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1. Full Text Amyloid-β precursor protein mediates neuronal toxicity of amyloid β through Go protein activation
by Sola Vigo, Francisco and Kedikian, Gabriela and Heredia, Lorena and Heredia, Florencia and Añel, Alberto Díaz and Rosa, Alberto Luis and Lorenzo, Alfredo
Neurobiology of aging, ISSN 0197-4580, 2007, Volume 30, Issue 9, pp. 1379 - 1392
Neurology | Internal Medicine | Neuronal degeneration | Alzheimer's disease (AD) | Pertussis toxin (PTX) | Amyloid beta (Aβ) | Amyloid-β precursor protein (APP) | Go protein | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Fundamental and applied biological sciences. Psychology | Vertebrates: nervous system and sense organs | Development. Senescence. Regeneration. Transplantation | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Biological and medical sciences | Medical sciences | GTP-Binding Protein alpha Subunits, Gi-Go - genetics | Neurons - pathology | Protein Binding - genetics | Humans | Nerve Degeneration - physiopathology | Nerve Degeneration - genetics | Nerve Degeneration - metabolism | Brain - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Neurons - metabolism | Neurons - drug effects | Pertussis Toxin - pharmacology | Alzheimer Disease - physiopathology | Amyloid beta-Peptides - toxicity | Brain - physiopathology | Cells, Cultured | Rats | Binding Sites - genetics | Hippocampus - metabolism | Animals | Alzheimer Disease - metabolism | Alzheimer Disease - genetics | GTP-Binding Protein alpha Subunits, Gi-Go - metabolism | Hippocampus - physiopathology | Protein Structure, Tertiary - physiology | Index Medicus
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2. Full Text Identification, Localization, and Quantification of Neuronal Cell Membrane Receptors with Plasmonic Probes: Role of Protein Kinase D1 in Their Distribution
by Fraire, Juan C and Masseroni, M. Lujan and Jausoro, Ignacio and Perassi, Eduardo M and Diaz Añel, Alberto M and Coronado, Eduardo A
ACS nano, ISSN 1936-0851, 09/2014, Volume 8, Issue 9, pp. 8942 - 8958
Nanoparticles | Immunolabels | Neurons | Sensing | Bioconjugation | Plasmonics | PKD1 | Neurotransmitter receptors | Sorting | Physical Sciences | Chemistry | Materials Science | Nanoscience & Nanotechnology | Technology | Materials Science, Multidisciplinary | Science & Technology - Other Topics | Chemistry, Multidisciplinary | Chemistry, Physical | Science & Technology | Gold - chemistry | Optical Imaging | Axons - metabolism | Gold - metabolism | Rats | Neurons - cytology | Receptors, Metabotropic Glutamate - metabolism | Protein Transport | Gene Expression Regulation, Enzymologic | Molecular Probes - chemistry | Animals | Molecular Probes - metabolism | Protein Kinase C - metabolism | Cell Membrane - metabolism | Metal Nanoparticles | Index Medicus
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3. Full Text How Do Cytotoxic Lymphocytes Kill Cancer Cells?
by Martínez-Lostao, Luis and Anel, Alberto and Pardo, Julián
Clinical cancer research, ISSN 1078-0432, 11/2015, Volume 21, Issue 22, pp. 5047 - 5056
Life Sciences & Biomedicine | Oncology | Science & Technology | T-Lymphocytes, Cytotoxic - immunology | Neoplasms - therapy | Apoptosis - immunology | Apoptosis - drug effects | Neoplasms - immunology | Humans | Immunotherapy | Killer Cells, Natural - immunology | Programmed Cell Death 1 Receptor - antagonists & inhibitors | CTLA-4 Antigen - antagonists & inhibitors | Cytotoxicity, Immunologic | Index Medicus
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4. Full Text PKCη Is Required for β1γ2/β3γ2- and PKD-Mediated Transport to the Cell Surface and the Organization of the Golgi Apparatus
by Alberto Marcelo Díaz Añel and Vivek Malhotra
The Journal of cell biology, ISSN 0021-9525, 4/2005, Volume 169, Issue 1, pp. 83 - 91
Phosphorylation | Microscopy | Polycystic kidney diseases | HeLa cells | Antibodies | Cell membranes | Physiological regulation | Protein transport | Cells | Golgi apparatus
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5. Full Text Editorial: The Natural Killer Cell Interactome in the Tumor Microenvironment: Basic Concepts and Clinical Application
by Anel, Alberto and Pardo, Julián and Villalba, Martín
Frontiers in immunology, ISSN 1664-3224, 05/2020, Volume 11, pp. 872 - 872
adoptive cell immunotherapy | ovarian cancer | NK cell | NK cell metabolism | off-the-shelf NK cells | checkpoint inhibitors | pediatric tumors | Life Sciences & Biomedicine | Immunology | Science & Technology | Index Medicus | Life Sciences | Innate immunity | Adaptive immunology | Cancer
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6. Full Text Identification of the gene encoding the TATA box-binding protein-associated factor 1 (TAF1) and its putative role in the heat shock response in the protozoan parasite Entamoeba histolytica
by Avendaño-Borromeo, Bartolo and Avendaño-Borromeo, Bartolo and Narayanasamy, Ravi Kumar and Narayanasamy, Ravi Kumar and García-Rivera, Guillermina and García-Rivera, Guillermina and Labra-Barrios, María Luisa and Labra-Barrios, María Luisa and Lagunes-Guillén, Anel E and Lagunes-Guillén, Anel E and Munguía-Chávez, Bibiana and Munguía-Chávez, Bibiana and Castañón-Sánchez, Carlos Alberto and Castañón-Sánchez, Carlos Alberto and Orozco, Esther and Orozco, Esther and Luna-Arias, Juan Pedro and Luna-Arias, Juan Pedro
Parasitology Research, ISSN 0932-0113, 2/2019, Volume 118, Issue 2, pp. 517 - 538
Medical Microbiology | Biomedicine | Immunology | TFllD | Microbiology | Cloning | Heat shock stress | Entamoeba histolytica | TAF1 | Life Sciences & Biomedicine | Parasitology | Science & Technology | Heat shock proteins | Protozoa | Transcription factors | Genetic aspects | Gene expression | Health aspects | Cell proliferation | Shock | Trophozoites | Tertiary structure | Genes | Genomes | C-Terminus | Proteins | TATA-binding protein | Cell growth | TFIID protein | Cell cycle | Protein structure | Tata box | Cytoplasm | Heat shock | Index Medicus
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7. Full Text Protein Kinase D Regulates Trafficking of Dendritic Membrane Proteins in Developing Neurons
by Bisbal, Mariano and Conde, Cecilia and Donoso, Maribel and Bollati, Flavia and Sesma, Juliana and Quiroga, Santiago and Diaz Anel, Alberto and Malhotra, Vivek and Marzolo, Maria Paz and Caceres, Alfredo
The Journal of neuroscience, ISSN 0270-6474, 09/2008, Volume 28, Issue 37, pp. 9297 - 9308
Vesicles | Dendritic membrane proteins | Neurons | PKD1 | Golgi apparatus | Sorting | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Embryo, Mammalian | Microtubule-Associated Proteins - metabolism | Protein Transport - drug effects | trans-Golgi Network - metabolism | Neurons - ultrastructure | Transfection - methods | Time Factors | Neurons - physiology | Neurons - drug effects | Videotape Recording - methods | Dendrites - drug effects | Dendrites - metabolism | Endocytosis - drug effects | RNA, Small Interfering - pharmacology | Cells, Cultured | Gene Expression Regulation - physiology | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Rats | Hippocampus - cytology | Microscopy, Confocal - methods | Receptors, Transferrin - metabolism | Endocytosis - physiology | trans-Golgi Network - drug effects | Gene Expression Regulation - drug effects | Animals | Protein Kinases - physiology | Luminescent Proteins - genetics | Vesicle-Associated Membrane Protein 2 - metabolism | Luminescent Proteins - metabolism | Protein Kinase C | Index Medicus | neurons | dendritic membrane proteins | sorting | vesicles
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8. Full Text Phospholipase C β3 is a key component in the Gβγ/PKCη/ PKD-mediated regulation of trans-Golgi network to plasma membrane transport
by Díaz Añel, Alberto M
Biochemical journal, ISSN 0264-6021, 08/2007, Volume 406, Issue 1, pp. 157 - 165
GTP-binding protein βγ subunits (Gβγ) | Golgi | Phospholipase C (PLC) | Diacylglycerol (DAG) | Protein kinase D (PKD) | Trafficking | HEK-293 cells, human embryonic kidney cells | HEK-293T cells, HEK-293 cells expressing the large T-antigen of SV40 (simian virus 40) | PLC, phospholipase C | NRK cell, normal rat kidney cell | DGK, sn-1,2-diacylglycerol kinase | GPCR, G-protein-coupled receptor | PH domain, pleckstrin homology domain | U73122, 1-(6-{[17-3-methoxyestra-1,3,5-trien-17-yl]amino}hexyl)-1H-pyrrole-2,5-dione | phospholipase C (PLC) | VSV-G, VSV glycoprotein | trafficking | diacylglycerol (DAG) | PA, phosphatidic acid | m-3M3FBS, 2,4,6-trimethyl-N-(m-3-trifluoromethylphenyl)benzenesulfonamide | GFP, green fluorescent protein | GST, glutathione S-transferase | PKC, protein kinase C | VSV, vesicular stomatitis virus | DAG, diacylglycerol | TGN, trans-Golgi network | wt, wild-type | IQ, ilimaquinone | protein kinase D (PKD) | HA, haemagglutinin | siRNA, small interfering RNA | NDGA, nordihydroguaiaretic acid | BFA, Brefeldin A | Gβγ, GTP-binding protein βγ subunits | PI-PLC, phosphatidylinositol-specific PLC | ER, endoplasmic reticulum
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9. Full Text Apoptotic Pathways Are Selectively Activated by Granzyme A and/or Granzyme B in CTL-Mediated Target Cell Lysis
by Julián Pardo and Alberto Bosque and Reina Brehm and Reinhard Wallich and Javier Naval and Arno Müllbacher and Alberto Anel and Markus M. Simon
The Journal of cell biology, ISSN 0021-9525, 11/2004, Volume 167, Issue 3, pp. 457 - 468
T lymphocytes | Cytolysis | Cell death | Cell lines | Viruses | Cultured cells | Cell membranes | Cells | Apoptosis | Tumors | Life Sciences & Biomedicine | Science & Technology | Cell Biology | T-Lymphocytes, Cytotoxic - immunology | Reactive Oxygen Species - metabolism | Serine Endopeptidases - deficiency | Granzymes | Phosphatidylserines - metabolism | Cells, Cultured | Serine Endopeptidases - physiology | T-Lymphocytes, Cytotoxic - enzymology | Mice, Knockout | Membrane Glycoproteins - physiology | Animals | Apoptosis - immunology | Membrane Potentials | Time Factors | Cell Line, Tumor | Mice | Pore Forming Cytotoxic Proteins | Kinetics | Perforin | Cytotoxicity, Immunologic | T cells | Research | Cellular biology | Pathogens | Index Medicus
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10. Full Text Expanded and activated allogeneic NK cells are cytotoxic against B-chronic lymphocytic leukemia (B-CLL) cells with sporadic cases of resistance
by Calvo, Tania and Reina-Ortiz, Chantal and Giraldos, David and Gascon, Maria and Woods, Daniel and Asenjo, Judit and Marco-Brualla, Joaquin and Azaceta, Gemma and Izquierdo, Isabel and Palomera, Luis and Sanchez-Martinez, Diego and Marzo, Isabel and Naval, Javier and Vilches, Carlos and Villalba, Martin and Anel, Alberto
Scientific reports, ISSN 2045-2322, 11/2020, Volume 10, Issue 1, pp. 19398 - 19398
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Disease resistance | Chronic lymphatic leukemia | CD16 antigen | Immunotherapy | PD-L1 protein | Killer cell immunoglobulin-like receptors | Cytotoxicity | Lymphatic leukemia | Natural killer cells | CD56 antigen | Patients | Adoptive transfer | Index Medicus | Life Sciences
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11. Resumen de la 1.a Reunión del Grupo Español de InmunoTerapia (GEIT)
by Anel, Alberto
Inmunología (1987), ISSN 0213-9626, 2014, Volume 33, Issue 2, pp. 60 - 62
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12. Full Text Inhibition of autophagy with chloroquine potentiates carfilzomib-induced apoptosis in myeloma cells in vitro and in vivo
by Jarauta, Vidal and Jaime, Paula and Gonzalo, Oscar and de Miguel, Diego and Ramírez-Labrada, Ariel and Martínez-Lostao, Luis and Anel, Alberto and Pardo, Julián and Marzo, Isabel and Naval, Javier
Cancer letters, ISSN 0304-3835, 2016, Volume 382, Issue 1, pp. 1 - 10
Hematology, Oncology and Palliative Medicine | Carfilzomib | Myeloma | Autophagy | Immunogenic cell death | Apoptosis | Life Sciences & Biomedicine | Oncology | Science & Technology | Proteasome Inhibitors - pharmacology | Apoptosis - drug effects | Humans | Autophagy - drug effects | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Apoptosis Regulatory Proteins - metabolism | Dose-Response Relationship, Drug | Drug Synergism | Xenograft Model Antitumor Assays | Chloroquine - pharmacology | Multiple Myeloma - drug therapy | Multiple Myeloma - pathology | Animals | Signal Transduction - drug effects | Time Factors | Mice, Nude | Calreticulin - metabolism | Cell Line, Tumor | Beclin-1 - metabolism | Multiple Myeloma - enzymology | Oligopeptides - pharmacology | Sequestosome-1 Protein - metabolism | Index Medicus
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13. Full Text Lipid nanoparticles decorated with TNF-related aptosis-inducing ligand (TRAIL) are more cytotoxic than soluble recombinant TRAIL in sarcoma
by Gallego-Lleyda, Ana and De Miguel, Diego and Anel, Alberto and Martinez-Lostao, Luis
International journal of molecular sciences, ISSN 1661-6596, 05/2018, Volume 19, Issue 5, p. 1449
Flavopiridol | TRAIL | Sarcoma | Immunotherapy | Lipid nanoparticles | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Sensitizing | Formulations | Medical research | Biotechnology | Secretion | Clinical trials | Cytotoxicity | Tethering | Radiation therapy | Tumor cell lines | Exosomes | Biological activity | Membrane proteins | Nanoparticles | Proteins | Chemotherapy | Tumor necrosis factor | Surgery | Ligands | TRAIL protein | Apoptosis | Tumors | Cancer | Index Medicus
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