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1. Atmospheric CO₂ concentration observed at Syowa Station from 1984 to 1992
by Aoki, Shuji and Nihon Nankyoku Chiiki Kansokutai and Kokuritsu Kyokuchi Kenkyūjo
2000, JARE data reports, Volume no. 251., 55
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2. Full Text Northern Hemisphere forcing of climatic cycles in Antarctica over the past 360,000 years
by Kawamura, Kenji and Parrenin, Frédéric and Lisiecki, Lorraine and Uemura, Ryu and Vimeux, Françoise and Severinghaus, Jeffrey P and Hutterli, Manuel A and Nakazawa, Takakiyo and Aoki, Shuji and Jouzel, Jean and Raymo, Maureen E and Matsumoto, Koji and Nakata, Hisakazu and Motoyama, Hideaki and Fujita, Shuji and Goto-Azuma, Kumiko and Fujii, Yoshiyuki and Watanabe, Okitsugu
Nature, ISSN 0028-0836, 08/2007, Volume 448, Issue 7156, pp. 912 - 916
The Milankovitch theory of climate change proposes that glacial interglacial cycles are driven by changes in summer insolation at high northern latitudes(1).... 
VARIABILITY | CORES | MULTIDISCIPLINARY SCIENCES | VOSTOK ICE | SEA-LEVEL | AIR | TRAPPED GAS-COMPOSITION | GLACIAL CYCLES | LATE PLEISTOCENE | TERMINATIONS | TEMPERATURE-CHANGES | Antarctic Regions | Models, Theoretical | History, Ancient | Climate | Nitrogen - analysis | Carbon Isotopes | Greenhouse Effect | Seawater - chemistry | Carbon Dioxide - analysis | Ice Cover | Oxygen - analysis | Oxygen Isotopes | Time Factors | Geologic Sediments - chemistry | Atmosphere - chemistry | Seasons | Hypothesis testing | Climate change | Summer | Atmospheric chemistry | Theory | Glaciology | Earth Sciences | Sciences of the Universe
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3. Full Text Periostin promotes chronic allergic inflammation in response to Th2 cytokines
by Masuoka, Miho and Shiraishi, Hiroshi and Ohta, Shoichiro and Suzuki, Shoichi and Arima, Kazuhiko and Aoki, Shigehisa and Toda, Shuji and Inagaki, Naoki and Kurihara, Yuichi and Hayashida, Sayaka and Takeuchi, Satoshi and Koike, Kenta and Ono, Junya and Noshiro, Hirokazu and Furue, Masutaka and Conway, Simon J and Narisawa, Yutaka and Izuhara, Kenji
Journal of Clinical Investigation, ISSN 0021-9738, 07/2012, Volume 122, Issue 7, pp. 2590 - 2600
Allergic inflammation triggered by exposure of an allergen frequently leads to the onset of chronic inflammatory diseases such as atopic dermatitis (AD) and... 
MEDICINE, RESEARCH & EXPERIMENTAL | ATOPIC-DERMATITIS | DENDRITIC CELLS | CANCER DEVELOPMENT | EPITHELIAL-CELLS | EXTRACELLULAR-MATRIX | MITE ALLERGEN | NF-KAPPA-B | THYMIC STROMAL LYMPHOPOIETIN | BRONCHIAL-ASTHMA | TENASCIN-C | Ear, External - immunology | Cell Adhesion Molecules - physiology | Cell Proliferation | Coculture Techniques | Ear, External - pathology | Humans | Cell Adhesion Molecules - antagonists & inhibitors | NF-kappa B - metabolism | Th2 Cells - immunology | Mice, 129 Strain | Case-Control Studies | Allergens - immunology | Dermatitis, Atopic - immunology | Cell Differentiation | Integrin alphaV - metabolism | Skin - pathology | Fibroblasts - metabolism | Skin - immunology | Cytokines - metabolism | Interleukin-4 - metabolism | Mice, Inbred C57BL | Cells, Cultured | Dermatitis, Atopic - pathology | STAT6 Transcription Factor - metabolism | Interleukin-13 - metabolism | Cell Adhesion Molecules - metabolism | Th2 Cells - metabolism | Keratinocytes - immunology | Animals | Keratinocytes - metabolism | Protein Binding | Mice | Mice, Inbred BALB C | Dermatitis, Atopic - metabolism | Keratinocytes - physiology | Pyroglyphidae - immunology | Proteins | Physiological aspects | Research | Cytokines | Atopic dermatitis | Risk factors
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4. Full Text Long-term variations of the mole fraction and carbon isotope ratio of atmospheric methane observed at Ny-Ålesund, Svalbard from 1996 to 2013
by Morimoto, Shinji and Fujita, Ryo and Aoki, Shuji and Goto, Daisuke and Nakazawa, Takakiyo
Tellus B: Chemical and Physical Meteorology, ISSN 0280-6509, 01/2017, Volume 69, Issue 1, pp. 1380497 - 7
We have conducted systematic observations of the CH 4 mole fraction and its carbon isotope ratio (δ 13 C) at Ny-Ålesund, Svalbard (78°55′N, 11°56′E) using air... 
stable carbon isotope | atmospheric methane | Arctic | greenhouse gas | Methane | Air samples | Stagnation | Fossil fuels | Methane in the atmosphere | Carbon | Carbon isotopes | Emissions | Wetlands | Gases | Microorganisms | Carbon isotope ratio | Weekly | Polar environments | Temporal variations | Long-term changes | Isotope ratios | Isotopes
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5. Full Text SaO058A thread type high-density collagen material prevents progression of peritoneal fibrosis
by Nagase, Kei and Aoki, Shigehisa and Noguchi, Mitsuru and Toda, Shuji
Nephrology Dialysis Transplantation, ISSN 0931-0509, 06/2019, Volume 34, Issue Supplement_1
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6. Full Text Progress in cell culture systems for pathological research
by Aoki, Shigehisa and Takezawa, Toshiaki and Sugihara, Hajime and Toda, Shuji
Pathology International, ISSN 1320-5463, 10/2016, Volume 66, Issue 10, pp. 554 - 562
Cell culture is a well‐established standard technique and a fundamental tool in biology and medicine. Establishment of a novel culture method by meeting... 
air–liquid interface | shear stress | ceiling culture | Ceiling culture | Shear stress | Air-liquid interface | GEL MATRIX CULTURE | FLUID SHEAR-STRESS | COLLAGEN GEL | MATURE ADIPOCYTES | MESENCHYMAL STEM-CELL | PATHOLOGY | UNILOCULAR FAT-CELLS | EPIDERMAL REGENERATION | IN-VITRO | air-liquid interface | ENDOTHELIAL-CELLS | ADIPOSE-TISSUE | Animals | Pathology - methods | Research | Cell Culture Techniques - trends | Cell Culture Techniques - methods | Humans | Cells | Streaming | Cell culture | Biotechnology | Mesenchyme | Cytokines | Fluid dynamics | Tissue engineering | Fluid flow | Homeostasis | Dermis | Epidermis | Biology | Cell interactions | Regeneration (physiology) | Medicine | Regeneration | Collagen | Fibrosis | Yield strength | Physical stress | Skin | Peritoneum
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7. Full Text Sa1625 - Fluid Flow Stress Modulates Gastric Carcinoma Cell Kinetics in Cancer-Adipose Tissue Interactions
by Akutagawa, Takashi and Aoki, Shigehisa and Sakata, Yasuhisa and Fujimoto, Kazuma and Toda, Shuji
Gastroenterology, ISSN 0016-5085, 05/2018, Volume 154, Issue 6, pp. S-332 - S-333
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8. Full Text The NF90-NF45 Complex Functions as a Negative Regulator in the MicroRNA Processing Pathway
by Shuji Sakamoto and Kazuma Aoki and Takuma Higuchi and Hiroshi Todaka and Keiko Morisawa and Nobuyuki Tamaki and Etsuro Hatano and Atsuki Fukushima and Taketoshi Taniguchi and Yasutoshi Agata
Molecular and Cellular Biology, ISSN 0270-7306, 07/2009, Volume 29, Issue 13, pp. 3754 - 3769
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
DROSHA-DGCR8 COMPLEX | CANCER CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | GENE-EXPRESSION | NUCLEAR EXPORT | MICROPROCESSOR COMPLEX | CELL-PROLIFERATION | C-ELEGANS | LET-7 | RNA-INTERFERENCE | CELL BIOLOGY | Recombinant Proteins - metabolism | Cell Line | Ribonuclease III - genetics | Ribonuclease III - metabolism | Humans | Nuclear Factor 45 Protein - genetics | Nuclear Factor 45 Protein - metabolism | MicroRNAs - metabolism | RNA Precursors - genetics | Recombinant Proteins - genetics | RNA-Binding Proteins | Nuclear Factor 90 Proteins - metabolism | Proteins - genetics | Multiprotein Complexes - metabolism | Proteins - metabolism | RNA Interference | RNA Precursors - metabolism | MicroRNAs - genetics | Nuclear Factor 90 Proteins - genetics
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9. Full Text Nationwide Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS): first analysis on survival
by Ito, Kazuto and Saito, Shiro and Yorozu, Atsunori and Kojima, Shinsuke and Kikuchi, Takashi and Higashide, Satoshi and Aoki, Manabu and Koga, Hirofumi and Satoh, Takefumi and Ohashi, Toshio and Nakamura, Katsumasa and Katayama, Norihisa and Tanaka, Nobumichi and Nakano, Masahiro and Shigematsu, Naoyuki and Dokiya, Takushi and Fukushima, Masanori and J-POPS Investigators and For the J-POPS Investigators
International Journal of Clinical Oncology, ISSN 1341-9625, 12/2018, Volume 23, Issue 6, pp. 1148 - 1159
Investigating oncological outcomes in patients registered in the Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS) in... 
External beam radiation therapy | Iodine-125 | Medicine & Public Health | Oncology | Cancer Research | Brachytherapy | Surgical Oncology | Prostate cancer | ANDROGEN SUPPRESSION | DEFINITION | BIOCHEMICAL FAILURE | ANTIGEN BOUNCE | RADIATION | ONCOLOGY | PSA KINETICS | MEN | RECTAL MORBIDITY | RADIOTHERAPY | Prostate-Specific Antigen | Multivariate Analysis | Prostatic Neoplasms - pathology | Prostatic Neoplasms - radiotherapy | Follow-Up Studies | Humans | Japan | Middle Aged | Risk Factors | Brachytherapy - methods | Male | Treatment Outcome | Prostatic Neoplasms - mortality | Iodine Radioisotopes - therapeutic use | Survival Analysis | Aged | Research | Oncology, Experimental | Analysis | Patient outcomes | Cancer
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10. Full Text Weak Northern and Strong Tropical Land Carbon Uptake from Vertical Profiles of Atmospheric CO2
by Stephens, Britton B and Gurney, Kevin R and Tans, Pieter P and Sweeney, Colm and Peters, Wouter and Bruhwiler, Lori and Ciais, Philippe and Ramonet, Michel and Bousquet, Philippe and Nakazawa, Takakiyo and Aoki, Shuji and Machida, Toshinobu and Inoue, Gen and Vinnichenko, Nikolay and Lloyd, Jon and Jordan, Armin and Heimann, Martin and Shibistova, Olga and Langenfelds, Ray L and Steele, L. Paul and Francey, Roger J and Denning, A. Scott
Science, ISSN 0036-8075, 06/2007, Volume 316, Issue 5832, pp. 1732 - 1735
Measurements of midday vertical atmospheric CO2 distributions reveal annual-mean vertical CO2 gradients that are inconsistent with atmospheric models that... 
LONG-TERM | SEQUESTRATION | TRANSPORT | SINK | EMISSIONS | FOREST ECOSYSTEMS | MULTIDISCIPLINARY SCIENCES | DIOXIDE | TERRESTRIAL BIOSPHERE | PLANT-GROWTH | INVERSIONS | Atmospheric circulation | Models | Atmospheric chemistry | Ecosystems | Carbon dioxide | Meteorology | plant-growth | inversions | sink | sequestration | terrestrial biosphere | transport | dioxide | emissions | long-term | forest ecosystems
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11. Full Text Discovery of 3-Chloro-N-{(S)-[3-(1-ethyl-1H-pyrazol-4-yl)phenyl][(2S)-piperidine-2-yl]methyl}-4-(trifluoromethyl)pyridine-2-carboxamide as a Potent Glycine Transporter 1 Inhibitor
by Yamamoto, Shuji and Shibata, Tsuyoshi and Abe, Kumi and Oda, Koji and Aoki, Takeshi and Kawakita, Yasunori and Kawamoto, Hiroshi
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2016, Volume 64, Issue 9, pp. 1321 - 1337
A novel glycine transporter 1 (GlyT1) inhibitor was designed by the superposition of different chemotypes to enhance its inhibitory activity. Starting from... 
structure–activity relationship | schizophrenia | glycine transporter 1 inhibitor | ligand based drug design | Schizophrenia | Glycine transporter 1 inhibitor | Structure-activity relationship | Ligand based drug design | GLYT1 INHIBITORS | SELECTIVE INHIBITOR | CHEMISTRY, MEDICINAL | SERIES | EFFICACY | PHARMACOLOGY & PHARMACY | RECEPTORS | structure-activity relationship | CHEMISTRY, MULTIDISCIPLINARY | Piperidines - chemistry | Pyrazoles - chemical synthesis | Pyridines - chemistry | Humans | Pyridines - chemical synthesis | Models, Molecular | Structure-Activity Relationship | Piperidines - chemical synthesis | Drug Discovery | Dose-Response Relationship, Drug | Pyrazoles - chemistry | Piperidines - pharmacology | Molecular Structure | Pyridines - pharmacology | Glycine Plasma Membrane Transport Proteins - antagonists & inhibitors | Pyrazoles - pharmacology | Brain | Pyridines | Animal models | Mental disorders | Central nervous system | Pharmacology | Glycine | Benzamide | Superposition (mathematics) | Optimization | Side effects | Inhibitors | Glycine transporter | Rodents | Piperidine | Transporter
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12. Full Text Discovery of 3-Chloro-N-{(S)-[3-(1-ethyl-1H-pyrazol-4-yl)phenyl] [(2S)-piperidine-2-yl]methyl}-4-(trifluoromethyl)pyridine-2-carboxamide as a Potent Glycine Transporter 1 Inhibitor
by Shuji Yamamotoa and Tsuyoshi Shibataa and Kumi Abea and Koji Odaa and Takeshi Aokib and Yasunori Kawakitac and Hiroshi Kawamotoa and aChemistry Laboratories and Taisho Pharmaceutical Co and bPharmacology Laboratories and Ltd and cDrug Safety and Pharmacokinetics Laboratories
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2016, Volume 64, Issue 9, pp. 1321 - 1337
A novel glycine transporter 1 (GlyT1) inhibitor was designed by the superposition of different chemotypes to enhance its inhibitory activity. Starting from... 
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13. Full Text Seasonal characteristics of trace gas transport into the extratropical upper troposphere and lower stratosphere
by Inai, Yoichi and Fujita, Ryo and Machida, Toshinobu and Matsueda, Hidekazu and Sawa, Yousuke and Tsuboi, Kazuhiro and Katsumata, Keiichi and Morimoto, Shinji and Aoki, Shuji and Nakazawa, Takakiyo
Atmospheric Chemistry and Physics, ISSN 1680-7316, 05/2019, Volume 19, Issue 10, pp. 7073 - 7103
To investigate the seasonal characteristics of trace gas distributions in the extratropical upper troposphere and lower stratosphere (ExUTLS) as well as... 
Gas utilities | Weather forecasting | Troposphere | Age of air | Temperature | Carbon dioxide | Trace gases | Stratosphere | Ground-based observation | Ozone | Air masses | Trajectories | Gases | Organic chemistry | Lower troposphere | Tropical environment | Airborne observation | Nitrous oxide | Transport | Tracers
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14. Full Text Contributions of natural and anthropogenic sources to atmospheric methane variations over western Siberia estimated from its carbon and hydrogen isotopes
by Umezawa, Taku and Machida, Toshinobu and Aoki, Shuji and Nakazawa, Takakiyo
Global Biogeochemical Cycles, ISSN 0886-6236, 12/2012, Volume 26, Issue 4, p. n/a
Aircraft measurements of carbon and hydrogen isotopic ratios of atmospheric CH4 (δ13CH4 and δD‐CH4), with the respective precisions of 0.08‰ and 2.2‰, as well... 
methane | fossil fuel | isotope | wetland | western Siberia | RATIOS | EMISSIONS | GROWTH-RATE | MODEL | CH4 | ENVIRONMENTAL SCIENCES | GEOSCIENCES, MULTIDISCIPLINARY | TROPOSPHERIC METHANE | SOURCE IDENTIFICATION | WETLANDS | AIRCRAFT MEASUREMENTS | METEOROLOGY & ATMOSPHERIC SCIENCES | HIGH-PRECISION | Geobiology | Atmospheric sciences | Isotopes | Troposphere | Wetlands
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15. Full Text Phytochrome B regulates Heading date 1 (Hd1)-mediated expression of rice florigen Hd3a and critical day length in rice
by Ishikawa, Ryo and Aoki, Mayumi and Kurotani, Ken-ichi and Yokoi, Shuji and Shinomura, Tomoko and Takano, Makoto and Shimamoto, Ko
Molecular Genetics and Genomics, ISSN 1617-4615, 6/2011, Volume 285, Issue 6, pp. 461 - 470
Many plants require circadian clock and light information for the photoperiodic control of flowering. In Arabidopsis, a long-day plant (LDP), flowering is... 
Life Sciences | Biochemistry, general | Oryza sativa | Florigen | Phytochrome B | Microbial Genetics and Genomics | Flowering | Photoperiod | Plant Genetics & Genomics | Cell Biology | Animal Genetics and Genomics | SIGNAL | PLANT | BIOCHEMISTRY & MOLECULAR BIOLOGY | TIME | DISTINCT ROLES | CONSTANS | PHOTOPERIODIC FLOWERING RESPONSE | GENE | GENETICS & HEREDITY | ARABIDOPSIS | FLORAL INDUCTION | FT PROTEIN | Plant Proteins - physiology | Gene Expression Regulation, Plant | Oryza - physiology | Flowers | Phytochrome B - physiology | Circadian Rhythm | Chromophores | Universities and colleges | Plant molecular genetics | Phytochrome | Rice
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16. Full Text A long-term cultivation of an anaerobic methane-oxidizing microbial community from deep-sea methane-seep sediment using a continuous-flow bioreactor
by Aoki, Masataka and Ehara, Masayuki and Saito, Yumi and Yoshioka, Hideyoshi and Miyazaki, Masayuki and Saito, Yayoi and Miyashita, Ai and Kawakami, Shuji and Yamaguchi, Takashi and Ohashi, Akiyoshi and Nunoura, Takuro and Takai, Ken and Imachi, Hiroyuki
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e105356
Anaerobic oxidation of methane (AOM) in marine sediments is an important global methane sink, but the physiological characteristics of AOM-associated... 
MESSENGER-RNA | UASB REACTOR | MULTIDISCIPLINARY SCIENCES | IN-SITU HYBRIDIZATION | MUD VOLCANO | SP NOV | MARINE SUBSURFACE SEDIMENTS | 16S RIBOSOMAL-RNA | SULFATE-REDUCING BACTERIA | HANGING SPONGE-CUBES | METHANOTROPHIC ARCHAEA | Seawater - microbiology | Methane - metabolism | Gammaproteobacteria - metabolism | Molecular Sequence Data | Archaea - isolation & purification | Gammaproteobacteria - growth & development | Gammaproteobacteria - isolation & purification | Archaea - metabolism | Microbiota | Base Sequence | Bioreactors - microbiology | Gammaproteobacteria - genetics | Archaea - genetics | Archaea - growth & development | Methane | Polyurethane resins | Anaerobic microorganisms | Marine sediments | Cultivation | Incubation | Communities | Research & development--R&D | Archaea | Fluorescence | Phylogeny | Earth science | Sediments | Studies | Consortia | Engineering | Microorganisms | Bioreactors | Polyurethane | Fluorescence in situ hybridization | Phylogenetics | Hybridization analysis | Bacteria | Oxidation | Research & development | R&D
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