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Gastroenterology, ISSN 0016-5085, 2016, Volume 150, Issue 2, pp. 513 - 525.e10
Background & Aims Cancer cells with high metastatic potential and stem cell–like characteristics express the cell surface marker CD44. CD44 isoforms that... 
Gastroenterology and Hepatology | Tumor Development | Signal Transduction | Pancreas | Oncogene | CARCINOMA-CELLS | CABOZANTINIB | STEM-CELLS | MANAGEMENT | ANGIOGENESIS | MARKER | CHEMOTHERAPY | RNA-SEQ | C-MET | THERAPEUTIC TARGET | GASTROENTEROLOGY & HEPATOLOGY | Proto-Oncogene Proteins c-met - metabolism | Pancreatic Neoplasms - metabolism | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Male | RNA, Messenger - metabolism | Pancreatic Neoplasms - drug therapy | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Neoplasm Metastasis | Transfection | Lung Neoplasms - secondary | Time Factors | Hyaluronan Receptors - metabolism | Antineoplastic Agents - pharmacology | Pancreatic Neoplasms - mortality | Pyrazoles - pharmacology | Lung Neoplasms - genetics | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Pancreatic Neoplasms - pathology | Kaplan-Meier Estimate | Rats | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Mice, Transgenic | Pancreatic Neoplasms - genetics | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Hyaluronan Receptors - genetics | Peptides - pharmacology | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Lung Neoplasms - prevention & control | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Mutation | Genes, ras | Tyrosine | Medical colleges | Growth | Oncology, Experimental | Radiation | Metastasis | Research | Endothelium | Analysis | Pancreatic cancer | Stem cells | Research institutes | Vascular endothelial growth factor | Phosphotransferases | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2004, Volume 101, Issue 24, pp. 9085 - 9090
Journal Article
ELIFE, ISSN 2050-084X, 07/2019, Volume 8
The inability of differentiated cells to maintain their identity is a hallmark of age-related diseases. We found that the transcription factor Hey supervises... 
STEM-CELLS | INTEGRATIVE ANALYSIS | TISSUE HOMEOSTASIS | BIOLOGY | NOTCH | DIFFERENTIATION | FATE | DROSOPHILA MIDGUT | GENOME | CHROMATIN STATE | DIGESTIVE-TRACT | Stem cells | Medical research | Phenotypes | Young adults | Ontology | Midgut | Genes | Homeostasis | Lamins | Cell differentiation | Proteins | Enterocytes | Insects | Morphology | Aging | Physiology
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 04/2015, Volume 230, Issue 4, pp. 842 - 852
The E3 ubiquitin ligase and tumor suppressor SCFFbw7 exists as three isoforms that govern the degradation of a host of critical cell regulators, including... 
LOCALIZATION | PHYSIOLOGY | PROTEIN | NUCLEAR | RECEPTOR-GAMMA | RECOGNITION | C-MYC | TUMOR-SUPPRESSOR | CONTROLLING MITOCHONDRIAL BIOGENESIS | TRANSCRIPTIONAL COACTIVATOR | DEPENDENT DEGRADATION | CELL BIOLOGY | proteasome | PGC-1α | Fbw7 | protein degradation | ubiquitin | energy metabolism
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1492 - 16
Journal Article
Cell Reports, ISSN 2211-1247, 09/2016, Volume 16, Issue 12, pp. 3388 - 3400
Ubiquitylation regulates signaling pathways critical for cancer development and, in many cases, targets proteins for degradation. Here, we report that... 
oncogenes | SUMO | gene regulation | ubiquitin | STUbL | E3 LIGASE | COLON-CANCER | IN-VITRO | MEDIATED TRANSCRIPTION | DNA-DAMAGE | TARGETED UBIQUITIN LIGASE | C-MYC | KAPPA-B-ALPHA | BETA-CATENIN | CANCER STEM-CELLS | CELL BIOLOGY | Index Medicus
Journal Article
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 2000, Volume 77, Issue 34, pp. 40 - 51
Proteolysis via the ubiquitin system plays important roles in a variety of basic cellular processes. Among these are regulation of cell cycle and division,... 
Degradation | Ubiquitin | Disease states | SYSTEM | CELL-CYCLE REGULATION | disease states | PROTEIN-DEGRADATION | 20S | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEASOME | degradation | END | CANCER | ubiquitin | CELL BIOLOGY
Journal Article
Journal Article
International Journal of Developmental Biology, ISSN 0214-6282, 2017, Volume 61, Issue 3-5, pp. 319 - 327
The ability of metazoans to combat pathogenic infection involves both systemic and local responses to the invading pathogens. Ubiquitin and SUMO pathways... 
Ubiquitin | Innate-immunity | SUMO | Drosophila | STUbL | PATHWAYS | innate-immunity | ACTIVATION | INFECTIONS | DEVELOPMENTAL BIOLOGY | BACTERIAL | ubiquitin | MEDIATED REPRESSION | SUMOYLATION | DEGRINGOLADE | GENE-EXPRESSION | NF-KAPPA-B | MELANOGASTER
Journal Article