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Science, ISSN 0036-8075, 9/2012, Volume 337, Issue 6101, pp. 1541 - 1546
De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur... 
Spleen | Myeloid cells | Genes | DNA | REPORTS | Stem cells | Neutrophils | Bone marrow | Bone marrow cells | Genetic mutation | Tumors | ASXL1 | MULTIDISCIPLINARY SCIENCES | MOUSE | GENE-EXPRESSION | MUTATIONS | LEUKEMIA | UBIQUITIN HYDROLASE | PREDISPOSE | MYELODYSPLASTIC SYNDROMES | Myeloid Cells - cytology | Humans | Leukemia, Myelomonocytic, Chronic - genetics | Myeloid Cells - physiology | Host Cell Factor C1 - metabolism | Leukemia, Myelomonocytic, Chronic - metabolism | Chromatin Immunoprecipitation | Hematopoiesis | Gene Deletion | Tumor Suppressor Proteins - chemistry | Tumor Suppressor Proteins - genetics | Bone Marrow Transplantation | Myeloid Progenitor Cells - cytology | Ubiquitin Thiolesterase - metabolism | Leukemia, Myelomonocytic, Chronic - pathology | Genes, Tumor Suppressor | Repressor Proteins - metabolism | Promoter Regions, Genetic | Myelodysplastic Syndromes - metabolism | Tumor Suppressor Proteins - metabolism | Gene Expression Regulation | Embryonic Development | Ubiquitin Thiolesterase - genetics | N-Acetylglucosaminyltransferases - metabolism | Gene Knock-In Techniques | Mice, Knockout | Animals | Myeloid Progenitor Cells - physiology | Cell Transformation, Neoplastic | Mice | Myelodysplastic Syndromes - genetics | Myelodysplastic Syndromes - pathology | Ubiquitin Thiolesterase - chemistry | Gene silencing | Tumor suppressor genes | Genetic engineering | Research | Properties | Observations | Enzymes | Mutation | Gene expression | Molecular biology | Leukemia
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 12/2008, Volume 7, Issue 12, pp. 1031 - 1040
The p53 and nuclear factor-kappa B (NF-kappa B) pathways play crucial roles in human cancer, in which inactivation of p53 and hyperactivation of NF-kappa B is... 
MULTIPLE-MYELOMA | TUMOR-NECROSIS-FACTOR | 1-TRANSFORMED CELLS | SELICICLIB CYC202 | P53-DEPENDENT APOPTOSIS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CYC202 R-ROSCOVITINE | DOWN-REGULATION | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | DEPENDENT KINASE INHIBITOR | RENAL-CELL CARCINOMA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2014, Volume 111, Issue 46, pp. 16538 - 16543
Why different species are predisposed to different tumor spectra is not well understood. In particular, whether the physical location of tumor suppressor genes... 
Kidneys | Cysts | Renal cell carcinoma | Alleles | Tumor suppressor genes | Kidney cells | Lesions | Genetic mutation | Tumors | Cancer | HIF | MULTIDISCIPLINARY SCIENCES | HIPPEL-LINDAU-DISEASE | kidney stem cells | CELL CARCINOMA | LESIONS | kidney cancer | INACTIVATION | Six2-Cre | EVOLUTION | GENE | TUMOR-SUPPRESSOR | VHL | MUTATIONS | EXPRESSION | BAP1 | Kidney Neoplasms - genetics | Species Specificity | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Multipotent Stem Cells - metabolism | Carcinoma, Renal Cell - genetics | Male | Kidney Failure, Chronic - pathology | Tumor Suppressor Proteins - genetics | Kidney Diseases, Cystic - genetics | Female | Precancerous Conditions - pathology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Von Hippel-Lindau Tumor Suppressor Protein - antagonists & inhibitors | Genes, Tumor Suppressor | Ubiquitin Thiolesterase - antagonists & inhibitors | Genes, Reporter | Disease Models, Animal | Genetic Predisposition to Disease | Mice, Inbred C57BL | Genes, Synthetic | Von Hippel-Lindau Tumor Suppressor Protein - physiology | Mice, Transgenic | Chromosome Mapping | Ubiquitin Thiolesterase - physiology | Ubiquitin Thiolesterase - genetics | Precancerous Conditions - genetics | Kidney Diseases, Cystic - pathology | Mice, Knockout | Kidney Failure, Chronic - genetics | Cell Lineage | Tumor Suppressor Proteins - physiology | Multipotent Stem Cells - pathology | Phenotype | Animals | Kidney Failure, Chronic - blood | Age of Onset | Mice | Models, Genetic | Mutation | Physiological aspects | Carcinoma | Kidney cancer | Biological Sciences
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2013, Volume 210, Issue 12, pp. 2641 - 2659
Journal Article
Journal of Chemical Sciences, ISSN 0974-3626, 9/2018, Volume 130, Issue 9, pp. 1 - 11
The reactivity of cis-$$[\hbox {Pt}(\hbox {pipen})(\hbox {H}_{2}\hbox {O})_{2}]^{2+}$$ [Pt(pipen)(H2O)2]2+ ($$\hbox {pipen} = 2\hbox {-aminomethylpiperidine}$$... 
platinum(II) | 2-aminomethylpiperidine | Chemistry | Kinetics | Chemistry/Food Science, general | vicinal dioximes | DESIGN | PLATINUM | CHEMISTRY | CHEMISTRY, MULTIDISCIPLINARY | METAL-COMPLEXES
Journal Article
Cell Cycle, ISSN 1538-4101, 09/2007, Volume 6, Issue 17, pp. 2178 - 2185
Nutlins were identified as the first potent and specific small molecule Mdm2 antagonists that inhibit the p53- Mdm2 interaction. We show in this study that... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Nutlin-3 | MCP-1 | ICAM-1 | NFκB | p53 | ATHEROSCLEROTIC LESIONS | ACTIVATION | INTERCELLULAR-ADHESION MOLECULE-1 | nutlin-3 | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | NECROSIS-FACTOR-ALPHA | P53 PATHWAY | CELL-GROWTH | CELL BIOLOGY | MDM2 | CHRONIC LYMPHOCYTIC-LEUKEMIA | EXPRESSION | NF kappa B
Journal Article
Pigment Cell & Melanoma Research, ISSN 1755-1471, 03/2019, Volume 32, Issue 2, pp. 269 - 279
Journal Article
Cell Cycle, ISSN 1538-4101, 12/2008, Volume 7, Issue 23, pp. 3759 - 3767
Hexamethylene Bisacetamide (HMBA) is a hybrid polar compound originally developed as a differentiation inducing agent. We show in this study that HMBA can... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Akt | ERK/MAPK | HMBA | NfκB | APOPTOSIS | ACTIVATED PROTEIN-KINASE | HYBRID POLAR COMPOUNDS | PHOSPHATIDYLINOSITOL 3-KINASE | NECROSIS-FACTOR-ALPHA | INDUCED-DIFFERENTIATION | PTEN EXPRESSION | CELL BIOLOGY | CELL LUNG-CANCER | RIBOSOMAL S6 KINASE | NF kappa B | TRANSFORMED-CELLS
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2004, Volume 337, Issue 2, pp. 427 - 442
The full length, positive-strand genome of the Moloney Murine Leukemia Virus contains a "core encapsidation signal" that is essential for efficient genome... 
NMR | stem loop | A-minor K-turn | MLV | MLV, Moloney Murine Leukaemia Virus | RDC, residual dipolar coupling | Stem loop |