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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 41, pp. 16618 - 16623
Although the role of TGF-ß in tumor progression has been studied extensively, its impact on drug delivery in tumors remains far from understood. In this study,... 
Cell growth | Receptors | Perfusion | Collagens | Antineoplastics | Blood vessels | Metastasis | Tumors | Cancer | Apoptosis | Breast cancer | Drug delivery | Vessel normalization | CANCER-CELLS | COLLAGEN | METASTASIS | SOLID TUMORS | MULTIDISCIPLINARY SCIENCES | VESSEL MATURATION | breast cancer | drug delivery | DELIVERY | GROWTH-FACTOR-BETA | SOLUBLE BETAGLYCAN | vessel normalization | PROSTATE-CANCER | EXTRACELLULAR TRANSPORT | Antibodies, Neutralizing - administration & dosage | Doxorubicin - therapeutic use | Receptors, Transforming Growth Factor beta - genetics | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Breast Neoplasms - metabolism | Tissue Distribution | Antibodies, Neutralizing - immunology | Lung Neoplasms - secondary | Transforming Growth Factor beta - antagonists & inhibitors | Female | Antibiotics, Antineoplastic - pharmacokinetics | Protein-Serine-Threonine Kinases - metabolism | Transforming Growth Factor beta - immunology | Collagen Type I - metabolism | Protein-Serine-Threonine Kinases - genetics | Treatment Outcome | Signal Transduction - genetics | Breast Neoplasms - drug therapy | Blotting, Western | Doxorubicin - pharmacokinetics | Antibiotics, Antineoplastic - administration & dosage | Xenograft Model Antitumor Assays | Animals | Lung Neoplasms - prevention & control | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Transforming Growth Factor beta - metabolism | Biological Sciences | Physical Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2015, Volume 112, Issue 46, pp. 14325 - 14330
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2013, Volume 110, Issue 47, pp. 19059 - 19064
Antiangiogenic therapy has shown clear activity and improved survival benefit for certain tumor types. However, an incomplete understanding of the mechanisms... 
Oxygen | Perfusion | Glioblastoma | Biological markers | Radiotherapy | Blood | Tissue oxygenation | Tumors | Cancer | Blood plasma | VEGFR2 | VASCULAR NORMALIZATION | BEVACIZUMAB | MULTIDISCIPLINARY SCIENCES | brain tumor | RADIATION | personalized treatment | TEMOZOLOMIDE | GROWTH-FACTOR RECEPTOR | ANTIANGIOGENIC THERAPY | AMPLIFICATION | MICROENVIRONMENT | TYROSINE KINASE INHIBITOR | Prospective Studies | Humans | Brain Neoplasms - pathology | Quinazolines | Glioblastoma - radiotherapy | Brain Neoplasms - metabolism | Oxygen - metabolism | DNA Repair Enzymes - metabolism | Dacarbazine - analogs & derivatives | Polymerase Chain Reaction | Statistics, Nonparametric | Glioblastoma - metabolism | Brain Neoplasms - radiotherapy | Tumor Suppressor Proteins - metabolism | DNA Modification Methylases - metabolism | Enzyme-Linked Immunosorbent Assay | Angiogenesis Inhibitors - pharmacology | Treatment Outcome | Brain Neoplasms - drug therapy | Receptor Protein-Tyrosine Kinases - metabolism | Biomarkers, Tumor - blood | Magnetic Resonance Imaging | Glioblastoma - pathology | Protein Kinase Inhibitors - pharmacology | Glioblastoma - drug therapy | Cancer patients | Chemotherapy | Patient outcomes | Physiological aspects | Dosage and administration | Drug therapy | Glioblastoma multiforme | Methods | Cediranib | Index Medicus | Biological Sciences
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2010, Volume 28, Issue 17, pp. 2817 - 2823
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2009, Volume 27, Issue 18, pp. 3020 - 3026
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 06/2009, Volume 27, Issue 18, pp. 3027 - 3035
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2015, Volume 112, Issue 5, pp. 1547 - 1552
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2014, Volume 90, Issue 3, pp. 493 - 500
Journal Article
Journal Article
International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2014, Volume 89, Issue 4, pp. 830 - 838
Purpose To evaluate the safety, efficacy and biomarkers of short-course proton beam radiation and capecitabine, followed by pancreaticoduodenectomy in a phase... 
Radiology | Hematology, Oncology and Palliative Medicine | RECTAL-CANCER | ONCOLOGY-GROUP | ONCOLOGY | RESECTION | LONG-TERM SURVIVAL | RANDOMIZED CONTROLLED-TRIAL | PERIAMPULLARY CARCINOMA | SHORT-COURSE RADIOTHERAPY | FAILURE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | CHEMOTHERAPY | RADIATION-THERAPY | Pancreatic Neoplasms - chemistry | Proto-Oncogene Proteins p21(ras) | Receptors, CXCR - analysis | Prognosis | Prospective Studies | Capecitabine | Carcinoembryonic Antigen - blood | Humans | Middle Aged | Male | Pancreaticoduodenectomy | Chemoradiotherapy, Adjuvant - mortality | Fluorouracil - therapeutic use | Deoxycytidine - therapeutic use | Proto-Oncogene Proteins - analysis | Aged, 80 and over | Carcinoma, Pancreatic Ductal - mortality | Female | Pancreatic Neoplasms - mortality | CA-19-9 Antigen - blood | Genes, ras - genetics | Pancreatic Neoplasms - blood | Fluorouracil - analogs & derivatives | Biomarkers, Tumor - analysis | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - therapy | ras Proteins - analysis | Carcinoma, Pancreatic Ductal - pathology | Chemoradiotherapy, Adjuvant - methods | Carcinoma, Pancreatic Ductal - blood | Carcinoma, Pancreatic Ductal - chemistry | Antimetabolites, Antineoplastic - therapeutic use | Hepatocyte Growth Factor - blood | Aged | Proton Therapy - methods | Deoxycytidine - analogs & derivatives | Pancreatic Neoplasms - therapy | Adenocarcinoma | Sects | Nuclear radiation | Index Medicus | SURGERY | GLYCINE | PATIENTS | BIOPSY | GENE MUTATIONS | PANCREAS | PROTON BEAMS | RADIATION DOSES | TOXICITY | CHEST | PAIN | BIOLOGICAL MARKERS | ASPARTIC ACID | CARCINOMAS | RADIOLOGY AND NUCLEAR MEDICINE | RADIOTHERAPY | BLOOD
Journal Article