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1. Kikai nē Taiwan
: yi ge Riben nü sheng yan zhong de Taiwan
by Aoki, Yuka and Huang, Bijun, 1973
2012, Chu ban., Bu ke sheng huo, Volume 3, 153
Taiwan Social life and customs
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2. Consideration of Transport of Ammonium Nitrogen in a Tidal River
by Hiroyuki YAMANISHI and Yuka AOKI
Mizu Kankyo Gakkaishi = Journal of Japan Society on Water Environment, ISSN 0916-8958, 01/2019, Volume 42, Issue 3, p. 117
This study was aimed at investigating the influence of a sewage treatment plant's seasonal operation on the water quality and nutrient transport of a tidal... 
Removal | Sedimentation rates | Ammonium | Nutrient transport | Waste treatment | Suspended particulate matter | Empirical equations | Sewage treatment | Sewage treatment plants | Rivers | Nitrogen | Wastewater facilities | Sedimentation | Wastewater treatment | Surveys | Ammonium compounds | Sewage | Suspended solids | Water quality | Transport | Solid suspensions | Fluvial sediments | Tidal waterways
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3. Full Text Consideration of Transport of Ammonium Nitrogen in a Tidal River
by YAMANISHI, Hiroyuki and AOKI, Yuka
Journal of Japan Society on Water Environment, ISSN 0916-8958, 2019, Volume 42, Issue 3, pp. 117 - 122
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4. Full Text Prevalence of Atrial Fibrillation in Community-Dwelling Japanese Aged 40 Years or Older in Japan Analysis of 41,436 Non-Employee Residents in Kurashiki-City
by Iguchi, Yasuyuki and Kimura, Kazumi and Aoki, Junya and Kobayashi, Kazuto and Terasawa, Yuka and Sakai, Kenichiro and Shibazaki, Kensaku
Circulation Journal, ISSN 1346-9843, 2008, Volume 72, Issue 6, pp. 909 - 913
Background A community-based study was conducted to estimate the prevalence of atrial fibrillation (AF) in Japanese adults aged ≥40 years in Kurashiki-city and... 
Prevention | Cardiovascular disease | Stroke | Chronic kidney disease | Atrial fibrillation | cardiovascular disease | POPULATION | atrial fibrillation | chronic kidney disease | CARDIAC & CARDIOVASCULAR SYSTEMS | RISK-FACTORS | DISEASE | SECULAR TRENDS | stroke | prevention | Japan - epidemiology | Multivariate Analysis | Urban Population - statistics & numerical data | Age Distribution | Prevalence | Humans | Middle Aged | Risk Factors | Male | Liver Diseases - epidemiology | Hyperlipidemias - epidemiology | Renal Insufficiency, Chronic - epidemiology | Atrial Fibrillation - epidemiology | Employment | Smoking - epidemiology | Diabetes Mellitus - epidemiology | Aged, 80 and over | Sex Distribution | Adult | Female | Aged | Hypertension - epidemiology | Asian Continental Ancestry Group - statistics & numerical data
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5. Full Text A nonclassical vitamin D receptor pathway suppresses renal fibrosis
by Ito, Ichiaki and Waku, Tsuyoshi and Aoki, Masato and Abe, Rumi and Nagai, Yu and Watanabe, Tatsuya and Nakajima, Yuka and Ohkido, Ichiro and Yokoyama, Keitaro and Miyachi, Hiroyuki and Shimizu, Toshiyuki and Murayama, Akiko and Kishimoto, Hiroyuki and Nagasawa, Kazuo and Yanagisawa, Junn
Journal of Clinical Investigation, ISSN 0021-9738, 11/2013, Volume 123, Issue 11, pp. 4579 - 4594
The TGF-beta superfamily comprises pleiotropic cytokines that regulate SMAD and non-SMAD signaling. TGF-beta-SMAD signal transd.uction is known to be involved... 
MEDICINE, RESEARCH & EXPERIMENTAL | GROWTH-FACTOR-BETA | COMPLEX-FORMATION | TGF-BETA | NUCLEAR RECEPTORS | CRYSTAL-STRUCTURE | INTERSTITIAL FIBROSIS | GENE-EXPRESSION | 1,25-DIHYDROXYVITAMIN D-3 | MICE LACKING SMAD3 | EXPERIMENTAL GLOMERULONEPHRITIS | Kidney - pathology | Humans | Ureteral Obstruction - metabolism | RNA, Messenger - metabolism | Receptors, Calcitriol - genetics | Gene Knockdown Techniques | Calcitriol - analogs & derivatives | Kidney - metabolism | HEK293 Cells | Lactams - pharmacology | Ureteral Obstruction - genetics | Calcitriol - metabolism | Receptors, Calcitriol - antagonists & inhibitors | Promoter Regions, Genetic | Kidney - drug effects | Mice, Inbred C57BL | RNA, Messenger - genetics | Models, Molecular | Receptors, Calcitriol - metabolism | Drug Discovery | Animals | Signal Transduction - drug effects | Calcitriol - pharmacology | Ureteral Obstruction - pathology | Fibrosis | Ligands | Mice | Smad Proteins - metabolism | Transforming Growth Factor beta - metabolism | Care and treatment | Usage | Vitamin D | Physiological aspects | Calcifediol | Genetic aspects | Research | Alfacalcidol | Transforming growth factors | Health aspects | Kidneys | Gene expression | Experiments | Proteins | Studies | Signal transduction | Acids | Metabolites | Rodents | Collagen | Genetic engineering | Laboratory animals | Crystal structure
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6. Full Text Stochastic ERK Activation Induced by Noise and Cell-to-Cell Propagation Regulates Cell Density-Dependent Proliferation
by Aoki, Kazuhiro and Kumagai, Yuka and Sakurai, Atsuro and Komatsu, Naoki and Fujita, Yoshihisa and Shionyu, Clara and Matsuda, Michiyuki
Molecular Cell, ISSN 1097-2765, 11/2013, Volume 52, Issue 4, pp. 529 - 540
The extracellular signal-regulated kinase (ERK) plays a central role in the signaling cascades of cell growth. Here, we show that stochastic ERK activity... 
TUMOR PROGRESSION | PHOSPHORYLATION | PROTEIN-KINASE | FRET BIOSENSORS | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | EPIDERMAL-GROWTH-FACTOR | CONTACT INHIBITION | OSCILLATIONS | FIBROBLASTS | FEEDBACK | CELL BIOLOGY | Cell Line | Promoter Regions, Genetic | Cell Proliferation | raf Kinases - antagonists & inhibitors | Cell Count | Humans | Gene Expression Regulation | Cell Communication | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Rats | Imidazoles - pharmacology | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Time-Lapse Imaging | MAP Kinase Signaling System | Algorithms | Animals | Sequence Analysis, RNA | Stochastic Processes | Models, Biological | Benzamides - pharmacology | Enzyme Activation | Kinetics | RNA | Fluorescence | Genetic transcription
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7. Full Text Hydrogen sulfide‐induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice
by Okubo, Kazumasa and Matsumura, Midori and Kawaishi, Yudai and Aoki, Yuka and Matsunami, Maho and Okawa, Yasumasa and Sekiguchi, Fumiko and Kawabata, Atsufumi
British Journal of Pharmacology, ISSN 0007-1188, 07/2012, Volume 166, Issue 5, pp. 1738 - 1743
BACKGROUND AND PURPOSE Hydrogen sulfide, a gasotransmitter, facilitates somatic pain signals via activation of Cav3.2 T‐type calcium channels in rats. Given... 
pain | allodynia | hydrogen sulfide | T‐type calcium channel | transient receptor potential ankyrin‐1 (TRPA1) | hyperalgesia | Cav3.2 | T-type calcium channel | 3.2 | transient receptor potential ankyrin-1 (TRPA1) | Cav3 | RAT | INVOLVEMENT | MUSTARD OIL | INHIBITION | CALCIUM-CHANNELS | ROLES | NG108-15 CELLS | COVALENT MODIFICATION | NEURONS | PHARMACOLOGY & PHARMACY | BRAIN | Hyperalgesia - chemically induced | Transient Receptor Potential Channels - antagonists & inhibitors | Calcium Channels, T-Type - physiology | Gene Silencing | Male | Calcium Channel Blockers - pharmacology | Hyperalgesia - physiopathology | Animals | Sensory Receptor Cells - physiology | TRPA1 Cation Channel | Hydrogen Sulfide | Transient Receptor Potential Channels - physiology | Mice | Oligodeoxyribonucleotides - pharmacology | Isothiocyanates - pharmacology | Calcium | Medical research | Rodents | Research Papers
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8. Full Text Epidermal Growth Factor Plays a Crucial Role in Mitogenic Regulation of Human Brain Tumor Stem Cells
by Akio Soeda and Akihito Inagaki and Naoki Oka and Yuka Ikegame and Hitomi Aoki and Shin-ichi Yoshimura and Shigeru Nakashima and Takahiro Kunisada and Toru Iwama
Journal of Biological Chemistry, ISSN 0021-9258, 04/2008, Volume 283, Issue 16, pp. 10958 - 10966
A cancer stem cell population in malignant brain tumors takes an essential part in brain tumor initiation, growth, and recurrence. Growth factors, such as... 
FACTOR-RECEPTOR | NEURAL PROGENITORS | GLIOMAS | IN-VITRO | HUMAN GLIOBLASTOMA | EGF | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | PROLIFERATION | DIFFERENTIATION | CANCER-THERAPY | Phosphorylation | Epidermal Growth Factor - physiology | Peptides | Signal Transduction | Antigens, CD - biosynthesis | Humans | Enzyme Inhibitors - pharmacology | Gene Expression Regulation, Neoplastic | Tyrphostins - pharmacology | Stem Cells - metabolism | AC133 Antigen | Brain Neoplasms - metabolism | Glycoproteins - biosynthesis | Intercellular Signaling Peptides and Proteins - metabolism | Models, Biological | Tumor Cells, Cultured | Quinazolines - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors
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9. Full Text The Trifunctional Antibody (tri-31C2) Targeting CD38 and CD3 Has a Stronger Anti-Myeloma Effect Than the Chimeric Anti-CD38 Monoclonal Antibody (ch-31C2)
by Ishida, Tadao and Yasui, Hiroshi and Ishiguro, Kazuya and Aoki, Yuka and Ikeda, Hiroshi
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 2097 - 2097
Abstract 【Introduction】 The application of trifunctional, bispecific antibodies directed against CD38, a transmembrane glycoprotein, and CD3, a T-cell antigen,... 
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10. Full Text Upregulation of Cav3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain
by Takahashi, Tomoko and Aoki, Yuka and Okubo, Kazumasa and Maeda, Yumi and Sekiguchi, Fumiko and Mitani, Kenji and Nishikawa, Hiroyuki and Kawabata, Atsufumi
Pain, ISSN 0304-3959, 07/2010, Volume 150, Issue 1, pp. 183 - 191
Hydrogen sulfide (H S) formed from l-cysteine by multiple enzymes including cystathionine-γ-lyase (CSE) is now considered a gasotransmitter in the mammalian... 
Hydrogen sulfide | Pain | RNA interference | T-type calcium channel | Hyperalgesia | Neuropathic pain
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11. Full Text MT1-MMP recruits the ER-Golgi SNARE Bet1 for efficient MT1-MMP transport to the plasma membrane
by Miyagawa, T and Hasegawa, K and Aoki, Y and Watanabe, T and Otagiri, Y and Arasaki, K and Wakana, Y and Asano, K and Tanaka, M and Yamaguchi, H and Tagaya, M and Inoue, H
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 10/2019, Volume 218, Issue 10, pp. 3355 - 3371
Metastasis is a major cause of cancer-related death. Membrane type 1-matrix metalloproteinase (MT1-MMP) is a critical protease for local invasion and... 
COMPLEX | INVASION | INTERMEDIATE COMPARTMENT | METALLOPROTEINASE | TRAFFICKING | INVADOPODIUM FORMATION | VESICULAR TRANSPORT | EXTRACELLULAR-MATRIX DEGRADATION | ENDOPLASMIC-RETICULUM | MOLECULAR-MECHANISMS | CELL BIOLOGY | Membranes | Matrix metalloproteinases | Invasiveness | Trafficking | SNAP receptors | Metastasis | Matrix metalloproteinase | Cell surface | Golgi apparatus | Metastases | Syntaxin | Syntaxin 4 | Metalloproteinase | Transport | Endoplasmic reticulum | Endosomes
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12. Full Text Plant-derived polyphenols interact with staphylococcal enterotoxin A and inhibit toxin activity
by Shimamura, Yuko and Aoki, Natsumi and Sugiyama, Yuka and Tanaka, Takashi and Murata, Masatsune and Masuda, Shuichi
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, p. e0157082
This study was performed to investigate the inhibitory effects of 16 different plant-derived polyphenols on the toxicity of staphylococcal enterotoxin A (SEA).... 
METABOLITES | PROANTHOCYANIDINS | SUPERANTIGENS | MULTIDISCIPLINARY SCIENCES | TANNINS | DISEASE | AUREUS | HEALTH | OUTBREAK | EXTRACTS | FOOD | Gene Expression Regulation, Bacterial - drug effects | Plant Extracts - chemistry | Animals | Enterotoxins - toxicity | Plant Extracts - pharmacology | Polyphenols - chemistry | Polyphenols - pharmacology | Mice | Staphylococcal Food Poisoning - drug therapy | Staphylococcus aureus - drug effects | Disease Models, Animal | Staphylococcus aureus - metabolism | Bacterial toxins | Care and treatment | Staphylococcus aureus infections | Physiological aspects | Polyphenols | Genetic aspects | Research | Incubation | Toxicity | Staphylococcal enterotoxin A | Food contamination | Food poisoning | Enterotoxin A | Inhibition | Plants
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13. Full Text Hyperalgesia induced by spinal and peripheral hydrogen sulfide: Evidence for involvement of Cav3.2 T-type calcium channels
by Maeda, Yumi and Aoki, Yuka and Sekiguchi, Fumiko and Matsunami, Maho and Takahashi, Tomoko and Nishikawa, Hiroyuki and Kawabata, Atsufumi
Pain, ISSN 0304-3959, 03/2009, Volume 142, Issue 1-2, pp. 127 - 132
Hydrogen sulfide (H S), a gasotransmitter, facilitates membrane currents through T-type Ca channels, and intraplantar (i.pl.) administration of NaHS, a donor... 
Hydrogen sulfide | Spinal cord | Pain | T-type Ca | 3.2 | channel | Hyperalgesia | Hyperalgesia - chemically induced | Pain Threshold - physiology | Spinal Cord - drug effects | Hyperalgesia - metabolism | Rats, Wistar | Cerebellum - metabolism | Calcium Channel Blockers - therapeutic use | Oligodeoxyribonucleotides, Antisense - therapeutic use | Rats | Male | Hydrogen Sulfide - adverse effects | Mibefradil - therapeutic use | Hyperalgesia - pathology | Animals | Analysis of Variance | Calcium Channels, T-Type - metabolism | Hyperalgesia - drug therapy | Pain Threshold - drug effects | Calcium Channels, T-Type - genetics | Ganglia, Spinal - drug effects | Disease Models, Animal | Ganglia, Spinal - metabolism | Index Medicus
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14. Full Text Increased PD-1 expression and altered T cell repertoire diversity predict mortality in patients with septic shock: A preliminary study
by Tomino, Atsutoshi and Tsuda, Masanobu and Aoki, Ruri and Kajita, Yuka and Hashiba, Masamitsu and Terajima, Tsuguaki and Kano, Hideki and Takeyama, Naoshi
PLoS ONE, ISSN 1932-6203, 01/2017, Volume 12, Issue 1, p. e0169653
Sepsis causes impairment of innate and adaptive immunity by multiple mechanisms, including depletion of immune effector cells and T cell exhaustion. Although... 
IMMUNE DYSFUNCTIONS | HLA-DR | LIGANDS | IMMUNOTHERAPY | IMMUNOSUPPRESSION | MULTIDISCIPLINARY SCIENCES | DR EXPRESSION | INFECTION | TIME | INFLAMMATORY RESPONSE | SEVERE SEPSIS | T-Lymphocyte Subsets - immunology | Prognosis | Humans | Middle Aged | Male | Cytomegalovirus Infections - immunology | Cytomegalovirus Infections - genetics | Shock, Septic - immunology | Case-Control Studies | HLA-DR Antigens - genetics | Aged, 80 and over | Cytomegalovirus Infections - virology | Female | Shock, Septic - genetics | Cytomegalovirus | Gene Expression | Receptors, Antigen, T-Cell - metabolism | Immunophenotyping | Shock, Septic - mortality | Phenotype | T-Lymphocyte Subsets - metabolism | Biomarkers | Aged | HLA-DR Antigens - immunology | Receptors, Antigen, T-Cell - genetics | Programmed Cell Death 1 Receptor - genetics | Septic shock | Research | T cells | Health aspects | Mortality | Analysis | Shock | Flow cytometry | PD-1 protein | Effector cells | Critical care | Leukocytes (mononuclear) | Activation | Lymphocytes T | Infections | Recovery | Immunity | Blood | T-cell receptor | Lymphocytes | Immunotherapy | Peripheral blood mononuclear cells | Nosocomial infections | Deoxyribonucleic acid--DNA | Chronic illnesses | Cytokines | T cell receptors | Adaptive immunity | Patients | CD4 antigen | Polymerase chain reaction | Medicine | Cytometry | Monocytes | Antibiotics | Lymphopenia | Exhaustion | Sepsis | Ligands | Histocompatibility antigen HLA | Viral infections | Apoptosis | Deoxyribonucleic acid | DNA
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15. Full Text Inter-rater reliability of the Oral Assessment Guide for oral cancer patients between nurses and dental hygienists: the difficulties in objectively assessing oral health
by Aoki, Takayuki and Aoki, Takayuki and Kudo, Miyuki and Kudo, Miyuki and Endo, Maho and Endo, Maho and Nakayama, Yuka and Nakayama, Yuka and Amano, Akiyuki and Amano, Akiyuki and Naito, Mariko and Naito, Mariko and Ota, Yoshihide and Ota, Yoshihide
Supportive Care in Cancer, ISSN 0941-4355, 5/2019, Volume 27, Issue 5, pp. 1673 - 1677
Perioperative oral care is effective for the prevention and reduction of complications following surgery. However, oral cancer patients’ oral health is often... 
Pain Medicine | Inter-rater reliability | Nursing | Rehabilitation Medicine | Medicine & Public Health | Nursing Research | Oral assessment guide | Oral cancer | Nurses | Oncology | Dental hygienists | HEAD | ONCOLOGY | HEALTH CARE SCIENCES & SERVICES | REHABILITATION | PNEUMONIA | CARE | Medical colleges | Medical research | Care and treatment | Cancer patients | Medicine, Experimental | Mouth cancer | Oral health
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16. Full Text A novel type bacterial flagellar motor that can use divalent cations as a coupling ion
by Imazawa, Riku and Takahashi, Yuka and Aoki, Wataru and Sano, Motohiko and Ito, Masahiro
Scientific Reports, ISSN 2045-2322, 01/2016, Volume 6, Issue 1, p. 19773
The bacterial flagellar motor is a sophisticated nanomachine embedded in the cell envelope and powered by an electrochemical gradient of H+, Na+, or K+ across... 
MAGNESIUM | SODIUM | BACILLUS-SUBTILIS | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | SP-NOV | MOTILITY | Amino Acid Sequence | Movement - drug effects | Bacterial Proteins - chemistry | Amiloride - analogs & derivatives | Magnesium - metabolism | Cations, Monovalent - pharmacology | Paenibacillus - drug effects | Phylogeny | Cations, Divalent - pharmacology | Molecular Motor Proteins - chemistry | Mutation - genetics | Protein Subunits - metabolism | Paenibacillus - growth & development | Paenibacillus - metabolism | Flagella - metabolism | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Intracellular Space - metabolism | Amiloride - pharmacology | Flagella - drug effects | Bacterial Proteins - metabolism | Molecular Motor Proteins - metabolism | Protein Subunits - chemistry | Molecular modelling | Calcium | Bacterial proteins | Metals | Swimming | Magnesium | Flagella | Motor task performance
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17. Full Text Selective sensitization of C-fiber nociceptors by hydrogen sulfide
by Aoki, Yuka and Tsubota, Maho and Nishimoto, Yuta and Maeda, Yumi and Sekiguchi, Fumiko and Kawabata, Atsufumi
Journal of Pharmacological Sciences, ISSN 1347-8613, 01/2016, Volume 130, Issue 1, pp. 38 - 41
We examined the effects of intraplantar (i.pl.) administration of NaHS, an H S donor, known to cause T-type Ca channel (T-channel)-dependent mechanical... 
Hydrogen sulfide | C-fiber nociceptor | T-type calcium channel | ACTIVATION | PAIN | CALCIUM-CHANNELS | ELECTRICAL-STIMULATION | INVOLVEMENT | PHARMACOLOGY & PHARMACY | HYPERALGESIA | MICE | BLADDER | Calcium Channels, T-Type - physiology | Hydrogen Sulfide - pharmacology | Phosphorylation | Rats, Wistar | Calcium Channel Blockers - therapeutic use | Spinal Cord - enzymology | Nociceptors - physiology | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Calcium Channel Blockers - pharmacology | Sulfides - administration & dosage | Animals | Hyperalgesia - drug therapy | Sulfides - adverse effects | Hyperalgesia - etiology | Nociceptors - metabolism | Electric Stimulation - methods | Nociceptors - drug effects
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18. Full Text Somatic BRAF c.1799T>A p.V600E Mosaicism syndrome characterized by a linear syringocystadenoma papilliferum, anaplastic astrocytoma, and ocular abnormalities
by Watanabe, Yuko and Shido, Kosuke and Niihori, Tetsuya and Niizuma, Hidetaka and Katata, Yu and Iizuka, Chie and Oba, Daiju and Moriya, Kunihiko and Saito‐Nanjo, Yuka and Onuma, Masaei and Rikiishi, Takeshi and Sasahara, Yoji and Watanabe, Mika and Aiba, Setsuya and Saito, Ryuta and Sonoda, Yukihiko and Tominaga, Teiji and Aoki, Yoko and Kure, Shigeo
American Journal of Medical Genetics Part A, ISSN 1552-4825, 01/2016, Volume 170, Issue 1, pp. 189 - 194
Genetic mosaicism for somatic mutations of oncogenes is common in genodermatoses, which can be complicated with extra‐cutaneous abnormalities. Here we describe... 
vemurafenib | BRAF c.1799T>A p.V600E | Schimmelpenning‐Feuerstein‐Mims syndrome | anaplastic astrocytoma | Schimmelpenning-Feuerstein-Mims syndrome | Vemurafenib | Anaplastic astrocytoma | Astrocytoma - genetics | Eye - pathology | Sweat Gland Neoplasms - drug therapy | Premature Birth | Humans | Brain Neoplasms - genetics | Infant | Brain Neoplasms - drug therapy | Eye Abnormalities - genetics | Sweat Gland Neoplasms - genetics | Adenoma, Sweat Gland - genetics | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Adenoma, Sweat Gland - drug therapy | Sulfonamides - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Astrocytoma - drug therapy | Nevus, Sebaceous of Jadassohn - genetics | Indoles - therapeutic use | Mosaicism | Eye diseases | Chemotherapy | Cancer
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