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Chemical Communications, ISSN 1359-7345, 2018, Volume 54, Issue 65, pp. 8999 - 9002
We have found that cyclic perfluorinated iodanes react with electrophiles (E+= Br, Cl, F, I) to afford perfluorinated E-R-F compounds. This reactivity is... 
TETRAFLUOROETHYLATION | TRIFLUOROMETHYL | REAGENTS | HYPOXIA | PERFLUOROALKYLATION | CHEMISTRY, MULTIDISCIPLINARY | Nucleophiles | Cyclotrons | Reagents
Journal Article
ISSN 1359-7345, 8/2018, Volume 54, Issue 65, pp. 8999 - 92
We have found that cyclic perfluorinated iodanes react with electrophiles (E + = Br, Cl, F, I) to afford perfluorinated E-R F compounds. This reactivity is... 
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 08/2019, Volume 27, Issue 16, pp. 3559 - 3567
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 09/2019, Volume 62, Issue 17, pp. 8090 - 8100
The costimulatory molecule CD80 is an early marker for immune activation. It is upregulated on activated antigen-presenting cells. We aimed at developing a... 
BELATACEPT | ACTIVATION | CHEMISTRY, MEDICINAL | INHIBITION | PHARMACOKINETICS | LIGANDS | COSTIMULATION | MECHANISMS | GLYCOPROTEIN | CELL | BINDING
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2019, Volume 177, pp. 47 - 62
The class of tetrahydro-1 -3-benzazepines was systematically modified in 1-, 3- and 7-position. In particular, a F-atom was introduced in β- or γ-position of... 
Structure activity relationships | Tetrahydro-3-benzazepines | Fluorinated side chain | Receptor selectivity | Antiallodynic activity | GluN2B subunit selective NMDA receptor antagonist | NMDA receptor | σ1 receptor selectivity | PET
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2019, Volume 177, p. 47
The class of tetrahydro-1H-3-benzazepines was systematically modified in 1-, 3- and 7-position. In particular, a F-atom was introduced in [beta]- or... 
Pets | Methyl ether
Journal Article
Pharmaceuticals, ISSN 1424-8247, 03/2018, Volume 11, Issue 1, p. 24
The Sonogashira cross-coupling, a key step in the syntheses of the mGlu₅ antagonists MMPEP and MTEP, provided an improved three-step method for the preparation... 
MMPEP | antagonist | MTEP | MGlu | Sonogashira cross-coupling | Medical imaging | mGlu5 antagonist
Journal Article
Journal of Pharmaceutical and Biomedical Analysis, ISSN 0731-7085, 08/2019, Volume 172, pp. 214 - 222
Recently, the eutomers of highly potent GluN2B selective NMDA receptor antagonists with 3-benzazepine scaffold were identified. Herein, pharmacokinetic... 
Metabolic stability | Plasma protein binding | Glun2B selective NMDA antagonists | logD7.4 value | Pharmacokinetic properties | Enantioselective biotransformation | Identification of metabolites
Journal Article
Bioconjugate Chemistry, ISSN 1043-1802, 04/2018, Volume 29, Issue 4, pp. 1119 - 1130
5-Methyltetrahydrofolate (5-MTHF), a reduced folate form, is the biologically active folate involved in many different metabolic processes. To date, there are... 
Journal Article
Sleep, ISSN 0161-8105, 07/2019
Sleep and brain glutamatergic signaling are homeostatically regulated. Recovery sleep following prolonged wakefulness restores efficient functioning of the... 
Journal Article
EJNMMI Research, ISSN 2191-219X, 12/2019, Volume 9, Issue 1, pp. 1 - 6
(E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(3-(2-[18F]-fluoroethoxy)propyl) oxime ([18F]-PSS232) is a new PET tracer for imaging of metabotropic glutamate... 
Medicine & Public Health | Orthopedics | Tracer | [ 18 F]-PSS232 | Oncology | mGlu5 receptors | Nuclear Medicine | Dosimetry | Imaging / Radiology | Cardiac Imaging | F]-PSS232 | Dosimeters | Thigh | Positron emission | Organs | Fluorine isotopes | Receptors | Mathematical analysis | Rodents | Computer aided tomography | Tomography | Gallbladder | Software | [18F]-PSS232
Journal Article
Journal of Labelled Compounds and Radiopharmaceuticals, ISSN 0362-4803, 06/2019, Volume 62, Issue 8, pp. 552 - 560
Journal Article
Neurotoxicity research, ISSN 1029-8428, 05/2019
Using positron emission tomography (PET), a profound alteration of the metabotropic glutamate receptor 5 (mGluR5) was found in human smoking addiction and... 
Journal Article
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