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Lancet, The, ISSN 0140-6736, 2017, Volume 389, Issue 10073, pp. 1011 - 1024
Summary Background The ESPAC-3 trial showed that adjuvant gemcitabine is the standard of care based on similar survival to and less toxicity than adjuvant... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | THERAPY | ADENOCARCINOMA | CHEMORADIOTHERAPY | FOLINIC ACID | MODEL | CHEMOTHERAPY | Capecitabine - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Carcinoma, Pancreatic Ductal - surgery | Antimetabolites, Antineoplastic - administration & dosage | Pancreatic Neoplasms - drug therapy | Aged, 80 and over | Adult | Carcinoma, Pancreatic Ductal - mortality | Deoxycytidine - adverse effects | Female | Pancreatic Neoplasms - mortality | Chemotherapy, Adjuvant | Deoxycytidine - administration & dosage | Pancreatic Neoplasms - surgery | Kaplan-Meier Estimate | Treatment Outcome | Carcinoma, Pancreatic Ductal - drug therapy | Capecitabine - adverse effects | Antimetabolites, Antineoplastic - adverse effects | Aged | Deoxycytidine - analogs & derivatives | Antimitotic agents | Cancer patients | Care and treatment | Pancreatic cancer | Clinical trials | Product development | Metastasis | Comparative analysis | Antineoplastic agents | Studies | Antigens | Chemotherapy | Acids | Pragmatism | Pharmaceutical industry | Cancer therapies | Abdomen | Clinical Medicine | Medical and Health Sciences | Cancer and Oncology | Klinisk medicin | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2014, Volume 15, Issue 8, pp. 829 - 840
Summary Background We aimed to assess the efficacy and safety of sequential or simultaneous telomerase vaccination (GV1001) in combination with chemotherapy in... 
Hematology, Oncology and Palliative Medicine | COLONY-STIMULATING FACTOR | ONCOLOGY | DUCTAL ADENOCARCINOMA | IMMUNOTHERAPY | METAANALYSES | SUPPRESSOR-CELLS | RESISTANT PROSTATE-CANCER | T-CELLS | CHEMOTHERAPY | IPILIMUMAB | TUMOR-ANTIGEN | Cell Proliferation | Capecitabine | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Fatigue - chemically induced | Pain - chemically induced | Pancreatic Neoplasms - drug therapy | Fluorouracil - administration & dosage | Female | Neutropenia - chemically induced | Granulocyte-Macrophage Colony-Stimulating Factor - administration & dosage | Fluorouracil - analogs & derivatives | Cancer Vaccines - administration & dosage | Deoxycytidine - administration & dosage | Pancreatic Ducts | Pancreatic Neoplasms - pathology | Peptide Fragments - administration & dosage | Immunologic Factors - administration & dosage | Kaplan-Meier Estimate | Cancer Vaccines - adverse effects | Adenocarcinoma - drug therapy | Adenocarcinoma - secondary | Telomerase - administration & dosage | Disease-Free Survival | Telomerase - adverse effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Intention to Treat Analysis | T-Lymphocytes - immunology | Aged | Peptide Fragments - adverse effects | Deoxycytidine - analogs & derivatives | Care and treatment | Chemotherapy | Hospitals | Gemcitabine | Peptides | Pancreatic cancer | Vaccination | Product development | Vaccines | Metastasis | Telomerase | Cancer
Journal Article
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 8, pp. 967 - 978
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2010, Volume 362, Issue 14, pp. 1273 - 1281
Journal Article
Development (Cambridge), ISSN 0950-1991, 05/2018, Volume 145, Issue 9, pp. dev156018 - dev156018
Journal Article
Journal Article
BMC Cancer, ISSN 1471-2407, 11/2012, Volume 12, Issue 1, pp. 536 - 536
Background: A Phase I dose escalation first in man study assessed maximum tolerated dose (MTD), dose-limiting toxicity (DLT) and recommended Phase II dose of... 
Phase I study | Pharmacodynamics | Topoisomerase-I inhibitor | Pharmacokinetics | Pharmacogenomics | Safety profile | CPT-11 | DNA-DAMAGE | CANCER | TRIAL | INHIBITION | ONCOLOGY | IRINOTECAN | Neoplasms - metabolism | Area Under Curve | Dipeptides - pharmacokinetics | Humans | Middle Aged | Male | Metabolic Clearance Rate | Dose-Response Relationship, Drug | Glucuronosyltransferase - genetics | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Neoplasms - genetics | Adult | Female | Molecular Structure | Topoisomerase I Inhibitors - pharmacokinetics | Aldehyde Oxidase - genetics | Cytochrome P-450 CYP2D6 - genetics | Pharmacogenetics - methods | Dipeptides - therapeutic use | Dipeptides - adverse effects | Heterocyclic Compounds, 4 or More Rings - chemistry | Heterocyclic Compounds, 4 or More Rings - adverse effects | Treatment Outcome | Thrombocytopenia - chemically induced | Dipeptides - chemistry | Neoplasms - drug therapy | Polymorphism, Genetic | Prodrugs - adverse effects | Topoisomerase I Inhibitors - adverse effects | Heterocyclic Compounds, 4 or More Rings - pharmacokinetics | Prodrugs - pharmacokinetics | Topoisomerase I Inhibitors - therapeutic use | Aged | Prodrugs - therapeutic use | DNA Damage | Infusions, Intravenous | Prodrugs | Research | Health aspects | Analysis | Tumors | Medical research | Care and treatment | Pharmacogenetics | Metabolites | Cytochrome P-450 | Medicine, Experimental | Genetic polymorphisms
Journal Article
JAMA, ISSN 0098-7484, 07/2012, Volume 308, Issue 2, pp. 147 - 156
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 02/2014, Volume 32, Issue 6, pp. 504 - 512
Journal Article
BMC Cancer, ISSN 1471-2407, 10/2016, Volume 16, Issue 1, p. 779
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 10/2019, Volume 9, Issue 1, pp. 1 - 14
The neuronal ceroid lipofuscinoses (NCLs) are a group of fatal, monogenic neurodegenerative disorders with an early onset in infancy or childhood. Despite... 
THIOESTERASE-1 | HOMEOSTASIS | ACTIVATION | SIGNALING PATHWAY | TERMINALS | MULTIDISCIPLINARY SCIENCES | GROWTH | RECEPTOR | AUTOPHAGY | CLN7/MFSD8 | MOUSE MODELS | Proteins | Neuronal ceroid lipofuscinosis | Children | Neurodegenerative diseases
Journal Article