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Journal Article
Science, ISSN 0036-8075, 11/2009, Volume 326, Issue 5957, pp. 1231 - 1235
Loss-of-function genetic screens in model organisms have elucidated numerous biological processes, but the diploid genome of mammalian cells has precluded... 
Haploidy | B lymphocytes | Genes | Cell lines | Medical genetics | Cell cycle | HeLa cells | Toxins | Genetic screening | Human genetics | Research Article | TARGET | PROTEIN | ADP-RIBOSYLATING TOXINS | DIPHTHAMIDE | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | INFLUENZA | RECEPTOR | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | DIPHTHERIA-TOXIN | ADP Ribose Transferases - toxicity | Histidine - analogs & derivatives | Genetic Testing | Humans | N-Acylneuraminate Cytidylyltransferase - genetics | Adenosine Diphosphate Ribose - metabolism | Bacterial Toxins - toxicity | Molecular Sequence Data | Diphtheria Toxin - toxicity | N-Acylneuraminate Cytidylyltransferase - metabolism | Exotoxins - metabolism | Antigens, Bacterial - toxicity | Monosaccharide Transport Proteins - metabolism | ADP Ribose Transferases - metabolism | Monosaccharide Transport Proteins - genetics | Virulence Factors - toxicity | Amino Acid Sequence | Histidine - biosynthesis | Influenza A Virus, H1N1 Subtype - pathogenicity | Biosynthetic Pathways | Diphtheria Toxin - metabolism | Host-Pathogen Interactions | Proteins - genetics | Bacterial Toxins - metabolism | Proteins - metabolism | Cell Line, Tumor | Exotoxins - toxicity | Virulence Factors - metabolism | Mutagenesis, Insertional | Proteins - chemistry | Antigens, Bacterial - metabolism | Peptide Elongation Factor 2 - metabolism | Research | Mutagenesis | Methods | Testing | Models | Cellular biology | Medical screening | Genomics | Influenza | Index Medicus
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 10/2018, Volume 62, Issue 10
APX001 is a first-in-class, intravenous and orally available, broadspectrum antifungal agent in clinical development for the treatment of life-threatening... 
Efficacy | 1-aminobenzotriazole | APX001 | Pharmacokinetics | Candida | APX001A | VITRO ACTIVITY | GLABRATA | MICAFUNGIN | MECHANISM | E1210 | MICROBIOLOGY | BROAD-SPECTRUM ANTIFUNGAL | COMBINATION | efficacy | INHIBITION | pharmacokinetics | PHARMACOLOGY & PHARMACY | BROTH MICRODILUTION METHODS | ALBICANS
Journal Article
Journal of the American Academy of Child & Adolescent Psychiatry, ISSN 0890-8567, 2016, Volume 55, Issue 4, pp. 310 - 318.e4
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2018, Volume 57, Issue 1, p. 348
The spread of antibiotic resistance is a major challenge for the treatment of Mycobacterium tuberculosis infections. In addition, the efficacy of drugs is... 
Enzymes | Drug resistance in microorganisms | Tuberculosis | Metabolites | Cell death | Physiological aspects | Hydrolases | Biosynthesis | Permeability | Antibacterial agents | Drugs | Antibiotics | Acids | Serine | Antibiotic resistance | Proteomics | Bactericidal activity | Lactones
Journal Article
Journal of Materials Chemistry B, ISSN 2050-7518, 2019, Volume 7, Issue 1, pp. 65 - 79
The combination of chemotherapy and photodynamic therapy (chemo-PDT) has been suggested as an alternative therapy for drug-resistant cancers. In this study,... 
IN-VITRO | MATERIALS SCIENCE, BIOMATERIALS | ACID | RESISTANCE | CANCER | CARRIER | DELIVERY
Journal Article
Journal of Liposome Research, ISSN 0898-2104, 01/2019, Volume 29, Issue 1, pp. 44 - 52
Resistance to chemotherapy is a key factor in the inefficacy of various forms of treatments for cancer. In the present study, chemo-resistant proteins,... 
Liposome | clusterin | siRNA | cancer stem cells | drug delivery | GRP 78 | DRUG | VITRO | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOXORUBICIN | CAMPTOTHECIN | NANOSTRUCTURED LIPID CARRIERS | PHARMACOLOGY & PHARMACY | MULTIDRUG-RESISTANCE | TOPOISOMERASE-I INHIBITORS | Index Medicus
Journal Article
Journal Article
Translational Psychiatry, ISSN 2158-3188, 12/2018, Volume 8, Issue 1, pp. 191 - 10
Obsessive-compulsive disorder (OCD) is a heritable childhood-onset psychiatric disorder that may represent the extreme of obsessive-compulsive (OC) traits that... 
ETIOLOGY | METAANALYSIS | CHILD-BEHAVIOR CHECKLIST | SYMPTOM DIMENSIONS | PSYCHIATRY | DISORDER SYMPTOMS | ADOLESCENTS | SCALE | ENVIRONMENTAL CONTRIBUTIONS | TWIN | FAMILY | Genetic research | Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 03/2014, Volume 10, Issue 3
  Unlike most bacterial species, Mycobacterium tuberculosis depends on the Clp proteolysis system for survival even in in vitro conditions. We hypothesized... 
Proteins | Studies | Tuberculosis | Plasmids | Proteomics | Bacteria | Data processing | Regulation | Experiments
Journal Article
by McRae, Jeremy F and Clayton, Stephen and Fitzgerald, Tomas W and Kaplanis, Joanna and Prigmore, Elena and Rajan, Diana and Sifrim, Alejandro and Aitken, Stuart and Akawi, Nadia and Alvi, Mohsan and Ambridge, Kirsty and Barrett, Daniel M and Bayzetinova, Tanya and Jones, Philip and Jones, Wendy D and King, Daniel and Krishnappa, Netravathi and Mason, Laura E and Singh, Tarjinder and Tivey, Adrian R and Ahmed, Munaza and Anjum, Uruj and Archer, Hayley and Armstrong, Ruth and Awada, Jana and Balasubramanian, Meena and Banka, Siddharth and Baralle, Diana and Barnicoat, Angela and Batstone, Paul and Baty, David and Bennett, Chris and Berg, Jonathan and Bernhard, Birgitta and Bevan, A. Paul and Bitner-Glindzicz, Maria and Blair, Edward and Blyth, Moira and Bohanna, David and Bourdon, Louise and Bourn, David and Bradley, Lisa and Brady, Angela and Brent, Simon and Brewer, Carole and Brunstrom, Kate and Bunyan, David J and Burn, John and Canham, Natalie and Castle, Bruce and Chandler, Kate and Chatzimichali, Elena and Cilliers, Deirdre and Clarke, Angus and Clasper, Susan and Clayton-Smith, Jill and Clowes, Virginia and Coates, Andrea and Cole, Trevor and Colgiu, Irina and Collins, Amanda and Collinson, Morag N and Connell, Fiona and Cooper, Nicola and Cox, Helen and Cresswell, Lara and Cross, Gareth and Crow, Yanick and D'Alessandro, Mariella and Dabir, Tabib and Davidson, Rosemarie and Davies, Sally and De Vries, Dylan and Dean, John and Deshpande, Charu and Devlin, Gemma and Dixit, Abhijit and Dobbie, Angus and Donaldson, Alan and Donnai, Dian and Donnelly, Deirdre and Donnelly, Carina and Douglas, Angela and Douzgou, Sofia and Duncan, Alexis and Eason, Jacqueline and Ellard, Sian and Ellis, Ian and Elmslie, Frances and Evans, Karenza and Everest, Sarah and Fendick, Tina and Fisher, Richard and Flinter, Frances and Foulds, Nicola and Fry, Andrew and Fryer, Alan and Gardiner, Carol and Gaunt, Lorraine and Ghali, Neeti and ... and Deciphering Developmental Disorders Study
Nature, ISSN 0028-0836, 02/2017, Volume 542, Issue 7642, pp. 433 - 438
The genomes of individuals with severe, undiagnosed developmental disorders are enriched in damaging de novo mutations (DNMs) in developmentally important... 
INTELLECTUAL DISABILITY | METAANALYSIS | VARIANTS | GENETICS | HEART-DEFECTS | MULTIDISCIPLINARY SCIENCES | GENES | SEQUENCE | FRAMEWORK | DISCOVERY | GENOME | Prevalence | Humans | Middle Aged | Parents | Male | Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics | Developmental Disabilities - genetics | Casein Kinase II - genetics | Autoantigens - genetics | Young Adult | ras GTPase-Activating Proteins - genetics | Adult | Female | Child | CDC2 Protein Kinase - genetics | Histone-Lysine N-Methyltransferase - genetics | Repressor Proteins - genetics | Sex Characteristics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mutation - genetics | Nerve Tissue Proteins - genetics | Sequence Analysis, DNA | Homeodomain Proteins - genetics | DEAD-box RNA Helicases - genetics | Exome - genetics | Phenotype | Myeloid-Lymphoid Leukemia Protein - genetics | Adolescent | Heredity - genetics | Protein Phosphatase 2C - genetics | Cohort Studies | Child development deviations | Genetic aspects | Genetic disorders | Developmental disabilities | Distribution | Genes | Families & family life | Births | Genomes | Mutation | Causality | Estimates | Age | Index Medicus | TRIO | MYT1L | EHMT1 | HNRNPU | SUV420H1 | COL4A3BP | SYNGAP1 | PPP2R1A | POGZ | EP300 | KCNH1 | SCN1A | MEF2C | CDKL5 | CSNK2A1 | DYRK1A | CASK | ALG13 | FOXP1 | KAT6B | TBL1XR1 | KAT6A | SCN8A | KCNQ2 | EEF1A2 | KCNQ3 | ADNP | PhenIcons | SET | KMT2A | ANKRD11 | STXBP1 | FOXG1 | ZC4H2 | ITPR1 | De novo mutation | Seizures | ZBTB18 | CREBBP | SMAD4 | PDHA1 | IQSEC2 | AUTS2 | BCL11A | BRAF | SMARCA2 | GRIN2B | MED13L | GNAO1 | CNOT3 | TCF4 | SCN2A | CDK13 | GABRB3 | SETD5 | KDM5B | Developmental Disease | DDX3X | CHD8 | PTEN | CHD4 | TCF20 | CTCF | CHD2 | WDR45 | SLC6A1 | MECP2 | CHAMP1 | KIF1A | Average Faces | MSL3 | PPP2R5D | SMC1A | ARID1B | DNM1 | CNKSR2 | PACS1 | WAC | ZMYND11 | AHDC1 | NFIX | SATB2 | HDAC8 | PPM1D | GNAI1 | PURA | PUF60 | NSD1 | Intellectual Disability | SLC35A2 | DYNC1H1 | NAA10 | USP9X | PTPN11 | GATAD2B | ASXL1 | KANSL1 | ASXL3 | CTNNB1 | QRICH1
Journal Article