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The FEBS Journal, ISSN 1742-464X, 08/2017, Volume 284, Issue 15, pp. 2378 - 2395
The molecular chaperone heat shock protein 90 (Hsp90α) regulates cell proteostasis and mitigates the harmful effects of endogenous and exogenous stressors on... 
Hsp90α | double‐strand break | 17 | DNA | AAG | damage response | ATM | NBN | ionizing radiation | H2AX | DNA damage response | 17-AAG | DNA double-strand break | CANCER-CELLS | DEPENDENT PHOSPHORYLATION | GENOTOXIC STRESS | MRE11 COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | Hsp90 alpha | HISTONE H2AX | HEAT-SHOCK-PROTEIN | HSP90 INHIBITORS | DAMAGE RESPONSE | CELL-CYCLE | IONIZING-RADIATION | Nijmegen Breakage Syndrome - pathology | Ataxia Telangiectasia Mutated Proteins - metabolism | Checkpoint Kinase 2 - chemistry | Humans | Checkpoint Kinase 1 - chemistry | DNA Breaks, Double-Stranded | Cell Cycle Proteins - chemistry | Checkpoint Kinase 2 - metabolism | Proteasome Endopeptidase Complex - drug effects | Ubiquitination - drug effects | Protein Processing, Post-Translational - drug effects | RNA Interference | Gene Deletion | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Cell Cycle Proteins - genetics | HSP90 Heat-Shock Proteins - chemistry | Phosphorylation - drug effects | Nuclear Proteins - genetics | DNA Repair - drug effects | Ataxia Telangiectasia Mutated Proteins - chemistry | Nijmegen Breakage Syndrome - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Nuclear Proteins - metabolism | Lactams, Macrocyclic - pharmacology | Nuclear Proteins - chemistry | Nijmegen Breakage Syndrome - genetics | Benzoquinones - pharmacology | Checkpoint Kinase 1 - metabolism | Point Mutation | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Models, Biological | Protein Stability - drug effects | HSP90 Heat-Shock Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins - genetics | Cell Line, Transformed | Protein Multimerization - drug effects | Amino Acid Substitution | Biotechnology | Hsp90 protein | Phosphorylation | DNA damage | Irradiated | Kinases | DNA repair | Degradation | Proteins | Ionizing radiation | MRE11 protein | Fibroblasts | Ataxia | Inhibition | Localization | Repair | Deoxyribonucleic acid--DNA | CHK2 protein | BRCA1 protein | Alpha rays | Lymphoblastoid cell lines | Heat shock proteins | I.R. radiation | Breast cancer | Clients | Damage localization | DNA-dependent protein kinase | Ataxia telangiectasia | Ataxia telangiectasia mutated protein | Control stability | Iridium | Position (location) | Radiation damage | Adenosine triphosphatase | Heat shock | Index Medicus
Journal Article
Science, ISSN 0036-8075, 9/2012, Volume 337, Issue 6102, pp. 1678 - 1684
Journal Article
The FEBS Journal, ISSN 1742-464X, 10/2018, Volume 285, Issue 20, pp. 3769 - 3785
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, pp. e114651 - e114651
Nibrin (also named NBN or NBS1) is a component of the MRE11/RAD50/NBN complex, which is involved in early steps of DNA double strand breaks sensing and repair.... 
RNA-POLYMERASE-II | OXIDATIVE STRESS | DNA-DAMAGE RESPONSE | MULTIDISCIPLINARY SCIENCES | DEPENDENT PROTEIN-KINASE | NIJMEGEN-BREAKAGE-SYNDROME | ATM ACTIVATION | DISTINCT FUNCTIONAL DOMAINS | ATAXIA-TELANGIECTASIA | DOUBLE-STRAND-BREAK | NUCLEAR FOCUS FORMATION | Nijmegen Breakage Syndrome - pathology | Sequence Deletion | Electrophoresis, Polyacrylamide Gel | Humans | Nijmegen Breakage Syndrome - metabolism | Cell Cycle Proteins - metabolism | Nuclear Proteins - metabolism | Gene Regulatory Networks | Mutation - genetics | DNA Breaks, Double-Stranded | Nijmegen Breakage Syndrome - genetics | Blotting, Western | Homozygote | Tandem Mass Spectrometry | Cell Nucleus - genetics | Cell Nucleus - radiation effects | X-Rays | Fluorescent Antibody Technique | HEK293 Cells | Cell Cycle Proteins - genetics | Heterozygote | Protein Interaction Domains and Motifs | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Nuclear Proteins - genetics | Proteins | Ionizing radiation | Genetic aspects | Reactive oxygen species | DNA damage | Nijmegen breakage syndrome | Fragments | Science | Amino acids | Breast cancer | DNA repair | Fragmentation | NAD | Poly(ADP-ribose) Polymerase 1 | Affinity chromatography | Protein folding | MRE11 protein | Breakage | Proteomics | Cell cycle | Irradiation | Lymphomas | Mutation | Deoxyribonucleic acid--DNA | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, pp. e0142259 - e0142259
Journal Article
Current Genomics, ISSN 1389-2029, 11/2013, Volume 14, Issue 7, pp. 425 - 440
The relationship between DNA repair failure and cancer is well established as in the case of rare, high penetrant genes in high cancer risk families. Beside... 
DSBs | SNPs | E185Q | NBN | Polymorphisms | DNA repair | Cancer | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-REPAIR GENES | DOUBLE-STRAND BREAKS | VITAMIN-D-RECEPTOR | URINARY-BLADDER CANCER | ACUTE MYELOID-LEUKEMIA | CELL LUNG-CANCER | ACUTE LYMPHOBLASTIC-LEUKEMIA | GENETICS & HEREDITY | NIJMEGEN-BREAKAGE-SYNDROME | EPSTEIN-BARR-VIRUS | SINGLE NUCLEOTIDE POLYMORPHISMS
Journal Article
Journal Article
FEBS Journal, ISSN 1742-464X, 08/2017, Volume 284, Issue 15, p. 2378
Journal Article
Journal Article
Cell Cycle, ISSN 1538-4101, 06/2012, Volume 11, Issue 11, pp. 2149 - 2158
Reversine is a small synthetic molecule that inhibits multiple mitotic kinases, including MPS1 as well as Aurora kinase A and B (AURKA and AURKB). Here, we... 
HDM2 | aneuploidy | HCT 116 | H2B-GFP | mitochondrial membrane permeabilization | SP600125 | Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Aneuploidy | Mitochondrial membrane permeabilization | APOPTOSIS | PROTEIN | SMALL-MOLECULE | DEATH | CELL BIOLOGY | ARREST | ONCOGENE | MUTANT P53 | CYCLE CHECKPOINTS | INHIBITOR | CARCINOMA | Apoptotic Protease-Activating Factor 1 - antagonists & inhibitors | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Humans | Apoptotic Protease-Activating Factor 1 - genetics | Tumor Suppressor Protein p53 - genetics | Aurora Kinase A | Cell Cycle Proteins - antagonists & inhibitors | Aurora Kinase B | Protein-Tyrosine Kinases - genetics | Caspases - metabolism | RNA Interference | Purines - toxicity | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | bcl-2-Associated X Protein - genetics | M Phase Cell Cycle Checkpoints - drug effects | HCT116 Cells | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Aurora Kinases | bcl-2-Associated X Protein - antagonists & inhibitors | Caspase Inhibitors | Apoptotic Protease-Activating Factor 1 - metabolism | Morpholines - toxicity | Protein-Tyrosine Kinases - antagonists & inhibitors | RNA, Small Interfering - metabolism |