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1. Full Text FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular subgroup analyses of the open-label, phase 3 TRIBE study
by Cremolini, Chiara, MD and Loupakis, Fotios, PhD and Antoniotti, Carlotta, MD and Lupi, Cristiana, BSc and Sensi, Elisa, PhD and Lonardi, Sara, MD and Mezi, Silvia, MD and Tomasello, Gianluca, MD and Ronzoni, Monica, MD and Zaniboni, Alberto, MD and Tonini, Giuseppe, Prof and Carlomagno, Chiara, PhD and Allegrini, Giacomo, MD and Chiara, Silvana, MD and D'Amico, Mauro, MD and Granetto, Cristina, MD and Cazzaniga, Marina, MD and Boni, Luca, MD and Fontanini, Gabriella, Prof and Falcone, Alfredo, Prof
The lancet oncology, ISSN 1470-2045, 2015, Volume 16, Issue 13, pp. 1306 - 1315
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology | Leucovorin - administration & dosage | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Bevacizumab - therapeutic use | Bevacizumab - adverse effects | Colorectal Neoplasms - genetics | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Male | Angiogenesis Inhibitors - administration & dosage | Neoplasm Metastasis | Organoplatinum Compounds - administration & dosage | Fluorouracil - administration & dosage | Time Factors | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Angiogenesis Inhibitors - therapeutic use | Camptothecin - administration & dosage | Female | Angiogenesis Inhibitors - adverse effects | Camptothecin - analogs & derivatives | Colorectal Neoplasms - mortality | Bevacizumab - administration & dosage | Drug Administration Schedule | Kaplan-Meier Estimate | Proportional Hazards Models | Proto-Oncogene Proteins - genetics | Treatment Outcome | Disease-Free Survival | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Intention to Treat Analysis | Italy | Aged | Infusions, Intravenous | Mutation | Colorectal Neoplasms - pathology | Antimitotic agents | Cancer patients | Care and treatment | Patient outcomes | Analysis | Colorectal cancer | Leucovorin | Metastasis | Antineoplastic agents | Index Medicus
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2. Full Text TRIBE2 results and toxicity – Authors' reply
by Antoniotti, Carlotta and Cremolini, Chiara and Rossini, Daniele and Falcone, Alfredo
The lancet oncology, ISSN 1470-2045, 06/2020, Volume 21, Issue 6, pp. e300 - e301
Index Medicus
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3. Full Text Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
by Siravegna, Giulia and Mussolin, Benedetta and Buscarino, Michela and Corti, Giorgio and Cassingena, Andrea and Crisafulli, Giovanni and Ponzetti, Agostino and Cremolini, Chiara and Amatu, Alessio and Lauricella, Calogero and Lamba, Simona and Hobor, Sebastijan and Avallone, Antonio and Valtorta, Emanuele and Rospo, Giuseppe and Medico, Enzo and Motta, Valentina and Antoniotti, Carlotta and Tatangelo, Fabiana and Bellosillo, Beatriz and Veronese, Silvio and Budillon, Alfredo and Montagut, Clara and Racca, Patrizia and Marsoni, Silvia and Falcone, Alfredo and Corcoran, Ryan B and Di Nicolantonio, Federica and Loupakis, Fotios and Siena, Salvatore and Sartore-Bianchi, Andrea and Bardelli, Alberto
Nature medicine, ISSN 1078-8956, 07/2015, Volume 21, Issue 7, pp. 795 - 801
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Antibodies - therapeutic use | Receptor, Epidermal Growth Factor - genetics | Receptor, Epidermal Growth Factor - immunology | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Colorectal Neoplasms - blood | Antibodies, Neoplasm - blood | Colorectal Neoplasms - genetics | Humans | Proto-Oncogene Proteins - genetics | Antineoplastic Agents - therapeutic use | Mutation - genetics | Antibodies - pharmacology | Drug Resistance, Neoplasm - genetics | DNA, Neoplasm - blood | Colorectal Neoplasms - drug therapy | Alleles | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Antineoplastic Agents - pharmacology | Clone Cells | Colorectal Neoplasms - pathology | Clonal Evolution | Index Medicus
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4. Full Text First-line chemotherapy for mCRC-a review and evidence-based algorithm
by Cremolini, Chiara and Schirripa, Marta and Antoniotti, Carlotta and Moretto, Roberto and Salvatore, Lisa and Masi, Gianluca and Falcone, Alfredo and Loupakis, Fotios
Nature reviews. Clinical oncology, ISSN 1759-4774, 10/2015, Volume 12, Issue 10, pp. 607 - 619
Life Sciences & Biomedicine | Oncology | Science & Technology | Colorectal Neoplasms - mortality | Decision Making | Algorithms | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Colorectal Neoplasms - drug therapy | Humans | Survival Analysis | Randomized Controlled Trials as Topic | Care and treatment | Chemotherapy | Oncology, Experimental | Colorectal cancer | Research | Methods | Cancer | Index Medicus
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5. Full Text The winding roadmap of biomarkers toward clinic: Lessons from predictors of resistance to anti-EGFRs in metastatic colorectal cancer
by Antoniotti, Carlotta and Ongaro, Elena and Falcone, Alfredo and Cremolini, Chiara
International journal of molecular sciences, ISSN 1661-6596, 08/2018, Volume 19, Issue 8, p. 2298
Biomarkers | Negative selection | Anti-EGFR agents | Primary resistance | Metastatic colorectal cancer | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Literature reviews | Epidermal growth factor | Epidermal growth factor receptors | Colorectal carcinoma | Colorectal cancer | Monoclonal antibodies | Metastasis | Growth factors | Cancer | Metastases | Index Medicus | anti-EGFR agents | primary resistance | metastatic colorectal cancer | biomarkers | negative selection
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6. Full Text First-line therapy for mCRC-the influence of primary tumour location on the therapeutic algorithm
by Cremolini, Chiara and Antoniotti, Carlotta and Moretto, Roberto and Masi, Gianluca and Falcone, Alfredo
Nature reviews. Clinical oncology, ISSN 1759-4774, 02/2017, Volume 14, Issue 2, pp. 113 - 113
Life Sciences & Biomedicine | Oncology | Science & Technology | Practice guidelines (Medicine) | Evaluation | Development and progression | Care and treatment | Colorectal cancer | Index Medicus
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7. Full Text Erratum: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
by Siravegna, Giulia and Mussolin, Benedetta and Buscarino, Michela and Corti, Giorgio and Cassingena, Andrea and Crisafulli, Giovanni and Ponzetti, Agostino and Cremolini, Chiara and Amatu, Alessio and Lauricella, Calogero and Lamba, Simona and Hobor, Sebastijan and Avallone, Antonio and Valtorta, Emanuele and Rospo, Giuseppe and Medico, Enzo and Motta, Valentina and Antoniotti, Carlotta and Tatangelo, Fabiana and Bellosillo, Beatriz and Veronese, Silvio and Budillon, Alfredo and Montagut, Clara and Racca, Patrizia and Marsoni, Silvia and Falcone, Alfredo and Corcoran, Ryan B and Di Nicolantonio, Federica and Loupakis, Fotios and Siena, Salvatore and Sartore-Bianchi, Andrea and Bardelli, Alberto
Nature medicine, ISSN 1078-8956, 07/2015, Volume 21, Issue 7, pp. 827 - 827
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8. Full Text Role of NRAS mutations as prognostic and predictive markers in metastatic colorectal cancer
by Schirripa, Marta and Cremolini, Chiara and Loupakis, Fotios and Morvillo, Manfredi and Bergamo, Francesca and Zoratto, Federica and Salvatore, Lisa and Antoniotti, Carlotta and Marmorino, Federica and Sensi, Elisa and Lupi, Cristiana and Fontanini, Gabriella and Gregorio, Veronica De and Giannini, Riccardo and Basolo, Fulvio and Masi, Gianluca and Falcone, Alfredo
International journal of cancer, ISSN 0020-7136, 01/2015, Volume 136, Issue 1, pp. 83 - 90
metastatic colorectal cancer | NRAS | BRAF | KRAS | anti‐EGFR | anti-EGFR | Life Sciences & Biomedicine | Oncology | Science & Technology | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Prognosis | Colorectal Neoplasms - genetics | Humans | Middle Aged | Male | Mutation, Missense | Liver Neoplasms - mortality | DNA Mutational Analysis | Antibodies, Monoclonal, Humanized - pharmacology | Colorectal Neoplasms - drug therapy | Aged, 80 and over | Adult | Female | Retrospective Studies | Cetuximab | Liver Neoplasms - secondary | Colorectal Neoplasms - mortality | Antibodies, Monoclonal, Humanized - therapeutic use | Genetic Association Studies | Liver Neoplasms - genetics | Membrane Proteins - genetics | Kaplan-Meier Estimate | Liver Neoplasms - drug therapy | Proportional Hazards Models | Proto-Oncogene Proteins - genetics | Disease-Free Survival | Drug Resistance, Neoplasm - genetics | GTP Phosphohydrolases - genetics | Proto-Oncogene Proteins B-raf - genetics | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Aged | Biomarkers, Tumor - genetics | Colorectal Neoplasms - pathology | Chemotherapy | Gene mutations | Analysis | Colorectal cancer | Monoclonal antibodies | Genetic aspects | Metastasis | Cancer | Mutation | Medical prognosis | Tumors | Index Medicus
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9. Full Text A still missing piece of the FIRE-3 puzzle
by Antoniotti, Carlotta and Moretto, Roberto and Rossini, Daniele and Falcone, Alfredo and Cremolini, Chiara
The lancet oncology, ISSN 1470-2045, 2016, Volume 17, Issue 12, pp. e515 - e515
Hematology, Oncology and Palliative Medicine | Life Sciences & Biomedicine | Oncology | Science & Technology
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10. Full Text Treatments after first progression in metastatic colorectal cancer. A literature review and evidence-based algorithm
by Antoniotti, Carlotta and Moretto, Roberto and Rossini, Daniele and Masi, Gianluca and Falcone, Alfredo and Cremolini, Chiara
Cancer treatment reviews, ISSN 0305-7372, 01/2021, Volume 92, pp. 102135 - 102135
Re-introduction | Therapeutic algorithm | Treatment after progression | Metastatic colorectal cancer | Index Medicus
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11. Full Text The role of primary tumour sidedness, EGFR gene copy number and EGFR promoter methylation in RAS/BRAF wild-type colorectal cancer patients receiving irinotecan/cetuximab
by Demurtas, Laura and Puzzoni, Marco and Giampieri, Riccardo and Ziranu, Pina and Pusceddu, Valeria and Mandolesi, Alessandra and Cremolini, Chiara and Masi, Gianluca and Gelsomino, Fabio and Antoniotti, Carlotta and Loretelli, Cristian and Meriggi, Fausto and Zaniboni, Alberto and Falcone, Alfredo and Cascinu, Stefano and Scartozzi, Mario
British journal of cancer, ISSN 0007-0920, 07/2017, Volume 117, Issue 3, pp. 315 - 321
Life Sciences & Biomedicine | Oncology | Science & Technology | Leucovorin - administration & dosage | Follow-Up Studies | Colorectal Neoplasms - genetics | Humans | Male | DNA Methylation | Neoplasm Metastasis | Fluorouracil - administration & dosage | DNA Mutational Analysis | Colorectal Neoplasms - drug therapy | Camptothecin - administration & dosage | Female | DNA, Neoplasm - analysis | Retrospective Studies | Camptothecin - analogs & derivatives | Genes, ras - genetics | Promoter Regions, Genetic | Survival Rate | Gene Dosage | Disease-Free Survival | Retreatment | Genes, erbB-1 | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Cetuximab - administration & dosage | Aged | Colorectal Neoplasms - pathology | Index Medicus | sidedness | colorectal cancer | RAS | primary tumour location | cetuximab | EGFR promoter methylation | BRAF | Clinical Study | EGFR gene copy number
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12. Full Text Treatments after progression to first-line FOLFOXIRI and bevacizumab in metastatic colorectal cancer: a pooled analysis of TRIBE and TRIBE2 studies by GONO
by Rossini, Daniele and Lonardi, Sara and Antoniotti, Carlotta and Santini, Daniele and Tomasello, Gianluca and Ermacora, Paola and Germani, Marco Maria and Bergamo, Francesca and Ricci, Vincenzo and Caponnetto, Salvatore and Moretto, Roberto and Zaniboni, Alberto and Pietrantonio, Filippo and Buonadonna, Angela and Ritorto, Giuliana and Masi, Gianluca and Latiano, Tiziana Pia and Rapisardi, Stefania and Falcone, Alfredo and Cremolini, Chiara
British journal of cancer, ISSN 0007-0920, 10/2020, Volume 124, Issue 1, pp. 183 - 190
Life Sciences & Biomedicine | Oncology | Science & Technology | Index Medicus
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