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Archiv der Pharmazie, ISSN 0365-6233, 12/2017, Volume 350, Issue 12
Journal Article
Archiv der Pharmazie, ISSN 0365-6233, 12/2017, Volume 350, Issue 12, p. 1700258
Journal Article
MOLECULES, ISSN 1420-3049, 06/2019, Volume 24, Issue 12, p. 2331
Journal Article
Journal Article
Molbank, ISSN 1422-8599, 02/2019, Volume 2019, Issue 1, p. M1048
The title compound N1-{4-[2-(methylthio)-1H-imidazol-5-yl]pyridin-2-yl}benzene-1,4-diamine (2) was synthesized via nucleophilic aromatic substitution of... 
single crystal diffraction | kinase inhibitor | c-Jun N-terminal kinase 3 | pyridinylimidazole | heterocycle | JNK3
Journal Article
Analytical Biochemistry, ISSN 0003-2697, 06/2016, Volume 503, p. 28
Two fluorescein-labeled pyridinylimidazoles were synthesized and evaluated as probes for the binding affinity determination of potential kinase inhibitors to... 
Fluorescence | Enzymes | Protein kinases | Mitogens | Fluorescein | Proteins | Dimethylformamide | Ionization | Mass spectrometry | High performance liquid chromatography | Adenosine triphosphate
Journal Article
by Fechner, Uli and de Graaf, Chris and Torda, Andrew E and Güssregen, Stefan and Evers, Andreas and Matter, Hans and Hessler, Gerhard and Richmond, Nicola J and Schmidtke, Peter and Segler, Marwin H. S and Waller, Mark P and Pleik, Stefanie and Shea, Joan-Emma and Levine, Zachary and Mullen, Ryan and van den Broek, Karina and van den Broek, Karina and Epple, Matthias and Kuhn, Hubert and Truszkowski, Andreas and Zielesny, Achim and Fraaije, Johannes (Hans) and Gracia, Ruben Serral and Kast, Stefan M and Bulusu, Krishna C and Bender, Andreas and Yosipof, Abraham and Nahum, Oren and Senderowitz, Hanoch and Krotzky, Timo and Schulz, Robert and Wolber, Gerhard and Bietz, Stefan and Rarey, Matthias and Rarey, Matthias and Zimmermann, Markus O and Lange, Andreas and Ruff, Manuel and Heidrich, Johannes and Onlia, Ionut and Exner, Thomas E and Boeckler, Frank M and Boeckler, Frank M and Bermudez, Marcel and Firaha, Dzmitry S and Hollóczki, Oldamur and Kirchner, Barbara and Tautermann, Christofer S and Volkamer, Andrea and Eid, Sameh and Turk, Samo and Rippmann, Friedrich and Fulle, Simone and Saleh, Noureldin and Saladino, Giorgio and Gervasio, Francesco L and Haensele, Elke and Banting, Lee and Whitley, David C and Oliveira Santos, Jana Sopkova-de and Bureau, Ronan and Clark, Timothy and Sandmann, Achim and Lanig, Harald and Kibies, Patrick and Heil, Jochen and Hoffgaard, Franziska and Frach, Roland and Engel, Julian and Smith, Steven and Basu, Debjit and Rauh, Daniel and Kohlbacher, Oliver and Essex, Jonathan W and Bodnarchuk, Michael S and Ross, Gregory A and Finkelmann, Arndt R and Göller, Andreas H and Schneider, Gisbert and Husch, Tamara and Schütter, Christoph and Balducci, Andrea and Korth, Martin and Ntie-Kang, Fidele and Ntie-Kang, Fidele and Ntie-Kang, Fidele and Günther, Stefan and Sippl, Wolfgang and Mbaze, Luc Meva’a and Simoben, Conrad V and Lifongo, Lydia L and Judson, Philip and Barilla, Jiří and Lokajíček, Miloš V and Pisaková, Hana and Simr, Pavel and Kireeva, Natalia and Petrov, Alexandre and Ostroumov, Denis and Solovev, Vitaly P and ...
Journal of Cheminformatics, ISSN 1758-2946, 4/2016, Volume 8, Issue S1, pp. 1 - 27
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2019, Volume 175, p. 309
Compounds simultaneously inhibiting two targets that are involved in the progression of the same complex disease may exhibit additive or even synergistic... 
Nervous system diseases | Synthesis | Glycogen | Molecular dynamics | Development and progression | Alzheimer's disease | Mitogens | Protein kinases
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2019, Volume 175, pp. 309 - 329
Compounds simultaneously inhibiting two targets that are involved in the progression of the same complex disease may exhibit additive or even synergistic... 
Pyridinylimidazoles | p38α MAP kinase | Kinase inhibitors | Alzheimer's disease | Glycogen synthase kinase 3β | Dual inhibitors | Glycogen synthase kinase 3 beta | CHEMISTRY, MEDICINAL | ASSAY | p38 alpha MAP kinase | SYNAPTIC DYSFUNCTION | P38-ALPHA MAPK | IMIDAZOLES | IDENTIFICATION | P38 MAP KINASE | PREDICTION | MOLECULES | CYTOKINE UP-REGULATION | OPTIMIZATION
Journal Article
by Fechner, Uli and de Graaf, Chris and Torda, Andrew E and Gussregen, Stefan and Evers, Andreas and Matter, Hans and Hessler, Gerhard and Richmond, Nicola J and Schmidtke, Peter and Segler, Marwin H. S and Waller, Mark P and Pleik, Stefanie and Shea, Joan-Emma and Levine, Zachary and Mullen, Ryan and van den Broek, Karina and Epple, Matthias and Kuhn, Hubert and Truszkowski, Andreas and Zielesny, Achim and Fraaije, Johannes (Hans) and Gracia, Ruben Serral and Kast, Stefan M and Bulusu, Krishna C and Bender, Andreas and Yosipof, Abraham and Nahum, Oren and Senderowitz, Hanoch and Krotzky, Timo and Schulz, Robert and Wolber, Gerhard and Bietz, Stefan and Rarey, Matthias and Zimmermann, Markus O and Lange, Andreas and Ruff, Manuel and Heidrich, Johannes and Onlia, Ionut and Exner, Thomas E and Boeckler, Frank M and Bermudez, Marcel and Firaha, Dzmitry S and Holloczki, Oldamur and Kirchner, Barbara and Tautermann, Christofer S and Volkamer, Andrea and Eid, Sameh and Turk, Samo and Rippmann, Friedrich and Fulle, Simone and Saleh, Noureldin and Saladino, Giorgio and Gervasio, Francesco L and Haensele, Elke and Banting, Lee and Whitley, David C and Oliveira Santos, Jana Sopkova-de and Bureau, Ronan and Clark, Timothy and Sandmann, Achim and Lanig, Harald and Kibies, Patrick and Heil, Jochen and Hoffgaard, Franziska and Frach, Roland and Engel, Julian and Smith, Steven and Basu, Debjit and Rauh, Daniel and Kohlbacher, Oliver and Essex, Jonathan W and Bodnarchuk, Michael S and Ross, Gregory A and Finkelmann, Arndt R and Goller, Andreas H and Schneider, Gisbert and Husch, Tamara and Schutter, Christoph and Balducci, Andrea and Korth, Martin and Ntie-Kang, Fidele and Gunther, Stefan and Sippl, Wolfgang and Mbaze, Luc Meva'a and Simoben, Conrad V and Lifongo, Lydia L and Judson, Philip and Barilla, JiAi and Lokajicek, MiloA V and Pisakova, Hana and Simr, Pavel and Kireeva, Natalia and Petrov, Alexandre and Ostroumov, Denis and Solovev, Vitaly P and Pervov, Vladislav S and Friedrich, Nils-Ole and Sommer, Kai and Kirchmair, Johannes and Proschak, Eugen and ...
Journal of Cheminformatics, ISSN 1758-2946, 04/2016, Volume 8, Issue 1
Journal Article
ACS MEDICINAL CHEMISTRY LETTERS, ISSN 1948-5875, 10/2019, Volume 10, Issue 10, pp. 1407 - 1414
Glycogen synthase kinase-3 beta (GSK3 beta) is involved in many pathological conditions and represents an attractive drug target. We previously reported dual... 
tautomerism | quantum mechanics | DESIGN | CHEMISTRY, MEDICINAL | glycogen synthase kinase-3 beta | molecular dynamics simulation | GLYCOGEN-SYNTHASE KINASE-3 | GSK-3 INHIBITION | Protein kinase inhibitors | pyridinylimidazoles | DISCOVERY
Journal Article
Molecules (Basel, Switzerland), 06/2019, Volume 24, Issue 12
Glycogen synthase kinase-3β (GSK-3β) represents a relevant drug target for the treatment of neurodegenerative pathologies including Alzheimer's disease. We... 
Journal Article
IUCrData, ISSN 2414-3146, 05/2016, Volume 1, Issue 5, p. x160840
The title compound, which crystallized as a methanol monosolvate, C41H27FN6O5S·CH3OH, was synthesized as a probe for a fluorescence polarization-based... 
fluorescein | crystal structure | pyridinylimidazole | thiourea
Journal Article
ACS Omega, ISSN 2470-1343, 07/2018, Volume 3, Issue 7, pp. 7809 - 7831
Starting from known p38α mitogen-activated protein kinase (MAPK) inhibitors, a series of inhibitors of the c-Jun N-terminal kinase (JNK) 3 was obtained.... 
P38 MAP-KINASES | DESIGN | ASSAY | JNK | TARGETS | INHIBITORS | IMIDAZOLES | BINDING SITE | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY
Journal Article
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