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Science, ISSN 0036-8075, 1/2012, Volume 335, Issue 6065, pp. 229 - 232
Innate immune responses are vital for pathogen defense but can result in septic shock when excessive. A key mediator of septic shock is tumor necrosis factor-α... 
Pathology | Splenocytes | Liver | REPORTS | Septic shock | Innate immunity | Immunoblotting | Infections | Gene expression regulation | Cellular immunity | Research universities | RHEUMATOID-ARTHRITIS | CELLS | MONOCYTOGENES | DISINTEGRIN | METALLOPROTEINASE | MULTIDISCIPLINARY SCIENCES | NECROSIS-FACTOR-ALPHA | MICE | INFECTION | MATURATION | FAMILY | ADAM17 Protein | Tumor Necrosis Factor-alpha - metabolism | Tumor Necrosis Factor-alpha - blood | Tumor Necrosis Factor-alpha - genetics | Molecular Sequence Data | Listeria monocytogenes - immunology | Shock, Septic - immunology | Lipopolysaccharides - immunology | Shock, Septic - metabolism | Base Sequence | Gene Deletion | Listeriosis - immunology | Carrier Proteins - chemistry | Cell Membrane - metabolism | Listeria monocytogenes - physiology | B-Lymphocytes - metabolism | Macrophages - immunology | Amino Acid Sequence | Cell Line | Listeriosis - metabolism | Macrophages, Peritoneal - immunology | Spleen - cytology | Immunity, Innate | Protein Transport | Carrier Proteins - genetics | ADAM Proteins - metabolism | Macrophages - metabolism | Animals | B-Lymphocytes - immunology | Carrier Proteins - metabolism | Macrophages, Peritoneal - microbiology | Listeriosis - pathology | Listeriosis - microbiology | Mice | ADAM Proteins - genetics | Macrophages, Peritoneal - metabolism | Prevention | Immune response | Listeria | Properties | Tumor necrosis factor
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 27, pp. 12186 - 12191
Journal Article
Genes and Development, ISSN 0890-9369, 10/2008, Volume 22, Issue 19, pp. 2677 - 2691
Journal Article
Genes and Development, ISSN 0890-9369, 03/2010, Volume 24, Issue 6, pp. 549 - 560
Journal Article
Science, ISSN 0036-8075, 2/2000, Volume 287, Issue 5455, pp. 1040 - 1046
Phosphoinositide 3-kinases (PI3Ks) regulate fundamental cellular responses such as proliferation, apoptosis, cell motility, and adhesion. Viable gene-targeted... 
T lymphocytes | Spleen | Receptors | Thymocytes | B lymphocytes | Neutrophils | Cell lines | Reports | Mice | Chemotaxis | Apoptosis | SYSTEM | INHIBITION | PI3K | 3-KINASE | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | KINASE | WORTMANNIN | PEPTIDE
Journal Article
Nature Immunology, ISSN 1529-2908, 09/2003, Volume 4, Issue 9, pp. 899 - 906
Journal Article
Nature, ISSN 0028-0836, 04/2002, Volume 416, Issue 6882, pp. 750 - 756
Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns, and members of the pro-inflammatory interleukin-1 receptor (IL-1R) family,... 
RESPONSES | SIGNALING PATHWAYS | PROTEIN | GENE | MULTIDISCIPLINARY SCIENCES | KINASE | ADAPTER | MYD88 | DEFICIENCY | FAMILY | MEMBER | Protein Kinases - metabolism | Protein Kinases - genetics | Membrane Glycoproteins - metabolism | Staphylococcus aureus - physiology | Interleukin-1 Receptor-Associated Kinases | NF-kappa B - metabolism | Interleukin-1 - biosynthesis | Toll-Like Receptors | Gene Deletion | JNK Mitogen-Activated Protein Kinases | Killer Cells, Natural - immunology | Lymphocytic choriomeningitis virus - physiology | Protein Kinases - deficiency | Arenaviridae Infections - immunology | p38 Mitogen-Activated Protein Kinases | B-Lymphocytes - metabolism | Macrophages - immunology | Staphylococcal Infections - metabolism | Drosophila Proteins | Staphylococcal Infections - immunology | Cells, Cultured | Receptors, Cell Surface - metabolism | Interleukin-1 - pharmacology | Receptors, Interleukin-1 - metabolism | B-Lymphocytes - drug effects | Immunity, Innate - immunology | Tumor Necrosis Factor-alpha - pharmacology | Interferon-gamma - analysis | Macrophages - metabolism | Animals | B-Lymphocytes - immunology | Signal Transduction - drug effects | Arenaviridae Infections - metabolism | Lipopolysaccharides - pharmacology | Interleukin-6 - biosynthesis | Ligands | Macrophages - drug effects | Killer Cells, Natural - drug effects | Mice | Nitric Oxide - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | Mitogen-Activated Protein Kinases - metabolism | Proteins | Molecules | Genes | Rodents | Cells | Medical immunity
Journal Article
Journal Article
Nature, ISSN 0028-0836, 01/1999, Volume 397, Issue 6717, pp. 315 - 323
Journal Article
Nature, ISSN 0028-0836, 01/2001, Volume 409, Issue 6816, pp. 105 - 109
Journal Article
Immunity, ISSN 1074-7613, 06/2000, Volume 12, Issue 6, pp. 633 - 642
Journal Article