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Clinical Cancer Research, ISSN 1078-0432, 12/2015, Volume 21, Issue 23, pp. 5222 - 5234
Purpose: Targeted MEK inhibition is an emerging therapy in a number of solid tumors. It holds particular promise in BRAF V600E mutation-positive malignant... 
TYROSINE KINASE INHIBITORS | CELLS | ACTIVATION | ONCOLOGY | RAF | BCR-ABL | RESISTANCE | FOLLOW-UP | PATIENTS RECEIVING IMATINIB | SYNERGISTIC INTERACTIONS | PROGRESSION | Melanoma - diagnosis | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Male | Antineoplastic Agents - therapeutic use | Neoplasm Metastasis | Bcl-2-Like Protein 11 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - diagnosis | Apoptosis Regulatory Proteins - genetics | Adult | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Neoplasms, Multiple Primary - diagnosis | Neoplasms, Multiple Primary - etiology | Proto-Oncogene Proteins - metabolism | Membrane Proteins - genetics | Neoplasms, Unknown Primary | Proto-Oncogene Proteins - genetics | Treatment Outcome | Melanoma - secondary | Apoptosis Regulatory Proteins - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Fusion Proteins, bcr-abl - genetics | MAP Kinase Signaling System - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - etiology | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Mutation | Melanoma - therapy | Neoplasms, Multiple Primary - drug therapy | Fusion Proteins, bcr-abl - metabolism
Journal Article
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2018, Volume 24, Issue 11, pp. 1649 - 1654
Journal Article
British Journal of Cancer, ISSN 0007-0920, 06/2017, Volume 116, Issue 12, pp. 1558 - 1563
Journal Article
Molecular Cancer, ISSN 1476-4598, 06/2017, Volume 16, Issue 1, pp. 112 - 5
BRAF inhibitors (BRAFi) are standard of care for the treatment of BRAF V600 mutation-driven metastatic melanoma, but can lead to paradoxical activation of the... 
MAPK pathway | BRAF | Paradoxical activation | Colorectal cancer | Melanoma | MUTANT PANCREATIC ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | CANCER | LINES | METASTATIC MELANOMA | MEK INHIBITION | ONCOLOGY | RAF INHIBITORS | MUTATIONS | CARCINOMA | PROGRESSION | Colonic Neoplasms - drug therapy | Humans | Melanoma - pathology | Sulfonamides - pharmacology | Adenocarcinoma - drug therapy | Colonic Neoplasms - metabolism | Heterocyclic Compounds, 2-Ring - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Adenocarcinoma - metabolism | MAP Kinase Signaling System - drug effects | Melanoma - genetics | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Mutation | Proto-Oncogene Proteins B-raf - metabolism | Antimitotic agents | Treatment outcome | Analysis | Dosage and administration | Pharmacology | Research | Drug therapy | Antineoplastic agents | Cell proliferation | Adenocarcinoma | Biotechnology | Phosphorylation | Colorectal carcinoma | Activation | Metastasis | Promotion | Neoplasms | K-Ras protein | Metastases | Case studies | Signal transduction | Cell growth | Lesions | Activation analysis | MAP kinase | Patients | Signaling | Inhibitors | Protein kinase | Pancreatic cancer | Cell lines
Journal Article
Expert Review of Clinical Immunology, ISSN 1744-666X, 08/2014, Volume 10, Issue 8, pp. 1107 - 1123
Metastatic malignant melanoma is a frequently fatal cancer. In recent years substantial therapeutic progress has occurred with the development of targeted... 
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 11/2019, Volume 116, Issue 45, pp. 22699 - 22709
Journal Article
Future oncology (London, England), 06/2014, Volume 10, Issue 8, p. 1457
Human tumor rejection antigens recognized by T lymphocytes were first defined in the early 1990s and the identification of shared tumor-restricted antigens... 
Adaptive Immunity | Melanoma - metabolism | Immunotherapy, Adoptive | Antigens, Neoplasm - immunology | Immunomodulation | Melanoma - immunology | Cancer Vaccines | Humans | Antigens, Neoplasm - metabolism | Melanoma - therapy | Tumor Escape - immunology
Journal Article
by Amaria, Rodabe N and Menzies, Alexander M and Burton, Elizabeth M and Scolyer, Richard A and Tetzlaff, Michael T and Antdbacka, Robert and Ariyan, Charlotte and Bassett, Roland and Carter, Brett and Daud, Adil and Faries, Mark and Fecher, Leslie A and Flaherty, Keith T and Gershenwald, Jeffrey E and Hamid, Omid and Hong, Angela and Kirkwood, John M and Lo, Serigne and Margolin, Kim and Messina, Jane and Postow, Michael A and Rizos, Helen and Ross, Merrick I and Rozeman, Elisa A and Saw, Robyn P M and Sondak, Vernon and Sullivan, Ryan J and Taube, Janis M and Thompson, John F and van de Wiel, Bart A and Eggermont, Alexander M and Davies, Michael A and Andrews, Miles C and Berry, Donald A and Block, Matthew S and Boland, Genevieve M and Bollin, Kathryn B and Carlino, Matteo S and Carvajal, Richard D and Cohen, Jonathan and Davar, Diwakar and Delman, Keith A and Dummer, Reinhard and Farwell, Michael D and Fisher, David E and Fusi, Alberto and Glitza, Isabella C and de Gruijl, Tanja D and Gyorki, David E and Hauschild, Axel and Hieken, Tina J and Larkin, James and Lawson, David H and Lebbe, Celeste and Lee, Jeffrey E and Lowe, Michael C and Luke, Jason J and McArthur, Grant A and McDermott, David F and McQuade, Jennifer L and Mitchell, Tara C and Petrella, Teresa M and Prieto, Peter A and Puzanov, Igor and Robert, Caroline and Salama, April K and Sandhu, Shaneen and Schadendorf, Dirk and Shoushtari, Alexander N and Sosman, Jeffrey A and Swetter, Susan M and Tanabe, Ken K and Turajlic, Samra and Tyler, Douglas S and Woodman, Scott E and Wright, Frances C and Zager, Jonathan S and Ascierto, Paolo A and Spillane, Andrew J and van Akkooi, Alexander C J and Wargo, Jennifer A and Blank, Christian U and Tawbi, Hussein A and Long, Georgina V and Int Neoadjuvant Melanoma and International Neoadjuvant Melanoma Consortium members
The Lancet Oncology, ISSN 1470-2045, 07/2019, Volume 20, Issue 7, pp. e378 - e389
Advances in the treatment of metastatic melanoma have improved responses and survival. However, many patients continue to experience resistance or toxicity to... 
SURVIVAL | PREOPERATIVE CHEMOTHERAPY | RESPONSE CRITERIA | ONCOLOGY | IMMUNOTHERAPY | TRAMETINIB | ADJUVANT DABRAFENIB | DISEASE | GUIDELINES | STAGE-III | BREAST | Antimitotic agents | Care and treatment | Antineoplastic agents | Analysis | Melanoma | Cancer
Journal Article