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PLoS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4, pp. e34341 - e34341
Background: Recent Alzheimer's disease (AD) research has focused on finding biomarkers to identify disease at the preclinical stage of mild cognitive... 
ALLELE | BIOMARKERS | E GENE | APOE POLYMORPHISM | E POLYMORPHISM | OLDER-ADULTS | BIOLOGY | APOLIPOPROTEIN-E GENOTYPE | CEREBROSPINAL-FLUID | ASSOCIATION | MICROARRAY DATA | Multivariate Analysis | Humans | Middle Aged | Genotype | Male | Cognitive Dysfunction - blood | Biomarkers - blood | Blood Proteins - metabolism | Case-Control Studies | Alzheimer Disease - diagnosis | Apolipoproteins E - blood | Apolipoproteins E - genetics | Sensitivity and Specificity | Aged, 80 and over | Female | Aged | Cognitive Dysfunction - diagnosis | Early Diagnosis | Proteome - metabolism | Alzheimer Disease - blood | Medicine, Experimental | Advertising executives | Medical research | Apolipoproteins | Alzheimer's disease | Blood proteins | Neuroimaging | Peptides | Identification methods | Neuropathology | Cognitive ability | Cognition | Cerebrospinal fluid | Optimization | Datasets | Proteins | Accuracy | Apolipoprotein E | Classification | Bioindicators | Signatures | Bioinformatics | Test sets | Electrical engineering | Sensitivity analysis | Medical imaging | Cytokines | Neurodegenerative diseases | Computer engineering | Data processing | Computer science | Medicine | Studies | Neurology | Sensitivity | Brain research | Relative abundance | Biomarkers | Brain damage | Cost analysis | Alzheimers disease | Combinatorial analysis | Index Medicus | Plasma proteins | biomarkers | Abundance | Blood
Journal Article
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, ISSN 1552-5260, 2015, Volume 11, Issue 12, pp. 1417 - 1429
Abstract Introduction This study assessed apolipoprotein E ( APOE ) ε4 carrier status effects on Alzheimer's disease imaging and cerebrospinal fluid (CSF)... 
Neurology | Neuroimaging | ADNI | SMC | FDG | Cerebrospinal fluid | Significant memory concern | Alzheimer's Disease Neuroimaging Initiative | Subjective cognitive decline | SCD | Apolipoprotein E | [18F]Florbetapir PET | CSF | APOE | PET | [18F]Fluorodeoxyglucose | Structural magnetic resonance imaging (MRI) | F]Fluorodeoxyglucose | F]Florbetapir PET | SURFACE-BASED ANALYSIS | BRAIN ATROPHY | COMPLAINTS | DEMENTIA | NEUROIMAGING INITIATIVE ADNI | [F-18] Florbetapir PET | PATHOLOGY | CLINICAL NEUROLOGY | APOLIPOPROTEIN-E | VOLUME LOSS | [F-18] Fluorodeoxyglucose | MILD COGNITIVE IMPAIRMENT | GLUCOSE-METABOLISM | Apolipoprotein E4 - genetics | Humans | Genotype | Male | Positron-Emission Tomography | tau Proteins - cerebrospinal fluid | Cognitive Dysfunction - cerebrospinal fluid | Alzheimer Disease - cerebrospinal fluid | Healthy Volunteers | Alzheimer Disease - pathology | Brain - metabolism | Neuropsychological Tests | Magnetic Resonance Imaging | Alzheimer Disease - metabolism | Aged, 80 and over | Amyloid beta-Peptides - cerebrospinal fluid | Brain - pathology | Adult | Female | Heterozygote | Aged | Cognitive Dysfunction - diagnosis | Biomarkers - cerebrospinal fluid | Memory - physiology | Medical colleges | Molecular genetics | Apolipoproteins | Biological markers | Alzheimer's disease | Index Medicus | 60 APPLIED LIFE SCIENCES
Journal Article
International Journal of Alzheimer's Disease, ISSN 2090-0252, 2011, Volume 2011, pp. 729478 - 10
Copy number variants (CNVs) are DNA sequence alterations, resulting in gains (duplications) and losses (deletions) of genomic segments. They often overlap... 
Gene mutations | Genetic aspects | Diagnosis | Research | Cognition disorders | Alzheimer's disease | Health aspects
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 7, pp. e21935 - e21935
Journal Article
BMC Medical Genomics, ISSN 1755-8794, 05/2017, Volume 10, Issue S1, pp. 45 - 52
Abstract Background The APOE ε4 allele is the most significant common genetic risk factor for late-onset Alzheimer’s disease (LOAD). The region surrounding... 
ADNI | Neuroimaging | Near APOE | Whole genome sequencing | CSF | Rare variants
Journal Article
Frontiers in Neuroscience, ISSN 1662-453X, 05/2019, Volume 13
Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases. In the last decade, studies on AD diagnosis has attached great significance to... 
deep learning | multi-modality | CNN | hippocampal | Alzheimer’s disease | image classification
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, pp. e70269 - e70269
Proteins, widely studied as potential biomarkers, play important roles in numerous physiological functions and diseases. Genetic variation may modulate... 
QUANTITATIVE TRAIT LOCI | ANGIOTENSINOGEN GENE | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | NEUROIMAGING INITIATIVE ADNI | WHOLE-GENOME ASSOCIATION | FACTOR-H | FUNCTIONAL ANNOTATION | MILD COGNITIVE IMPAIRMENT | THYROXINE-BINDING GLOBULIN | APOLIPOPROTEIN-E | Genome-Wide Association Study | Humans | Middle Aged | Complement C3b Inactivator Proteins - genetics | Linear Models | Male | Complement C3b Inactivator Proteins - analysis | Apolipoproteins E - blood | Apolipoproteins E - genetics | Aged, 80 and over | Female | Aged | Polymorphism, Single Nucleotide | Alzheimer Disease - genetics | Alzheimer Disease - blood | Medical research | Genomics | Medicine, Experimental | Genetic aspects | Genomes | Single nucleotide polymorphisms | Alzheimer's disease | Chromosomes | Blood proteins | Multiplexing | Neuroimaging | Haplotypes | Elderly people | Plasma | Disease | Laboratories | Physicians | Linkage disequilibrium | Genes | Interleukin | Biology | Single-nucleotide polymorphism | Interleukin 6 | Proteins | Complement factor H | Peptidyl-dipeptidase A | Older people | Angiotensinogen | Aging | Genetics | Blood pressure | Bioindicators | Bioinformatics | Hypertension | Medical imaging | Data processing | Genetic diversity | Regression analysis | Disease control | Medicine | Studies | Neurology | Pathology | Proteomics | Angiotensin | Biomarkers | Adults | Variation | Index Medicus
Journal Article
by Jiang, S and Yang, WL and Qiu, Y and Chen, HZ and ADNI
CURRENT ALZHEIMER RESEARCH, ISSN 1567-2050, 2015, Volume 12, Issue 3, pp. 218 - 227
APOE epsilon 4 allele is a major risk factor in Late-Onset Alzheimer's Disease (AD). Distinct phenotypes that depend on the APOE epsilon 4 status have been... 
ALLELE | haplotype | single nucleotide polymorphism | brain atrophy | NEUROIMAGING INITIATIVE ADNI | RISK | POLYMORPHISM | CEREBROSPINAL-FLUID | NEUROSCIENCES | CLINICAL NEUROLOGY | apolipoprotein E epsilon 4 | APOLIPOPROTEIN-E | GENE | AMYLOID-BETA | EARLY-ONSET | WHOLE-GENOME ASSOCIATION | Alzheimer's disease | diagnostic biomarker
Journal Article
Alzheimer's Research & Therapy, ISSN 1758-9193, 12/2017, Volume 9, Issue 1, pp. 1 - 13
Abstract Background The relative performance of semi-quantitative amyloid positron emission tomography (PET) and cerebrospinal fluid (CSF) markers in... 
ADNI | MCI | CSF markers | Alzheimer’s disease | Amyloid PET
Journal Article
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 12/2016, Volume 132, Issue 6, pp. 841 - 858
Journal Article
PLOS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, pp. e0182098 - e0182098
To determine if a multi-analyte cerebrospinal fluid (CSF) peptide signature can be used to differentiate Alzheimer's Disease (AD) and normal aged controls... 
FATTY-ACID-BINDING | PROTEIN | DEMENTIA | CEREBROSPINAL-FLUID BIOMARKERS | MULTIDISCIPLINARY SCIENCES | BRAIN-TYPE | SERUM | MILD COGNITIVE IMPAIRMENT | MASS-SPECTROMETRY | DISCOVERY | PROTEOMICS | Models, Theoretical | Severity of Illness Index | Amino Acid Sequence | Multivariate Analysis | Peptide Fragments - cerebrospinal fluid | Area Under Curve | Humans | Male | tau Proteins - cerebrospinal fluid | Alzheimer Disease - cerebrospinal fluid | Case-Control Studies | Disease Progression | Alzheimer Disease - pathology | Algorithms | Apolipoproteins E - cerebrospinal fluid | Aged, 80 and over | Amyloid beta-Peptides - cerebrospinal fluid | Female | ROC Curve | Aged | Databases, Factual | Cerebrospinal fluid | Research | Peptides | Biological markers | Alzheimer's disease | Analysis | Neuroimaging | Nuclear magnetic resonance--NMR | Cognitive ability | Identification | Multivariate analysis | Proteins | Ethics | Apolipoprotein E | Classification | Signatures | Pentraxins | Medical imaging | Neurodegenerative diseases | Review boards | Metabolism | Apolipoproteins | Fatty acids | Disease control | Heart fatty acid-binding protein | Medicine | Studies | Human subjects | Neurology | Hypotheses | Brain research | Hospitals | Tau protein | Fatty acid-binding protein | Proteomics | Biomarkers | β-Amyloid | Scientific imaging | Alzheimers disease | Mass spectrometry | Dementia | Index Medicus | Nuclear magnetic resonance | NMR
Journal Article