 0885-3185, 10/2014, Volume 29, Issue 12, pp. 1476 - 1485
Alpha‐synuclein (α‐Syn) aggregates are the main component of Lewy bodies, which are the characteristic pathological feature in Parkinson's disease (PD) brain.... 
α‐Syn | siRNA | transgenic mice | RVG‐exosomes | RVG-exosomes | α-Syn | Transgenic mice | alpha-Syn | PHOSPHORYLATION | PATHOLOGY | NEUROPATHOLOGY | DEFICITS | MOTOR DYSFUNCTION | RAT MODEL | CLINICAL NEUROLOGY | PARKINSONS-DISEASE | Humans | RNA, Messenger - metabolism | Brain - metabolism | Transfection | Time Factors | Exosomes - physiology | Viral Proteins - administration & dosage | alpha-Synuclein - genetics | Peptide Fragments - genetics | Dendritic Cells - metabolism | Neuroblastoma - pathology | Glycoproteins - genetics | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Gene Expression Regulation - physiology | Viral Proteins - genetics | Mice, Transgenic | Mutation - genetics | Genetic Vectors - genetics | Glycoproteins - administration & dosage | Gene Expression Regulation - drug effects | Animals | Cell Line, Tumor | Mice | RNA, Small Interfering - administration & dosage | alpha-Synuclein - metabolism | Index Medicus
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3. Full Text Exosome-mediated delivery of siRNA in vitro and in vivo
by El-Andaloussi, Samir and Lee, Yi and Lakhal-Littleton, Samira and Li, Jinghuan and Seow, Yiqi and Gardiner, Chris and Alvarez-Erviti, Lydia and Sargent, Ian L and Wood, Matthew J.A
Nature Protocols, ISSN 1754-2189, 2012, Volume 7, Issue 12, pp. 2112 - 2126
The use of small interfering RNAs (siRNAs) to induce gene silencing has opened a new avenue in drug discovery. However, their therapeutic potential is hampered... 
MULTIVESICULAR BODIES | DENDRITIC CELLS | MESSENGER-RNA | MECHANISM | DISEASE | BIOCHEMICAL RESEARCH METHODS | MICRORNAS | BRAIN | Brain - metabolism | Gene Transfer Techniques | RNA, Small Interfering - genetics | Animals | Transfection - methods | Gene Silencing | Exosomes - genetics | Mice | Genetic Vectors | RNA, Small Interfering - administration & dosage | Drugs | Drug delivery systems | RNA | Genetic engineering | Cell organelles | Research | Properties | Methods | Vehicles | Index Medicus
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4. Full Text Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line
by Alvarez-Erviti, Lydia and Couch, Yvonne and Richardson, Jill and Cooper, J. Mark and Wood, Matthew J.A
Neuroscience Research, ISSN 0168-0102, 04/2011, Volume 69, Issue 4, pp. 337 - 342
► Alpha-synuclein directly activates the inflammatory response in BV-2 cells. ► Conditioned medium from alpha-synuclein expressing cells induces inflammation.... 
Inflammation | Parkinson's disease | BV-2 | Alpha-synuclein | Microglia | DEATH | DOPAMINERGIC-NEURONS | SUBSTANTIA-NIGRA | NEUROSCIENCES | TUMOR-NECROSIS-FACTOR | NEUROBLASTOMA SH-SY5Y CELLS | TNF-ALPHA | GROWTH-FACTOR | MPTP | RECEPTORS | PARKINSONS-DISEASE | Cell Line | Microglia - metabolism | Gene Expression | Humans | alpha-Synuclein - immunology | Inflammation - immunology | alpha-Synuclein - secretion | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Animals | Microglia - immunology | Neurons - secretion | Mice | Cytokines - biosynthesis | Culture Media, Conditioned - metabolism | Index Medicus
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5. Full Text Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting
by Wiklander, Oscar P. B and Nordin, Joel Z and O'Loughlin, Aisling and Gustafsson, Ylva and Corso, Giulia and Mäger, Imre and Vader, Pieter and Lee, Yi and Sork, Helena and Seow, Yiqi and Heldring, Nina and Alvarez-Erviti, Lydia and Smith, CI Edvard and Le Blanc, Katarina and Macchiarini, Paolo and Jungebluth, Philipp and Wood, Matthew J. A and Andaloussi, Samir EL
Journal of Extracellular Vesicles, ISSN 2001-3078, 01/2015, Volume 4, Issue 1, pp. 1 - 13
Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication in a diverse range of biological processes. For future... 
biodistribution | extracellular vesicles | exosomes | tissue targeting | nanotechnology | drug delivery | microvesicles | Tissue targeting | Extracellular vesicles | Drug delivery | Microvesicles | Exosomes | Biodistribution | Nanotechnology | Medicine | Nanoparticles | Laboratories | Colleges & universities | Science | Nervous system | Physiology | Anatomy & physiology | Labeling
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6. Full Text The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation
by Couch, Yvonne and Alvarez-Erviti, Lydia and Sibson, Nicola R and Wood, Matthew J.A and Anthony, Daniel C
Journal of Neuroinflammation, ISSN 1742-2094, 11/2011, Volume 8, Issue 1, pp. 166 - 166
Background: Activated microglia are a feature of the host response to neurodegeneration in Parkinson's disease (PD) and are thought to contribute to disease... 
Chemokine | Brain | Parkinson's | Cytokine | Inflammation | α-synuclein | Snca | cytokine | chemokine | MURINE PRION DISEASE | HUMAN MACROPHAGES | IFN-GAMMA | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | brain | alpha-synuclein | CEREBROSPINAL-FLUID | HUMAN MONOCYTES | NEUROSCIENCES | inflammation | CHRONIC NEURODEGENERATION | TNF-ALPHA | LEWY BODIES | SNCA | PARKINSONS-DISEASE | Inflammation - pathology | Substantia Nigra - pathology | Amyloid beta-Peptides - pharmacology | alpha-Synuclein - immunology | Cell Death - immunology | Substantia Nigra - immunology | Lipopolysaccharides - immunology | Transcription Factor RelA - genetics | alpha-Synuclein - pharmacology | Serum Albumin - immunology | Microglia - immunology | Tumor Necrosis Factor-alpha - immunology | Transcription Factor RelA - immunology | Female | Cytokines - genetics | Cytokines - immunology | Microglia - cytology | Cell Line | Parkinson Disease - pathology | Microglia - drug effects | Parkinson Disease - immunology | Interleukin-1beta - immunology | Inflammation - immunology | Substantia Nigra - drug effects | Animals | Serum Albumin - pharmacology | Lipopolysaccharides - pharmacology | Mice | Index Medicus
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7. Full Text Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
by Alvarez-Erviti, Lydia and Seow, Yiqi and Schapira, Anthony H and Gardiner, Chris and Sargent, Ian L and Wood, Matthew J.A and Cooper, J. Mark
Neurobiology of Disease, ISSN 0969-9961, 2011, Volume 42, Issue 3, pp. 360 - 367
Abstract Alpha-synuclein aggregation plays a central role in Parkinson's disease pathology. Direct transmission of alpha-synuclein from pathologically affected... 
Neurology | Ammonium chloride | Lysosomal inhibition | Exosome | Bafilomycin A1 | Alpha-synuclein | Transmission | PRIONS | PHOSPHORYLATION | INFECTIVITY | MARKERS | AUTOPHAGY | PATHOLOGY | NEUROSCIENCES | CELL-DEATH | LEWY BODIES | PARKINSONS-DISEASE | Exosomes - metabolism | Immunohistochemistry | Cell Line | Cell Proliferation | Enzyme-Linked Immunosorbent Assay | Humans | Cells, Cultured | Blotting, Western | Lysosomes - metabolism | Statistics, Nonparametric | Neurons - metabolism | Parkinson Disease - metabolism | alpha-Synuclein - metabolism | Ammonium compounds | Disease transmission | Parkinson's disease | Ammonium paratungstate | Index Medicus
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8. Full Text IGF1R deficiency attenuates acute inflammatory response in a bleomycin-induced lung injury mouse model
by Piñeiro-Hermida, Sergio and López, Icíar P and Alfaro-Arnedo, Elvira and Torrens, Raquel and Iñiguez, María and Alvarez-Erviti, Lydia and Ruíz-Martínez, Carlos and Pichel, José G
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 4290 - 13
IGF1R (Insulin-like Growth Factor 1 Receptor) is a tyrosine kinase with pleiotropic cellular functions. IGF activity maintains human lung homeostasis and is... 
ACTIVATION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | EPITHELIAL-CELL | RECEPTOR | CURRENT PERSPECTIVES | MICE | GROWTH-FACTOR | IDIOPATHIC PULMONARY-FIBROSIS | CANCER | PROTECTS | Oxidative stress | Lung cancer | Homeostasis | Insulin-like growth factors | Gene deletion | Macrophages | Bleomycin | Clonal deletion | Down-regulation | Insulin-like growth factor I receptors | Bone marrow | Chronic obstructive pulmonary disease | Protein-tyrosine kinase | Tyrosine | Lung diseases | Leukocytes (neutrophilic) | Inflammation | Permeability | Gene expression | Insulin | Asthma | Lungs | Fibrosis | Epigenetics | Cancer | Index Medicus
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9. Full Text Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
by Klionsky, Daniel J and Abdelmohsen, Kotb and Abe, Akihisa and Abedin, Md Joynal and Abeliovich, Hagai and Acevedo Arozena, Abraham and Adachi, Hiroaki and Adams, Christopher M and Adams, Peter D and Adeli, Khosrow and Adhihetty, Peter J and Adler, Sharon G and Agam, Galila and Agarwal, Rajesh and Aghi, Manish K and Agnello, Maria and Agostinis, Patrizia and Aguilar, Patricia V and Aguirre-Ghiso, Julio and Airoldi, Edoardo M and Ait-Si-Ali, Slimane and Akematsu, Takahiko and Akporiaye, Emmanuel T and Al-Rubeai, Mohamed and Albaiceta, Guillermo M and Albanese, Chris and Albani, Diego and Albert, Matthew L and Aldudo, Jesus and Algül, Hana and Alirezaei, Mehrdad and Alloza, Iraide and Almasan, Alexandru and Almonte-Beceril, Maylin and Alnemri, Emad S and Alonso, Covadonga and Altan-Bonnet, Nihal and Altieri, Dario C and Alvarez, Silvia and Alvarez-Erviti, Lydia and Alves, Sandro and Amadoro, Giuseppina and Amano, Atsuo and Amantini, Consuelo and Ambrosio, Santiago and Amelio, Ivano and Amer, Amal O and Amessou, Mohamed and Amon, Angelika and An, Zhenyi and Anania, Frank A and Andersen, Stig U and Andley, Usha P and Andreadi, Catherine K and Andrieu-Abadie, Nathalie and Anel, Alberto and Ann, David K and Anoopkumar-Dukie, Shailendra and Antonioli, Manuela and Aoki, Hiroshi and Apostolova, Nadezda and Aquila, Saveria and Aquilano, Katia and Araki, Koichi and Arama, Eli and Aranda, Agustin and Araya, Jun and Arcaro, Alexandre and Arias, Esperanza and Arimoto, Hirokazu and Ariosa, Aileen R and Armstrong, Jane L and Arnould, Thierry and Arsov, Ivica and Asanuma, Katsuhiko and Askanas, Valerie and Asselin, Eric and Atarashi, Ryuichiro and Atherton, Sally S and Atkin, Julie D and Attardi, Laura D and Auberger, Patrick and Auburger, Georg and Aurelian, Laure and Autelli, Riccardo and Avagliano, Laura and Avantaggiati, Maria Laura and Avrahami, Limor and Awale, Suresh and Azad, Neelam and Bachetti, Tiziana and Backer, Jonathan M and Bae, Dong-Hun and Bae, Jae-sung and Bae, Ok-Nam and Bae, Soo Han and Baehrecke, Eric H and Baek, Seung-Hoon and Baghdiguian, Stephen and Bagniewska-Zadworna, Agnieszka and ... and Medicinska fakulteten and Region Östergötland and Linköpings universitet and Institutionen för klinisk och experimentell medicin and Diagnostikcentrum and Klinisk patologi och klinisk genetik and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Avdelningen för cellbiologi
Autophagy, ISSN 1554-8627, 01/2016, Volume 12, Issue 1, pp. 1 - 222
stress | chaperone-mediated autophagy | vacuole | autolysosome | macroautophagy | flux | autophagosome | LC3 | lysosome | phagophore | Phagophore | Lysosome | Autolysosome | Flux | Autophagosome | Vacuole | Chaperonemediated autophagy | Macroautophagy | Stress | ACTIVATED PROTEIN-KINASE | ENDOPLASMIC-RETICULUM STRESS | STARVATION-INDUCED AUTOPHAGY | GLUCAGON-INDUCED AUTOPHAGY | CELL BIOLOGY | PROGRAMMED CELL-DEATH | LIFE-SPAN EXTENSION | BETAINE HOMOCYSTEINE METHYLTRANSFERASE | VACUOLAR MEMBRANE DYNAMICS | NF-KAPPA-B | Autophagy - physiology | Biological Assay - methods | Animals | Biological Assay - standards | Computer Simulation | Humans | Index Medicus | Life Sciences | Medical and Health Sciences | Medicin och hälsovetenskap
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