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Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2013, Volume 56, Issue 22, pp. 8972 - 8983
Histone H3 lysine79 (H3K79) methyltransferase DOT1L plays an important role in the activation and maintenance of gene transcription. It is essential for... 
Methyltransferases - chemistry | Animals | Methyltransferases - antagonists & inhibitors | Disease | Enzyme Inhibitors - metabolism | Histones - chemistry | Humans | Methyltransferases - metabolism | Enzyme Inhibitors - pharmacology | Lysine - metabolism | Histones - metabolism | Chemistry, Pharmaceutical
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2013, Volume 56, Issue 22, pp. 8972 - 8983
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 11/2013, Volume 56, Issue 22, pp. 8972 - 8983
Histone H3 lysine79 (H3K79) methyltransferase DOT1L plays an important role in the activation and maintenance of gene transcription. It is essential for... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2016, Volume 113, Issue 7, p. 1778
  Cancer cells reprogram their metabolism to promote growth and proliferation. The genetic evidence pointing to the importance of the amino acid serine in... 
Molecules | Amino acids | Biosynthesis | Metabolism | Cancer | Tumors
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2011, Volume 133, Issue 42, pp. 16746 - 16749
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2019, Volume 116, Issue 13, pp. 6435 - 6440
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 07/2011, Volume 208, Issue 7, pp. 1547 - 1559
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 10/2017, Volume 12, Issue 10, pp. 2671 - 2681
Lipids play critical roles in cell biology, often through direct interactions with proteins. We recently described the use of photoreactive lipid probes... 
CHOLESTEROL | LIPOLYSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REACTIVITY | FAT | SPHINGOSINE | MECHANISMS | DIFFERENTIATION | MODULATION | DISCOVERY | PROBES | Small Molecule Libraries - pharmacology | Lipids - chemistry | Proteins - metabolism | Humans | Mass Spectrometry | Drug Design | HEK293 Cells | Protein Binding | Drug Discovery - methods | Proteomics - methods
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 06/2013, Volume 4, Issue 6, pp. 542 - 546
Mutations in isocitrate dehydrogenase (IDH), a key enzyme in the tricarboxylic acid cycle, have recently been found in similar to 75% glioma and similar to 20%... 
Enzyme inhibition | Gene mutation | Protein crystallography | Isocitrate dehydrogenase | GLIOMAS | protein crystallography | IDH2 MUTATIONS | CHEMISTRY, MEDICINAL | isocitrate dehydrogenase | enzyme inhibition | LEUKEMIA | DIFFERENTIATION | CANCER | 2-HYDROXYGLUTARATE
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2012, Volume 134, Issue 42, pp. 17834 - 17834
Journal Article
The Journal of Experimental Medicine, ISSN 0022-1007, 05/2012, Volume 209, Issue 5, pp. 1051 - 1051
Journal Article
The Journal of Experimental Medicine, ISSN 0022-1007, 07/2011, Volume 208, Issue 7, pp. 1547 - 1559
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2011, Volume 208, Issue 7, pp. 1547 - 1559
Apicomplexa are important pathogens that include the causative agents of malaria, toxoplasmosis, and cryptosporidiosis. Apicomplexan parasites contain a relict... 
Journal Article
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