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science & technology (262) 262
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1. Full Text Mechanisms of lysophosphatidic acid production
by Aoki, Junken
Seminars in cell & developmental biology, ISSN 1084-9521, 2004, Volume 15, Issue 5, pp. 477 - 489
Phospholipase A 1 | LPA receptor | Phospholipase A 2 | Autotaxin | Phospholipase A | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Glucose-6-Phosphate Isomerase - metabolism | Receptors, Lysophosphatidic Acid - metabolism | Phosphoric Diester Hydrolases - metabolism | Humans | Glycoproteins - metabolism | Lysophospholipids - biosynthesis | Phospholipases - metabolism | Multienzyme Complexes - metabolism | Pyrophosphatases | Phosphodiesterase I | Cell Movement - physiology | Index Medicus
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2. Full Text Identification of P2Y receptors involved in oleamide-suppressing inflammatory responses in murine microglia and human dendritic cells
by Kita, Masahiro and Ano, Yasuhisa and Inoue, Asuka and Aoki, Junken
Scientific reports, ISSN 2045-2322, 02/2019, Volume 9, Issue 1, pp. 3135 - 3135
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neuroprotection | Dairy products | G protein-coupled receptors | Dendritic cells | Neurodegenerative diseases | Transforming growth factor-a | Central nervous system | Inflammation | Tumor necrosis factor-α | Anti-inflammatory agents | Microglia | Cannabinoids | Oleamide | Tumor necrosis factor-TNF | Index Medicus
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3. Full Text Crystal structures of human ETB receptor provide mechanistic insight into receptor activation and partial activation
by Shihoya, Wataru and Izume, Tamaki and Inoue, Asuka and Yamashita, Keitaro and Kadji, Francois Marie Ngako and Hirata, Kunio and Aoki, Junken and Nishizawa, Tomohiro and Nureki, Osamu
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 11
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neuroprotection | Drug delivery systems | Endothelin | Endothelin 3 | Activation | Functional analysis | Drug delivery | Drug development | Hydrogen bonding | Vasodilation | Proteins | Coupling (molecular) | Receptors | Vasoactive agents | Endothelin receptors | Blood pressure | Disruption | Receptor mechanisms | Crystal structure | Tumors | Index Medicus
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4. Full Text Autotaxin-An LPA producing enzyme with diverse functions
by Nakanaga, Keita and Hama, Kotaro and Aoki, Junken
Journal of biochemistry (Tokyo), ISSN 0021-924X, 07/2010, Volume 148, Issue 1, pp. 13 - 24
G protein-coupled receptor | lysophosphatidic acid | nucleotide pyrophosphatase | phosphodiesterase | autotaxin | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Small Molecule Libraries - pharmacology | Animals | Phosphoric Diester Hydrolases - metabolism | Substrate Specificity - drug effects | Lysophospholipids - chemistry | Humans | Lysophospholipids - biosynthesis | Models, Animal | Embryonic Development - drug effects | Phosphoric Diester Hydrolases - chemistry | Index Medicus
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5. Full Text Development of a Novel Intraocular-Pressure-Lowering Therapy Targeting ATX
by Norimichi Naganoa and Megumi Honjoa and Mitsuyasu Kawaguchib and Hiroshi Nishimasuc and Osamu Nurekic and Kuniyuki Kanod and e and Junken Aokid and Toru Komatsuf and Takayoshi Okabeg and Hirotatsu Kojimag and Tetsuo Naganog and Makoto Aiharaa and eCore Research for Evolutional Science and Technology (CREST and aDepartment of Ophthalmology and The University of Tokyo and Tohoku University and Graduate School of Medicine and dGraduate School of Pharmaceutical Sciences and fGraduate School of Pharmaceutical Sciences and Nagoya City University and cGraduate School of Science and bGraduate School of Pharmaceutical Sciences and gDrug Discovery Initiative
Biological & pharmaceutical bulletin, ISSN 0918-6158, 2019, Volume 42, Issue 11, pp. 1926 - 1935
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Cell Line | Phosphodiesterase Inhibitors - therapeutic use | Intraocular Pressure - drug effects | Humans | Mice, Inbred C57BL | Trabecular Meshwork - drug effects | Aqueous Humor | Macaca fascicularis | Phosphoric Diester Hydrolases - drug effects | Ocular Hypertension - drug therapy | Animals | Ocular Hypertension - chemically induced | Models, Animal | Mice | Molecular Structure | Glaucoma - metabolism | Phosphodiesterase Inhibitors - chemistry | Drug Evaluation, Preclinical | Glaucoma - physiopathology | Endothelial Cells - drug effects | Glaucoma | Inhibitors | Aqueous humour | Blindness | High-throughput screening | Pressure | Optimization | Intraocular pressure | Index Medicus
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6. Full Text Biological roles of lysophosphatidic acid signaling through its production by autotaxin
by Okudaira, Shinichi and Yukiura, Hiroshi and Aoki, Junken
Biochimie, ISSN 0300-9084, 2010, Volume 92, Issue 6, pp. 698 - 706
Lysophospholipid | Phospholipase | Lysophosphatidic acid | Autotaxin | G-protein-coupled receptors | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Receptors, Lysophosphatidic Acid - metabolism | Lysophospholipids - metabolism | Animals | Phosphoric Diester Hydrolases - metabolism | Signal Transduction | Models, Biological | Humans | Mice | Cell Movement | Phosphoric Diester Hydrolases - chemistry | Index Medicus
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7. Full Text Molecular mechanism of lysophosphatidic acid-induced hypertensive response
by Kano, Kuniyuki and Matsumoto, Hirotaka and Inoue, Asuka and Yukiura, Hiroshi and Kanai, Motomu and Chun, Jerold and Ishii, Satoshi and Shimizu, Takao and Aoki, Junken
Scientific reports, ISSN 2045-2322, 02/2019, Volume 9, Issue 1, pp. 2662 - 2662
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Hypertension | G protein-coupled receptors | Lysophosphatidic acid | Vasoactive agents | Blood pressure | Kinases | Rho-associated kinase | Index Medicus
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8. Full Text Two pathways for lysophosphatidic acid production
by Aoki, Junken and Inoue, Asuka and Okudaira, Shinichi
Biochimica et biophysica acta. Molecular and cell biology of lipids, ISSN 1388-1981, 2008, Volume 1781, Issue 9, pp. 513 - 518
G protein-coupled receptor | Lysophosphatidic acid | Autotaxin | LPA receptor | P2Y5 | LPA | mPA-PLA 1α/LIPH | mPA-PLA | α/LIPH | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Pyrophosphatases - metabolism | Receptors, Lysophosphatidic Acid - metabolism | Animals | Lysophospholipids - chemistry | Humans | Phosphodiesterase I - metabolism | Lysophospholipids - biosynthesis | Lipase - metabolism | Glycerin | Phosphates | Isoenzymes | Nuclear radiation | Genetic research | Glycerol | Family | Phospholipases | Neovascularization | G proteins | Cells | Membrane proteins
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