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Protein engineering, design & selection : PEDS, ISSN 1741-0126, 09/2019
Monoclonal antibody-based therapeutics are an integral part of treatment of different human diseases, and the selection of suitable antibody candidates during... 
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 2217 - 2217
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 01/2015, Volume 56, pp. 66 - 80
Regulatory T cells (Tregs) expressing FOXP3 are essential for the maintenance of self-tolerance and are deficient in many common autoimmune diseases. Immune... 
Autoimmunity | Graft versus host disease | IL-2 fusion proteins | Regulatory T cells | Cytokine therapy
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 1836 - 1836
Abstract Despite the recent advancements in treatment options with the introduction of anti-CD20 monoclonal antibody therapy, approximately 50% of patients... 
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 09/2016, Volume 22, Issue 17, pp. 4417 - 4427
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2018, Volume 24, Issue 19, pp. 4785 - 4797
Purpose: Despite promising clinical activity, T-cell-engaging therapies including T-cell bispecific antibodies (TCB) are associated with severe side effects... 
B-CELL LYMPHOMA | TCB | MODELS | ONCOLOGY | IBRUTINIB | NON-HODGKIN-LYMPHOMA | ANTIBODY | BLINATUMOMAB | COMBINATION | CHEMOTHERAPY
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 03/2016, Volume 57, Issue 3, pp. 467 - 467
Rheumatoid arthritis is an autoimmune disease resulting in chronic synovial inflammation. Molecular imaging could be used to monitor therapy response, thus... 
Journal Article
The Journal of Nuclear Medicine, ISSN 0161-5505, 03/2016, Volume 57, Issue 3, p. 467
  Rheumatoid arthritis is an autoimmune disease resulting in chronic synovial inflammation. Molecular imaging could be used to monitor therapy response, thus... 
Proteins | Nuclear medicine | Rheumatoid arthritis | Collagen | Tomography | Clinical outcomes
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 2592 - 2592
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 2014, Volume 56, pp. 66 - 80
Abstract Regulatory T cells (Tregs) expressing FOXP3 are essential for the maintenance of self-tolerance and are deficient in many common autoimmune diseases.... 
Allergy and Immunology | Autoimmunity | Graft versus host disease | IL-2 fusion proteins | Regulatory T cells | Cytokine therapy | NONHUMAN-PRIMATES | IMMUNITY | LOW-DOSE INTERLEUKIN-2 | RECOMBINANT INTERLEUKIN-2 | IMMUNOLOGY | FOXP3 | THERAPY | PHARMACOKINETICS | EXPANSION | EXPRESSION | IMMUNODEFICIENCY | T-Lymphocyte Subsets - immunology | T-Lymphocytes, Regulatory - metabolism | Eosinophilia - chemically induced | Recombinant Fusion Proteins - pharmacology | Humans | Macaca fascicularis | Male | T-Lymphocytes, Regulatory - immunology | Dose-Response Relationship, Drug | STAT5 Transcription Factor - metabolism | Forkhead Transcription Factors - metabolism | T-Lymphocyte Subsets - drug effects | Female | Interleukin-2 - analogs & derivatives | Phosphorylation - drug effects | Biomarkers - metabolism | Interleukin-2 - metabolism | Interleukin-2 Receptor alpha Subunit - deficiency | CTLA-4 Antigen - metabolism | Recombinant Proteins - pharmacology | Mice, Knockout | Phenotype | T-Lymphocytes, Regulatory - drug effects | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Signal Transduction - drug effects | T-Lymphocyte Subsets - metabolism | Interleukin-2 - pharmacology | Lymphocyte Count | Protein Binding | Mice | Proteins | Epigenetic inheritance | T cells | Immunoglobulin G | Medical genetics | PK, pharmacokinetics | GVHD, graft versus host disease
Journal Article
Journal of Autoimmunity, ISSN 0896-8411, 12/2018, Volume 95, pp. 1 - 14
Susceptibility to multiple autoimmune diseases is associated with common gene polymorphisms influencing IL-2 signaling and T function, making T -specific... 
Autoimmunity | IL-2 mutein | Cytokine therapy | Immunotherapy | Treg expansion | T(reg) expansion | expansion | FOXP3 EXPRESSION | HOMEOSTASIS | STIMULATION | LOW-DOSE INTERLEUKIN-2 | RECEPTOR | SELF | IMMUNOLOGY | EFFECTOR | RESPONSES | T-reg expansion | EXPANSION | TIGIT | Killer cells | T cells | Immunoglobulin G
Journal Article
Science translational medicine, ISSN 1946-6234, 10/2018, Volume 10, Issue 461, p. eaat1445
T cell bispecific antibodies (TCBs) are engineered molecules that include, within a single entity, binding sites to the T cell receptor and to tumor-associated... 
MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR RECEPTOR | CARBOXY-TERMINAL FRAGMENT | METASTASIS | TRASTUZUMAB | IMMUNOTHERAPY | PROTEIN EXPRESSION | CHIMERIC ANTIGEN RECEPTOR | HER2 | BLOOD-BRAIN-BARRIER | T-CELLS | CELL BIOLOGY
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 6, pp. 7162 - 7174
Interleukin-2 (IL2) is a cytokine that can stimulate cytotoxic immune cells to attack infected and malignant cells. Unfortunately, IL2 can also cause serious... 
Peripheral blood mononuclear cells | Animal studies | Interleukin-2 | Positron emission tomography | Activated T lymphocytes
Journal Article
by Holt, R.A and Mani Subramanian, G and Halpern, A and Sutton, G.G and Charlab, R and Nusskern, D.R and Wincker, P and Clark, A.G and Ribeiro, J.M.C and Wides, R and Salzberg, S.L and Loftus, B and Yandell, M and Majoros, W.H and Rusch, D.B and Lai, Z and Kraft, C.L and Abril, J.F and Anthouard, V and Arensburger, P and Atkinson, P.W and Baden, H and de Berardinis, V and Baldwin, D and Benes, V and Biedler, J and Blass, C and Bolanos, R and Boscus, D and Barnstead, M and Cai, S and Center, A and Chatuverdi, K and Christophides, G.K and Chrystal, M.A and Clamp, M and Cravchik, A and Curwen, V and Dana, A and Delcher, A and Dew, I and Evans, C.A and Flanigan, M and Grundschober-Freimoser, A and Friedli, L and Gu, Z and Guan, P and Guigo, R and Hillenmeyer, M.E and Hladun, S.L and Hogan, J.R and Hong, Y.S and Hoover, J and Jaillon, O and Ke, Z and Kodira, C and Kokoza, E and Koutsos, A and Letunic, I and Levitsky, A and Liang, Y and Lin, J.-J and Lobo, N.F and Lopez, J.R and Malek, J.A and McIntosh, T.C and Meister, S and Miller, J and Mobarry, C and Mongin, E and Murphy, S.D and O'Brochta, D.A and Pfannkoch, C and Qi, R and Regier, M.A and Remington, K and Shao, H and Sharakhova, M.V and Sitter, C.D and Shetty, J and Smith, T.J and Strong, R and Sun, J and Thomasova, D and Ton, L.Q and Topalis, P and Tu, Z and Unger, M.F and Walenz, B and Wang, A and Wang, J and Wang, M and Wang, X and Woodford, K.J and Wortman, J.R and Wu, M and Yao, A and Zdobnov, E.M and Zhang, H and Zhao, Q and ...
Science, ISSN 0036-8075, 10/2002, Volume 298, Issue 5591, pp. 129 - 149
Anopheles gambiae is the principal vector of malaria, a disease that afflicts more than 500 million people and causes more than 1 million deaths each year.... 
EVOLUTION | DROSOPHILA-MELANOGASTER | FAMILIES | MULTIDISCIPLINARY SCIENCES | TRANSPOSABLE ELEMENTS | RESISTANCE | INCIPIENT SPECIATION | LOCI | DIFFERENTIATION | IDENTIFICATION | REFRACTORINESS | Enzymes - chemistry | Haplotypes | Transcription Factors - chemistry | Species Specificity | Anopheles - genetics | Humans | Molecular Sequence Data | Chromosome Inversion | Drosophila melanogaster - genetics | Mosquito Control | Blood | Genetic Variation | Malaria, Falciparum - transmission | Enzymes - genetics | Chromosomes, Artificial, Bacterial | Enzymes - metabolism | Expressed Sequence Tags | Genes, Insect | Transcription Factors - physiology | Insect Proteins - physiology | Anopheles - parasitology | Physical Chromosome Mapping | Computational Biology | Gene Expression Regulation | Insect Proteins - genetics | Feeding Behavior | Proteome | Digestion | Transcription Factors - genetics | Sequence Analysis, DNA | Anopheles - physiology | DNA Transposable Elements | Anopheles - classification | Biological Evolution | Animals | Insect Vectors - genetics | Insect Vectors - physiology | Insect Proteins - chemistry | Insect Vectors - parasitology | Polymorphism, Single Nucleotide | Plasmodium falciparum - growth & development | Genome | Anopheles | Genomes | Genetic aspects | Research | Malaria | Mosquitoes | Disease control | Genomics
Journal Article
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 06/2019, Volume 11, Issue 496, p. eaav5989
Endogenous costimulatory molecules on T cells such as 4-1BB (CD137) can be leveraged for cancer immunotherapy. Systemic administration of agonistic anti-4-1BB... 
PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | IGG | COSTIMULATION | ANTI-CD137 | CARCINOEMBRYONIC ANTIGEN | INDUCTION | MODEL | LYMPHOCYTES | CELL BIOLOGY
Journal Article